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The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

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Histone Deacetylases: the Biology and Clinical Implication

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 206))

Abstract

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer’s disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.

Akiko Satoh, Liana Stein These two authors contributed to this work equally

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Acknowledgments

We apologize to those whose work is not cited due to space limitations. L.S. is supported by the NIH training program in cellular and molecular biology (5T32GM007067-36). S.I. is supported by grants from the National Institute of Health (AG024150 and HL097817), Ellison Medical Foundation, and Longer Life Foundation. S.I. serves as a scientific advisory board member for and has a sponsored research agreement with Sirtris pharmaceuticals, a GSK company.

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  1. Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    Akiko Satoh, Liana Stein & Shin Imai

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  1. Akiko Satoh
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Correspondence to Shin Imai .

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  1. , Department of Pharmacology, Duke University, Durham, 27710, North Carolina, USA

    Tso-Pang Yao

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    Edward Seto

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Satoh, A., Stein, L., Imai, S. (2011). The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity. In: Yao, TP., Seto, E. (eds) Histone Deacetylases: the Biology and Clinical Implication. Handbook of Experimental Pharmacology, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21631-2_7

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