Abstract
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in melanoma. For example, members of the ABC family were shown to support cancer stemness-like features in melanoma cells, while several members of the TRP channel family were reported to act as tumor suppressors.
Also, many transporter proteins support tumor cell viability and thus suppress apoptosis induction by anticancer therapy. Due to the high number of ion channels and transporters and the resulting high complexity of the field, progress in understanding is often focused on single molecules and is in total rather slow. In this review, we aim at giving an overview about a broad subset of ion transporters, also illustrating some aspects of the field, which have not been addressed in detail in melanoma. In context with the other chapters in this special issue on “Transportome Malfunctions in the Cancer Spectrum,” a comparison between melanoma and these tumors will be possible.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abele R, Tampe R (2004) The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing. Physiology (Bethesda) 19:216–224. https://doi.org/10.1152/physiol.00002.2004
Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T (2003) Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol 285:F1188–F1197. https://doi.org/10.1152/ajprenal.00402.2002
Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F (2012) Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res 72:2957–2969. https://doi.org/10.1158/0008-5472.CAN-11-1947
Adinolfi E, Capece M, Franceschini A, Falzoni S, Giuliani AL, Rotondo A, Sarti AC, Bonora M, Syberg S, Corigliano D, Pinton P, Jorgensen NR, Abelli L, Emionite L, Raffaghello L, Pistoia V, Di Virgilio F (2015) Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Res 75:635–644. https://doi.org/10.1158/0008-5472.CAN-14-1259
Alexander SPH, Mathie A, Peters JA (2011) Transporters. Br J Pharmacol 164:S213–S278. https://doi.org/10.1111/j.1476-5381.2011.01649_8.x
Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA (2017) The concise guide to pharmacology 2017/2018:transporters: transporters. Br J Pharmacol 174(Suppl 1):S360–S446. https://doi.org/10.1111/bph.13883
Almasi S, Sterea AM, Fernando W, Clements DR, Marcato P, Hoskin DW, Gujar S, El Hiani Y (2019) TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway. Sci Rep 9:4182. https://doi.org/10.1038/s41598-019-40330-1
Alonso SR, Tracey L, Ortiz P, Pérez-Gómez B, Palacios J, Pollán M, Linares J, Serrano S, Sáez-Castillo AI, Sánchez L, Pajares R, Sánchez-Aguilera A, Artiga MJ, Piris MA, Rodríguez-Peralto JL (2007) A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res 67:3450–3460. https://doi.org/10.1158/0008-5472.CAN-06-3481
Ambrosini G, Pratilas CA, Qin L-X, Tadi M, Surriga O, Carvajal RD, Schwartz GK (2012) Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance. Clin Cancer Res 18:3552–3561. https://doi.org/10.1158/1078-0432.CCR-11-3086
Ambrosio AL, Boyle JA, Aradi AE, Christian KA, Di Pietro SM (2016) TPC2 controls pigmentation by regulating melanosome pH and size. Proc Natl Acad Sci U S A 113:5622–5627. https://doi.org/10.1073/pnas.1600108113
Anaya J (2016) OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs. Peer J Comp Sci 2:e67. https://doi.org/10.7717/peerj-cs.67
Arcangeli A, Romoli MR, Boni L, Gerlini G, Tofani L, Urso C, Borgognoni L (2013) High hERG1 expression in advanced melanoma. Melanoma Res 23:185–190. https://doi.org/10.1097/CMR.0b013e32835fc6c9
Assan F, Vilaine E, Wagner S, Longvert C, Saiag P, Seidowsky A, Bourgault-Villada I, Massy ZA (2019) Hyponatremia and MAP-kinase inhibitors in malignant melanoma: frequency, pathophysiological aspects and clinical consequences. Pigment Cell Melanoma Res 32:326–331. https://doi.org/10.1111/pcmr.12749
Bai X, Moraes TF, Reithmeier RAF (2017) Structural biology of solute carrier (SLC) membrane transport proteins. Mol Membr Biol 34:1–32. https://doi.org/10.1080/09687688.2018.1448123
Bakry OA, Hagag MM, Kandil MA, Shehata WA (2016) Aquaporin 3 and E-Cadherin expression in perilesional vitiligo skin. J Clin Diagn Res: JCDR 10:Wc01–wc06. https://doi.org/10.7860/jcdr/2016/22730.8959
Barneaud-Rocca D, Borgese F, Guizouarn H (2011) Dual transport properties of anion exchanger 1: the same transmembrane segment is involved in anion exchange and in a cation leak. J Biol Chem 286:8909–8916. https://doi.org/10.1074/jbc.M110.166819
Bauer D, Werth F, Nguyen HA, Kiecker F, Eberle J (2017) Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells. Cell Death Dis 8:e2594. https://doi.org/10.1038/cddis.2017.6
Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK (2011) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476:341–345. https://doi.org/10.1038/nature10234
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt S-E, Julius D (2007) The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448:204–208. https://doi.org/10.1038/nature05910
Beck D, Niessner H, Smalley KSM, Flaherty K, Paraiso KHT, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Driessen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F (2013) Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. Sci Signal 6:ra7. https://doi.org/10.1126/scisignal.2003057
Begicevic R-R, Falasca M (2017) ABC transporters in cancer stem cells: beyond chemoresistance. Int J Mol Sci 18:1–23. https://doi.org/10.3390/ijms18112362
Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM (2002) NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem 277:47399–47406. https://doi.org/10.1074/jbc.M204759200
Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000) Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289:957–960. https://doi.org/10.1126/science.289.5481.957
Bellono NW, Najera JA, Oancea E (2014) UV light activates a Galphaq/11-coupled phototransduction pathway in human melanocytes. J Gen Physiol 143:203–214. https://doi.org/10.1085/jgp.201311094
Bergeron M-A, Champagne S, Gaudreault M, Deschambeault A, Landreville S (2012) Repression of genes involved in melanocyte differentiation in uveal melanoma. Mol Vis 18:1813–1822
Bian G-H, Cao G, Lv X-Y, Li Q-W, Sun H, Xiao Y, Ai J-Z, Yang Q-T, Duan J-J, Wang Y-D, Zhang Z, Tan R-Z, Liu Y-H, Yang Y, Wei Y-Q, Zhou Q (2010) Down-regulation of Pkd2 by siRNAs suppresses cell-cell adhesion in the mouse melanoma cells. Mol Biol Rep 37:2387–2395. https://doi.org/10.1007/s11033-009-9746-5
Biasiotta A, D’Arcangelo D, Passarelli F, Nicodemi EM, Facchiano A (2016) Ion channels expression and function are strongly modified in solid tumors and vascular malformations. J Transl Med 14:285. https://doi.org/10.1186/s12967-016-1038-y
Biel M, Wahl-Schott C, Michalakis S, Zong X (2009) Hyperpolarization-activated cation channels: from genes to function. Physiol Rev 89:847–885. https://doi.org/10.1152/physrev.00029.2008
Bin B-H, Bhin J, Yang SH, Shin M, Nam Y-J, Choi D-H, Shin DW, Lee A-Y, Hwang D, Cho E-G, Lee TR (2015) Membrane-associated transporter protein (MATP) regulates melanosomal pH and influences tyrosinase activity. PLoS One 10:e0129273. https://doi.org/10.1371/journal.pone.0129273
Boedtkjer E, Moreira JMA, Mele M, Vahl P, Wielenga VT, Christiansen PM, Jensen VED, Pedersen SF, Aalkjaer C (2013) Contribution of Na+,HCO3(−)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7). Int J Cancer 132:1288–1299. https://doi.org/10.1002/ijc.27782
Bohme I, Bosserhoff AK (2016) Acidic tumor microenvironment in human melanoma. Pigment Cell Melanoma Res 29:508–523. https://doi.org/10.1111/pcmr.12495
Bohme I, Bosserhoff A (2019) Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells. Pigment Cell Melanoma Res 33(1):41–51. https://doi.org/10.1111/pcmr.12811
Bootman MD, Lipp P, Berridge MJ (2001) The organisation and functions of local Ca(2+) signals. J Cell Sci 114:2213–2222
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947–956. https://doi.org/10.1016/j.cell.2005.08.020
Brackenbury WJ (2016) Ion channels in cancer: chapter 6. In: Pitt GS (ed) Ion channels in health and disease. Academic Press is an imprint of Elsevier. Academic Press, London, pp 131–163
Buchanan PJ, McCloskey KD (2016) CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics. Eur Biophys J 45:621–633. https://doi.org/10.1007/s00249-016-1144-z
Burnstock G (2016) An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration. Neuropharmacology 104:4–17. https://doi.org/10.1016/j.neuropharm.2015.05.031
Bustos G, Cruz P, Lovy A, Cárdenas C (2017) Endoplasmic reticulum-mitochondria calcium communication and the regulation of mitochondrial metabolism in cancer: a novel potential target. Front Oncol 7:199. https://doi.org/10.3389/fonc.2017.00199
Cardoso MFS, Castelletti CHM, de Lima-Filho J, Martins DBG, Teixeira JAC (2017) Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. Mutat Res 773:161–173. https://doi.org/10.1016/j.mrrev.2017.06.002
Carpi S, Polini B, Poli G, Alcantara Barata G, Fogli S, Romanini A, Tuccinardi T, Guella G, Frontini FP, Nieri P, Di Giuseppe G (2018) Anticancer activity of Euplotin C, isolated from the marine ciliate Euplotes crassus, against human melanoma cells. Mar Drugs 16:1–15. https://doi.org/10.3390/md16050166
Castiglioni S, Maier JAM (2011) Magnesium and cancer: a dangerous liason. Magnes Res 24:92–100. https://doi.org/10.1684/mrh.2011.0285
Catterall WA (2011) Voltage-gated calcium channels. Cold Spring Harb Perspect Biol 3:a003947. https://doi.org/10.1101/cshperspect.a003947
Chalmers SB, Monteith GR (2018) ORAI channels and cancer. Cell Calcium 74:160–167. https://doi.org/10.1016/j.ceca.2018.07.011
Chang C-Y, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E (2013) NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature 495:98–102. https://doi.org/10.1038/nature11847
Cheli Y, Luciani F, Khaled M, Beuret L, Bille K, Gounon P, Ortonne J-P, Bertolotto C, Ballotti R (2009) {alpha}MSH and cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism. J Biol Chem 284:18699–18706. https://doi.org/10.1074/jbc.M109.005819
Chen KG, Szakacs G, Annereau J-P, Rouzaud F, Liang X-J, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM (2005) Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res 18:102–112. https://doi.org/10.1111/j.1600-0749.2005.00214.x
Chen Y, Wei X, Yan P, Han Y, Sun S, Wu K, Fan D (2009a) Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. Cancer Biol Ther 8:607–614. https://doi.org/10.4161/cbt.8.7.7920
Chen KG, Valencia JC, Gillet J-P, Hearing VJ, Gottesman MM (2009b) Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res 22:740–749. https://doi.org/10.1111/j.1755-148X.2009.00630.x
Chen RS, Song YM, Zhou ZY, Tong T, Li Y, Fu M, Guo XL, Dong LJ, He X, Qiao HX, Zhan QM, Li W (2009c) Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Oncogene 28:599–609. https://doi.org/10.1038/onc.2008.414
Chen Y-F, Chen Y-T, Chiu W-T, Shen M-R (2013) Remodeling of calcium signaling in tumor progression. J Biomed Sci 20:23. https://doi.org/10.1186/1423-0127-20-23
Chen X, Wang R, Chen A, Wang Y, Zhou J, Cao R (2019) Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193. Biomed Pharmacother 111:1124–1131. https://doi.org/10.1016/j.biopha.2019.01.012
Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (2003) VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (New York, NY) 301:513–517. https://doi.org/10.1126/science.1083995
Cherepanova NA, Shrimal S, Gilmore R (2014) Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins. J Cell Biol 206:525–539. https://doi.org/10.1083/jcb.201404083
Chiche J, Brahimi-Horn MC, Pouyssegur J (2010) Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14:771–794. https://doi.org/10.1111/j.1582-4934.2009.00994.x
Chintala S, Li W, Lamoreux ML, Ito S, Wakamatsu K, Sviderskaya EV, Bennett DC, Park YM, Gahl WA, Huizing M, Spritz RA, Ben S, Novak EK, Tan J, Swank RT (2005) Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells. Proc Natl Acad Sci U S A 102:10964–10969. https://doi.org/10.1073/pnas.0502856102
Chung H, Jung H, Jho E-H, Multhaupt HAB, Couchman JR, Oh E-S (2018) Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation. Biochem Biophys Res Commun 503:615–620. https://doi.org/10.1016/j.bbrc.2018.06.050
Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst J, Schlessinger A (2015) Ligand discovery for the alanine-serine-cysteine transporter (ASCT2, SLC1A5) from homology modeling and virtual screening. PLoS Comput Biol 11:e1004477. https://doi.org/10.1371/journal.pcbi.1004477
Colombini M (2016) The VDAC channel: molecular basis for selectivity. Biochim Biophys Acta 1863:2498–2502. https://doi.org/10.1016/j.bbamcr.2016.01.019
Colone M, Calcabrini A, Toccacieli L, Bozzuto G, Stringaro A, Gentile M, Cianfriglia M, Ciervo A, Caraglia M, Budillon A, Meo G, Arancia G, Molinari A (2008) The multidrug transporter P-glycoprotein: a mediator of melanoma invasion? J Investig Dermatol 128:957–971. https://doi.org/10.1038/sj.jid.5701082
Curry MC, Roberts-Thomson SJ, Monteith GR (2011) Plasma membrane calcium ATPases and cancer. Biofactors 37:132–138. https://doi.org/10.1002/biof.146
D’Arcangelo D, Scatozza F, Giampietri C, Marchetti P, Facchiano F, Facchiano A (2019) Ion channel expression in human melanoma samples: in Silico identification and experimental validation of molecular targets. Cancers (Basel) 11:446. https://doi.org/10.3390/cancers11040446
Das A, Pushparaj C, Bahi N, Sorolla A, Herreros J, Pamplona R, Vilella R, Matias-Guiu X, Marti RM, Canti C (2012) Functional expression of voltage-gated calcium channels in human melanoma. Pigment Cell Melanoma Res 25:200–212. https://doi.org/10.1111/j.1755-148X.2012.00978.x
Dawson PA, Lan T, Rao A (2009) Bile acid transporters. J Lipid Res 50:2340–2357. https://doi.org/10.1194/jlr.R900012-JLR200
de Stefani D, Bononi A, Romagnoli A, Messina A, de Pinto V, Pinton P, Rizzuto R (2012) VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria. Cell Death Differ 19:267–273. https://doi.org/10.1038/cdd.2011.92
Dean M, Hamon Y, Chimini G (2001) The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 42:1007–1017
Decker AR, McNeill MS, Lambert AM, Overton JD, Chen Y-C, Lorca RA, Johnson NA, Brockerhoff SE, Mohapatra DP, MacArthur H, Panula P, Masino MA, Runnels LW, Cornell RA (2014) Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Dev Biol 386:428–439. https://doi.org/10.1016/j.ydbio.2013.11.015
Deli T, Varga N, Adam A, Kenessey I, Raso E, Puskas LG, Tovari J, Fodor J, Feher M, Szigeti GP, Csernoch L, Timar J (2007) Functional genomics of calcium channels in human melanoma cells. Int J Cancer 121:55–65. https://doi.org/10.1002/ijc.22621
Deliot N, Constantin B (2015) Plasma membrane calcium channels in cancer: alterations and consequences for cell proliferation and migration. Biochim Biophys Acta 1848:2512–2522. https://doi.org/10.1016/j.bbamem.2015.06.009
Deng Y, Li H, Yin X, Liu H, Liu J, Guo D, Shi Z (2018) C-terminal binding protein 1 modulates cellular redox via feedback regulation of MPC1 and MPC2 in melanoma cells. Med Sci Monit 24:7614–7624. https://doi.org/10.12659/MSM.912735
Depeille P, Cuq P, Mary S, Passagne I, Evrard A, Cupissol D, Vian L (2004) Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects. Mol Pharmacol 65:897–905. https://doi.org/10.1124/mol.65.4.897
Ding XW, Luo HS, Luo B, Xu DQ, Gao S (2008) Overexpression of hERG1 in resected esophageal squamous cell carcinomas: a marker for poor prognosis. J Surg Oncol 97:57–62. https://doi.org/10.1002/jso.20891
Dissemond J, Götte P, Mörs J, Lindeke A, Goos M, Ferrone S, Wagner SN (2003) Association of TAP1 downregulation in human primary melanoma lesions with lack of spontaneous regression. Melanoma Res 13:253–258. https://doi.org/10.1097/01.cmr.0000056237.78713.65
Dixon WT, Sikora LK, Demetrick DJ, Jerry LM (1990) Isolation and characterization of a heterodimeric surface antigen on human melanoma cells and evidence that it is the 4F2 cell activation/proliferation molecule. Int J Cancer 45:59–68
Dolderer JH, Schuldes H, Bockhorn H, Altmannsberger M, Lambers C, von Zabern D, Jonas D, Schwegler H, Linke R, Schroder UH (2010) HERG1 gene expression as a specific tumor marker in colorectal tissues. Eur J Surg Oncol 36:72–77. https://doi.org/10.1016/j.ejso.2009.05.009
Domenichini A, Adamska A, Falasca M (2019) ABC transporters as cancer drivers: potential functions in cancer development. Biochim Biophys Acta Gen Subj 1863:52–60. https://doi.org/10.1016/j.bbagen.2018.09.019
Draoui N, Feron O (2011) Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech 4:727–732. https://doi.org/10.1242/dmm.007724
Du J, Fisher DE (2002) Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem 277:402–406. https://doi.org/10.1074/jbc.M110229200
Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515–1520
Dunne BM, McNamara M, Clynes M, Shering SG, Larkin AM, Moran E, Barnes C, Kennedy SM (1998) MDR1 expression is associated with adverse survival in melanoma of the uveal tract. Hum Pathol 29:594–598
Dura M, Nemejcova K, Jaksa R, Bartu M, Kodet O, Ticha I, Michalkova R, Dundr P (2019) Expression of Glut-1 in malignant melanoma and melanocytic nevi: an immunohistochemical study of 400 cases. Pathol Oncol Res 25:361–368. https://doi.org/10.1007/s12253-017-0363-7
Durmus S, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH (2012) Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Mol Pharm 9:3236–3245. https://doi.org/10.1021/mp3003144
Dutta B, Huang W, Molero M, Kekuda R, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (1999) Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem 274:31925–31929. https://doi.org/10.1074/jbc.274.45.31925
Eberle J (2019) Countering TRAIL resistance in melanoma. Cancers (Basel) 11:656. https://doi.org/10.3390/cancers11050656
Elliott AM, Al-Hajj MA (2009) ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res 7:79–87. https://doi.org/10.1158/1541-7786.MCR-08-0235
Etoga J-LG, Ahmed SK, Patel S, Bridges RJ, Thompson CM (2010) Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(−) over the vesicular glutamate transporter. Bioorg Med Chem Lett 20:2680–2683. https://doi.org/10.1016/j.bmcl.2009.10.020
Fahrner M, Schindl R, Muik M, Derler I, Romanin C (2017) The STIM-Orai pathway: the interactions between STIM and Orai. Adv Exp Med Biol 993:59–81. https://doi.org/10.1007/978-3-319-57732-6_4
Fernandez LP, Milne RL, Pita G, Aviles JA, Lazaro P, Benitez J, Ribas G (2008) SLC45A2: a novel malignant melanoma-associated gene. Hum Mutat 29:1161–1167. https://doi.org/10.1002/humu.20804
Fernandez-Salas E, Suh KS, Speransky VV, Bowers WL, Levy JM, Adams T, Pathak KR, Edwards LE, Hayes DD, Cheng C, Steven AC, Weinberg WC, Yuspa SH (2002) mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. Mol Cell Biol 22:3610–3620. https://doi.org/10.1128/mcb.22.11.3610-3620.2002
Fiorio Pla A, Kondratska K, Prevarskaya N (2016) STIM and ORAI proteins: crucial roles in hallmarks of cancer. Am J Physiol Cell Physiol 310:C509–C519. https://doi.org/10.1152/ajpcell.00364.2015
Finn RN, Chauvigne F, Hlidberg JB, Cutler CP, Cerda J (2014) The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation. PloS One 9:e113686. https://doi.org/10.1371/journal.pone.0113686
Fischer W, Urban N, Immig K, Franke H, Schaefer M (2014) Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal 10:313–326. https://doi.org/10.1007/s11302-013-9392-1
Flaherty KT, Hennig M, Lee SJ, Ascierto PA, Dummer R, Eggermont AMM, Hauschild A, Kefford R, Kirkwood JM, Long GV, Lorigan P, Mackensen A, McArthur G, O’Day S, Patel PM, Robert C, Schadendorf D (2014) Surrogate endpoints for overall survival in metastatic melanoma: a meta-analysis of randomised controlled trials. Lancet Oncol 15:297–304. https://doi.org/10.1016/S1470-2045(14)70007-5
Fletcher JI, Haber M, Henderson MJ, Norris MD (2010) ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 10:147–156. https://doi.org/10.1038/nrc2789
Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh MH, Frank MH (2003) Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem 278:47156–47165. https://doi.org/10.1074/jbc.M308700200
Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser A-M, Kupper TS, Murphy GF, Frank MH (2011) VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res 71:1474–1485. https://doi.org/10.1158/0008-5472.CAN-10-1660
Fraser SP, Pardo LA (2008) Ion channels: functional expression and therapeutic potential in cancer. Colloquium on ion channels and cancer. EMBO Rep 9:512–515. https://doi.org/10.1038/embor.2008.75
Fredriksson R, Nordstrom KJV, Stephansson O, Hagglund MGA, Schioth HB (2008) The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett 582:3811–3816. https://doi.org/10.1016/j.febslet.2008.10.016
Fu S, Hirte H, Welch S, Ilenchuk TT, Lutes T, Rice C, Fields N, Nemet A, Dugourd D, Piha-Paul S, Subbiah V, Liu L, Gong J, Hong D, Stewart JM (2017) First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Investig New Drugs 35:324–333. https://doi.org/10.1007/s10637-017-0438-z
Fukumoto S, Hanazono K, Fu DR, Endo Y, Kadosawa T, Iwano H, Uchide T (2013) A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model. Biochem Biophys Res Commun 439:103–108. https://doi.org/10.1016/j.bbrc.2013.08.020
Funato Y, Yamazaki D, Mizukami S, Du L, Kikuchi K, Miki H (2014) Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression. J Clin Investig 124:5398–5410. https://doi.org/10.1172/JCI76614
Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T (2006) Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res 66:6080–6086. https://doi.org/10.1158/0008-5472.CAN-06-0157
Gao Y, Liao P (2019) TRPM4 channel and cancer. Cancer Lett 454:66–69. https://doi.org/10.1016/j.canlet.2019.04.012
Gao K, Lockwood WW, Li J, Lam W, Li G (2008) Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells. Int J Oncol 32:1343–1349
Gao L, Gao Y, Li X, Howell P, Kumar R, Su X, Vlassov AV, Piazza GA, Riker AI, Sun D, Xi Y (2012) Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Mol Oncol 6:81–87. https://doi.org/10.1016/j.molonc.2011.11.001
Gao Z, Shang Q, Liu Z, Deng C, Guo C (2015) Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. Oncotarget 6:36338–36353. https://doi.org/10.18632/oncotarget.5537
Gao J, Zeng K, Liu Y, Gao L, Liu L (2019) LncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR-26a-5p/TRPC3 pathway. Onco Targets Therapy 12:169–179. https://doi.org/10.2147/OTT.S184078
Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891–899. https://doi.org/10.1038/nrc1478
Giannopoulou AF, Konstantakou EG, Velentzas AD, Avgeris SN, Avgeris M, Papandreou NC, Zoi I, Filippa V, Katarachia S, Lampidonis AD, Prombona A, Syntichaki P, Piperi C, Basdra EK, Iconomidou V, Papadavid E, Anastasiadou E, Papassideri IS, Papavassiliou AG, Voutsinas GE, Scorilas A, Stravopodis DJ (2019) Gene-specific intron retention serves as molecular signature that distinguishes melanoma from non-melanoma cancer cells in Greek patients. Int J Mol Sci 20:1–34. https://doi.org/10.3390/ijms20040937
Goldman M, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, Zhu J, Haussler D (2018) The UCSC Xena platform for public and private cancer genomics data visualization and interpretation. BioRxiv:326470. http://xena.ucsc.edu/
Gorbatenko A, Olesen CW, Boedtkjer E, Pedersen SF (2014) Regulation and roles of bicarbonate transporters in cancer. Front Physiol 5:130. https://doi.org/10.3389/fphys.2014.00130
Graf J, Hodgson R, van Daal A (2005) Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation. Hum Mutat 25:278–284. https://doi.org/10.1002/humu.20143
Grottker J (2019) Expression von SLC-Transportern in Melanomzelllinien und Charakterisierung von MATE1 und OCT1 in ihrer Funktion als Zytostatikatransporter. https://ediss.uni-goettingen.de/handle/11858/00-1735-0000-0006-B07B-5?locale-attribute=en. Accessed 31 July 2019
Grunewald TGP, Bach H, Cossarizza A, Matsumoto I (2012) The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. Biol Cell 104:641–657. https://doi.org/10.1111/boc.201200027
Guedj M, Bourillon A, Combadieres C, Rodero M, Dieude P, Descamps V, Dupin N, Wolkenstein P, Aegerter P, Lebbe C, Basset-Seguin N, Prum B, Saiag P, Grandchamp B, Soufir N (2008) Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population. Hum Mutat 29:1154–1160. https://doi.org/10.1002/humu.20823
Hagenbuch B, Meier PJ (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447:653–665. https://doi.org/10.1007/s00424-003-1168-y
Halestrap AP, Meredith D (2004) The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619–628. https://doi.org/10.1007/s00424-003-1067-2
Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, Jia Z (2019) Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol 55:629–644. https://doi.org/10.3892/ijo.2019.4839
Hantute-Ghesquier A, Haustrate A, Prevarskaya N, Lehen’kyi VY (2018) TRPM family channels in cancer. Pharmaceuticals (Basel) 11:1–14. https://doi.org/10.3390/ph11020058
Hanukoglu I, Hanukoglu A (2016) Epithelial sodium channel (ENaC) family: phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene 579:95–132. https://doi.org/10.1016/j.gene.2015.12.061
Harada M, Li YF, El-Gamil M, Rosenberg SA, Robbins PF (2001) Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A*0201-restricted T cells. Cancer Res 61:1089–1094
Hattori F, Ohshima Y, Seki S, Tsukimoto M, Sato M, Takenouchi T, Suzuki A, Takai E, Kitani H, Harada H, Kojima S (2012) Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7. Eur J Pharmacol 695:20–26. https://doi.org/10.1016/j.ejphar.2012.09.001
Hauschild A, Larkin J, Ribas A, Dreno B, Flaherty KT, Ascierto PA, Lewis KD, McKenna E, Zhu Q, Mun Y, McArthur GA (2018) Modeled prognostic subgroups for survival and treatment outcomes in BRAF V600-mutated metastatic melanoma: pooled analysis of 4 randomized clinical trials. JAMA Oncol 4:1382–1388. https://doi.org/10.1001/jamaoncol.2018.2668
Haustrate A, Hantute-Ghesquier A, Prevarskaya N, Lehen’kyi VY (2019) TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer. Cell Calcium 80:117–124. https://doi.org/10.1016/j.ceca.2019.04.006
Hegedus L, Garay T, Molnar E, Varga K, Bilecz A, Torok S, Padanyi R, Paszty K, Wolf M, Grusch M, Kallay E, Dome B, Berger W, Hegedus B, Enyedi A (2017) The plasma membrane Ca(2+) pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells. Int J Cancer 140:2758–2770. https://doi.org/10.1002/ijc.30503
Heimerl S, Bosserhoff AK, Langmann T, Ecker J, Schmitz G (2007) Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells. Melanoma Res 17:265–273. https://doi.org/10.1097/CMR.0b013e3282a7e0b9
Hemmerlein B, Weseloh RM, Mello de Queiroz F, Knotgen H, Sanchez A, Rubio ME, Martin S, Schliephacke T, Jenke M, Heinz Joachim R, Stuhmer W, Pardo LA (2006) Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer 5:41. https://doi.org/10.1186/1476-4598-5-41
Hirschhaeuser F, Sattler UGA, Mueller-Klieser W (2011) Lactate: a metabolic key player in cancer. Cancer Res 71:6921–6925. https://doi.org/10.1158/0008-5472.CAN-11-1457
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008) Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res 21:665–676. https://doi.org/10.1111/j.1755-148X.2008.00505.x
Hofschröer V, Koch KA, Ludwig FT, Friedl P, Oberleithner H, Stock C, Schwab A (2017) Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells. Sci Rep 7:42369. https://doi.org/10.1038/srep42369
Hoth M, Penner R (1992) Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355:353–356. https://doi.org/10.1038/355353a0
Hu J, Verkman AS (2006) Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J 20:1892–1894. https://doi.org/10.1096/fj.06-5930fje
Huang L, Li B, Li W, Guo H, Zou F (2009) ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis 30:737–744. https://doi.org/10.1093/carcin/bgp034
Huber S, Huettner JP, Hacker K, Bernhardt G, Konig J, Buschauer A (2015) Esters of bendamustine are by far more potent cytotoxic agents than the parent compound against human sarcoma and carcinoma cells. PLoS One 10:e0133743. https://doi.org/10.1371/journal.pone.0133743
Imredi E, Toth B, Doma V, Barbai T, Raso E, Kenessey I, Timar J (2016) Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma. Melanoma Res 26:254–260. https://doi.org/10.1097/cmr.0000000000000243
Imredi E, Liszkay G, Kenessey I, Plotar V, Godeny M, Toth B, Fedorcsak I, Timar J (2018) Aquaporin-1 protein expression of the primary tumor may predict cerebral progression of cutaneous melanoma. Pathol Oncol Res:1–6. https://doi.org/10.1007/s12253-018-0513-6
IUPHAR (2019) SLC13 family of sodium-dependent sulphate/carboxylate transporters. http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185. Accessed 26 June 2019
Jiang L, Zhao Y-D, Chen W-X (2017) The function of the novel mechanical activated ion channel Piezo1 in the human osteosarcoma cells. Med Sci Monit 23:5070–5082. https://doi.org/10.12659/msm.906959
Jung J, Cho K-J, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K (2019) HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep 20:e46685. https://doi.org/10.15252/embr.201846685
Kamer KJ, Mootha VK (2015) The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol 16:545–553. https://doi.org/10.1038/nrm4039
Kanekura T, Miyauchi T, Tashiro M, Muramatsu T (1991) Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct Funct 16:23–30
Kang HY, Kim NS, Lee CO, Lee JY, Kang WH (2000) Expression and function of ryanodine receptors in human melanocytes. J Cell Physiol 185:200–206. https://doi.org/10.1002/1097-4652(200011)185:2<200::Aid-jcp4>3.0.Co;2-6
Kappelmann M, Kuphal S, Meister G, Vardimon L, Bosserhoff A-K (2013) MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. Oncogene 32:2984–2991. https://doi.org/10.1038/onc.2012.307
Katano K, Kondo A, Safaei R, Holzer A, Samimi G, Mishima M, Kuo YM, Rochdi M, Howell SB (2002) Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper. Cancer Res 62:6559–6565
Kato Y, Ozawa S, Miyamoto C, Maehata Y, Suzuki A, Maeda T, Baba Y (2013) Acidic extracellular microenvironment and cancer. Cancer Cell Int 13:89. https://doi.org/10.1186/1475-2867-13-89
Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003) Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Mol Cell 12:101–111
Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, Treves AJ, Schachter J, Amariglio N, Rechavi G (2008) MDR1 expression identifies human melanoma stem cells. Biochem Biophys Res Commun 368:930–936. https://doi.org/10.1016/j.bbrc.2008.02.022
Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP (2000) CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19:3896–3904. https://doi.org/10.1093/emboj/19.15.3896
Klaassen CD, Aleksunes LM (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62:1–96. https://doi.org/10.1124/pr.109.002014
Kobayashi H, Nagato T, Sato K, Aoki N, Kimura S, Murakami M, Iizuka H, Azumi M, Kakizaki H, Tateno M, Celis E (2007) Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner. Cancer Res 67:5498–5504. https://doi.org/10.1158/0008-5472.Can-07-0304
Koch A, Lang SA, Wild PJ, Gantner S, Mahli A, Spanier G, Berneburg M, Muller M, Bosserhoff AK, Hellerbrand C (2015) Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 6:32748–32760. https://doi.org/10.18632/oncotarget.4977
Koepsell H, Endou H (2004) The SLC22 drug transporter family. Pflugers Archiv 447:666–676. https://doi.org/10.1007/s00424-003-1089-9
Kostantin E, Hardy S, Valinsky WC, Kompatscher A, de Baaij JHF, Zolotarov Y, Landry M, Uetani N, Martinez-Cruz LA, Hoenderop JGJ, Shrier A, Tremblay ML (2016) Inhibition of PRL-2.CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth. J Biol Chem 291:10716–10725. https://doi.org/10.1074/jbc.M115.705863
Kosztka L, Rusznak Z, Nagy D, Nagy Z, Fodor J, Szucs G, Telek A, Gonczi M, Ruzsnavszky O, Szentandrassy N, Csernoch L (2011) Inhibition of TASK-3 (KCNK9) channel biosynthesis changes cell morphology and decreases both DNA content and mitochondrial function of melanoma cells maintained in cell culture. Melanoma Res 21:308–322. https://doi.org/10.1097/CMR.0b013e3283462713
Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calve B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D (2013) Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res 73:5253–5265. https://doi.org/10.1158/0008-5472.CAN-12-3690
Lamarca V, Marzo I, Sanz-Clemente A, Carrodeguas JA (2008) Exposure of any of two proapoptotic domains of presenilin 1-associated protein/mitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a Bax/Bak-independent manner. Eur J Cell Biol 87:325–334. https://doi.org/10.1016/j.ejcb.2008.02.004
Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabo I (2012) Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med 4:577–593. https://doi.org/10.1002/emmm.201200235
Lefranc F, Kiss R (2008) The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas. Neoplasia 10:198–206. https://doi.org/10.1593/neo.07928
Lehen’kyi VY, Raphael M, Prevarskaya N (2012) The role of the TRPV6 channel in cancer. J Physiol Lond 590:1369–1376. https://doi.org/10.1113/jphysiol.2011.225862
Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen P-H, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD (2010) Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell 40:841–849. https://doi.org/10.1016/j.molcel.2010.11.020
Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol 7:1202–1212. https://doi.org/10.1038/ncb1326
Liang X-J, Shen D-W, Garfield S, Gottesman MM (2003) Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines. Cancer Res 63:5909–5916
Liedert B, Materna V, Schadendorf D, Thomale J, Lage H (2003) Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. J Investig Dermatol 121:172–176. https://doi.org/10.1046/j.1523-1747.2003.12313.x
Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q, Zhu D (2013) Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell Death Dis 4:e494. https://doi.org/10.1038/cddis.2013.31
Liu X, Zhang P, Xie C, Sham KWY, Ng SSM, Chen Y, Cheng CHK (2019) Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development. Cell Death Dis 10:460. https://doi.org/10.1038/s41419-019-1700-4
López S, Smith-Zubiaga I, García de Galdeano A, Boyano MD, García O, Gardeazábal J, Martinez-Cadenas C, Izagirre N, de La Rúa C, Alonso S (2015) Comparison of the transcriptional profiles of melanocytes from dark and light skinned individuals under basal conditions and following ultraviolet-B irradiation. PLoS One 10:e0134911. https://doi.org/10.1371/journal.pone.0134911
Lotz C, Kelleher DK, Gassner B, Gekle M, Vaupel P, Thews O (2007) Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells. Oncol Rep 17:239–244
Lou W, Liu J, Ding B, Jin L, Xu L, Li X, Chen J, Fan W (2019) Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer. Aging (Albany NY) 11:2628–2652. https://doi.org/10.18632/aging.101934
Lu’o’ng KVQ, Nguyen LTH (2013) The role of thiamine in cancer: possible genetic and cellular signaling mechanisms. Cancer Genomics Proteomics 10:169–185
Ludwig FT, Schwab A, Stock C (2013) The Na+ /H+ -exchanger (NHE1) generates pH nanodomains at focal adhesions. J Cell Physiol 228:1351–1358. https://doi.org/10.1002/jcp.24293
Luke JJ, Flaherty KT, Ribas A, Long GV (2017) Targeted agents and immunotherapies: optimizing outcomes in melanoma. Nat Rev Clin Oncol 14:463 EP
Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, O’Connell D, Zhang P, Li Y, Gao T, Ren W, Yang Y (2018) miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ 25:1457–1472. https://doi.org/10.1038/s41418-017-0053-8
Malik M, Shukla A, Amin P, Niedelman W, Lee J, Jividen K, Phang JM, Ding J, Suh KS, Curmi PMG, Yuspa SH (2010) S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4. J Biol Chem 285:23818–23828. https://doi.org/10.1074/jbc.M109.091611
Mallee JJ, Atta MG, Lorica V, Rim JS, Kwon HM, Lucente AD, Wang Y, Berry GT (1997) The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. Genomics 46:459–465. https://doi.org/10.1006/geno.1997.5055
Mallilankaraman K, Cardenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenar T, Csordas G, Madireddi P, Yang J, Muller M, Miller R, Kolesar JE, Molgo J, Kaufman B, Hajnoczky G, Foskett JK, Madesh M (2012) MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol 14:1336–1343. https://doi.org/10.1038/ncb2622
Mantel A, Harvey V (2015) P2X7/PANX1 as a new target for melanoma? Exp Dermatol 24:336–337. https://doi.org/10.1111/exd.12633
Mathieu V, Pirker C, Martin de Lassalle E, Vernier M, Mijatovic T, DeNeve N, Gaussin J-F, Dehoux M, Lefranc F, Berger W, Kiss R (2009) The sodium pump alpha1 sub-unit: a disease progression-related target for metastatic melanoma treatment. J Cell Mol Med 13:3960–3972. https://doi.org/10.1111/j.1582-4934.2009.00708.x
Matsui MS, Petris MJ, Niki Y, Karaman-Jurukovska N, Muizzuddin N, Ichihashi M, Yarosh DB (2015) Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. J Investig Dermatol 135:834–841. https://doi.org/10.1038/jid.2014.461
Mazar J, DeYoung K, Khaitan D, Meister E, Almodovar A, Goydos J, Ray A, Perera RJ (2010) The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS One 5:e13779. https://doi.org/10.1371/journal.pone.0013779
Mazzio EA, Soliman KFA (2018) Whole-transcriptomic profile of SK-MEL-3 melanoma cells treated with the histone deacetylase inhibitor: Trichostatin A. Cancer Genomics Proteomics 15:349–364. https://doi.org/10.21873/cgp.20094
McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li J-L, Russell A, Swietach P, Harris AL (2016) Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth. Cancer Res 76:3744–3755. https://doi.org/10.1158/0008-5472.CAN-15-1862
McNamara M, Clynes M, Dunne B, NicAmhlaoibh R, Lee WR, Barnes C, Kennedy SM (1996) Multidrug resistance in ocular melanoma. Br J Ophthalmol 80:1009–1012. https://doi.org/10.1136/bjo.80.11.1009
Meyer R, Schonherr R, Gavrilova-Ruch O, Wohlrab W, Heinemann SH (1999) Identification of ether a go-go and calcium-activated potassium channels in human melanoma cells. J Membr Biol 171:107–115
Miettinen M, Wang ZF, Lasota J (2009) DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 33:1401–1408. https://doi.org/10.1097/PAS.0b013e3181a90e1a
Mijatovic T, van Quaquebeke E, Delest B, Debeir O, Darro F, Kiss R (2007) Cardiotonic steroids on the road to anti-cancer therapy. Biochim Biophys Acta 1776:32–57. https://doi.org/10.1016/j.bbcan.2007.06.002
Miller BA (2019) TRPM2 in cancer. Cell Calcium 80:8–17. https://doi.org/10.1016/j.ceca.2019.03.002
Mitchell P, Moyle J (1967) Chemiosmotic hypothesis of oxidative phosphorylation. Nature 213:137–139. https://doi.org/10.1038/213137a0
Miyaji T, Omote H, Moriyama Y (2011) Functional characterization of vesicular excitatory amino acid transport by human sialin. J Neurochem 119:1–5. https://doi.org/10.1111/j.1471-4159.2011.07388.x
Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, Mihara K (2001) NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276:49221–49227. https://doi.org/10.1074/jbc.M106267200
Moitra K, Scally M, McGee K, Lancaster G, Gold B, Dean M (2011) Molecular evolutionary analysis of ABCB5: the ancestral gene is a full transporter with potentially deleterious single nucleotide polymorphisms. PLoS One 6:e16318. https://doi.org/10.1371/journal.pone.0016318
Molinari A, Calcabrini A, Meschini S, Stringaro A, Del Bufalo D, Cianfriglia M, Arancia G (1998) Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells. Int J Cancer 75:885–893
Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell 3:297–302
Nagane M, Kanai E, Shibata Y, Shimizu T, Yoshioka C, Maruo T, Yamashita T (2018) Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma. PLoS One 13:e0195151. https://doi.org/10.1371/journal.pone.0195151
Nagy D, Gonczi M, Dienes B, Szoor A, Fodor J, Nagy Z, Toth A, Fodor T, Bai P, Szucs G, Rusznak Z, Csernoch L (2014) Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells. Arch Dermatol Res 306:885–902. https://doi.org/10.1007/s00403-014-1511-5
Nakamura N, Tanaka S, Teko Y, Mitsui K, Kanazawa H (2005) Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280:1561–1572. https://doi.org/10.1074/jbc.M410041200
Napolitano L, Scalise M, Galluccio M, Pochini L, Albanese LM, Indiveri C (2015) LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter. Int J Biochem Cell Biol 67:25–33. https://doi.org/10.1016/j.biocel.2015.08.004
Newton JM, Cohen-Barak O, Hagiwara N, Gardner JM, Davisson MT, King RA, Brilliant MH (2001) Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4. Am J Hum Genet 69:981–988. https://doi.org/10.1086/324340
Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG (2019) Opening TRPP2 (PKD2L1) requires the transfer of gating charges. Proc Natl Acad Sci U S A 116(31):15540–15549. https://doi.org/10.1073/pnas.1902917116
Nicchia GP, Stigliano C, Sparaneo A, Rossi A, Frigeri A, Svelto M (2013) Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma. J Mol Med (Berl) 91:613–623. https://doi.org/10.1007/s00109-012-0977-x
Noda M, Hiyama TY (2015) The Na(x) channel: what it is and what it does. Neuroscientist 21:399–412. https://doi.org/10.1177/1073858414541009
Noyer L, Grolez GP, Prevarskaya N, Gkika D, Lemonnier L (2018) TRPM8 and prostate: a cold case? Pflugers Arch 470:1419–1429. https://doi.org/10.1007/s00424-018-2169-1
Numata M, Orlowski J (2001) Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. J Biol Chem 276:17387–17394. https://doi.org/10.1074/jbc.M101319200
Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE (2009) TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal 2:ra21. https://doi.org/10.1126/scisignal.2000146
Oda K, Hosoda N, Endo H, Saito K, Tsujihara K, Yamamura M, Sakata T, Anzai N, Wempe MF, Kanai Y, Endou H (2010) L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci 101:173–179. https://doi.org/10.1111/j.1349-7006.2009.01386.x
Oda K, Umemura M, Nakakaji R, Tanaka R, Sato I, Nagasako A, Oyamada C, Baljinnyam E, Katsumata M, Xie L-H, Narikawa M, Yamaguchi Y, Akimoto T, Ohtake M, Fujita T, Yokoyama U, Iwatsubo K, Aihara M, Ishikawa Y (2017) Transient receptor potential cation 3 channel regulates melanoma proliferation and migration. J Physiol Sci 67:497–505. https://doi.org/10.1007/s12576-016-0480-1
Oehler B, Scholze A, Schaefer M, Hill K (2012) TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde. Naunyn Schmiedeberg’s Arch Pharmacol 385:555–563. https://doi.org/10.1007/s00210-012-0747-x
Oka Y, Asano T, Shibasaki Y, Lin JL, Tsukuda K, Katagiri H, Akanuma Y, Takaku F (1990) C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity. Nature 345:550–553. https://doi.org/10.1038/345550a0
Okabe M, Szakács G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN, Gottesman MM (2008) Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther 7:3081–3091. https://doi.org/10.1158/1535-7163.MCT-08-0539
Ono K, Viet CT, Ye Y, Dang D, Hitomi S, Toyono T, Inenaga K, Dolan JC, Schmidt BL (2017) Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling. Sci Rep 7:9181. https://doi.org/10.1038/s41598-017-09682-4
Orfanelli U, Wenke A-K, Doglioni C, Russo V, Bosserhoff AK, Lavorgna G (2008) Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res 18:1128–1140. https://doi.org/10.1038/cr.2008.296
Pafumi I, Festa M, Papacci F, Lagostena L, Giunta C, Gutla V, Cornara L, Favia A, Palombi F, Gambale F, Filippini A, Carpaneto A (2017) Naringenin impairs two-pore channel 2 activity and inhibits VEGF-induced angiogenesis. Sci Rep 7:5121. https://doi.org/10.1038/s41598-017-04974-1
Palm-Espling ME, Lundin C, Bjorn E, Naredi P, Wittung-Stafshede P (2014) Interaction between the anticancer drug Cisplatin and the copper chaperone Atox1 in human melanoma cells. Protein Pept Lett 21:63–68
Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S, Stuhmer W (1999) Oncogenic potential of EAG K(+) channels. EMBO J 18:5540–5547. https://doi.org/10.1093/emboj/18.20.5540
Park YR, Chun JN, So I, Kim HJ, Baek S, Jeon J-H, Shin S-Y (2016) Data-driven analysis of TRP channels in cancer: linking variation in gene expression to clinical significance. Cancer Genomics Proteomics 13:83–90
Park J, Talukder AH, Lim SA, Kim K, Pan K, Melendez B, Bradley SD, Jackson KR, Khalili JS, Wang J, Creasy C, Pan B-F, Woodman SE, Bernatchez C, Hawke D, Hwu P, Lee K-M, Roszik J, Lizee G, Yee C (2017) SLC45A2: a melanoma antigen with high tumor selectivity and reduced potential for autoimmune toxicity. Cancer Immunol Res 5:618–629. https://doi.org/10.1158/2326-6066.CIR-17-0051
Parker MD, Boron WF (2013) The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev 93:803–959. https://doi.org/10.1152/physrev.00023.2012
Parks SK, Pouyssegur J (2015) The Na(+)/HCO3(−) Co-transporter SLC4A4 plays a role in growth and migration of colon and Breast cancer cells. J Cell Physiol 230:1954–1963. https://doi.org/10.1002/jcp.24930
Patel F, Brackenbury WJ (2015) Dual roles of voltage-gated sodium channels in development and cancer. Int J Dev Biol 59:357–366. https://doi.org/10.1387/ijdb.150171wb
Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R (2017) Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. elife 6:e26232. https://doi.org/10.7554/eLife.26232
Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T (2003) Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc Natl Acad Sci U S A 100:7803–7807. https://doi.org/10.1073/pnas.1232448100
Pelster MS, Amaria RN (2019) Combined targeted therapy and immunotherapy in melanoma: a review of the impact on the tumor microenvironment and outcomes of early clinical trials. Ther Adv Med Oncol 11:1758835919830826. https://doi.org/10.1177/1758835919830826
Peretti M, Angelini M, Savalli N, Florio T, Yuspa SH, Mazzanti M (2015) Chloride channels in cancer: focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. Biochim Biophys Acta 1848:2523–2531. https://doi.org/10.1016/j.bbamem.2014.12.012
Perez-Neut M, Haar L, Rao V, Santha S, Lansu K, Rana B, Jones WK, Gentile S (2016) Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma. Oncotarget 7:21991–22004. https://doi.org/10.18632/oncotarget.7831
Peruzzo R, Biasutto L, Szabò I, Leanza L (2016) Impact of intracellular ion channels on cancer development and progression. Eur Biophys J 45:685–707. https://doi.org/10.1007/s00249-016-1143-0
Pinheiro C, Miranda-Gonçalves V, Longatto-Filho A, Vicente ALSA, Berardinelli GN, Scapulatempo-Neto C, Costa RFA, Viana CR, Reis RM, Baltazar F, Vazquez VL (2016) The metabolic microenvironment of melanomas: prognostic value of MCT1 and MCT4. Cell Cycle 15:1462–1470. https://doi.org/10.1080/15384101.2016.1175258
Plotz M, Gillissen B, Hossini AM, Daniel PT, Eberle J (2012) Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells. Cell Death Differ 19:1928–1938. https://doi.org/10.1038/cdd.2012.71
Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, de Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK (2013) MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One 8:e55785. https://doi.org/10.1371/journal.pone.0055785
Pocsai K, Kosztka L, Bakondi G, Gonczi M, Fodor J, Dienes B, Szentesi P, Kovacs I, Feniger-Barish R, Kopf E, Zharhary D, Szucs G, Csernoch L, Rusznak Z (2006) Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture. Cell Mol Life Sci 63:2364–2376. https://doi.org/10.1007/s00018-006-6166-8
proteinatlas.org (2019) The human protein atlas. https://www.proteinatlas.org/. Accessed 12 Aug 2019
Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J (2017) Sodium channel subunit SCNN1B suppresses gastric cancer growth and metastasis via GRP78 degradation. Cancer Res 77:1968–1982. https://doi.org/10.1158/0008-5472.CAN-16-1595
Quast SA, Berger A, Buttstadt N, Friebel K, Schonherr R, Eberle J (2012) General sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC. PLoS One 7:e39290. https://doi.org/10.1371/journal.pone.0039290
Raaijmakers MHGP, de Grouw EPLM, van der Reijden BA, de Witte TJM, Jansen JH, Raymakers RAP (2006) ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia. Clin Cancer Res 12:3452–3458. https://doi.org/10.1158/1078-0432.CCR-05-1945
Rabjerg M, Olivan-Viguera A, Hansen LK, Jensen L, Sevelsted-Moller L, Walter S, Jensen BL, Marcussen N, Kohler R (2015) High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. PLoS One 10:e0122992. https://doi.org/10.1371/journal.pone.0122992
Raemy E, Montessuit S, Pierredon S, van Kampen AH, Vaz FM, Martinou J-C (2016) Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell Death Differ 23:1165–1174. https://doi.org/10.1038/cdd.2015.166
Rajgopal A, Edmondnson A, Goldman ID, Zhao R (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta 1537:175–178. https://doi.org/10.1016/s0925-4439(01)00073-4
Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA (2011) Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol 13:1146–1156. https://doi.org/10.1007/s11307-010-0457-z
Riker AI, Enkemann SA, Fodstad O, Liu S, Ren S, Morris C, Xi Y, Howell P, Metge B, Samant RS, Shevde LA, Li W, Eschrich S, Daud A, Ju J, Matta J (2008) The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genet 1:13. https://doi.org/10.1186/1755-8794-1-13
Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005) Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes. Clin Cancer Res 11:4545–4552. https://doi.org/10.1158/1078-0432.Ccr-04-2235
Rodriguez-Rasgado JA, Acuna-Macias I, Camacho J (2012) Eag1 channels as potential cancer biomarkers. Sensors 12:5986–5995. https://doi.org/10.3390/s120505986
Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD (2002) Identification of a novel glucose transporter-like protein-GLUT-12. Am J Physiol Endocrinol Metab 282:E733–E738. https://doi.org/10.1152/ajpendo.2002.282.3.E733
Romero MF, Chen A-P, Parker MD, Boron WF (2013) The SLC4 family of bicarbonate (HCO(3)(−)) transporters. Mol Asp Med 34:159–182. https://doi.org/10.1016/j.mam.2012.10.008
Ruffini F, Tentori L, Dorio AS, Arcelli D, D’Amati G, D’Atri S, Graziani G, Lacal PM (2013) Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness. Oncol Rep 30:2887–2896. https://doi.org/10.3892/or.2013.2791
Sanguinetti MC (2010) HERG1 channelopathies. Pflugers Arch 460:265–276. https://doi.org/10.1007/s00424-009-0758-8
Sarangarajan R, Shumaker H, Soleimani M, Le Poole C, Boissy RE (2001) Molecular and functional characterization of sodium–hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes 1Part of this study was presented as a poster at the 8th meeting of the PanAmerican Society for Pigment Cell Research, Snowmass, Colorado, August 15–18, 1998. 1. Biochim Biophys Acta Biomembr 1511:181–192. https://doi.org/10.1016/S0005-2736(01)00273-5
Sawada K, Echigo N, Juge N, Miyaji T, Otsuka M, Omote H, Yamamoto A, Moriyama Y (2008) Identification of a vesicular nucleotide transporter. Proc Natl Acad Sci U S A 105:5683–5686. https://doi.org/10.1073/pnas.0800141105
Schaar A, Sukumaran P, Sun Y, Dhasarathy A, Singh BB (2016) TRPC1-STIM1 activation modulates transforming growth factor beta-induced epithelial-to-mesenchymal transition. Oncotarget 7:80554–80567. https://doi.org/10.18632/oncotarget.12895
Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH (2008) Identification of cells initiating human melanomas. Nature 451:345–349. https://doi.org/10.1038/nature06489
Schickling BM, England SK, Aykin-Burns N, Norian LA, Leslie KK, Frieden-Korovkina VP (2015) BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncol Rep 33:533–538. https://doi.org/10.3892/or.2014.3617
Schonherr R, Lober K, Heinemann SH (2000) Inhibition of human ether a go-go potassium channels by Ca(2+)/calmodulin. EMBO J 19:3263–3271. https://doi.org/10.1093/emboj/19.13.3263
Seithel A, Glaeser H, Fromm MF, Konig J (2008) The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members. Expert Opin Drug Metab Toxicol 4:51–64. https://doi.org/10.1517/17425255.4.1.51
Setty SR, Tenza D, Sviderskaya EV, Bennett DC, Raposo G, Marks MS (2008) Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature 454:1142–1146. https://doi.org/10.1038/nature07163
Shen W-W, Wu J, Cai L, Liu B-Y, Gao Y, Chen G-Q, Fu G-H (2007) Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. Neoplasia 9:812–819. https://doi.org/10.1593/neo.07403
Shin SS, Jeong BS, Wall BA, Li J, Shan NL, Wen Y, Goydos JS, Chen S (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogene 7:86. https://doi.org/10.1038/s41389-018-0098-7
Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, Suh KS, Yuspa SH (2009) TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol 11:777–784. https://doi.org/10.1038/ncb1885
Simone L, Gargano CD, Pisani F, Cibelli A, Mola MG, Frigeri A, Svelto M, Nicchia GP (2018) Aquaporin-1 inhibition reduces metastatic formation in a mouse model of melanoma. J Cell Mol Med 22:904–912. https://doi.org/10.1111/jcmm.13378
Slominski A (2008) Cooling skin cancer: menthol inhibits melanoma growth. Focus on “TRPM8 activation suppresses cellular viability in human melanoma”. Am J Physiol Cell Physiol 295:C293–C295. https://doi.org/10.1152/ajpcell.00312.2008
Spugnini EP, Sonveaux P, Stock C, Perez-Sayans M, de Milito A, Avnet S, Garcia AG, Harguindey S, Fais S (2015) Proton channels and exchangers in cancer. Biochim Biophys Acta 1848:2715–2726. https://doi.org/10.1016/j.bbamem.2014.10.015
Stanisz H, Stark A, Kilch T, Schwarz EC, Muller CS, Peinelt C, Hoth M, Niemeyer BA, Vogt T, Bogeski I (2012) ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. J Investig Dermatol 132:1443–1451. https://doi.org/10.1038/jid.2011.478
Stanisz H, Saul S, Muller CS, Kappl R, Niemeyer BA, Vogt T, Hoth M, Roesch A, Bogeski I (2014) Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Pigment Cell Melanoma Res 27:442–453. https://doi.org/10.1111/pcmr.12222
Stanisz H, Vultur A, Herlyn M, Roesch A, Bogeski I (2016) The role of Orai-STIM calcium channels in melanocytes and melanoma. J Physiol 594:2825–2835. https://doi.org/10.1113/JP271141
Stock C, Gassner B, Hauck CR, Arnold H, Mally S, Eble JA, Dieterich P, Schwab A (2005) Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol Lond 567:225–238. https://doi.org/10.1113/jphysiol.2005.088344
Stüwe L, Müller M, Fabian A, Waning J, Mally S, Noël J, Schwab A, Stock C (2007) pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol Lond 585:351–360. https://doi.org/10.1113/jphysiol.2007.145185
Su J, Chen X, Kanekura T (2009) A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett 273:140–147. https://doi.org/10.1016/j.canlet.2008.07.034
Su Y, Vilgelm AE, Kelley MC, Hawkins OE, Liu Y, Boyd KL, Kantrow S, Splittgerber RC, Short SP, Sobolik T, Zaja-Milatovic S, Dahlman KB, Amiri KI, Jiang A, Lu P, Shyr Y, Stuart DD, Levy S, Sosman JA, Richmond A (2012) RAF265 inhibits the growth of advanced human melanoma tumors. Clin Cancer Res 18:2184–2198. https://doi.org/10.1158/1078-0432.CCR-11-1122
Su Q, Hu F, Ge X, Lei J, Yu S, Wang T, Zhou Q, Mei C, Shi Y (2018) Structure of the human PKD1-PKD2 complex. Science 361:eaat9819. https://doi.org/10.1126/science.aat9819
Suh KS, Yuspa SH (2005) Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy. Curr Pharm Des 11:2753–2764. https://doi.org/10.2174/1381612054546806
Suh KS, Mutoh M, Nagashima K, Fernandez-Salas E, Edwards LE, Hayes DD, Crutchley JM, Marin KG, Dumont RA, Levy JM, Cheng C, Garfield S, Yuspa SH (2004) The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis. J Biol Chem 279:4632–4641. https://doi.org/10.1074/jbc.M311632200
Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH (2007) Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res 13:121–131. https://doi.org/10.1158/1078-0432.CCR-06-1562
Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH (2012) CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. Carcinogenesis 33:986–995. https://doi.org/10.1093/carcin/bgs115
Sun J, Lu F, He H, Shen J, Messina J, Mathew R, Wang D, Sarnaik AA, Chang WC, Kim M, Cheng H, Yang S (2014) STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol 207:535–548. https://doi.org/10.1083/jcb.201407082
Szakács G, Annereau J-P, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM (2004) Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 6:129–137. https://doi.org/10.1016/j.ccr.2004.06.026
Tajima N, Schonherr K, Niedling S, Kaatz M, Kanno H, Schonherr R, Heinemann SH (2006) Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. J Physiol 571:349–359. https://doi.org/10.1113/jphysiol.2005.096818
Takahashi N, Chen H-Y, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS (2018) Cancer cells Co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance. Cancer Cell 33:985–1003.e7. https://doi.org/10.1016/j.ccell.2018.05.001
Takaoka Y, Konno M, Koseki J, Colvin H, Asai A, Tamari K, Satoh T, Mori M, Doki Y, Ogawa K, Ishii H (2019) Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance. Cancer Sci 110:1331–1339. https://doi.org/10.1111/cas.13980
Takata N, Ohshima Y, Suzuki-Karasaki M, Yoshida Y, Tokuhashi Y, Suzuki-Karasaki Y (2017) Mitochondrial Ca2+ removal amplifies TRAIL cytotoxicity toward apoptosis-resistant tumor cells via promotion of multiple cell death modalities. Int J Oncol 51:193–203. https://doi.org/10.3892/ijo.2017.4020
Tanamachi K, Nishino K, Mori N, Suzuki T, Tanuma S-I, Abe R, Tsukimoto M (2017) Radiosensitizing effect of P2X7 receptor antagonist on melanoma in vitro and in vivo. Biol Pharm Bull 40:878–887. https://doi.org/10.1248/bpb.b17-00083
Tang H, Yang K, Song Y, Han J (2018) Meta-analysis of the association between sodium-glucose co-transporter-2 inhibitors and risk of skin cancer among patients with type 2 diabetes. Diabetes Obes Metab 20(12):2919–2924. https://doi.org/10.1111/dom.13474
Tang X-P, Chen Q, Li Y, Wang Y, Zou H-B, Fu W-J, Niu Q, Pan Q-G, Jiang P, Xu X-S, Zhang K-Q, Liu H, Bian X-W, Wu X-F (2019) Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma. Lab Investig 99:191–199. https://doi.org/10.1038/s41374-018-0138-0
Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour ME, Martinou J-C, Kunji ER (2019) The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. EMBO J 38:e100785. https://doi.org/10.15252/embj.2018100785
Teisseyre A, Gasiorowska J, Michalak K (2015) Voltage-gated potassium channels Kv1.3--potentially new molecular target in cancer diagnostics and therapy. Adv Clin Exp Med 24:517–524. https://doi.org/10.17219/acem/22339
Theodosakis N, Micevic G, Sharma R, Baras AS, Lazova R, Bosenberg MW, Rodic N (2016) Integrative discovery of CD98 as a melanoma biomarker. Pigment Cell Melanoma Res 29:385–387. https://doi.org/10.1111/pcmr.12464
Tian Y, Qin L, Qiu H, Shi D, Sun R, Li W, Liu T, Wang J, Xu T, Guo W, Kang T, Huang W, Wang G, Deng W (2015) RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling. Oncotarget 6:29614–29625. https://doi.org/10.18632/oncotarget.4868
Timar J, Gyorffy B, Raso E (2010) Gene signature of the metastatic potential of cutaneous melanoma: too much for too little? Clin Exp Metastasis 27:371–387. https://doi.org/10.1007/s10585-010-9307-2
Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769
Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030–9037. https://doi.org/10.1074/jbc.M511397200
Ulrich H, Abbracchio MP, Burnstock G (2012) Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair. Stem Cell Rev Rep 8:755–767. https://doi.org/10.1007/s12015-012-9372-9
Umemura M, Baljinnyam E, Feske S, de Lorenzo MS, Xie LH, Feng X, Oda K, Makino A, Fujita T, Yokoyama U, Iwatsubo M, Chen S, Goydos JS, Ishikawa Y, Iwatsubo K (2014) Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration. PLoS One 9:e89292. https://doi.org/10.1371/journal.pone.0089292
Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou J-C (2016) MPC1-like is a placental mammal-specific mitochondrial pyruvate carrier subunit expressed in postmeiotic male germ cells. J Biol Chem 291:16448–16461. https://doi.org/10.1074/jbc.M116.733840
Vazquez-Sanchez AY, Hinojosa LM, Parraguirre-Martinez S, Gonzalez A, Morales F, Montalvo G, Vera E, Hernandez-Gallegos E, Camacho J (2018) Expression of KATP channels in human cervical cancer: potential tools for diagnosis and therapy. Oncol Lett 15:6302–6308. https://doi.org/10.3892/ol.2018.8165
Vitavska O, Wieczorek H (2013) The SLC45 gene family of putative sugar transporters. Mol Asp Med 34:655–660. https://doi.org/10.1016/j.mam.2012.05.014
Vultur A, Gibhardt CS, Stanisz H, Bogeski I (2018) The role of the mitochondrial calcium uniporter (MCU) complex in cancer. Pflugers Arch 470:1149–1163. https://doi.org/10.1007/s00424-018-2162-8
Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS (2002) Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther 1:617–628
Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M (1997) A proton-gated cation channel involved in acid-sensing. Nature 386:173–177. https://doi.org/10.1038/386173a0
Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, Haass NK, Rasko JE, Holst J (2014) Targeting glutamine transport to suppress melanoma cell growth. Int J Cancer 135:1060–1071. https://doi.org/10.1002/ijc.28749
Wang T, Ning K, Lu T-X, Hua D (2017) Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer. Oncol Rep 37:1059–1065. https://doi.org/10.3892/or.2016.5322
Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, Bosma A, Song JY, Zevenhoven J, Los-de Vries GT, Horlings H, Nuijen B, Beijnen JH, Schellens JHM, Bernards R (2018) An acquired vulnerability of drug-resistant melanoma with therapeutic potential. Cell 173:1413–1425.e14. https://doi.org/10.1016/j.cell.2018.04.012
Wang X, Liu H, Xu Y, Xie J, Zhu D, Amos CI, Fang S, Lee JE, Li X, Nan H, Song Y, Wei Q (2019) Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival. Carcinogenesis 40:279–288. https://doi.org/10.1093/carcin/bgy188
Wanitchakool P, Wolf L, Koehl GE, Sirianant L, Schreiber R, Kulkarni S, Duvvuri U, Kunzelmann K (2014) Role of anoctamins in cancer and apoptosis. Philos Trans R Soc Lond Ser B Biol Sci 369:20130096. https://doi.org/10.1098/rstb.2013.0096
Warburg O (1956) On respiratory impairment in cancer cells. Science 124:269–270
Weber LV, Al-Refae K, Wolk G, Bonatz G, Altmuller J, Becker C, Gisselmann G, Hatt H (2016) Expression and functionality of TRPV1 in breast cancer cells. Breast Cancer 8:243–252. https://doi.org/10.2147/BCTT.S121610
Weeraratna AT (2005) A Wnt-er wonderland--the complexity of Wnt signaling in melanoma. Cancer Metastasis Rev 24:237–250. https://doi.org/10.1007/s10555-005-1574-z
Wei M, Korotkov KV, Blackburn JS (2018) Targeting phosphatases of regenerating liver (PRLs) in cancer. Pharmacol Ther 190:128–138. https://doi.org/10.1016/j.pharmthera.2018.05.014
White N, Butler PEM, Burnstock G (2005) Human melanomas express functional P2 X(7) receptors. Cell Tissue Res 321:411–418. https://doi.org/10.1007/s00441-005-1149-x
Whitlock JM, Hartzell HC (2017) Anoctamins/TMEM16 proteins: chloride channels flirting with lipids and extracellular vesicles. Annu Rev Physiol 79:119–143. https://doi.org/10.1146/annurev-physiol-022516-034031
Williams S, Bateman A, O’Kelly I (2013) Altered expression of two-pore domain potassium (K2P) channels in cancer. PLoS One 8:e74589. https://doi.org/10.1371/journal.pone.0074589
Willmes C, Kumar R, Becker JC, Fried I, Rachakonda PS, Poppe LM, Hesbacher S, Schadendorf D, Sucker A, Schrama D, Ugurel S (2016) SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma. Oncotarget 7:10117–10132. https://doi.org/10.18632/oncotarget.6956
Wilson BJ, Saab KR, Ma J, Schatton T, Putz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH (2014) ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res 74:4196–4207. https://doi.org/10.1158/0008-5472.CAN-14-0582
Winklmeier A, Poser I, Hoek KS, Bosserhoff AK (2009) Loss of full length CtBP1 expression enhances the invasive potential of human melanoma. BMC Cancer 9:52. https://doi.org/10.1186/1471-2407-9-52
Wolf S, Janzen A, Vekony N, Martine U, Strand D, Closs EI (2002) Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity. Biochem J 364:767–775. https://doi.org/10.1042/BJ20020084
Wonderlin WF, Strobl JS (1996) Potassium channels, proliferation and G1 progression. J Membr Biol 154:91–107
Wu C-P, Ambudkar SV (2014) The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy. Acta Pharm Sin B 4:105–111. https://doi.org/10.1016/j.apsb.2013.12.001
Wu C-P, Sim H-M, Huang Y-H, Liu Y-C, Hsiao S-H, Cheng H-W, Li Y-Q, Ambudkar SV, Hsu S-C (2013) Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells. Biochem Pharmacol 85:325–334. https://doi.org/10.1016/j.bcp.2012.11.003
Wu TTL, Peters AA, Tan PT, Roberts-Thomson SJ, Monteith GR (2014) Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression. Cell Calcium 56:59–67. https://doi.org/10.1016/j.ceca.2014.04.006
Xi Y, Riker A, Shevde-Samant L, Samant R, Morris C, Gavin E, Fodstad O, Ju J (2008) Global comparative gene expression analysis of melanoma patient samples, derived cell lines and corresponding tumor xenografts. Cancer Genomics Proteomics 5:1–35
Xiao J, Egger ME, McMasters KM, Hao H (2018) Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines. BMC Cancer 18:675. https://doi.org/10.1186/s12885-018-4583-3
Xie R, Xu J, Xiao Y, Wu J, Wan H, Tang B, Liu J, Fan Y, Wang S, Wu Y, Dong TX, Zhu MX, Carethers JM, Dong H, Yang S (2017) Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel. Cancer Res 77:6499–6512. https://doi.org/10.1158/0008-5472.CAN-17-0360
Xie A, Gallant B, Guo H, Gonzalez A, Clark M, Madigan A, Feng F, Chen H-D, Cui Y, Dudley SC, Wan Y (2018) Functional cardiac Na(+) channels are expressed in human melanoma cells. Oncol Lett 16:1689–1695. https://doi.org/10.3892/ol.2018.8865
Xu H, Delling M, Li L, Dong X, Clapham DE (2007) Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A 104:18321–18326. https://doi.org/10.1073/pnas.0709096104
Xu L, Li X, Cai M, Chen J, Li X, Wu WKK, Kang W, Tong J, To KF, Guan X-Y, Sung JJY, Chan FKL, Yu J (2016a) Increased expression of solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer. Gut 65:635–646. https://doi.org/10.1136/gutjnl-2014-308257
Xu S, Liu C, Ma Y, Ji H-L, Li X (2016b) Potential roles of amiloride-sensitive sodium channels in cancer development. Biomed Res Int 2016:2190216. https://doi.org/10.1155/2016/2190216
Xu J, Yang Y, Xie R, Liu J, Nie X, An J, Wen G, Liu X, Jin H, Tuo B (2018) The NCX1/TRPC6 complex mediates TGFbeta-driven migration and invasion of human hepatocellular carcinoma cells. Cancer Res 78:2564–2576. https://doi.org/10.1158/0008-5472.CAN-17-2061
Yamamura H, Ugawa S, Ueda T, Nagao M, Joh T, Shimada S (2008a) Epithelial Na+ channel delta subunit is an acid sensor in the human oesophagus. Eur J Pharmacol 600:32–36. https://doi.org/10.1016/j.ejphar.2008.10.022
Yamamura H, Ugawa S, Ueda T, Morita A, Shimada S (2008b) TRPM8 activation suppresses cellular viability in human melanoma. Am J Physiol Cell Physiol 295:C296–C301. https://doi.org/10.1152/ajpcell.00499.2007
Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H (2001) Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 1514:291–302
Yang M, Brackenbury WJ (2013) Membrane potential and cancer progression. Front Physiol 4:185. https://doi.org/10.3389/fphys.2013.00185
Yang Y, Luo Z, Hao Y, Ba W, Wang R, Wang W, Ding X, Li C (2017) mTOR-mediated Na(+)/Ca(2+) exchange affects cell proliferation and metastasis of melanoma cells. Biomed Pharmacother 92:744–749. https://doi.org/10.1016/j.biopha.2017.05.104
Yang Y, Guo W, Ma J, Xu P, Zhang W, Guo S, Liu L, Ma J, Shi Q, Jian Z, Liu L, Wang G, Gao T, Han Z, Li C (2018) Downregulated TRPV1 expression contributes to melanoma growth via the Calcineurin-ATF3-p53 pathway. J Investig Dermatol 138:2205–2215. https://doi.org/10.1016/j.jid.2018.03.1510
Yu FH, Catterall WA (2004) The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis. Sci STKE 2004:re15. https://doi.org/10.1126/stke.2532004re15
Yuasa I, Umetsu K, Watanabe G, Nakamura H, Endoh M, Irizawa Y (2004) MATP polymorphisms in Germans and Japanese: the L374F mutation as a population marker for Caucasoids. Int J Legal Med 118:364–366. https://doi.org/10.1007/s00414-004-0490-z
Zhang Z, Chen J, He Y, Zhan X, Zhao R, Huang Y, Xu H, Zhu Z, Liu Q (2014) miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene. Arch Virol 159:3335–3343. https://doi.org/10.1007/s00705-014-2208-y
Zhao Q, Zhou H, Li X, Xiao B (2019) The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism. FEBS J 286:2461–2470. https://doi.org/10.1111/febs.14711
Zheng X, Li Y, Zhao R, Yan F, Ma Y, Zhao L, Qiao H (2016) xCT deficiency induces autophagy via endoplasmic reticulum stress activated p38-mitogen-activated protein kinase and mTOR in sut melanocytes. Eur J Cell Biol 95:175–181. https://doi.org/10.1016/j.ejcb.2016.03.002
Zheng J, Liu F, Du S, Li M, Wu T, Tan X, Cheng W (2019) Mechanism for regulation of melanoma cell death via activation of thermo-TRPV4 and TRPV2. J Oncol 2019:7362875. https://doi.org/10.1155/2019/7362875
Zhou X, Xiong Z-J, Xiao S-M, Zhou J, Ding Z, Tang L-C, Chen X-D, Xu R, Zhao P (2017) Overexpression of MPC1 inhibits the proliferation, migration, invasion, and stem cell-like properties of gastric cancer cells. Onco Targets Therapy 10:5151–5163. https://doi.org/10.2147/OTT.S148681
Zhu S, Zhou H-Y, Deng S-C, Deng S-J, He C, Li X, Chen J-Y, Jin Y, Hu Z-L, Wang F, Wang C-Y, Zhao G (2017) ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway. Cell Death Dis 8:e2806. https://doi.org/10.1038/cddis.2017.189
Acknowledgments
The work of AKB is supported by the DFG (BO1573), the German Cancer Aid, and the Wilhelm-Sander foundation. JE presently receives support from the German Cancer Aid (7011 2382).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Böhme, I., Schönherr, R., Eberle, J., Bosserhoff, A.K. (2020). Membrane Transporters and Channels in Melanoma. In: Stock, C., Pardo, L.A. (eds) Transportome Malfunction in the Cancer Spectrum. Reviews of Physiology, Biochemistry and Pharmacology, vol 181. Springer, Cham. https://doi.org/10.1007/112_2020_17
Download citation
DOI: https://doi.org/10.1007/112_2020_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-90919-2
Online ISBN: 978-3-030-90920-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)