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Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases

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Nutrigenomics and the Brain

Part of the book series: Nutritional Neurosciences ((NN))

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Abstract

Proteostasis refers to the dynamic regulation of protein homeostasis which is mediated by a network of molecular machines responsible for both protein synthesis and degradation. With age and various diseases, proteostasis can be disrupted, leading to the formation of intracellular protein aggregates (Labbadia and Morimoto 2015). Under normal conditions, aggregated proteins are broken down through the ubiquitin-proteasomal system or through activation of the autophagy pathway. In pathological conditions however, these protein degradation pathways can be dysregulated. Protein misfolding is a hallmark of many neurodegenerative disorders and is associated with numerous disease processes in autophagy (Watanabe et al. 2020; Limanaqi et al. 2020).

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Author notes

  1. Amal O. Amer and Candice M. Brown contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Biology, School of Science, Penn State Erie, The Behrend College, Erie, PA, USA

    Ashley E. Russell

  2. Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, OH, USA

    Asmaa Badr, Cierra Carafice, Kylene P. Daily, Owen Whitham & Amal O. Amer

  3. Benjamin M Statler, College of Engineering, Chemical and Biomedical Engineering Department, West Virginia University, Morgantown, WV, USA

    Ali Rai

  4. Department of Neuroradiology, Health Science Center, West Virginia University, Morgantown, WV, USA

    Ansaar Rai

  5. Department of Neuroscience, Center for Basic and Translational Stroke Research, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV, USA

    Candice M. Brown

  6. Institute of Global Health and Human Ecology, School of Sciences & Engineering, The American University of Cairo, New Cairo, Egypt

    Duaa Dakhlallah

  7. Microbiology, Immunology and Cell Biology, and Mary Babb Randolph Cancer Center, Erma Byrd Biomedical Research Center, West Virginia University, Morgantown, WV, USA

    Duaa Dakhlallah

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  1. The Institute of Global Public Health and Human Ecology, American University in Cairo, New Cairo, Egypt

    Mohamed Salama

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Russell, A.E. et al. (2022). Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases. In: Salama, M. (eds) Nutrigenomics and the Brain. Nutritional Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-16-9205-5_13

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