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Angiographic Evaluation of Carotid Artery Grafting with Prefabricated Small-Diameter, Small-Intestinal Submucosa Grafts in Sheep

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Abstract

The purpose of this study was to report the longitudinal angiographic evaluation of prefabricated lyophilized small-intestinal submucosa (SIS) grafts placed in ovine carotid arteries and to demonstrate a variety of complications that developed. A total of 24 grafts, 10 cm long and 6 mm in diameter, were placed surgically as interposition grafts. Graft patency at 1 week was evaluated by Doppler ultrasound, and angiography was used for follow-up at 1 month and at 3 to 4 months. A 90% patency rate was found at 1 week, 65% at 1 month, and 30% at 3 to 4 months. On the patent grafts, angiography demonstrated a variety of changes, such as anastomotic stenoses, graft diffuse dilations and dissections, and aneurysm formation. These findings have not been previously demonstrated angiographically by other investigators reporting results with small-diameter vessel grafts made from fresh small-intestinal submucosa (SIS). The complications found were partially related to the graft construction from four SIS layers. Detailed longitudinal angiographic study should become an essential part of any future evaluation of small-vessel SIS grafting.

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Acknowledgment

This study was supported in part by a grant from Cook Biotech.

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Authors and Affiliations

  1. Dotter Interventional Institute, Oregon Health Sciences University, L342, 3181 SW Sam Jackson Park Road, Portland, OR, 97201, USA

    Dusan Pavcnik, Barry T. Uchida, Gregory J. Landry, John A. Kaufman, Frederick S. Keller & Josef Rösch

  2. Cook Biotech, West Lafayette, IN, USA

    Josef Obermiller

  3. Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN, USA

    William Van Alstine

  4. Division of Vascular Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR, USA

    James M. Edwards & Gregory J. Landry

Authors
  1. Dusan Pavcnik
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  2. Josef Obermiller
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  3. Barry T. Uchida
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  4. William Van Alstine
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  5. James M. Edwards
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  6. Gregory J. Landry
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  7. John A. Kaufman
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  8. Frederick S. Keller
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  9. Josef Rösch
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Correspondence to Dusan Pavcnik.

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Pavcnik, D., Obermiller, J., Uchida, B.T. et al. Angiographic Evaluation of Carotid Artery Grafting with Prefabricated Small-Diameter, Small-Intestinal Submucosa Grafts in Sheep. Cardiovasc Intervent Radiol 32, 106–113 (2009). https://doi.org/10.1007/s00270-008-9449-7

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  • DOI: https://doi.org/10.1007/s00270-008-9449-7

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