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Roles of Hepatic Drug Transporters in Drug Disposition and Liver Toxicity

  • Guoyu PanEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1141)

Abstract

Hepatic drug transporters are mainly distributed in parenchymal liver cells (hepatocytes), contributing to drug’s liver disposition and elimination. According to their functions, hepatic transporters can be roughly divided into influx and efflux transporters, translocating specific molecules from blood into hepatic cytosol and mediating the excretion of drugs and metabolites from hepatic cytosol to blood or bile, respectively. The function of hepatic transport systems can be affected by interspecies differences and inter-individual variability (polymorphism). In addition, some drugs and disease can redistribute transporters from the cell surface to the intracellular compartments, leading to the changes in the expression and function of transporters. Hepatic drug transporters have been associated with the hepatic toxicity of drugs. Gene polymorphism of transporters and altered transporter expressions and functions due to diseases are found to be susceptible factors for drug-induced liver injury (DILI). In this chapter, the localization of hepatic drug transporters, their regulatory factors, physiological roles, and their roles in drug’s liver disposition and DILI are reviewed.

Keywords

Hepatic drug transporters Drug disposition Hepatotoxicity DILI 

Notes

Acknowledgments

This chapter was completed with the help of Yaru Xue, Li Han, Ying Wang, Le Wang, and other students of Dr. Guoyu Pan.

Funding

TBD

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghaiChina

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