Clinical Scales of Cerebellar Ataxias

Bürk, Katrin; Sival, Deborah A.

doi:10.1007/978-3-319-97911-3_80-2

Katrin Bürk^6,7 &
Deborah A. Sival⁸

105 Accesses

Abstract

Clinical scales represent an important tool not only for the initial grading/scoring of disease and assessment of progression but also for the quantification of therapeutic effects in clinical trials. There are several scales available for the clinical evaluation of cerebellar symptoms. While some scales have been developed and evaluated for specific cerebellar disorders such as Friedreich ataxia (FA), others reliably capture cerebellar symptoms with no respect to the underlying etiology. Each scale has its strengths and weaknesses. Extensive scales are certainly useful for thorough documentation of specific features of certain phenotypes, but this gain of information is not always essential for the purpose of a study. Therefore, compact and manageable scales like SARA or BARS are often preferred compared to more complex scales in observational and therapeutic studies.

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Abbreviations

ADL:: Activities of daily living
BARS:: Brief ataxia rating scale
CACG-EPNS:: Childhood Ataxia and Cerebellar Group of the European Pediatric Neurology Society
EA:: Episodic ataxia
MBI:: Barthel Index
CGI:: Clinical Global Impression
FA:: Friedreich ataxia
FARS:: Friedreich Ataxia Rating Scale
FIM:: Functional Independence Measure
ICARS:: International Cooperative Ataxia Rating Scale
ICC:: Intraclass correlation coefficient
IRR:: Interrater reliability
Min:: Minutes
MRI:: Magnetic resonance imaging
MRS:: Magnetic resonance spectroscopy
MSA:: Multiple system atrophy
NPC:: Niemann-Pick type C
PI:: Prediction interval
QoL:: Quality of life
SARA:: Scale for the Assessment and Rating of Ataxia
SCA:: Spinocerebellar ataxia
T25FW:: Timed 25-meter foot walk
UHDRS:: Unified Huntington’s Disease Rating Scale
UPDRS:: Unified Parkinson’s Disease Rating Scale

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Conflicts of Interest

K. Bürk and D. A. Sival do not have any conflict of interest.

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Authors and Affiliations

Department of Neurology, University of Marburg, Marburg, Germany
Katrin Bürk
Kliniken Schmieder, Stuttgart-Gerlingen, Germany
Katrin Bürk
Beatrix Kinderziekenhuis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Deborah A. Sival

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Katrin Bürk
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Deborah A. Sival
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Correspondence to Katrin Bürk .

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Editors and Affiliations

Bruxelles, Belgium
Mario Manto
Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA
Donna Gruol
Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA
Jeremy Schmahmann
Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan
Noriyuki Koibuchi
Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA
Roy Sillitoe

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Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Jeremy D. Schmahmann
CHU-Charleroi, University of Mons, UMons, Charleroi, Belgium
Mario U. Manto

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Bürk, K., Sival, D.A. (2019). Clinical Scales of Cerebellar Ataxias. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_80-2

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DOI: https://doi.org/10.1007/978-3-319-97911-3_80-2
Received: 25 October 2017
Accepted: 18 July 2018
Published: 19 February 2019
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-97911-3
Online ISBN: 978-3-319-97911-3
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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