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Different Forms of Decellularized Tissues and Their Characteristics, Applications in Tissue Repair as Well as Performance Optimization

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Decellularized Materials

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Abstract

Decellularized tissues, which could maintain cell phenotype or promote stem cell differentiation into specific tissue cells, play a central role in promoting the reconstruction of functional tissue/organ. Tissue ECM in diverse formats has been developed for tissue repair and regeneration, which can generally be divided into five categories: (1) Scaffolds that preserve the morphological structure of original tissues. (2) Powders obtained by cryogenic grinding. (3) Hydrogels. (4) Coatings. (5) 3D-printing. This chapter will elaborate the preparation methods for creating decellularized tissue scaffolds with the above formats. What is more, the characteristics of these materials will be studied, and the respective applications and the efforts in performance optimization in tissue repair will also be introduced.

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Authors and Affiliations

  1. Reproductive Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China

    Lincui Da

  2. Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China

    Xiongxin Lei, Yuting Song, Yizhou Huang & Huiqi Xie

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  1. Lincui Da
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  2. Xiongxin Lei
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  3. Yuting Song
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  4. Yizhou Huang
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  5. Huiqi Xie
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Correspondence to Huiqi Xie .

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  1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

    Xiaoming Li

  2. Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China

    Huiqi Xie

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Da, L., Lei, X., Song, Y., Huang, Y., Xie, H. (2021). Different Forms of Decellularized Tissues and Their Characteristics, Applications in Tissue Repair as Well as Performance Optimization. In: Li, X., Xie, H. (eds) Decellularized Materials. Springer, Singapore. https://doi.org/10.1007/978-981-33-6962-7_3

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