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Marine microorganisms as a source of bioactive agents

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Abstract

Several ecological factors of the marine environment were used in developing a strategy for discovering useful bioactive agents from marine microorganisms. By consideration of sea water requirements, production and degradation of marine polymers, and plasmid content, several novel anti-malarial antibiotics, anti-tumor polysaccharides, glucan-degrading enzymes, and aminoglycoside antibiotics were found.

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References

  1. Araragi M (1979) Comparison of actinomycete flora between tropical and Japanese upland farm soils. I. Physiological characteristics. Soil Sci Plant Nutr 25:245–254

    Google Scholar 

  2. Burkholder PR, Pfister RM, Leity FH (1966) Production of a pyrrolo antibiotic by a marine bacterium. Appl Microbiol 14:649–653

    PubMed  Google Scholar 

  3. Colwell RR (1983) Biotechnology in the marine science. Science 222:19–24

    Google Scholar 

  4. Demain AL (1981) Industrial microbiology. Science 214:987–995

    PubMed  Google Scholar 

  5. Fenical W (1982) Natural products chemistry in the marine environment. Science 215: 923–928

    Google Scholar 

  6. Ikeda D, Gomi S, Kondo S, Umezawa H (1983) Some chemical modifications of istamycin B. J Antib 36:331–334

    Google Scholar 

  7. Mitchell R, Nevo Z (1965) Decomposition of structural polysaccharides of bacteria by marine micro-organisms. Nature 205:1007–1008

    Google Scholar 

  8. Nakamura H, Iitaka Y, Kitahara T, Okazaki T, Okami Y (1977) Structure of aplasmomycin. J Antib 30:714–719

    Google Scholar 

  9. Nisbet LJ (1982) Current strategies in the search for bioactive microbial metabolites. J Chem Tech Biotechnol 32:251–270

    Google Scholar 

  10. Okami Y (1972) New samples for collection of sea mud. J Antib 25:467–468

    Google Scholar 

  11. Okami Y, Okazaki T, Kitahara T, Umezawa H (1976) Studies on marine microorganisms. V. A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud. J Antib 29:1019–1025

    Google Scholar 

  12. Okami Y, Hotta K, Yoshida M, Ikeda D, Kondo S, Umezawa H (1979) New aminoglycoside antibiotics, istamycin A and B. J Antib 32:964–966

    Google Scholar 

  13. Okami Y, Kurasawa S, Hirose Y (1980) A new glucanase produced by a marine bacillus. J Antib 44:1191–1192

    Google Scholar 

  14. Sato K, Okazaki T, Maeda K, Okami Y (1978) New antibiotics, aplasmomycin B and C. J Antib 31:632–635

    Google Scholar 

  15. Shigyo T, Hotta K, Okami Y, Umezawa H (1984) Plasmid variability in the istamycin-producing strains ofStreptomyces tenjimariensis. J Antib 37:635–640

    Google Scholar 

  16. Umezawa H, Okami Y, Kurasawa S, Ohnuki T, Ishizuka M, Takeuchi T, Shiio T, Yugari Y (1983) Marinactan, antitumor polysaccharide produced by marine bacteria. J Antib 36: 471–477

    Google Scholar 

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Authors and Affiliations

  1. Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan

    Yoshiro Okami

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  1. Yoshiro Okami
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Okami, Y. Marine microorganisms as a source of bioactive agents. Microb Ecol 12, 65–78 (1986). https://doi.org/10.1007/BF02153223

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  • DOI: https://doi.org/10.1007/BF02153223

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