Abstract
Modern scientific advancements and research on marine microbes has revealed their significance as producers of therapeutic products useful in treating various human diseases. Microbes in marine habitat have evolved to adapt to the harsh condition that prevails in the ocean. Their struggle to compete for space and nutrients has paved way for the synthesis of different novel enzymes possessing distinctive characteristics. Thus, marine habitat hosts many remarkable microorganisms that offer unique biologically active compounds, enzymes endowed with astonishing properties, and mechanism to survive in extreme environmental conditions. The utilization of marine biotic resources grows at an extraordinary growth rate of 12% per annum and is evident from about 4900 patents filed connected with marine genetic resources and 18,000 natural compounds. This concern has boosted research all over the world to explore the untapped potential hidden in marine microbes, which has lot of biotechnological applications that includes bioactive compounds (metabolites) for therapeutics, novel enzymes, cosmetics, and nutraceuticals. This book chapter will meticulously deliberate the utilization of marine resources by biotechnological applications for therapeutics like antibiotics, chemical compounds, biopolymer, enzymes, and various microbial biomedical purposes such as drug delivery and tissue engineering from marine biota (bacteria, fungi, and algae).
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References
Abdel-Lateff A (2008) Chaetominedione, a new tyrosine kinase inhibitor isolated from the algicolous marine fungus Chaetomium sp. Tetrahedron Lett 49:6398–6400
Abdel-Mageed WM, Milne BF, Wagner M, Schumacher M, Sandor P, Pathom-aree W, Goodfellow M, Bull AT, Horikoshi K, Ebel R, Diederich M (2010) Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment. Org Biomol Chem 8:2352–2362
Abdelmohsen UR, Pimentel-Elardo SM, Hanora A, Radwan M, Abou-El-Ela SH, Ahmed S et al (2010) Isolation, phylogenetic analysis and anti-infective activity screen-ing of marine sponge-associated actinomycetes. Mar Drugs 8:399–412
Adinaryan G, Venkateshan MR, Bpiraju VV, Sujatha P, Premkumar J, Ellaiah P, Zeeck A (2006) Cytotoxic compounds from the marine actinobacterium. Bio Org Khim 32:328–334
Antoszczak M, Steverding D, Huczyński A (2019) Anti-parasitic activity of polyether ionophores. Eur J Med Chem 166:32–47
Arumugam M, Mitra A, Jaisankar P, Dasgupta S, Sen T, Gachhui R, Mukhopadhyay UK, Mukherjee J (2010) Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium, its biological activities and applications. Appl Microbiol Biotechnol 86:109–117
Arun A, Murrugappan R, Ravindran AD, Veeramanikandan V, Balaji S (2006) Utilization of various industrial wastes for the production of poly-b-hydroxy butyrate (PHB) by Alcaligenes eutrophus. Afr J Biotechnol 5(17)
Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park E-J, Pezzuto JM (2008) ArenamidesA-C, cytotoxic NF B inhibitors from the marine Actinomycete Salinispora areni-cola. J Nat Prod 72:396–402
Awad NE (2000) Biologically active steroid fromthe green alga Ulva lactuca. Phytother Res 14:641–643
Bhatti AB, Usman M, Kandi V (2016) Current scenario of HIV/AIDS, treatment options, and major challenges with compliance to antiretroviral therapy. Cureus 8:1–12
Biscoe TJ, Evans RH, Headley PM, Martin M, Watkins JC (1975) Domic and quisqualic acids as potent amino acids excitants of frog and rat spinal neurons. Nature 255:166–167
Bister B, Bischoff D, Ströbele M, Riedlinger J, Reicke A, Wolter F, Bull AT, Zähner H, Fiedler HP, Süssmuth RD (2004) Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway. Angew Chem Int Ed Engl 43:2574–2576
Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR (2011) Marine natural products. Nat Prod Rep 28:196–268
Blunt JW, Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep MR (2018) Marine natural products. Nat Prod Rep 35:8–53
Bold HC, Wynne MJ (1985) Introduction to the algae: structure and reproduction, 2nd edn. Prentice-Hall Inc., Englewood Cliffs, NJ, pp 1–33
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, de la Cruz M, Díaz C, Vicente F, Reyes F (2017) Branimycins B and C, antibiotics produced by the abyssal actinobacterium Pseudonocardia carboxydivorans M-227. J Nat Prod 80:569–573
Bull AT, Stach JE (2007) Marine actinobacteria: new opportunities for natural product search and discovery. Trends Microbiol 15:491–499
Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep MR (2019) Natural product reports. Nat Prod Rep 36:122–173
Carter GT, Rinehart JR, Li LH, Kuentzel SL (1978) Brominated indoles from Laurencia Brongniartii. Tetrahedron Lett 19:4479–4482
Chen IL, Gerwick WH, Schatzman R, Laney M (1994) Isorawsonol and related IMO dehydrogenase inhibitors from the tropical alga Avrainvillea rawsoni. J Nat Prod 57:947–952
Cho JY, Kwon HC, Williams PG, Kauffman CA, Jensen PR, Fenical W (2006) Actinofuranones A and B, polyketides from a marine derived bacterium related to the genus Streptomyces (Actinomycetales). J Nat Prod 69:425–428
Cho JY, Williams PG, Kwon HC, Jensen PR, Fenical W (2007) Lucentamycins AD, cytotoxicpeptides from the marine-derived actinomycete Nocardiopsis lucentensis. J Nat Prod 70:1321–1328
Choi JS, Park HJ, Jung HA, Chung HY, Jung JH, Choi WC (2000) A cyclohexanonyl bromophenol from the red alga Symphyocladia latiuscula. J Nat Prod 63:1705–1706
Daferner M, Anke T, Sterner O (2002) Zopfiellamides A and B, antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes. Tetrahedron 58:7781–7784
Davyt D, Entz W, Fernandez R, Mariezcurrena R, Mombrú AW, Saldana J et al (1998) A new indol derivative from the red alga Chondra atropurpurea. Isolation, structure determination, and anthelmintic activity. J Nat Prod 61:1560–1563
Desjardine K, Pereira A, Wright H, Matainaho T, Kelly M, Andersen RJ (2007) Tauramamide, a lipopeptide antibiotic produced in culture by Brevibacillus laterosporus isolated from a marine habitat: structure elucidation and synthesis. J Nat Prod 70:1850–1853
Dharmaraj S (2010) Marine Streptomyces as a novel source of bioactive substances. World J Microbiol Biotechnol 26:2123–2139
El-Gendy MM, Shaaban M, Shaaban KA, El-Bondkly AM, Laatsch H (2008a) Ess-ramycin: a first triazolopyrimidine antibiotic isolated from nature. J Antibiot 61:149–157
El-Gendy MM, Hawas UW, Jaspars M (2008b) Novel bioactive metabolites from a marine derived bacterium Nocardia sp. ALAA 2000. J Antibiot 6:379
Eltamany EE, Abdelmohsen UR, Ibrahim AK, Hassanean HA, Hentschel U, Ahmed SA (2014) New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45. Bioorg Med Chem Lett 24:4939–4942
Engelhardt K, Degnes KF, Kemmler M, Bredholt H, Fjærvik E, Klinkenberg G, Sletta H, Ellingsen TE, Zotchev SB (2010) Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species. Appl Environ Microbiol 76:4969–4976
Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W (2003) Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinispora. Angew Chem Int End Engl 42:355–357
Fenical W, Jensen PR (2006) Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol 2:666–673
Fenical W, Sims JJ (1974) Cycloeudesmol, an antibiotic cyclopropane conatinnin sequiterpene from the marine alga, Chondriaoppositiclada Dawson. Tetrahedron Lett 13:1137–1140
Ferkany JW, Coyle JT (1985) Kainic acid selectivelystimulates the release of endogenous excitatory acidic amino acids. J Pharmacol Exp Ther 225:399–406
Fiedler HP, Bruntner C, Riedlinger J, Bull AT, Knutsen G, Goodfellow M, Jones A, Maldonado L, Pathom-Aree W, Beil W, Schneider K (2008) Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. J Antibiot 61:158
Finer I, Clardy I, Fenical W, Finer J, Clardy J, Fenical W et al (1979) Structures of dictyodial and dictyolactone, unusual marine diterpenoids. J Org Chem 44:2044–2047
Fu P, MacMillan JB (2015) Thiasporines A–C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora. J Nat Prod 78:548–551
Fukuyama Y, Kodaama M, Miura I, Fukuyama Y, Kodama M, Miura I et al (1989) Antiplasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome Okamura. Chem Pharm Bull 37:2438–2440
Fukuzawa A, Masamune T (1981) Laurepinnacin and isolaurepinnacin: new acetylenic cyclic ethers from the marine alga Laurencia pinnata Yamada. Tetrahedron Lett 22:4081–4084
Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM et al (1992) A pentahalogenated monoterepene from the red alga Portieria hornemannii produced a novel cytotoxicity profile against a diverse panel of human tumor celllin. J Med Chem 35:3007–3011
Gao X, Lu Y, Xing Y, Ma Y, Lu J, Bao W, Wang Y, Xi TA (2012) A novel anticancer and antifun-gus phenazine derivative from a marine actinomycete BM-17. Microbiol Res 167:616–622
Gerwick WH, Moore BS (2012) Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol 19:85–98
Gillet J-P, Efferth T, Remacle J (2007) Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim Biophys Acta (BBA) – Rev Cancer 1775:237–262
Han Y, Yang B, Zhang F, Miao X, Li Z (2009) Characterization of antifungal chitinase from marine Streptomyces sp., DA11 associated with South China Sea sponge Craniellaaustraliensis. Mar Biotechnol 11(1):132–140
Hawas UW, Shaaban M, Shaaban KA, Speitling M, Maier A, Kelter G, Fiebig HH, Meiners M, Helmke E, Laatsch H (2009) Mansouramycins A− D, cytotoxic isoquinolinequinones from a marine Streptomycete. J Nat Prod 72:2120–2124
Hayakawa Y, Shirasaki S, Kawasaki T, Matsuo Y, Adachi K, Shizuri Y (2007) Structures of new cytotoxic antibiotics, piericidins C 7 and C 8. J Antibiot 60:201
Hohmann C, Schneider K, Bruntner C, Brown R, Jones AL, Goodfellow M, Krämer M, Imhoff JF, Nicholson G, Fiedler HP, Süssmuth RD (2009a) Albidopyrone, a new α-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227⋆. J Antibiot 62:75
Hohmann C, Schneider K, Bruntner C, Irran E, Nicholson G, Bull AT, Jones AL, Brown R, Stach JE, Goodfellow M, Beil W (2009b) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937. J Antibiot 62:99
Hohmann C, Schneider K, Bruntner C, Irran E, Nicholson G, Bull AT, Jones AL, Brown R, Stach JE, Goodfellow M, Beil W (2009c) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp NTK 937& ast. J Antibiot 62:99–104
Huang H, Yao Y, He Z, Yang T, Ma J, Tian X, Li Y, Huang C, Chen X, Li W, Zhang S (2011) Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J Nat Prod 74:2122–2127
Huang P, Xie F, Ren B, Wang Q, Wang J, Wang Q, Abdel-Mageed WM, Liu M, Han J, Oyeleye A, Shen J (2016) Anti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp. MS100047. Appl Microbiol Biotechnol 100:7437–7447
Hughes CC, Prieto-Davo A, Jensen PR, Fenical W (2008) The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org Lett 10:629–631
Hwang Y, Rowley D, Rhodes D, Gertsch J, Fenical W, Bushman F (1999) Mechanism of inhibition of a poxvirus topoisomerase by the marine natural product sansalvamide A. Mol Pharmacol 55:1049–1053
Imhoff JF (2016) Natural products from marine fungi - still an underrepresented resource. Mar Drugs 14(1):19
Ishii T, OKino T, Suzuki M, Machiguchi M (2004) Tichocarpols A and B, two novel phenylpropanoids with feeding-deterrent activity from the red alga Tichocarpus crinitus. J Nat Prod 67:1764–1766
Itoh T, Kinoshita M, Aoki S, Kobayashi M (2003) Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp. KS3. J Nat Prod 66:1373–1377
Janardhan A, Kumar AP, Viswanath B, Saigopal DVR, Narasimha G (2014) Production of bioactive compounds by actinomycetes and their antioxidant properties. Biotechnol Res Int:1–8
Jensen PR, Williams PG, Oh DC, Zeigler L, Fenical W (2007) Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl Environ Microbiol 73(4):1146–1152
Jeong SY, Shin HJ, Kim TS, Lee HS, Park SK, Kim HM (2006) Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238. J Antibiot 5:234
Jiang Z-D, Jensen PR, Fenical W (1999) Lobophorins A and B, new anti-inflammatory macrolides produced by a tropical marine bacterium. Bioorg Med Chem Lett 9:2003–2006
Jiang P, Li J, Han F, Duan G, Lu X (2011) Antibiofilm activity of an exopolysaccharide from marine bacterium Vibrio sp. QY101. PLoS One 6:1–11
Jørgensen H, Degnes KF, Dikiy A, Fjærvik E, Klinkenberg G, Zotchev SB (2010) Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449. Appl Environ Microbiol 76:283–293
Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL et al (2008) Global trendsin emerging infectious diseases. Nature 451(7181):990–993
Kanoh K, Matsuo Y, Adachi K, Imagawa H, Nishizawa M, Shizuri Y (2005) Mechercharmycins A and B, cytotoxic substances from marine-derived Thermo actinomyces sp. YM3-251. J Antibiot 58:289
Karthik L, Kumar G, Keswan T, Bhattacharyya CSS, Rao KB (2014) Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound. PLoS One 9:1–13
Kawahara T, Itoh M, Izumikawa M, Kozone I, Sakata N, Tsuchida T, Shin-ya K (2014) New hydroxamate metabolite, MBJ-0003, from Micromonospora sp. 29867. J Antibiot 67:261
Khan S, Kong C, Kim J, Kim S (2015) Protective effect of Amphiroa dilatata on ROS induced oxidative damage and MMP expressions in HT1080 cells. Biotechnol Bioprocess Eng 1:191–198
Kijjoa A, Sawangwong P (2004) Drugs and cosmetics from the sea. Mar Drugs 2:73–82
Kim SK, Pangestuti R (2011) Biological activities and potential health benefits of fucoxanthin derived from marine brown algae. In: Advances in food and nutrition research, vol 64. Academic Press, Cambridge, MA, pp 111–128
Kim Y, Ogura H, Akasaka K, Oikawa T, Matsuura N, Imada C, Yasuda H, Igarashi Y (2014) Nocapyrones: α-and γ-Pyrones from a Marine-Derived Nocardiopsis sp. Mar Drugs 12:4110–4125
Kobayashi K, Fukuda T, Terahara T, Harunari E, Imada C, Tomoda H (2015) Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16. J Antibiot 68:638
Koehn E, Gunasekera SP, Niel DN, Cross SS (1991) Halitunal, an unusual diterpene Aldehyde from the marine alga Halimeda tuna. Tetrahedron Lett 32:169–172
Kogej T, Gostinčar C, Volkmann M, Gorbushina AA, Gunde-Cimerma N (2006) Mycosporines in extremophilic fungi–novel complementary osmolytes? Environ Chem 3:105–110
Kossuga MH, Romminger S, Xavier C, Milanetto MC, Valle MZ, Pimenta EF et al (2012) Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites. Rev Bras Farm 22(2):257–267
Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, Fenical W (2003) Seaweed resistance to microbial attack: a targeted chemical defense against marine fungi. Proc Natl Acad Sci 100:6916–6921
Lam KS (2006) Discovery of novel metabolites from marine actinomycetes. Curr Opin Microbiol 9:245–251
Leary D, Vierros M, Hamon G, Arico S, Monagle C (2009) Marine genetic resources: a review of scientific and commercial interest. Mar Policy 33:183–194
Lee YS, Shin KH, Kim BK, Lee S (2004) Antidiabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res 27:1120–1122
Lee J-G, Yoo I-D, Kim W-G (2007) Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus. Biol Pharm Bull 30(4):795–797
Li F, Maskey RP, Qin S, Sattler I, Fiebig HH, Maier A, Zeeck A, Laatsch H (2005) Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045, 1. J Nat Prod 68:349–353
Li DH, Zhu TJ, Liu HB, Fang YC, Gu QQ, Zhu WM (2006) Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium, Streptoverticillium luteoverticillatum 11014. Arch Pharm Res 29:624–626
López Y, Cepas V, Soto SM (2018) The marine ecosystem as a source of antibiotics. In: Rampelotto P, Trincone A (eds) Grand challenges in marine biotechnology. Grand challenges in biology and biotechnology. Springer, Cham
Macherla VR, Liu J, Bellows C, Teisan S, Nicholson B, Lam KS, Potts BC (2005) Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment. J Nat Prod 68:780–783
Macherla VR, Liu J, Sunga M, White DJ, Grodberg J, Teisan S, Lam KS, Potts BC (2007) Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. J Nat Prod 70:1454–1457
Maneerat S, Phetrong K (2007) Isolation of biosurfactant-producing marine bacteria and characteristics of selected biosurfactant. Songklanakarin J Sci Technol 29:781–791
Manivasagan P, Kang KH, Sivakumar K, Li-Chan EC, Oh HM, Kim SK (2014a) Marine actinobacteria: an important source of bioactive natural products. Environ Toxicol Pharmacol 38:172–188
Manivasagan P, Venkatesan J, Sivakumar K, Kim SK (2014b) Pharmaceutically active secondary metabolites of marine actinobacteria. Microbiol Res 169:262–278
Maskey RP, Helmke E, Laatsch H (2003) Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate. J Antibiot 25:56
Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H (2004) Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry. J Antibiot 57:771–779
Mayer AM, Rodríguez AD, Berlinck RG, Fusetani N (2011) Marine pharmacology in 2007–8: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol 153:191–222
McArthur KA, Mitchell SS, Tsueng G, Rheingold A, White DJ, Grodberg J, Lam KS, Potts BC (2008) Lynamicins A− E, chlorinated bisindole pyrrole antibiotics from a novel marine Actinomycete. J Nat Prod 71:1732–1737
Miller ED, Kauffman CA, Jensen PR, Fenical W (2007) Piperazimycins: cytotoxic hexadep-sipeptides from a marine-derived bacterium of the genus Streptomyces. J Org Chem 72(2):323–330
Mitchell SS, Nicholson B, Teisan S, Lam KS, Potts BC (2004) Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus. J Nat Prod 67:1400–1402
Mohanrasu K, Premnath N, Prakash GS, Sudhakar M, Boobalan T, Arun A (2018) Exploring multi potential uses of marine bacteria; an integrated approach for PHB production, PAHs and polyethylene biodegradation. J Photochem Photobiol 185:55–65
Mnif I, Ghribi D (2015) Review lipopeptides biosurfactants: mean classes and new insights for industrial, biomedical, and environmental applications. Pept Sci 104:129–147
Moore BS, Trischman JA, Seng D, Kho D, Jensen PR, Fenical W (1999) Salinamides, antiinflammatory depsipeptides from a marine Streptomycete. J Org Chem 64:1145–1150
Ngo DH, Kim SK (2013) Sulfated polysaccharides as bioactive agents from marine algae. Int J Biol Macromol 62:70–75
Oh DC, Gontang EA, Kauffman CA, Jensen PR, Fenical W (2008) Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica. J Nat Prod 71:570–575
Ohata K, Mizushina Y, Hirata N, Ohta K, Mizushima Y, Hirata N et al (1998) Sulphoquinovosyl diacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIVreverse transcriptase type from a marine red alga Gigartina tenella. Chem Pharm Bull 46:684–686
Okami Y (1986) Marine microorganisms as a source of bioactive agents. Microb Ecol 12:65–78
Okutani K (1984) Antitumor and immunostimulant activities of polysaccharides produced by a marine bacterium of the genus Vibrio. Bull Jap Soc Sci Fish 50:1035–1037
Okutani K (1992) Antiviral activities of sulfated derivatives of a fucosamine-containing polysaccharide of marine bacterial origin. Nippon Suisan Gakk 58:927–930
Osterhage C, Kaminsky R, Koeing GM, Wright AD (2000) Ascosalipyrrolidinone A, an antimicrobial alkaloid, from the obligate marine fungus Ascochyta salicorniae. J Org Chem 65:6412–6417
Pathom-aree W, Nogi Y, Ward AC, Horikoshi K, Bull AT, Goodfellow M (2006) Dermacoccus barathri sp. nov. and Dermacoccus profundi sp. nov., novel actinomycetes isolated from deep-sea mud of the Mariana Trench. Int J Syst Evol Microbiol 56(10):2303–2307
Pereira HS, Leao-Ferreira LR, Moussatche N, Pereira H, Leão-Ferreira LR, Moussatché N et al (2004) Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1). Antivir Res 64:69–76
Pimentel-Elardo SM, Kozytska S, Bugni TS, Ireland CM, Moll H, Hentschel U (2010) Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges. Mar Drugs 8(2):373–380
Prudhomme J, McDaniel E, Ponts N, Bertani S, Fenical W, Jensen P et al (2008) Marine actinomycetes: a new source of compounds against the human malaria parasite. PLoS One 3(6):2335
Puglisi MP, Tan LT, Jensen PR, Fenical W (2004) Capisterones A and B from the tropical green Alga Penicillus capitatus: unexpected anti-fungal defenses targeting the marine pathogen Lindra thallasiae. Tetrahedron 60:7035–7039
Rainbow PS (1995) Bio monitoring of heavy metal availability in the marine environment. Mar Pollut Bull 31:183–192
Rämä T, Davey M, Norden J, Halvorsen R, Blaalid R, Mathiassen G (2016) Fungi sailing the Arctic Ocean: speciose communities in North Atlantic driftwood as revealed by highthroughput amplicon sequencing. Microb Ecol 72:295–304
Rangel M, Falkenberg M (2015) An overview of the marine natural products in clinical trials and on the market. J Coast Life Med 3:421–428
Ravikumar S, Gnanadesigan M, Thajuddin N, Chakkaravarthi V, Banerjee B (2010) Anti-cancer property of sponge associated actinomycetes along Palk Strait. J Pharm Res 3(10):2415–2417
Ray S, Kalia VC (2017) Biomedical applications of polyhydroxyalkanoates. Indian J Microbiol 57:261–269
Rehm BHA (2003) Polyester synthases: natural catalysts for plastics. Biochem J 376:15–33
Richards TA, Jones MDM, Leonard G, Bass D (2012) Marine fungi: their ecology and molecular diversity. Annu Rev Mar Sci 4:495–522
Rl C, Barrow RA, Rochfort S, Capon RJ, Barrow RA, Rochfort S et al (1998) Marine nematodes: tetrahydrofuran from a southern Australian brown alga, Notheia anomala. Tetrahdron 5:2227–2242
Riedlinger J, Reicke A, Zähner HA, Krismer B, Bull AT, Maldonado LA, Ward AC, Good fellow M, Bister B, Bischoff D, Süssmuth RD (2004) Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032. J Antibiot 57:271–279
Risau W (1997) Mechanisms of angiogenesis. Nature 386:671–674
Romanenko LA, Uchino M, Tebo BM, Tanaka N, Frolova GM, Mikhailov VV (2008) Pseudomonas marincola sp. nov., isolated from marine environments. Int J Syst Evol Microbiol 58:706–710
Romero F, Espliego F, Jp B, De Quesada TG, Grávalos D, De La Calle FE, Fernández-Puentes JL (1997) Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. J Antibiot 5:734–737
Roy SS, Pal R (2015) Microalgae in aquaculture: a review with special references to nutritional value and fish dietetics. Proc Zool Soc 68(1):1–8
Saurav K, Kannabiran K (2012) Cytotoxicity and antioxidant activity of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one extracted from marine Streptomyces VITSVK5 spp. Saudi J Biol Sci 19:81–86. Vancouver
Schneider K, Keller S, Wolter FE, Röglin L, Beil W, Seitz O, Nicholson G, Bruntner C, Riedlinger J, Fiedler HP, Süssmuth RD (2008) Proximicins A, B,and C—antitumor furan analogues of netropsin from the marine actinomycete Verrucosispora induce upregulation of p53 and the cyclin kinase inhibitor p21. Angew Chem Int Ed 47(17):3258–3261
Schultz AW, Oh DC, Carney JR, Williamson RT, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore BS (2008) Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc 130:4507–4516
Schumacher RW, Talmage SC, Miller SA, Sarris KE, Davidson BS, Goldberg A (2003) Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium. J Nat Prod 66:1291–1293
Senni K, Pereira J, Gueniche F, Delbarre-Ladrat C, Sinquin C, Ratiskol J, Godeau G, Fischer AM, Helley D, Colliec-Jouault S (2011) Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineering. Mar Drugs 9:1664–1681
Shin HJ, Kim TS, Lee HS, Park JY, Choi IK, Kwon HJ (2008) Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973. Phytochemistry 69:2363–2366
Shin HJ, Mondol MM, Yu TK, Lee HS, Lee YJ, Jung HJ, Kim JH, Kwon HJ (2010) An angiogenesis inhibitor isolated from a marine-derived actinomycete, Nocardiopsis sp. 03N67. Phytochem Lett 3:194–197
Singh P, Cameotra SS (2004) Potential applications of microbial surfactants in biomedical sciences. Trends Biotechnol 22(3):142–146
Solanki R, Khanna M, Lal R (2008) Bioactive compounds from marine actinomycetes. Indian J Microbiol 48:410–431
Stritzke K, Schulz S, Laatsch H, Helmke E and Beil W (2004) Novel caprolactones from a marine Streptomycete. J Nat Prod 67:395–401
Subramani R, Aalbersberg W (2013) Culturable rare actinomycetes: diversity, isolation and marine natural product discovery. Appl Microbiol Biotechnol 97:9291–9321
Subramani R, Sipkema D (2019) Marine rare actinomycetes: a promising source of structurally diverse and unique novel natural products. Mar Drugs 17:249
Sun M, Chen X, Li W, Lu C, Shen Y (2017) New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066. J Antibiot 70:795
Takahashi C, Minoura K, Yamada T, Numata A, Kushida K, Shingu T, Hagishita S, Nakai H, Sato T, Harada H (1995) Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis. Tetrahedron 51(12):3483–3498
Taylor JD, Cunliffe M (2016) Multi-year assessment of coastal planktonic fungi reveals environmental drivers of diversity and abundance. ISME J 10:2118–2128
Thi QV, Tran VH, Mai HDT, Le CV, Hong MLT, Murphy BT, Chau VM, Pham VC (2016) Antimicrobial metabolites from a marine-derived actinomycete in Vietnam's East Sea. Nat Prod Commun 11:49–51
United States Environmental Protection Agency (2006) Marine ecosystems. http://www.epa.gov/bioiweb1/aquatic/marine.html
Uzair B, Ahmed N, Ahmad VU, Mohammad FV, Edwards DH (2008) The isolation, purification and biological activity of a novel antibacterial compound produced by Pseudomonas stutzeri. FEMS Microbiol Lett 279:243–250
Wanner LA (2009) A patchwork of Streptomyces species isolated from potato common scablesions in North America. Am J Potato Res 86(4):247–264
Weyland H (1969) Actinomycetes in North Sea and Atlantic Ocean sediments. Nature 223:858
Williams PG, Asolkar RN, Kondratyuk T, Pezzuto JM, Jensen PR, Fenical W (2007) Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J Nat Prod 70:83–88
World Health Organisation (2014) Antimicrobial resistance: 2014 global report on surveillance. World Health Organization, Geneva
Wu SJ, Fotso S, Li F, Qin S, Kelter G, Fiebig HH, Laatsch H (2006) N-Carboxamido-staurosporine and Selina-4 (14), 7 (11)-diene-8, 9-diol, New Metabolites from a Marine Streptomyces sp. J Antibiot 59:331
Wyche TP, Piotrowski JS, Hou Y, Braun D, Deshpande R, McIlwain S, Ong IM, Myers CL, Guzei IA, Westler WM, Andes DR (2014) Forazoline A: marine-derived polyketide with antifungal in vivo efficacy. Angew Chem Int Ed 53:11583–11586
Zotchev SB (2012) Marine actinomycetes as an emerging resource for the drug development pipelines. J Biotechnol 158:168–175
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Mohanrasu, K., Rao, R.G.R., Sudhakar, M., Raja, R., Jeyakanthan, J., Arun, A. (2020). Marine Microbial Pharmacognosy: Prospects and Perspectives. In: Nathani, N.M., Mootapally, C., Gadhvi, I.R., Maitreya, B., Joshi, C.G. (eds) Marine Niche: Applications in Pharmaceutical Sciences . Springer, Singapore. https://doi.org/10.1007/978-981-15-5017-1_5
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