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Small Leucine-Rich Proteoglycans

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The Extracellular Matrix: an Overview

Part of the book series: Biology of Extracellular Matrix ((BEM))

Abstract

The small leucine-rich proteoglycans (SLRPs) comprise an expanding family of proteoglycans and glycoproteins that now encompass five distinct groups including three canonical and two noncanonical classes based on shared structural and functional parameters. SLRPs are tissue organizers by orienting and ordering various collagenous matrices during ontogeny, wound repair, and cancer and interact with a number of surface receptors and growth factors, thereby regulating cell behavior. The focus of this chapter is on novel conceptual and functional advances in our understanding of SLRP biology with special emphasis on genetic diseases, cancer growth, fibrosis, osteoporosis, and other biological processes where these proteoglycans play a central role.

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Acknowledgments

We like to thank all the past and present members of our laboratories for their invaluable contribution to this field of research. We are indebted to Angela McQuillan for her outstanding help with the illustrations. The original work in Iozzo’s laboratory was supported in part by NIH grants RO1 CA39481, RO1 CA47282, and RO1 CA120975, and in the Young’s laboratory by the Intramural Program of the NIDCR, NIH.

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  1. Department of Pathology, Anatomy and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Room 249 JAH, 1020 Locust Street, Philadelphia, PA, 19107, USA

    Renato V. Iozzo & Silvia Goldoni

  2. Craniofacial and Skeletal Diseases Branch, Molecular Biology of Bones and Teeth Section, NIDCR, National Institutes of Health, Bethesda, MD, 20892, USA

    Agnes D. Berendsen & Marian F. Young

Authors
  1. Renato V. Iozzo
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  2. Silvia Goldoni
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  3. Agnes D. Berendsen
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  4. Marian F. Young
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Correspondence to Renato V. Iozzo .

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  1. School of Medicine, Dept. Cell Biology & Physiology, Washington University, S. Euclid Avenue 660, St. Louis, 63110, Missouri, USA

    Robert P. Mecham

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Iozzo, R.V., Goldoni, S., Berendsen, A.D., Young, M.F. (2011). Small Leucine-Rich Proteoglycans. In: Mecham, R. (eds) The Extracellular Matrix: an Overview. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16555-9_6

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