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Manipulation of Key Genes Involved in Biosynthesis of Terpenoid Compounds in Plants

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Metabolic Engineering in Plants

Abstract

Terpenoids represent the diverse class of plant secondary metabolites exhibiting immense applications in pharmaceutical and other industrial sectors. Commercial exploitation of terpenoid compounds is mostly hampered due to lower quantities of these compounds synthesized in their natural plant sources, difficulty in their isolation, and extreme structural diversity leading to expensive synthetic approaches. To overcome these shortcomings, plant-based systems provide an attractive platforms in manipulating the key genes of terpenoid pathways involved in biosynthesis of target terpenoid compounds. At cellular level, plants show compartmentalization and comprise cofactors which assist in metabolic manipulation of whole functional pathways taken from other plants. In this chapter, we have highlighted various attempts of metabolic engineering in host plants for enhanced production of target terpenoid compound. Besides, we have also discussed some important limitations associated with plant-based expression systems, future directions, and developments in harnessing the maximum potential of metabolic engineered plant systems.

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Authors and Affiliations

  1. Department of Bioresources, Faculty of Biological Science, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India

    Mahak Majeed & Reiaz Ul Rehman

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  1. Mahak Majeed
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  2. Reiaz Ul Rehman
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  1. Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Tariq Aftab

  2. Department of Biological Sciences, King Abdulaziz University, Faculty of Science, Jeddah, Saudi Arabia

    Khalid Rehman Hakeem

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Majeed, M., Rehman, R.U. (2022). Manipulation of Key Genes Involved in Biosynthesis of Terpenoid Compounds in Plants. In: Aftab, T., Hakeem, K.R. (eds) Metabolic Engineering in Plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-7262-0_12

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