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Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research

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Zebrafish Model for Biomedical Research

Abstract

Zebrafish is a powerful platform in the modern era of phenotype-based drug discovery and eminent vertebrate model to study disease progression and its pathophysiology. Zebrafish possess several advantages over rodent model including low cost, females that lay up to 300 eggs per week, the optical clarity of embryo, external fertilization, and highly amenable to transgenic modifications using various genetic toolkits. Zebrafish have almost 70% genetic homology with humans, and 82% of disease-causing human proteins are orthologue to zebrafish. The bottleneck in drug discovery is high cost, laborious, and time taking processes to generate hits. Zebrafish provide a novel option to overcome this bottleneck and have enabled rapid drug discovery in the area of cancer, cardiovascular diseases, endocrine diseases, and many more. However, zebrafish cannot completely replace the mammalian model in drug discovery, but it can form a bridge between cell-based assays and mammalian models, thus reducing the overall cost and time in lead generation. Therefore, in this chapter, we have discussed the role of zebrafish as an emerging vertebrate model in the area of endocrinology disorders.

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda, Punjab, India

    Umashanker Navik & Pushkar Singh Rawat

  2. Nanobiotechnology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Roorkee, Uttarakhand, India

    Prince Allawadhi

  3. Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, Hauz Khas, New Delhi, Delhi, India

    Amit Khurana

  4. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad, Telangana, India

    Amit Khurana & Anil Kumar Banothu

  5. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), PVNRTVU, Mamnoor, Warangal, Telangana, India

    Amit Khurana & Kala Kumar Bharani

  6. Department of Aquatic Animal Health Management, College of Fishery Science, PVNRTVU, Pebbair, Wanaparthy, Telangana, India

    Anil Kumar Banothu

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  1. Umashanker Navik
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  2. Pushkar Singh Rawat
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  6. Kala Kumar Bharani
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Editors and Affiliations

  1. Department of Pharmacology, Symbiosis Medical College for Women, Pune, Maharashtra, India

    Prasan R. Bhandari

  2. Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), P. V. Narsimha Rao Telangana Veterinary University (PVNRTVU), Warangal, Telangana, India

    Kala Kumar Bharani

  3. Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, New Delhi, Delhi, India

    Amit Khurana

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Navik, U., Rawat, P.S., Allawadhi, P., Khurana, A., Banothu, A.K., Bharani, K.K. (2022). Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research. In: Bhandari, P.R., Bharani, K.K., Khurana, A. (eds) Zebrafish Model for Biomedical Research . Springer, Singapore. https://doi.org/10.1007/978-981-16-5217-2_6

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