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Surgical Management of Intra-Hepatic Cholangiocarcinoma

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Biliary Tract and Gallbladder Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Intra-hepatic cholangiocarcinoma (ICC) arises from the biliary epithelium of secondary bile ducts or beyond. Many patients present with advanced, often unresectable disease due to vague or absent symptoms. Staging is based on tumor number, vascular invasion, extra-hepatic spread, lymph node involvement, and distant metastatic disease. When feasible, complete surgical resection offers the best hope of long-term survival, and may be approached via open or minimally invasive techniques depending on tumor location and surgeon expertise. Extended hepatic resection, vascular resection, and/or biliary-enteric reconstruction may be required for complete tumor resection. Mortality rates in most modern surgical series are 1–5 %. Five-year overall survival following resection ranges from 17 to 44 %. The role of liver transplant is limited to select centers with clinical trials including rigorous neoadjuvant therapy. The role of adjuvant therapy is still being explored as newer, potentially more effective systemic agents are developed.

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References

  1. Khan SA, Davidson BR, Goldin R, Pereira SP, Rosenberg WM, Taylor-Robinson SD, Thillainayagam AV, Thomas HC, Thursz MR, Wasan H (2002) Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut 51 Suppl 6:VI1–VI9

    Google Scholar 

  2. Shaib Y, El-Serag HB (2004) The epidemiology of cholangiocarcinoma. Semin Liver Dis 24:115–125

    Article  PubMed  Google Scholar 

  3. Chapman RW (1999) Risk factors for biliary tract carcinogenesis. Ann Oncol Off J Eur Soc Med Oncol (ESMO) 10 Suppl 4:308–311

    Article  Google Scholar 

  4. Shaib YH, El-Serag HB, Davila JA, Morgan R, McGlynn KA (2005) Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology 128:620–626

    Article  PubMed  Google Scholar 

  5. Patel T (2001) Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 33:1353–1357

    Article  PubMed  CAS  Google Scholar 

  6. Khan SA, Emadossadaty S, Ladep NG, Thomas HC, Elliott P, Taylor-Robinson SD, Toledano MB (2012) Rising trends in cholangiocarcinoma: is the ICD classification system misleading us? J Hepatol 56:848–854

    Article  PubMed  Google Scholar 

  7. Patel T (2002) Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 2:10

    Article  PubMed Central  PubMed  Google Scholar 

  8. Sempoux C, Jibara G, Ward SC, Fan C, Qin L, Roayaie S, Fiel MI, Schwartz M, Thung SN (2011) Intrahepatic cholangiocarcinoma: new insights in pathology. Semin Liver Dis 31:49–60

    Article  PubMed  Google Scholar 

  9. DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007) Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 245:755–762

    Article  PubMed Central  PubMed  Google Scholar 

  10. Paik KY, Jung JC, Heo JS, Choi SH, Choi DW, Kim YI (2008) What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol 23:766–770

    Article  PubMed  Google Scholar 

  11. Vauthey JN, Lauwers GY, Esnaola NF, Do KA, Belghiti J, Mirza N, Curley SA, Ellis LM, Regimbeau JM, Rashid A, Cleary KR, Nagorney DM (2002) Simplified staging for hepatocellular carcinoma. J Clin Oncol: Off J Am Soc Clin Oncol 20:1527–1536

    Article  Google Scholar 

  12. Nathan H, Aloia TA, Vauthey JN, Abdalla EK, Zhu AX, Schulick RD, Choti MA, Pawlik TM (2009) A proposed staging system for intrahepatic cholangiocarcinoma. Ann Surg Oncol 16:14–22

    Article  PubMed  Google Scholar 

  13. Nathan H, Pawlik TM (2010) Staging of intrahepatic cholangiocarcinoma. Curr Opin Gastroenterol 26:269–273

    Article  PubMed  CAS  Google Scholar 

  14. Farges O, Fuks D, Le Treut YP, Azoulay D, Laurent A, Bachellier P, Nuzzo G, Belghiti J, Pruvot FR, Regimbeau JM (2011) AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: by the AFC-IHCC-2009 study group. Cancer 117:2170–2177

    Article  PubMed  Google Scholar 

  15. de Jong MC, Nathan H, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, Aldrighetti L, Ferrone CR, Zhu AX, Bauer TW, Walters DM, Gamblin TC, Nguyen KT, Turley R, Popescu I, Hubert C, Meyer S, Schulick RD, Choti MA, Gigot JF, Mentha G, Pawlik TM (2011) Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol Off J Am Soc Clin Oncol 29:3140–3145

    Article  Google Scholar 

  16. Hirohashi K, Uenishi T, Kubo S, Yamamoto T, Tanaka H, Shuto T, Kinoshita H (2002) Macroscopic types of intrahepatic cholangiocarcinoma: clinicopathologic features and surgical outcomes. Hepato-Gastroenterology 49:326–329

    PubMed  Google Scholar 

  17. Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Ojima H (2007) Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma. World J Surg 31:2016–2022

    Article  PubMed  Google Scholar 

  18. Nguyen KT, Steel J, Vanounou T, Tsung A, Marsh JW, Geller DA, Gamblin TC (2009) Initial presentation and management of hilar and peripheral cholangiocarcinoma: is a node-positive status or potential margin-positive result a contraindication to resection? Ann Surg Oncol 16:3308–3315

    Article  PubMed Central  PubMed  Google Scholar 

  19. Endo I, Gonen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, D’Angelica M, DeMatteo RP, Fong Y, Schwartz L, Kemeny N, O’Reilly E, Abou-Alfa GK, Shimada H, Blumgart LH, Jarnagin WR (2008) Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg 248:84–96

    Article  PubMed  Google Scholar 

  20. Vauthey JN, Chaoui A, Do KA, Bilimoria MM, Fenstermacher MJ, Charnsangavej C, Hicks M, Alsfasser G, Lauwers G, Hawkins IF, Caridi J (2000) Standardized measurement of the future liver remnant prior to extended liver resection: methodology and clinical associations. Surgery 127:512–519

    Article  PubMed  CAS  Google Scholar 

  21. Couinaud C (1954) Lobes de segments hepatiques: notes sur l’architecture anatomique et chirurgical de foie. La Presse medicale 62:709–712

    PubMed  CAS  Google Scholar 

  22. Strasberg S, Gelghiti J, Clavien PA, Gadzijev E, Garden J, Lau W-Y, Makuuchi M, Strong R (2000) The Brisbane 2000 terminology of liver anatomy and resections. HPB 2:333–339

    Google Scholar 

  23. Ali SM, Clark CJ, Zaydfudim VM, Que FG, Nagorney DM (2012) Role of major vascular resection in patients with intrahepatic cholangiocarcinoma. Annals of surgical oncology 20:1–6

    Google Scholar 

  24. Konstadoulakis MM, Roayaie S, Gomatos IP, Labow D, Fiel MI, Miller CM, Schwartz ME (2008) Fifteen-year, single-center experience with the surgical management of intrahepatic cholangiocarcinoma: operative results and long-term outcome. Surgery 143:366–374

    Article  PubMed  Google Scholar 

  25. Madariaga JR, Iwatsuki S, Todo S, Lee RG, Irish W, Starzl TE (1998) Liver resection for hilar and peripheral cholangiocarcinomas: a study of 62 cases. Ann Surg 227:70–79

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  26. Nakagawa T, Kamiyama T, Kurauchi N, Matsushita M, Nakanishi K, Kamachi H, Kudo T, Todo S (2005) Number of lymph node metastases is a significant prognostic factor in intrahepatic cholangiocarcinoma. World J Surg 29:728–733

    Article  PubMed  Google Scholar 

  27. Shen WF, Zhong W, Xu F, Kan T, Geng L, Xie F, Sui CJ, Yang JM (2009) Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma. World J Gastroenterol (WJG) 15:5976–5982

    Article  CAS  Google Scholar 

  28. Weber SM, Jarnagin WR, Klimstra D, DeMatteo RP, Fong Y, Blumgart LH (2001) Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes. J Am Coll Surg 193:384–391

    Article  PubMed  CAS  Google Scholar 

  29. Lang H, Sotiropoulos GC, Sgourakis G, Schmitz KJ, Paul A, Hilgard P, Zopf T, Trarbach T, Malago M, Baba HA, Broelsch CE (2009) Operations for intrahepatic cholangiocarcinoma: single-institution experience of 158 patients. J Am Coll Surg 208:218–228

    Article  PubMed  Google Scholar 

  30. Lang H, Sotiropoulos GC, Fruhauf NR, Domland M, Paul A, Kind EM, Malago M, Broelsch CE (2005) Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC): when is it worthwhile? Single center experience with 27 resections in 50 patients over a 5-year period. Ann Surg 241:134–143

    PubMed Central  PubMed  Google Scholar 

  31. Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nagino M (2012) Portal vein embolization before extended hepatectomy for biliary cancer: current technique and review of 494 consecutive embolizations. Dig Surg 29:23–29

    Article  PubMed  Google Scholar 

  32. Abdalla EK, Barnett CC, Doherty D, Curley SA, Vauthey JN (2002) Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 137:675–680 (discussion 671–680)

    Article  PubMed  Google Scholar 

  33. Kishi Y, Abdalla EK, Chun YS, Zorzi D, Madoff DC, Wallace MJ, Curley SA, Vauthey JN (2009) Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Ann Surg 250:540–548

    PubMed  Google Scholar 

  34. Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H (1990) Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery 107:521–527

    PubMed  CAS  Google Scholar 

  35. Madoff DC, Hicks ME, Vauthey JN, Charnsangavej C, Morello FA Jr, Ahrar K, Wallace MJ, Gupta S (2002) Transhepatic portal vein embolization: anatomy, indications, and technical considerations. Radiographics: a review publication of the Radiological Society of North America, Inc 22:1063–1076

    Article  Google Scholar 

  36. Nagino M, Kamiya J, Nishio H, Ebata T, Arai T, Nimura Y (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up. Ann Surg 243:364–372

    Article  PubMed Central  PubMed  Google Scholar 

  37. Hemming AW, Reed AI, Howard RJ, Fujita S, Hochwald SN, Caridi JG, Hawkins IF, Vauthey JN (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg 237:686–691

    PubMed Central  PubMed  Google Scholar 

  38. Iida H, Aihara T, Ikuta S, Yoshie H, Yamanaka N (2012) Comparison of percutaneous transhepatic portal vein embolization and unilateral portal vein ligation. World J Gastroenterol (WJG) 18:2371–2376

    Article  Google Scholar 

  39. Simoneau E, Aljiffry M, Salman A, Abualhassan N, Cabrera T, Valenti D, El Baage A, Jamal M, Kavan P, Al-Abbad S, Chaudhury P, Hassanain M, Metrakos P (2012) Portal vein embolization stimulates tumour growth in patients with colorectal cancer liver metastases. Off J Int Heptol Pancreatol Biliary Assoc (HPB) 14:461–468

    Article  Google Scholar 

  40. Peng PD, Hyder O, Bloomston M, Marques H, Corona-Villalobos C, Dixon E, Pulitano C, Hirose K, Schulick RD, Barroso E, Aldrighetti L, Choti M, Shen F, Kamel I, Geschwind JF, Pawlik TM (2012) Sequential intra-arterial therapy and portal vein embolization is feasible and safe in patients with advanced hepatic malignancies. Off J Int Hepatol Pancreatol Biliary Assoc (HPB) 14:523–531

    Article  Google Scholar 

  41. John TG, Greig JD, Crosbie JL, Miles WF, Garden OJ (1994) Superior staging of liver tumors with laparoscopy and laparoscopic ultrasound. Ann Surg 220:711–719

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  42. Ohtsuka M, Ito H, Kimura F, Shimizu H, Togawa A, Yoshidome H, Miyazaki M (2002) Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing survival. Br J Surg 89:1525–1531

    Article  PubMed  CAS  Google Scholar 

  43. Callery MP, Strasberg SM, Doherty GM, Soper NJ, Norton JA (1997) Staging laparoscopy with laparoscopic ultrasonography: optimizing resectability in hepatobiliary and pancreatic malignancy. J Am Coll Surg 185:33–39

    Article  PubMed  CAS  Google Scholar 

  44. Tilleman EH, de Castro SM, Busch OR, Bemelman WA, van Gulik TM, Obertop H, Gouma DJ (2002) Diagnostic laparoscopy and laparoscopic ultrasound for staging of patients with malignant proximal bile duct obstruction. J Gastrointest Surg Off J Soc Surg Aliment Tract 6:426–430 (discussion 421–430)

    Article  Google Scholar 

  45. Goere D, Wagholikar GD, Pessaux P, Carrere N, Sibert A, Vilgrain V, Sauvanet A, Belghiti J (2006) Utility of staging laparoscopy in subsets of biliary cancers: laparoscopy is a powerful diagnostic tool in patients with intrahepatic and gallbladder carcinoma. Surg Endosc 20:721–725

    Article  PubMed  CAS  Google Scholar 

  46. Gaujoux S, Allen PJ (2010) Role of staging laparoscopy in peri-pancreatic and hepatobiliary malignancy. World J Gastrointest Surg 2:283–290

    Article  PubMed Central  PubMed  Google Scholar 

  47. Hoekstra LT, Bieze M, Busch OR, Gouma DJ, van Gulik TM (2012) Staging laparoscopy in patients with hepatocellular carcinoma: is it useful? Surg Endosc 27(3):826–831

    Article  PubMed  Google Scholar 

  48. Shirabe K, Shimada M, Harimoto N, Sugimachi K, Yamashita Y, Tsujita E, Aishima S (2002) Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. Surgery 131:S159–S164

    Article  PubMed  Google Scholar 

  49. Okami J, Dono K, Sakon M, Tsujie M, Hayashi N, Fujiwara Y, Nagano H, Umeshita K, Nakamori S, Monden M (2003) Patterns of regional lymph node involvement in intrahepatic cholangiocarcinoma of the left lobe. J Gastrointest Surg Off J Soc Surg Aliment Tract 7:850–856

    Article  Google Scholar 

  50. Guglielmi A, Ruzzenente A, Campagnaro T, Pachera S, Valdegamberi A, Nicoli P, Cappellani A, Malfermoni G, Iacono C (2009) Intrahepatic cholangiocarcinoma: prognostic factors after surgical resection. World J Surg 33:1247–1254

    Article  PubMed  Google Scholar 

  51. Nathan H, Pawlik TM, Wolfgang CL, Choti MA, Cameron JL, Schulick RD (2007) Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis. J Gastrointest Surg Off J Soc Surg Aliment Tract 11:1488–1496 (discussion 1487–1496)

    Article  Google Scholar 

  52. Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, Miyake H (2012) Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma. Surg Today 42:147–151

    Article  PubMed  Google Scholar 

  53. Reddy SK, Tsung A, Geller DA (2011) Laparoscopic liver resection. World J Surg 35:1478–1486

    Article  PubMed  Google Scholar 

  54. Nguyen KT, Gamblin TC, Geller DA (2009) World review of laparoscopic liver resection-2,804 patients. Ann Surg 250:831–841

    Article  PubMed  Google Scholar 

  55. Nguyen KT, Marsh JW, Tsung A, Steel JJ, Gamblin TC, Geller DA (2011) Comparative benefits of laparoscopic vs open hepatic resection: a critical appraisal. Arch Surg 146:348–356

    Article  PubMed  Google Scholar 

  56. Vanounou T, Steel JL, Nguyen KT, Tsung A, Marsh JW, Geller DA, Gamblin TC (2010) Comparing the clinical and economic impact of laparoscopic versus open liver resection. Ann Surg Oncol 17:998–1009

    Article  PubMed Central  PubMed  Google Scholar 

  57. Packiam V, Bartlett DL, Tohme S, Reddy S, Marsh JW, Geller DA, Tsung A (2012) Minimally invasive liver resection: robotic versus laparoscopic left lateral sectionectomy. J Gastrointest Surg Off J Soc Surg Aliment Tract 16:2233–2238

    Article  Google Scholar 

  58. Choi GH, Choi SH, Kim SH, Hwang HK, Kang CM, Choi JS, Lee WJ (2012) Robotic liver resection: technique and results of 30 consecutive procedures. Surg Endosc 26:2247–2258

    Article  PubMed  Google Scholar 

  59. Kitisin K, Packiam V, Bartlett DL, Tsung A (2011) A current update on the evolution of robotic liver surgery. Minerva Chir 66:281–293

    PubMed  CAS  Google Scholar 

  60. Casavilla FA, Marsh JW, Iwatsuki S, Todo S, Lee RG, Madariaga JR, Pinna A, Dvorchik I, Fung JJ, Starzl TE (1997) Hepatic resection and transplantation for peripheral cholangiocarcinoma. J Am Coll Surg 185:429–436

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  61. Iwatsuki S, Starzl TE, Sheahan DG, Yokoyama I, Demetris AJ, Todo S, Tzakis AG, Van Thiel DH, Carr B, Selby R et al (1991) Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg 214:221–228 (discussion 228–229)

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  62. Meyer CG, Penn I, James L (2000) Liver transplantation for cholangiocarcinoma: results in 207 patients. Transplantation 69:1633–1637

    Article  PubMed  CAS  Google Scholar 

  63. Ghali P, Marotta PJ, Yoshida EM, Bain VG, Marleau D, Peltekian K, Metrakos P, Deschenes M (2005) Liver transplantation for incidental cholangiocarcinoma: analysis of the Canadian experience. Liver Transplant 11:1412–1416 (Official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)

    Article  Google Scholar 

  64. Goldstein RM, Stone M, Tillery GW, Senzer N, Levy M, Husberg BS, Gonwa T, Klintmalm G (1993) Is liver transplantation indicated for cholangiocarcinoma? Am J Surg 166:768–771 (discussion 762–771)

    Article  PubMed  CAS  Google Scholar 

  65. Becker NS, Rodriguez JA, Barshes NR, O’Mahony CA, Goss JA, Aloia TA (2008) Outcomes analysis for 280 patients with cholangiocarcinoma treated with liver transplantation over an 18-year period. J Gastrointest Surg 12:117–122 (the official journal of the Society for Surgery of the Alimentary Tract)

    Article  PubMed  Google Scholar 

  66. Brandsaeter B, Isoniemi H, Broome U, Olausson M, Backman L, Hansen B, Schrumpf E, Oksanen A, Ericzon BG, Hockerstedt K, Makisalo H, Kirkegaard P, Friman S, Bjoro K (2004) Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy. J Hepatol 40:815–822

    Article  PubMed  CAS  Google Scholar 

  67. Hong JC, Petrowsky H, Kaldas FM, Farmer DG, Durazo FA, Finn RS, Saab S, Han SH, Lee P, Markovic D, Lassman C, Hiatt JR, Busuttil RW (2011) Predictive index for tumor recurrence after liver transplantation for locally advanced intrahepatic and hilar cholangiocarcinoma. J Am Coll Surg 212:514–520 (discussion 511–520)

    Article  PubMed  Google Scholar 

  68. Hong JC, Jones CM, Duffy JP, Petrowsky H, Farmer DG, French S, Finn R, Durazo FA, Saab S, Tong MJ, Hiatt JR, Busuttil RW (2011) Comparative analysis of resection and liver transplantation for intrahepatic and hilar cholangiocarcinoma: a 24-year experience in a single center. Arch Surg 146:683–689

    Article  PubMed  Google Scholar 

  69. Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M (2003) One thousand fifty-six hepatectomies without mortality in 8 years. Arch Surg 138:1198–1206 (discussion 1206)

    Article  PubMed  Google Scholar 

  70. Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O (2000) Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 191:38–46

    Article  PubMed  CAS  Google Scholar 

  71. Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Yamashita K, Taniguchi M, Shimamura T, Matsushita M, Todo S (2010) Perioperative management of hepatic resection toward zero mortality and morbidity: analysis of 793 consecutive cases in a single institution. J Am Coll Surg 211:443–449

    Article  PubMed  Google Scholar 

  72. Geller DA, Tsung A, Maheshwari V, Rutstein LA, Fung JJ, Marsh JW (2005) Hepatic resection in 170 patients using saline-cooled radiofrequency coagulation. HPB 7:208–213 (official journal of the International Hepato Pancreato Biliary Association)

    Article  PubMed Central  PubMed  Google Scholar 

  73. Aloia TA, Fahy BN, Fischer CP, Jones SL, Duchini A, Galati J, Gaber AO, Ghobrial RM, Bass BL (2009) Predicting poor outcome following hepatectomy: analysis of 2313 hepatectomies in the NSQIP database. HPB 11:510–515 (the official journal of the International Hepato Pancreato Biliary Association)

    Article  PubMed Central  PubMed  Google Scholar 

  74. Dimick JB, Wainess RM, Cowan JA, Upchurch GR Jr, Knol JA, Colletti LM (2004) National trends in the use and outcomes of hepatic resection. J Am Coll Surg 199:31–38

    Article  PubMed  Google Scholar 

  75. Farges O, Fuks D, Boleslawski E, Le Treut YP, Castaing D, Laurent A, Ducerf C, Rivoire M, Bachellier P, Chiche L, Nuzzo G, Regimbeau JM (2011) Influence of surgical margins on outcome in patients with intrahepatic cholangiocarcinoma: a multicenter study by the AFC-IHCC-2009 study group. Ann surg 254:824–829 (discussion 830)

    Article  PubMed  Google Scholar 

  76. Ducreux M, Van Cutsem E, Van Laethem JL, Gress TM, Jeziorski K, Rougier P, Wagener T, Anak O, Baron B, Nordlinger B (2005) A randomised phase II trial of weekly high-dose 5-fluorouracil with and without folinic acid and cisplatin in patients with advanced biliary tract carcinoma: results of the 40955 EORTC trial. Eur J Cancer 41:398–403

    Article  PubMed  CAS  Google Scholar 

  77. Choi CW, Choi IK, Seo JH, Kim BS, Kim JS, Kim CD, Um SH, Kim JS, Kim YH (2000) Effects of 5-fluorouracil and leucovorin in the treatment of pancreatic-biliary tract adenocarcinomas. Am J Clin Oncol 23:425–428

    Article  PubMed  CAS  Google Scholar 

  78. Raderer M, Hejna MH, Valencak JB, Kornek GV, Weinlander GS, Bareck E, Lenauer J, Brodowicz T, Lang F, Scheithauer W (1999) Two consecutive phase II studies of 5-fluorouracil/leucovorin/mitomycin C and of gemcitabine in patients with advanced biliary cancer. Oncology 56:177–180

    Article  PubMed  CAS  Google Scholar 

  79. Lin MH, Chen JS, Chen HH, Su WC (2003) A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas. Chemotherapy 49:154–158

    Article  PubMed  CAS  Google Scholar 

  80. Tsavaris N, Kosmas C, Gouveris P, Gennatas K, Polyzos A, Mouratidou D, Tsipras H, Margaris H, Papastratis G, Tzima E, Papadoniou N, Karatzas G, Papalambros E (2004) Weekly gemcitabine for the treatment of biliary tract and gallbladder cancer. Invest New Drugs 22:193–198

    Article  PubMed  CAS  Google Scholar 

  81. Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New Engl J Med 362:1273–1281

    Article  PubMed  CAS  Google Scholar 

  82. Glazer ES, Liu P, Abdalla EK, Vauthey JN, Curley SA (2012) Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins. Journal of Gastrointest Surg 16:1666–1671 (official journal of the Society for Surgery of the Alimentary Tract)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA

    Kimberly M. Brown

  2. Liver Cancer Center, University of Pittsburgh Medical Center, 459 Fifth Ave. UPMC Montefiore, 7 South Pittsburgh, Pittsburgh, PA, 15213-2582, USA

    David A. Geller

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  1. Kimberly M. Brown
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Correspondence to David A. Geller .

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Editors and Affiliations

  1. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA

    Joseph M. Herman

  2. Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA

    Timothy M. Pawlik

  3. Department of Radiation Oncology, Oregon Health and Science University, Portland, Oregon, USA

    Charles R. Thomas, Jr.

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Brown, K.M., Geller, D.A. (2014). Surgical Management of Intra-Hepatic Cholangiocarcinoma. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_15

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