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Surgical Outcomes of the Mass-Forming plus Periductal Infiltrating Types of Intrahepatic Cholangiocarcinoma: A Comparative Study with the Typical Mass-Forming Type of Intrahepatic Cholangiocarcinoma

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Abstract

Background

The purpose of this study was to clarify the clinicopathologic characteristics and surgical outcomes of patients with the mass-forming (MF) plus periductal infiltrating (PI) type of intrahepatic cholangiocellular carcinoma (ICC).

Methods

Between January 1, 1998, and December 31, 2004, a total of 94 patients with ICC underwent macroscopic curative resection, and the macroscopic type of the tumors was assessed prospectively. Among the 74 patients with the MF type (n = 46) and the MF plus PI type (n = 28) of ICC, multivariate analysis was conducted to identify the potential prognostic factors. The clinicopathologic data of the two groups were compared.

Results

The results revealed two independent prognostic factors: presence/absence of intrahepatic metastasis and the macroscopic type of the tumor. ICCs categorized macroscopically as the MF plus PI type were significantly associated with jaundice (p < 0.001), bile duct invasion (p < 0.001), portal vein invasion (p = 0.025), lymph node involvement (p = 0.017), and positive surgical margin (p = 0.038).

Conclusion

Identification of the macroscopic type of the tumor is useful for predicting survival after hepatectomy in patients with ICC. The MF plus PI type of ICC appears to have a more unfavorable prognosis, even after radical surgery, than the MF type of ICC.

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Acknowledgments

This study was supported by a Grant-in-Aid for cancer research from the Ministry of Health, Welfare, and Labor of Japan

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Authors and Affiliations

  1. Department of Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5-1-1Tsukiji; Chuo-ku, Tokyo, 104-0045, Japan

    Kazuaki Shimada, Yoshihiro Sakamoto, Minoru Esaki & Tomoo Kosuge

  2. Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

    Hidenori Ojima

  3. Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan

    Tsuyoshi Sano

Authors
  1. Kazuaki Shimada
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  2. Tsuyoshi Sano
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  3. Yoshihiro Sakamoto
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  4. Minoru Esaki
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  5. Tomoo Kosuge
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  6. Hidenori Ojima
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Correspondence to Kazuaki Shimada.

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Shimada, K., Sano, T., Sakamoto, Y. et al. Surgical Outcomes of the Mass-Forming plus Periductal Infiltrating Types of Intrahepatic Cholangiocarcinoma: A Comparative Study with the Typical Mass-Forming Type of Intrahepatic Cholangiocarcinoma. World J Surg 31, 2016–2022 (2007). https://doi.org/10.1007/s00268-007-9194-0

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  • DOI: https://doi.org/10.1007/s00268-007-9194-0

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