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Marine-Derived Pharmaceuticals and Future Prospects

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Springer Handbook of Marine Biotechnology

Part of the book series: Springer Handbooks ((SHB))

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Abstract

Over the last decades, the ocean has been identified as a sustained source for the requirements of human beings. The marine environment has an enormous biodiversity and is a source with huge potential for scientific applications. Among the potentials, the pharmaceutical perspective has been identified as having an important and substantial role for future therapeutic uses. Marine-derived secondary metabolites have become a promising source for the design and development of drugs. Therefore, in this chapter, we describe the recent findings of marine derived-secondary metabolites, including halogenated terpenes, steroids and sterols, and polyphenols, along with their therapeutic potentials. Marine proteins and lipids are also targeted to speculate on their role in human health. Moreover, molecular biology approaches and future trends in pharmaceuticals with a view of current drug developments will also be discussed.

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Abbreviations

ACE:

angiotensin-converting enzyme

AMP:

antimicrobial peptide

DAG:

diacylglycerol

DHA:

docosahexaenoic acid

E7389:

eribulin mesylate

EMEA:

European Medicines Agency

EPA:

eicosapentaenoic acid

EST:

express sequence tag

ET-743:

ecteinascidins

FDA:

Food and Drug Administration

GLA:

γ-linolenic acid

HIV-1:

human immunodeficiency virus

LDL:

low-density lipoprotein

NRPS:

nonribosomal peptide synthetase

PK:

polyketide synthase

PUFA:

polyunsaturated fatty acid

RT:

reverse transcriptase

UV:

ultraviolet

cDNA:

complementary DNA

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Authors and Affiliations

  1. Department of Marine Life Science, Jeju National University, 690-756, Jeju, Korea

    You-Jin Jeon & Don A. S. Elvitigala

  2. Herbal Technology Division, Industrial Technology Institute (CISIR), No: 363, Bauddhaloka Mawatha, Colombo, Sri Lanka

    Kalpa W. Samarakoon

Authors
  1. You-Jin Jeon
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  2. Kalpa W. Samarakoon
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  3. Don A. S. Elvitigala
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Corresponding author

Correspondence to You-Jin Jeon .

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Editors and Affiliations

  1. Department of Marine-Bio. Convergence Science Specialized Graduate School Science & Technology Convergence Marine Bioprocess Research Center, Pukyong National University, Yongdang Campus, 365, Sinseon-ro, Nam-gu, 608-739, Busan, Korea

    Se-Kwon Kim Prof.

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© 2015 Springer-Verlag Berlin Heidelberg

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Jeon, YJ., Samarakoon, K.W., Elvitigala, D.A.S. (2015). Marine-Derived Pharmaceuticals and Future Prospects. In: Kim, SK. (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53971-8_41

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