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Possible Therapeutic Potential of Flavonoids and Phenolic Acids from Honey in Age-Related Neurodegenerative Diseases Via Targeting NAD+ Degradation

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Therapeutic Applications of Honey and its Phytochemicals

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Abstract

Neurodegenerative disorder is the major age-related problem with no specific cure. The drugs available in the market relieve the severity of the disease and increase the average life span. There is always room for more novel therapeutic strategies for the prevention of neurodegenerative diseases. Honey has been used since ages for various disease prevention, and recently it has been used to combat these diseases too. The flavonoids and the phenolic acids of honey have preventive effects and have been known to exhibit antioxidant, anti-inflammatory, and anti-apoptotic effects. These phytochemicals can prevent the neurodegeneration via NAD pathway where they are responsible for inhibiting CD38, PARP and activating SIRT1 overall by increasing the concentration of NAD in the neurons. With an increase in the amount of NAD, Sirtuins can be activated which protects age-related neurodegenerative diseases. Therefore, honey can be used as “NAD compounds” in clinics but with further mechanistic research.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia

    Andleeb Khan & Saeed Alshahrani

  2. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Azher Arafah & Muneeb U. Rehman

  3. Department of Pharmacology and Toxicology, and Central lab, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Wajhul Qamar

  4. Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia

    Ambreen Shoaib & Saad Saeed Alqahtani

  5. Department of Pharmaceutical Chemistry, RAKCOPS, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates

    Adil Farooq Wali

  6. Faculty of Veterinary Sciences and Animal Husbandry, Division of Veterinary Biochemistry, Sheri Kashmir University of Agricultural Science and Technology (SKUAST-K), Srinagar, Jammu & Kashmir, India

    Insha Amin

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  1. Department of Clinical Pharmacy, King Saud University, Riyadh, Riyadh, Saudi Arabia

    Muneeb U. Rehman

  2. Department of Biochemistry, Govt. Medical College (GMC-Srinagar), Srinagar, Jammu and Kashmir, India

    Sabhiya Majid

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Khan, A. et al. (2020). Possible Therapeutic Potential of Flavonoids and Phenolic Acids from Honey in Age-Related Neurodegenerative Diseases Via Targeting NAD+ Degradation. In: Rehman, M.U., Majid, S. (eds) Therapeutic Applications of Honey and its Phytochemicals . Springer, Singapore. https://doi.org/10.1007/978-981-15-7305-7_2

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