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Plant Antioxidants in the Prevention of Early Life Programming Diseases

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Nutritional Antioxidant Therapies: Treatments and Perspectives

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Abstract

An unavoidable consequence of aerobic life is the production of reactive oxygen species (ROS), which can damage proteins, fatty acids and nucleotides that make up our cells and lead to organ dysfunction and diseases. Aerobic organisms elicit interrelated antioxidant mechanisms to keep ROS at physiological levels and to ensure cellular redox homeostasis and biological processes during the life cycle of organisms, namely, cell proliferation, differentiation, migration, survival and apoptosis. The delicate balance between ROS production and removal by antioxidants during pregnancy is crucial for the foetus to develop and mature into a healthy neonate, whereas early foetal life ROS-induced oxidative stress alters foetal developmental trajectory that could lead to increased risk of noncommunicable chronic diseases during adult life. Stressful events during the intrauterine life, such as undernutrition, malnutrition, unhealthy lifestyle behaviours and exposure to multiple human-made pollutants, adversely affect prenatal development and may contribute to foetal origin of disease in adulthood partly due to oxidative stress. Antioxidants present in most foods of vegetable origin are widely recommended for health promotion and disease prevention. In this chapter, the risk of adverse prenatal development related to antioxidant deficiencies and the importance of dietary antioxidants in the establishment of healthy pregnancy are highlighted. The potential of medicinal plants and plant-based functional foods and beverages with varied and balanced antioxidants, as well as diet quality and healthy dietary habits, as effective means in the prevention of oxidative stress and prenatal developmental disorders is also discussed.

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References

  • Abdel-Naim AB, Nagy AA, Mohamadin AM, El-Mazar HM, Ahmed AE. Chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal liver. Toxicol Lett. 2009;190:123–7.

    Article  CAS  PubMed  Google Scholar 

  • Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J. Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere. 2002;46:1485–9.

    Article  CAS  PubMed  Google Scholar 

  • Agani FH, Puchowicz M, Chavez JC, Pichiule P, LaManna J. Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia. Am J Physiol Cell Physiol. 2002;283:C178–86.

    Article  CAS  PubMed  Google Scholar 

  • Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009;30:85–94.

    Article  CAS  PubMed  Google Scholar 

  • Agha Fatma E, Hassannane MS, Omara EA, Hasan AM, El-Toumy SA. Protective effect of Punica granatum peel extract against pentachlorophenol-induced oxidative stress, cytogenetic toxicity and hepatic damage in rats. Aust J Basic Appl Sci. 2013;7:853–64.

    Google Scholar 

  • Ahmed AE, Jacob S, Campbell GA, Harirah HM, Perez-Polo JR, Johnson KM. Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain. Brain Res Dev Brain Res. 2005;159:1–11.

    Article  CAS  PubMed  Google Scholar 

  • Aimo L, Mackenzie GG, Keenan AH, Oteiza PI. Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain. J Nutr Biochem. 2010;21:1069–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Al-Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F. Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem. 2005;53:7592–9.

    Article  CAS  PubMed  Google Scholar 

  • Al-Gubory KH. Reactive oxygen species, antioxidant systems and prenatal developmental outcomes. In: Laher I, editor. Handbook of systems biology of free radicals and anti-oxidants. Berlin: Springer; 2014a.

    Google Scholar 

  • Al-Gubory KH. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reprod Biomed Online. 2014b;29:17–31.

    Article  CAS  PubMed  Google Scholar 

  • Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 2010;42:1634–50.

    Article  CAS  PubMed  Google Scholar 

  • Al-Kuran O, Al-Mehaisen L, Bawadi H, Beitawi S, Amarin Z. The effect of late pregnancy consumption of date fruit on labour and delivery. J Obstet Gynaecol. 2011;31:29–31.

    Article  CAS  PubMed  Google Scholar 

  • Al-Odat I, Chen H, Chan YL, Amgad S, Wong MG, Gill A, Pollock C, et al. The impact of maternal cigarette smoke exposure in a rodent model on renal development in the offspring. PLoS One. 2014;9:e103443.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Amaral Mendes JJ. The endocrine disrupters: a major medical challenge. Food Chem Toxicol. 2002;40:781–8.

    Article  CAS  PubMed  Google Scholar 

  • Amer OS, Dkhil MA, Hikal WM, Al-Quraishy S. Antioxidant and anti-inflammatory activities of pomegranate (Punica granatum) on Eimeria papillata-induced infection in mice. Biomed Res Int. 2015;2015:219670.

    PubMed  PubMed Central  Google Scholar 

  • Anselmo HM, Koerting L, Devito S, van den Berg JH, Dubbeldam M, Kwadijk C, Murk AJ. Early life developmental effects of marine persistent organic pollutants on the sea urchin Psammechinus miliaris. Ecotoxicol Environ Saf. 2011;74:2182–92.

    Article  CAS  PubMed  Google Scholar 

  • Ashok A, Rai NK, Tripathi S, Bandyopadhyay S. Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicol Sci. 2015;143:64–80.

    Article  CAS  PubMed  Google Scholar 

  • Ávila JG, Echeverri I, de Plata CA, Castillo A. Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases. Nutr Rev. 2015;73:12–21.

    Article  PubMed  Google Scholar 

  • Backes CH, Nelin T, Gorr MW, Wold LE. Early life exposure to air pollution: how bad is it? Toxicol Lett. 2013;216:47–53.

    Article  CAS  PubMed  Google Scholar 

  • Bada HS, Das A, Bauer CR, Shankaran S, Lester BM, Gard CC, Wright LL, Lagasse L, Higgins R. Low birth weight and preterm births: etiologic fraction attributable to prenatal drug exposure. J Perinatol. 2005;25:631–7.

    Article  PubMed  Google Scholar 

  • Bai N, Khazaei M, van Eeden SF, Laher I. The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. Pharmacol Ther. 2007;113:16–29.

    Article  CAS  PubMed  Google Scholar 

  • Bao W, Bowers K, Tobias DK, Hu FB, Zhang C. Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetes Care. 2013;36:2001–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barcroft J. Researches in perinatal life. Oxford, UK: Blackwell; 1946.

    Google Scholar 

  • Barger MK. Maternal nutrition and perinatal outcomes. J Midwifery Womens Health. 2010;55:502–11.

    Article  PubMed  Google Scholar 

  • Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993;341:938–41.

    Article  CAS  PubMed  Google Scholar 

  • Basu A, Lucas EA. Mechanisms and effects of green tea on cardiovascular health. Nutr Rev. 2007;65:361–75.

    Article  PubMed  Google Scholar 

  • Beazley D, Ahokas R, Livingston J, Griggs M, Sibai BM. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2005;192:520–1.

    Article  CAS  PubMed  Google Scholar 

  • Beckers-Trapp ME, Lanoue L, Keen CL, Rucker RB, Uriu-Adams JY. Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos. Free Radic Biol Med. 2006;40:35–44.

    Article  CAS  PubMed  Google Scholar 

  • Bernal AB, Vickers MH, Hampton MB, Poynton RA, Sloboda DM. Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS One. 2010;5:15558.

    Article  CAS  Google Scholar 

  • Biri A, Bozkurt N, Turp A, Kavutcu M, Himmetoglu O, Durak I. Role of oxidative stress in intrauterine growth restriction. Gynecol Obstet Investig. 2007;64:187–92.

    Article  CAS  Google Scholar 

  • Bloom MS, Neamtiu IA, Surdu S, Pop C, Anastasiu D, Appleton AA, Fitzgerald EF, et al. Low level arsenic contaminated water consumption and birth outcomes in Romania-an exploratory study. Reprod Toxicol. 2016;59:8–16.

    Article  CAS  PubMed  Google Scholar 

  • Bonefeld-Jørgensen EC, Ghisari M, Wielsøe M, Bjerregaard-Olesen C, Kjeldsen LS, Long M. Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo. Basic Clin Pharmacol Toxicol. 2014;115:118–28.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brantsaeter AL, Haugen M, Rasmussen SE, Alexander J, Samuelsen SO, Meltzer HM. Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Public Health Nutr. 2007;10:838–47.

    Article  PubMed  Google Scholar 

  • Caito SW, Aschner M. Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal. 2015;23:578–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Camps J, García-Heredia A. Introduction: oxidation and inflammation, a molecular link between non-communicable diseases. Adv Exp Med Biol. 2014;824:1–4.

    Article  CAS  PubMed  Google Scholar 

  • Caniggia I, Winter J, Lye SJ, Post M. Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta. 2000;21(Suppl A):S25–30.

    Article  PubMed  Google Scholar 

  • Capobianco E, Pelesson M, Careaga V, Fornes D, Canosa I, Higa R, Maier M, et al. Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil. Mol Nutr Food Res. 2015;59:1997–2007.

    Article  CAS  PubMed  Google Scholar 

  • Carlsen MH, Halvorsen BL, Holte K, Bøhn SK, Dragland S, Sampson L, Willey C, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. J Nutr. 2010;9:3.

    Article  Google Scholar 

  • Cederberg J, Eriksson UJ. Antioxidative treatment of pregnant diabetic rats diminishes embryonic dysmorphogenesis. Birth Defects Res A Clin Mol Teratol. 2005;73:498–505.

    Article  CAS  PubMed  Google Scholar 

  • Chand S, Mustafa MD, Banerjee BD, Guleria K. CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age. Eur J Obstet Gynecol Reprod Biol. 2014;180:100–5.

    Article  CAS  PubMed  Google Scholar 

  • Chang CS, Chang CL, Lai GH. Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta-carotene, and canthaxanthin. Kaohsiung J Med Sci. 2013;29:412–21.

    Article  PubMed  Google Scholar 

  • Chaudhari P, Ye Z, Jang YY. Roles of reactive oxygen species in the fate of stem cells. Antioxid Redox Signal. 2014;20:1881–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen B, Kan H. Air pollution and population health: a global challenge. Environ Health Prev Med. 2008;13:94–101.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen B, Tuuli MG, Longtine MS, Shin JS, Lawrence R, Inder T, Michael Nelson D. Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts. Am J Physiol Endocrinol Metab. 2012;302:E1142–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chidambara Murthy KN, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem. 2002;50:4791–5.

    Article  PubMed  CAS  Google Scholar 

  • Chu KO, Wang CC, Chu CY, Choy KW, Pang CP, Rogers MS. Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Hum Reprod. 2007;22:280–7.

    Article  CAS  PubMed  Google Scholar 

  • Cui K, Luo X, Xu K, Ven Murthy MR. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog Neuro-Psychopharmacol Biol Psychiatry. 2004;28:771–99.

    Article  CAS  Google Scholar 

  • Dadvand P, Parker J, Bell ML, Bonzini M, Brauer M, Darrow LA, Gehring U, et al. Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity. Environ Health Perspect. 2013;121:267–373.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dai J, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, et al. Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr. 2008;88:1364–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Davies KJ. Oxidative stress: the paradox of aerobic life. Biochem Soc Symp. 1995;61:1–31.

    Article  CAS  PubMed  Google Scholar 

  • Davis JM, Auten RL. Maturation of the antioxidant system and the effects on preterm birth. Semin Fetal Neonatal Med. 2010;15:191–5.

    Article  PubMed  Google Scholar 

  • De Blasio MJ, Gatford KL, Robinson JS, Owens JA. Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb. Am J Physiol Regul Integr Comp Physiol. 2007;292:R875–86.

    Article  PubMed  CAS  Google Scholar 

  • Del Donno M, Verduri A, Olivieri D. Air pollution and reversible chronic respiratory diseases. Monaldi Arch Chest Dis. 2002;57:164–6.

    PubMed  Google Scholar 

  • Dennery PA. Oxidative stress in development: nature or nurture? Free Radic Biol Med. 2010;49:1147–51.

    Article  CAS  PubMed  Google Scholar 

  • Desforges M, Ditchfield A, Hirst CR, Pegorie C, Martyn-Smith K, Sibley CP, Greenwood SL. Reduced placental taurine transporter (TauT) activity in pregnancies complicated by pre-eclampsia and maternal obesity. Adv Exp Med Biol. 2013;776:81–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dewan P, Jain V, Gupta P, Banerjee BD. Organochlorine pesticide residues in maternal blood, cord blood, placenta, and breastmilk and their relation to birth size. Chemosphere. 2013;90:1704–10.

    Article  CAS  PubMed  Google Scholar 

  • Ding G, Cui C, Chen L, Gao Y, Zhou Y, Shi R, Tian Y. Prenatal exposure to pyrethroid insecticides and birth outcomes in Rural Northern China. J Expo Sci Environ Epidemiol. 2015;5:264–70.

    Article  CAS  Google Scholar 

  • Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci. 1998;94:149–55.

    Article  CAS  PubMed  Google Scholar 

  • Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? Am J Epidemiol. 2007;166:880–8.

    Article  PubMed  Google Scholar 

  • Eastman NJ. Mount Everest in utero. Am J Obstet Gynecol. 1954;67:701–11.

    Article  CAS  PubMed  Google Scholar 

  • Erickson AC, Arbour L. The shared pathoetiological effects of particulate air pollution and the social environment on fetal-placental development. J Environ Public Health. 2014;2014:901017.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fall CHD, Fisher DJ, Osmond C, Margetts BM. Maternal Micronutrient Supplementation Study Group. Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food Nutr Bull. 2009;30:S533–46.

    Article  PubMed  PubMed Central  Google Scholar 

  • Feng MJ, Yan SE, Yan QS. Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring. Brain Res. 2005;1042:125–32.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Twinn DS, Ozanne SE. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome. Physiol Behav. 2006;88:234–43.

    Article  CAS  PubMed  Google Scholar 

  • Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Franco Mdo C, Dantas AP, Akamine EH, Kawamoto EM, Fortes ZB, Scavone C, Tostes RC, et al. Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero. J Cardiovasc Pharmacol. 2002;40:501–9.

    Article  PubMed  Google Scholar 

  • Franco MC, Akamine EH, Rebouças N, Carvalho MH, Tostes RC, Nigro D, Fortes ZB. Long-term effects of intrauterine malnutrition on vascular function in female offspring: implications of oxidative stress. Life Sci. 2007a;80:709–15.

    Article  CAS  PubMed  Google Scholar 

  • Franco JL, Braga HC, Stringari J, Missau FC, Posser T, Mendes BG, Leal RB, et al. Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin. Chem Res Toxicol. 2007b;20:1919–26.

    Article  CAS  PubMed  Google Scholar 

  • Fridovich I. Oxygen toxicity: a radical explanation. J Exp Biol. 1998;201:1203–9.

    CAS  PubMed  Google Scholar 

  • Fuliang HU, Hepburn HR, Xuan H, Chen M, Daya S, Radloff SE. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res. 2005;51:47–152.

    Article  CAS  Google Scholar 

  • Gardner EJ, Ruxton CH, Leeds AR. Black tea—helpful or harmful? A review of the evidence. Eur J Clin Nutr. 2007;61:3–18.

    Article  CAS  PubMed  Google Scholar 

  • Gäreskog M, Eriksson UJ, Wentzel P. Combined supplementation of folic acid and vitamin E diminishes diabetes-induced embryotoxicity in rats. Birth Defects Res A Clin Mol Teratol. 2006;76:483–90.

    Article  PubMed  CAS  Google Scholar 

  • Genc S, Zadeoglulari Z, Fuss SH, Genc K. The adverse effects of air pollution on the nervous system. J Toxicol. 2012;2012:782462.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gesteiro E, Bastida S, Rodríguez Bernal B, Sánchez-Muniz FJ. Adherence to Mediterranean diet during pregnancy and serum lipid, lipoprotein and homocysteine concentrations at birth. Eur J Nutr. 2015;54:1191–9.

    Article  CAS  PubMed  Google Scholar 

  • Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem. 2002;50:3050–5.

    Article  CAS  PubMed  Google Scholar 

  • Gheldof N, Wang XH, Engeseth NJ. Identification and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem. 2002;50:5870–7.

    Article  CAS  PubMed  Google Scholar 

  • Ghulmiyyah LM, Costantine MM, Yin H, Tamayo E, Clark SM, Hankins GD, Saade GR, Longo M. The role of oxidative stress in the developmental origin of adult hypertension. Am J Obstet Gynecol. 2011;205:155.e7–11.

    Article  CAS  Google Scholar 

  • Gill S, Bowers WJ, Nakai JS, Yagminas A, Mueller R, Pulido O. Effects of environmentally relevant mixtures of persistent organic pollutants on the developmental neurobiology in rats. Toxicol Pathol. 2013;41:38–47.

    Article  PubMed  CAS  Google Scholar 

  • Giussani DA, Niu Y, Herrera EA, Richter HG, Camm EJ, Thakor AS, et al. Heart disease link to fetal hypoxia and oxidative stress. Adv Exp Med Biol. 2014;814:77–87.

    Article  CAS  PubMed  Google Scholar 

  • Golbidi S, Laher I. Antioxidant therapy in human endocrine disorders. Med Sci Monit. 2010;16:RA9–RA24.

    CAS  PubMed  Google Scholar 

  • Gong P, Liu M, Hong G, Li Y, Xue P, Zheng M, Wu M, et al. Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway. Placenta. 2016;41:45–52.

    Article  CAS  PubMed  Google Scholar 

  • Görlach A, Dimova EY, Petry A, Martínez-Ruiz A, Hernansanz-Agustín P, Rolo AP, et al. Reactive oxygen species, nutrition, hypoxia and diseases: problems solved? Redox Biol. 2015;6:372–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gude NM, Roberts CT, Kalionis B, King RG. Growth and function of the normal human placenta. Thromb Res. 2004;114:397–407.

    Article  CAS  PubMed  Google Scholar 

  • Gupta P, Narang M, Banerjee BD, Basu S. Oxidative stress in term small for gestational age neonates born to undernourished mothers: a case control study. BMC Pediatr. 2004;4:14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect. 2002;110:749–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haron MN, Mohamed M. Effect of honey on the reproductive system of male rat offspring exposed to prenatal restraint stress. Andrologia. 2016;48:525–31.

    Article  CAS  PubMed  Google Scholar 

  • Hawk SN, Lanoue L, Keen CL, Kwik-Uribe CL, Rucker RB, Uriu-Adams JY. Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions. Biol Reprod. 2003;68:896–903.

    Article  CAS  PubMed  Google Scholar 

  • Hegazi AG, Abd El-Hady FK. Influence of honey on the suppression of human low density lipoprotein (LDL) peroxidation (in vitro). Evid Based Complement Alternat Med. 2009;6:113–21.

    Article  PubMed  Google Scholar 

  • Henning SM, Zhang Y, Rontoyanni VG, Huang J, Lee RP, Trang A, Nuernberger G, et al. Variability in the antioxidant activity of dietary supplements from pomegranate, milk thistle, green tea, grape seed, goji, and acai: effects of in vitro digestion. J Agric Food Chem. 2014;62:4313–21.

    Article  CAS  PubMed  Google Scholar 

  • Henriksen T. Foetal nutrition, foetal growth restriction and health later in life. Acta Paediatr Suppl. 1999;88:4–8.

    Article  CAS  PubMed  Google Scholar 

  • Higa R, White V, Martínez N, Kurtz M, Capobianco E, Jawerbaum A. Safflower and olive oil dietary treatments rescue aberrant embryonic arachidonic acid and nitric oxide metabolism and prevent diabetic embryopathy in rats. Mol Hum Reprod. 2010;16:286–95.

    Article  CAS  PubMed  Google Scholar 

  • Higa R, Roberti SL, Musikant D, Mazzucco MB, White V, Jawerbaum A. Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy. Reprod Toxicol. 2014;49:185–95.

    Article  CAS  PubMed  Google Scholar 

  • Hong YJ, Tomas-Barberan FA, Kader AA, Mitchell AE. The flavonoid glycosides and procyanidin composition of Deglet Noor dates (Phoenix dactylifera). J Agric Food Chem. 2006;54:2405–11.

    Article  CAS  PubMed  Google Scholar 

  • Horta BL, Victora CG, Menezes AM, Halpern R, Barros FC. Low birthweight, preterm births and intrauterine growth retardation in relation to maternal smoking. Paediatr Perinat Epidemiol. 1997;11:140–51.

    Article  CAS  PubMed  Google Scholar 

  • Hracsko Z, Orvos H, Novak Z, Pal A, Varga IS. Evaluation of oxidative stress markers in neonates with intra-uterine growth retardation. Redox Rep. 2008;13:11–6.

    Article  CAS  PubMed  Google Scholar 

  • Jaacks LM, Kavle J, Perry A, Nyaku A. Programming maternal and child overweight and obesity in the context of undernutrition: current evidence and key considerations for low- and middle-income countries. Public Health Nutr. 2017;20:1286–96.

    Article  PubMed  PubMed Central  Google Scholar 

  • Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, Kalyanaraman B, Finkel T, Stamler JS, et al. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med. 2008;45:1–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jansson T, Powell TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci. 2007;113:1–13.

    Article  CAS  PubMed  Google Scholar 

  • Ježek P, Hlavatá L. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int J Biochem Cell Biol. 2005;37:2478–503.

    Article  PubMed  CAS  Google Scholar 

  • Jiang Y, Su X, Wang C, Zhang L, Zhang X, Wang L, Cui Y. Prevalence and risk factors for stunting and severe stunting among children under three years old in mid-western rural areas of China. Child Care Health Dev. 2015;41:45–51.

    Article  CAS  PubMed  Google Scholar 

  • Kabuto H, Amakawa M, Shishibori T. Exposure to bisphenol A during embryonic/fetal life and infancy increases oxidative injury and causes underdevelopment of the brain and testis in mice. Life Sci. 2004;74:2931–40.

    Article  CAS  PubMed  Google Scholar 

  • Kalinka J, Hanke W. Tobacco smoking—a risk factor for intrauterine growth retardation, preterm delivery and low birth weight. Ginekol Pol. 1996;67:75–81.

    CAS  PubMed  Google Scholar 

  • Kamath U, Rao G, Kamath SU, Rai L. Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR). Indian J Clin Biochem. 2006;21:111–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kapoor P, Ansari MN, Bhandari U. Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats. Indian J Exp Biol. 2008;46:534–740.

    CAS  PubMed  Google Scholar 

  • Karowicz-Bilinska A, Kedziora-Kornatowska K, Bartosz G. Indices of oxidative stress in pregnancy with fetal growth restriction. Free Radic Res. 2007;41:870–3.

    Article  CAS  PubMed  Google Scholar 

  • Khalil ML. Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev. 2006;7:22–31.

    PubMed  Google Scholar 

  • Kimani-Murage EW, Muthuri SK, Oti SO, Mutua MK, van de Vijver S, Kyobutungi C. Evidence of a double burden of malnutrition in urban poor settings in Nairobi, Kenya. PLoS One. 2015;10:e0129943.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kinalski M, Sledziewski A, Telejko B, Zarzycki W, Kinalska I. Antioxidant therapy and streptozotocin-induced diabetes in pregnant rats. Acta Diabetol. 1999;36:113–7.

    Article  CAS  PubMed  Google Scholar 

  • Klingmüller D, Alléra A. Endocrine disruptors: hormone-active chemicals from the environment: a risk to humans? Dtsch Med Wochenschr. 2011;136:967–72.

    Article  PubMed  CAS  Google Scholar 

  • Kramer MS, Séguin L, Lydon J, Goulet L. Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly? Paediatr Perinat Epidemiol. 2000;14:194–210.

    Article  CAS  PubMed  Google Scholar 

  • Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol. 1996;175:1534–42.

    Article  CAS  PubMed  Google Scholar 

  • Kuhnert BR, Kuhnert PM. Placental transfer of drugs, alcohol, and components of cigarette smoke and their effects on the human fetus. NIDA Res Monogr. 1985;60:98–109.

    CAS  PubMed  Google Scholar 

  • Kumagai Y, Arimoto T, Shinyashiki M, Shimojo N, Nakai Y, Yoshikawa T, Sagai M. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med. 1997;22:479–87.

    Article  CAS  PubMed  Google Scholar 

  • Kumar D, Singh S, Singh AK, Rizvi SI. Pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats. Pharm Biol. 2013;51:441–6.

    Article  CAS  PubMed  Google Scholar 

  • Kurtz M, Capobianco E, Careaga V, Martinez N, Mazzucco MB, Maier M, Jawerbaum A. Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. J Endocrinol. 2014;220:345–59.

    Article  CAS  PubMed  Google Scholar 

  • Lakshmy R. Metabolic syndrome: role of maternal undernutrition and fetal programming. Rev Endocr Metab Disord. 2013;14:229–40.

    Article  CAS  PubMed  Google Scholar 

  • Langley-Evans SC. Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int J Food Sci Nutr. 2000;51:309–15.

    Article  CAS  PubMed  Google Scholar 

  • Langley-Evans SC. Nutrition in early life and the programming of adult disease: a review. J Hum Nutr Diet. 2015;28(Suppl 1):1–14.

    Article  PubMed  Google Scholar 

  • Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007;109:177–206.

    Article  CAS  PubMed  Google Scholar 

  • Leduc L, Levy E, Bouity-Voubou M, Delvin E. Fetal programming of atherosclerosis: possible role of the mitochondria. Eur J Obstet Gynecol Reprod Biol. 2010;149:127–30.

    Article  CAS  PubMed  Google Scholar 

  • Lee CH, Yu HS. Role of mitochondria, ROS, and DNA damage in arsenic induced carcinogenesis. Front Biosci (Schol Ed). 2016;8:312–20.

    Article  Google Scholar 

  • Leonardi-Bee J, Smyth A, Britton J, Coleman T. Environmental tobacco smoke and fetal health: systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2008;93:F351–61.

    Article  CAS  PubMed  Google Scholar 

  • Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem. 1995;270:13333–40.

    Article  CAS  PubMed  Google Scholar 

  • Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol. 2002;14:459–86.

    Article  CAS  PubMed  Google Scholar 

  • Li R, Kou X, Geng H, Xie J, Tian J, Cai Z, Dong C. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. J Hazard Mater. 2015;287:392–401.

    Article  CAS  PubMed  Google Scholar 

  • Liang C, Oest ME, Prater MR. Intrauterine exposure to high saturated fat diet elevates risk of adult-onset chronic diseases in C57BL/6 mice. Birth Defects Res B Dev Reprod Toxicol. 2009;86:377–84.

    Article  CAS  PubMed  Google Scholar 

  • Liang C, DeCourcy K, Prater MR. High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice. Metabolism. 2010;59:943–50.

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Chen D, Yao Y, Yu B, Mao X, He J, Huang Z, Zheng P. Intrauterine growth retardation increases the susceptibility of pigs to high-fat diet-induced mitochondrial dysfunction in skeletal muscle. PLoS One. 2012;7:34835.

    Article  CAS  Google Scholar 

  • Liu Y, Weldy CS, Chin MT. Neonatal diesel exhaust particulate exposure does not predispose mice to adult cardiac hypertrophy or heart failure. Int J Environ Res Public Health. 2016;13. pii:E1178.

    Google Scholar 

  • Lu JH, He JR, Shen SY, Wei XL, Chen NN, Yuan MY, Qiu L, et al. Does tea consumption during early pregnancy have an adverse effect on birth outcomes? Birth. 2017. https://doi.org/10.1111/birt.12285.

  • Luck W, Nau H, Hansen R, Steldinger R. Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers. Dev Pharmacol Ther. 1985;8:384–95.

    Article  CAS  PubMed  Google Scholar 

  • Lumey LH. Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944–1945. Paediatr Perinat Epidemiol. 1992;6:240–53.

    Article  CAS  PubMed  Google Scholar 

  • Luo ZC, Fraser WD, Julien P, Deal CL, Audibert F, Smith GN, Xiong X, Walker M. Tracing the origins of “fetal origins” of adult diseases: programming by oxidative stress? Med Hypotheses. 2006;66:38–44.

    Article  CAS  PubMed  Google Scholar 

  • Luo ZC, Liu JM, Fraser WD. Large prospective birth cohort studies on environmental contaminants and child health-goals, challenges, limitations and needs. Med Hypotheses. 2010;74:318–32.

    Article  PubMed  Google Scholar 

  • Lyall F, Greer IA, Young A, Myatt L. Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction. Placenta. 1996;17:165–8.

    Article  CAS  PubMed  Google Scholar 

  • Lyche JL, Nourizadeh-Lillabadi R, Karlsson C, Stavik B, Berg V, Skåre JU, Alestrøm P, et al. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquat Toxicol. 2011;102:197–204.

    Article  CAS  PubMed  Google Scholar 

  • Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294–309.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Margină D, Olaru OT, Ilie M, Grădinaru D, GuŢu C, Voicu S, Dinischiotu A, Spandidos DA, Tsatsakis AM. Assessment of the potential health benefits of certain total extracts from Vitis vinifera, Aesculus hyppocastanum and Curcuma longa. Exp Ther Med. 2015;10:1681–8.

    Google Scholar 

  • Marí-Sanchis A, Díaz-Jurado G, Basterra-Gortari FJ, de la Fuente-Arrillaga C, Martínez-González MA, Bes-Rastrollo M. Association between pre-pregnancy consumption of meat, iron intake, and the risk of gestational diabetes: the SUN project. Eur J Nutr. 2017. https://doi.org/10.1007/s00394-017-1377-3.

  • Mavalankar DV, Gray RH, Trivedi CR. Risk factors for preterm and term low birthweight in Ahmedabad, India. Int J Epidemiol. 1992;21:263–72.

    Article  CAS  PubMed  Google Scholar 

  • Mekonen HK, Nigatu B, Lamers WH. Birth weight by gestational age and congenital malformations in Northern Ethiopia. BMC Pregnancy Childbirth. 2015;15:76.

    Article  PubMed  PubMed Central  Google Scholar 

  • Merezak S, Hardikar AA, Yajnik CS, Remacle C, Reusens B. Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurine. J Endocrinol. 2001;171:299–308.

    Article  CAS  PubMed  Google Scholar 

  • Micle O, Muresan M, Antal L, Bodog F, Bodog A. The influence of homocysteine and oxidative stress on pregnancy outcome. J Med Life. 2012;5:68–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miller MW. Expression of transforming growth factor-beta in developing rat cerebral cortex: effects of prenatal exposure to ethanol. J Comp Neurol. 2003;460:410–24.

    Article  CAS  PubMed  Google Scholar 

  • Miller KP, Borgeest C, Greenfeld C, Tomic D, Flaws JA. In utero effects of chemicals on reproductive tissues in females. Toxicol Appl Pharmacol. 2004;198:111–31.

    Article  CAS  PubMed  Google Scholar 

  • Mole DR, Ratcliffe PJ. Cellular oxygen sensing in health and disease. Pediatr Nephrol. 2008;23:681–94.

    Article  PubMed  Google Scholar 

  • Molnár M, Sütö T, Tóth T, Hertelendy F. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am J Obstet Gynecol. 1994;170:1458–66.

    Article  PubMed  Google Scholar 

  • Monau TR, Vargas VE, King N, Yellon SM, Myers DA, Ducsay CA. Long-term hypoxia increases endothelial nitric oxide synthase expression in the ovine fetal adrenal. Reprod Sci. 2009;16:865–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Montezano AC, Touyz RM. Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxid Redox Signal. 2014;20:164–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moore VM, Davies MJ. Diet during pregnancy, neonatal outcomes and later health. Reprod Fertil Dev. 2005;17:341–8.

    Article  PubMed  Google Scholar 

  • Morrison JL, Riggs KW, Chien C, Gruber N, McMillen IC, Rurak DW. Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes. Pediatr Res. 2004;56:40–6.

    Article  CAS  PubMed  Google Scholar 

  • Morrison JL, Riggs KW, Rurak DW. Fluoxetine during pregnancy: impact on fetal development. Reprod Fertil Dev. 2005;17:641–50.

    Article  CAS  PubMed  Google Scholar 

  • Murray AJ. Oxygen delivery and fetal-placental growth: beyond a question of supply and demand? Placenta. 2012;33(Suppl 2):e16–22.

    Article  PubMed  Google Scholar 

  • Myatt L. Placental adaptive responses and fetal programming. J Physiol. 2006;572:25–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Myatt L, Cui X. Oxidative stress in the placenta. Histochem Cell Biol. 2004;122:369–82.

    Article  CAS  PubMed  Google Scholar 

  • Myatt L, Rosenfield RB, Eis AL, Brockman DE, Greer I, Lyall F. Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action. Hypertension. 1996;28:488–93.

    Article  CAS  PubMed  Google Scholar 

  • Naksen W, Prapamontol T, Mangklabruks A, Chantara S, Thavornyutikarn P, Srinual N, Panuwet P, et al. Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand. Environ Res. 2015;142:288–96.

    Google Scholar 

  • Neel NR, Alvarez JO. Maternal risk factors for low birth weight and intrauterine growth retardation in a Guatemalan population. Bull Pan Am Health Organ. 1991;25:152–65.

    CAS  PubMed  Google Scholar 

  • Negi R, Pande D, Kumar A, Khanna RS, Khanna HD. In vivo oxidative DNA damage and lipid peroxidation as a biomarker of oxidative stress in preterm low-birth weight infants. J Trop Pediatr. 2012;58:326–8.

    Article  PubMed  Google Scholar 

  • Neyrinck AM, Van Hée VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. Br J Nutr. 2013;109:802–9.

    Article  CAS  PubMed  Google Scholar 

  • Nogales F, Ojeda ML, Fenutría M, Murillo ML, Carreras O. Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring. Reproduction. 2013;146:659–67.

    Article  CAS  PubMed  Google Scholar 

  • Okubo H, Miyake Y, Sasaki S, Tanaka K, Murakami K, Hirota Y, Kanzaki H, et al. Maternal dietary patterns in pregnancy and fetal growth in Japan: the Osaka Maternal and Child Health Study. Br J Nutr. 2012;107:1526–33.

    Article  CAS  PubMed  Google Scholar 

  • Ooe H, Taira T, Iguchi-Ariga SM, Ariga H. Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. Toxicol Sci. 2005;88:114–26.

    Article  CAS  PubMed  Google Scholar 

  • Orsolić N, Saranović AB, Basić I. Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds. Planta Med. 2006;72:20–7.

    Article  PubMed  CAS  Google Scholar 

  • Ortega RM. Importance of functional foods in the Mediterranean diet. Public Health Nutr. 2006;9:1136–40.

    Article  CAS  PubMed  Google Scholar 

  • Orth DS. Use of parabens as cosmetic preservatives. Int J Dermatol. 1980;19:504–5.

    Article  CAS  PubMed  Google Scholar 

  • Ota H, Igarashi S, Tanaka T. Improved fertility through superoxide removal by Toki-shakuyaku-san in mice—a preliminary study. Reprod Fertil Dev. 1999;11:451–5.

    Article  CAS  PubMed  Google Scholar 

  • Palipoch S, Punsawad C, Koomhin P, Suwannalert P. Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress. BMC Complement Altern Med. 2014;14:–111.

    Google Scholar 

  • Pathak P, Kapil U. Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian J Pediatr. 2004;71:1003–5.

    Article  PubMed  Google Scholar 

  • Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. Toxicology. 2012;300:31–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perla-Kajan J, Twardowski T, Jakubowski H. Mechanisms of homocysteine toxicity in humans. Amino Acids. 2007;32:561–72.

    Article  CAS  PubMed  Google Scholar 

  • Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008;4:89–96.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Philipps AF, Holzman IR, Teng C, Battaglia FC. Tissue concentrations of free amino acids in term human placentas. Am J Obstet Gynecol. 1978;131:881–7.

    Article  CAS  PubMed  Google Scholar 

  • Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol. 2007;83:84–92.

    Article  CAS  PubMed  Google Scholar 

  • Poston L, Raijmakers MT. Trophoblast oxidative stress, antioxidants and pregnancy outcome—a review. Placenta. 2004;25(Suppl A):S72–8.

    Article  CAS  PubMed  Google Scholar 

  • Potdar N, Singh R, Mistry V, Evans MD, Farmer PB, Konje JC, Cooke MS. First-trimester increase in oxidative stress and risk of small-for-gestational-age fetus. Br J Obstet Gynaecol. 2009;116:637–42.

    Article  CAS  Google Scholar 

  • Poursafa P, Keikha M, Kelishadi R. Systematic review on adverse birth outcomes of climate change. J Res Med Sci. 2015;20:397–402.

    PubMed  PubMed Central  Google Scholar 

  • Qian Z, He Q, Lin HM, K ong L, Zhou D, Liang S, Zhu Z et al. Part 2. Association of daily mortality with ambient air pollution, and effect modification by extremely high temperature in Wuhan, China. Res Rep Health Eff Inst 2010;91–217.

    Google Scholar 

  • Rachmi CN, Agho KE, Li M, Baur LA. Stunting, underweight and overweight in children aged 2.0–4.9 years in Indonesia: prevalence trends and associated risk factors. PLoS One. 2016;11:e0154756.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rahman T, Hosen I, Islam MMT, Shekhar HU. Oxidative stress and human health. Adv Biosci Biotechnol. 2012;3:997–1019.

    Article  CAS  Google Scholar 

  • Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2004;40:1216–22.

    Article  PubMed  Google Scholar 

  • Ratcliffe PJ, O’Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol. 1998;201:1153–62.

    CAS  PubMed  Google Scholar 

  • Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24:981–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rechner AR, Wagner E, Van Buren L, Van De Put F, Wiseman S, Rice-Evans CA. Black tea represents a major source of dietary phenolics among regular tea drinkers. Free Radic Res. 2002;36:1127–35.

    Article  CAS  PubMed  Google Scholar 

  • Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta. 2016;1863:2977–92.

    Article  CAS  PubMed  Google Scholar 

  • Rhoden CR, Lawrence J, Godleski JJ, González-Flecha B. N-Acetylcysteine prevents lung inflammation after short-term inhalation exposure to concentrated ambient particles. Toxicol Sci. 2004;79:296–303.

    Article  CAS  PubMed  Google Scholar 

  • Rider CV, Furr JR, Wilson VS, Gray LE Jr. Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. Int J Androl. 2010;33:443–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, et al. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014;28:2466–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocha E, Silva IR, Lichtenfels AJ, Amador Pereira LA, Saldiva PH. Effects of ambient levels of air pollution generated by traffic on birth and placental weights in mice. Fertil Steril. 2008;90:1921–4.

    Article  Google Scholar 

  • Rodríguez PE, Sanchez MS. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development in Wistar rat offspring. J Toxicol Environ Health A. 2010;73:1678–88.

    Article  PubMed  CAS  Google Scholar 

  • Roels H, Hubermont G, Buchet JP, Lauwerys R. Placental transfer of lead, mercury, cadmium, and carbon monoxide in women. III. Factors influencing the accumulation of heavy metals in the placenta and the relationship between metal concentration in the placenta and in maternal and cord blood. Environ Res. 1978;16:236–47.

    Article  CAS  PubMed  Google Scholar 

  • Romieu I, Gouveia N, Cifuentes LA, de Leon AP, Junger W, Vera J, Strappa V, Hurtado-Díaz M, et al. Multicity study of air pollution and mortality in Latin America (the ESCALA study). Res Rep Health Eff Inst. 2012:5–86.

    Google Scholar 

  • Ronco AM, Montenegro M, Castillo P, Urrutia M, Saez D, Hirsch S, Zepeda R, et al. Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring. Toxicol Appl Pharmacol. 2011;251:137–45.

    Article  CAS  PubMed  Google Scholar 

  • Ross MG, Beall MH. Adult sequelae of intrauterine growth restriction. Semin Perinatol. 2008;32:213–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rossner P Jr, Milcova A, Libalova H, Novakova Z, Topinka J, Balascak I, Sram RJ. Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part II. Oxidative damage. Mutat Res. 2009;669:20–6.

    Article  CAS  PubMed  Google Scholar 

  • Rumbold A, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2005a;(1):CD004072. https://doi.org/10.1002/14651858.CD004072.

  • Rumbold A, Crowther CA. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev. 2005b;(2):CD004069. https://doi.org/10.1002/14651858.CD004069.

  • Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS, ACTS Study Group. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med. 2006;354:1796–806.

    Article  CAS  PubMed  Google Scholar 

  • Rylander C, Odland JØ, Sandanger TM. Climate change and the potential effects on maternal and pregnancy outcomes: an assessment of the most vulnerable—the mother, fetus, and newborn child. Glob Health Action. 2013;6:19538.

    Article  PubMed  Google Scholar 

  • Saad MI, Abdelkhalek TM, Haiba MM, Saleh MM, Hanafi MY, Tawfik SH, Kamel MA. Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring. J Endocrinol Investig. 2016;39:643–55.

    Article  CAS  Google Scholar 

  • Sarki M, Robertson A, Parlesak A. Association between socioeconomic status of mothers, food security, food safety practices and the double burden of malnutrition in the Lalitpur district, Nepal. Arch Public Health. 2016;74:35.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schettler T. Human exposure to phthalates via consumer products. Int J Androl. 2006;29:134–9.

    Article  CAS  PubMed  Google Scholar 

  • Schoenaker DA, Soedamah-Muthu SS, Callaway LK, Mishra GD. Prepregnancy dietary patterns and risk of developing hypertensive disorders of pregnancy: results from the Australian Longitudinal Study on Women’s Health. Am J Clin Nutr. 2015;102:94–101.

    Article  CAS  PubMed  Google Scholar 

  • Schoenaker DA, Soedamah-Muthu SS, Mishra GD. Quantifying the mediating effect of body mass index on the relation between a Mediterranean diet and development of maternal pregnancy complications: the Australian Longitudinal Study on Women’s Health. Am J Clin Nutr. 2016;104:638–45.

    Article  CAS  PubMed  Google Scholar 

  • Scifres CM, Nelson DM. Intrauterine growth restriction, human placental development and trophoblast cell death. J Physiol. 2009;587:3453–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Selak MA, Storey BT, Peterside I, Simmons RA. Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats. Am J Physiol Endocrinol Metab. 2003;285:E130–7.

    Article  CAS  PubMed  Google Scholar 

  • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12:5447–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Semenza GL, Agani F, Iyer N, Kotch L, Laughner E, Leung S, Yu A. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Ann N Y Acad Sci. 1999;874:262–8.

    Article  CAS  PubMed  Google Scholar 

  • Sen S, Simmons RA. Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes. 2010;59:3058–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Servili M, Esposto S, Fabiani R, Urbani S, Taticchi A, Mariucci F, Selvaggini R, et al. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure. Inflammopharmacology. 2009;17:76–84.

    Article  CAS  PubMed  Google Scholar 

  • Shah A, Reyes LM, Morton JS, Fung D, Schneider J, Davidge ST. Effect of resveratrol on metabolic and cardiovascular function in male and female adult offspring exposed to prenatal hypoxia and a high-fat diet. J Physiol. 2015;594:1465–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sharma D, Shastri S, Sharma P. Intrauterine growth restriction: antenatal and postnatal aspects. Clin Med Insights Pediatr. 2016;10:67–83.

    PubMed  PubMed Central  Google Scholar 

  • Shivananjappa MM, Muralidhara. Taurine attenuates maternal and embryonic oxidative stress in a streptozotocin-diabetic rat model. Reprod Biomed Online. 2012;24:558–66.

    Article  CAS  PubMed  Google Scholar 

  • Simán CM, Eriksson UJ. Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats. Diabetologia. 1997;40:1416–24.

    Article  PubMed  Google Scholar 

  • Simmons RA. Developmental origins of diabetes: the role of oxidative stress. Best Pract Res Clin Endocrinol Metab. 2012;26:701–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simon RA. Adverse reactions to food additives. N Engl Reg Allergy Proc. 1986;7:533–42.

    Article  CAS  PubMed  Google Scholar 

  • Simon MC, Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol. 2008;9:285–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simpson ME, Duggal S, Keiver K. Prenatal ethanol exposure has differential effects on fetal growth and skeletal ossification. Bone. 2005;36:521–32.

    Article  CAS  PubMed  Google Scholar 

  • Sims NR, Muyderman H. Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta. 2010;1802:80–91.

    Article  CAS  PubMed  Google Scholar 

  • Singer H, Müller S, Tixier C, Pillonel L. Triclosan: occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants, surface waters, and lake sediments. Environ Sci Technol. 2002;36:4998–5004.

    Google Scholar 

  • Singleton DW, Khan SA. Xenoestrogen exposure and mechanisms of endocrine disruption. Front Biosci. 2003;8:s110–8.

    Article  CAS  PubMed  Google Scholar 

  • Sinha D, Roy S, Roy M. Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. Food Chem Toxicol. 2010;48:1032–9.

    Article  CAS  PubMed  Google Scholar 

  • Smith CA. The effect of wartime starvation in Holland upon pregnancy and its product. Am J Obstet Gynecol. 1947;53:599–608.

    Article  CAS  PubMed  Google Scholar 

  • Snow ME, Keiver K. Prenatal ethanol exposure disrupts the histological stages of fetal bone development. Bone. 2007;41:181–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spencer N, Bambang S, Logan S, Gill L. Socioeconomic status and birth weight: comparison of an area-based measure with the Registrar General’s social class. J Epidemiol Community Health. 1999;53:495–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spinnato JA II, Freire S, Pinto E, Silva JL, Cunha Rudge MV, Martins-Costa S, Koch MA, Goco N, et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110:1311–8.

    Article  CAS  PubMed  Google Scholar 

  • Stangenberg S, Nguyen LT, Chen H, Al-Odat I, Killingsworth MC, Gosnell ME, Anwer AG, et al. Oxidative stress, mitochondrial perturbations and fetal programming of renal disease induced by maternal smoking. Int J Biochem Cell Biol. 2015;64:81–90.

    Article  CAS  PubMed  Google Scholar 

  • Stefek M, Benes L. In vitro studies on the activity of Japanese kampo herbalmedicines Oren-gedoku-to (TJ-15) and Toki-shakuyaku-san (TJ-23) as scavengers of free radicals. Drug Metabol Drug Interact. 1994;11:25–36.

    Article  CAS  PubMed  Google Scholar 

  • Stewart AJ, Mullen W, Crozier A. On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea. Mol Nutr Food Res. 2005;49:52–60.

    Article  CAS  PubMed  Google Scholar 

  • Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006;136:1652S–9S.

    Article  CAS  PubMed  Google Scholar 

  • Sturman JA. Taurine in development. J Nutr. 1988;118:1169–76.

    Article  CAS  PubMed  Google Scholar 

  • Subramaniam SR, Chesselet MF. Mitochondrial dysfunction and oxidative stress in Parkinson’s disease. Prog Neurobiol. 2013;106–107:17–32.

    Article  PubMed  CAS  Google Scholar 

  • Sweeney T. Is exposure to endocrine disrupting compounds during fetal/post-natal development affecting the reproductive potential of farm animals? Domest Anim Endocrinol. 2002;23:203–9.

    Article  CAS  PubMed  Google Scholar 

  • Tarin JJ, Perez-Albala S, Pertusa JF, Cano A. Oral administration of pharmacological doses of vitamins C and E reduces reproductive fitness and impairs the ovarian and uterine functions of female mice. Theriogenology. 2002;57:1539–50.

    Article  CAS  PubMed  Google Scholar 

  • Thompson L, Dong Y, Evans L. Chronic hypoxia increases inducible NOS-derived nitric oxide in fetal guinea pig hearts. Pediatr Res. 2009a;65:188–92.

    Google Scholar 

  • Thompson BL, Levitt P, Stanwood GD. Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nat Rev Neurosci. 2009b;10:303–12.

    Google Scholar 

  • Thorstensen EB, Derraik JG, Oliver MH, Jaquiery AL, Bloomfield FH, Harding JE. Effects of periconceptional undernutrition on maternal taurine concentrations in sheep. Br J Nutr. 2012;107:466–72.

    Article  CAS  PubMed  Google Scholar 

  • Tikvica A, Kusan Jukić M, Pintarić I, Medić M, Hudicek-Martincić G, Kosec V, Salihagić-Kadić A. Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia. Coll Antropol. 2008;32:565–70.

    PubMed  Google Scholar 

  • Todd AS, Street SJ, Ziviani J, Byrne NM, Hills AP. Overweight and obese adolescent girls: the importance of promoting sensible eating and activity behaviors from the start of the adolescent period. Int J Environ Res Public Health. 2015;12:2306–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Toklu HZ, Dumlu MU, Sehirli O, Ercan F, Gedik N, Gökmen V, Sener G. Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats. J Pharm Pharmacol. 2007;59:1287–95.

    Article  CAS  PubMed  Google Scholar 

  • Toledo E, Lopez-del Burgo C, Ruiz-Zambrana A, Donazar M, Navarro-Blasco I, Martínez-González MA, de Irala J. Dietary patterns and difficulty conceiving: a nested case-control study. Fertil Steril. 2011;96:1149–53.

    Article  PubMed  Google Scholar 

  • Torheim LE, Ferguson EL, Penrose K, Arimond M. Women in resource-poor settings are at risk of inadequate intakes of multiple micronutrients. J Nutr. 2010;140:2051S–8S.

    Article  CAS  PubMed  Google Scholar 

  • Tyagi V, Garg N, Mustafa MD, Banerjee BD, Guleria K. Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population. Environ Monit Assess. 2015;187:471.

    Article  PubMed  CAS  Google Scholar 

  • Uusitalo L, Kenward MG, Virtanen SM, Uusitalo U, Nevalainen J, Niinistö S, Kronberg-Kippilä C, et al. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced beta cell autoimmunity in the child. Am J Clin Nutr. 2008;88:458–64.

    Article  CAS  PubMed  Google Scholar 

  • Uusitalo U, Arkkola T, Ovaskainen ML, Kronberg-Kippilä C, Kenward MG, Veijola R, Simell O, et al. Unhealthy dietary patterns are associated with weight gain during pregnancy among Finnish women. Public Health Nutr. 2009;12:2392–9.

    Article  PubMed  Google Scholar 

  • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84.

    Article  CAS  PubMed  Google Scholar 

  • van den Berg AJ, van den Worm E, van Ufford HC, Halkes SB, Hoekstra MJ, Beukelman CJ. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care. 2008;17:172–4.

    Article  PubMed  Google Scholar 

  • Vayalil PK. Antioxidant and antimutagenic properties of aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae). J Agric Food Chem. 2002;50:610–7.

    Article  CAS  PubMed  Google Scholar 

  • Vayalil PK. Date fruits (Phoenix dactylifera Linn): an emerging medicinal food. Crit Rev Food Sci Nutr. 2012;52:249–71.

    Article  CAS  PubMed  Google Scholar 

  • Veal E, Day A. Hydrogen peroxide as a signaling molecule. Antioxid Redox Signal. 2011;15:147–51.

    Article  CAS  PubMed  Google Scholar 

  • Vega CC, Reyes-Castro LA, Rodríguez-González GL, Bautista CJ, Vázquez-Martínez M, Larrea F, Chamorro-Cevallos GA, et al. Resveratrol partially prevents oxidative stress and metabolic dysfunction in pregnant rats fed a low protein diet and their offspring. J Physiol. 2016;594:1483–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Venu L, Harishankar N, Prasanna Krishna T, Raghunath M. Maternal dietary vitamin restriction increases body fat content but not insulin resistance in WNIN rat offspring up to 6 months of age. Diabetologia. 2004;47:1493–501.

    Article  CAS  PubMed  Google Scholar 

  • Veras MM, Damaceno-Rodrigues NR, Caldini EG, Maciel Ribeiro AA, Mayhew TM, Saldiva PH, Dolhnikoff M. Particulate urban air pollution affects the functional morphology of mouse placenta. Biol Reprod. 2008;79:578–84.

    Article  CAS  PubMed  Google Scholar 

  • Vieira SE. The health burden of pollution: the impact of prenatal exposure to air pollutants. Int J Chron Obstruct Pulmon Dis. 2015;10:1111–21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vieira-Filho LD, Lara LS, Silva PA, Luzardo R, Einicker-Lamas M, Cardoso HD, Paixão AD, et al. Placental oxidative stress in malnourished rats and changes in kidney proximal tubule sodium ATPases in offspring. Clin Exp Pharmacol Physiol. 2009;36:1157–63.

    Article  CAS  PubMed  Google Scholar 

  • Vieira-Filho LD, Lara LS, Silva PA, Santos FT, Luzardo R, Oliveira FS, Paixão AD, et al. Placental malnutrition changes the regulatory network of renal Na-ATPase in adult rat progeny: reprogramming by maternal α-tocopherol during lactation. Arch Biochem Biophys. 2011;505:91–7.

    Article  CAS  PubMed  Google Scholar 

  • Vizcaino E, Grimalt JO, Fernández-Somoano A, Tardon A. Transport of persistent organic pollutants across the human placenta. Environ Int. 2014;65:107–15.

    Article  CAS  PubMed  Google Scholar 

  • Vosatka RJ, Hassoun PM, Harvey-Wilkes KB. Dietary L-arginine prevents fetal growth restriction in rats. Am J Obstet Gynecol. 1998;178:242–6.

    Article  CAS  PubMed  Google Scholar 

  • Vuguin PM, Hartil K, Kruse M, Kaur H, Lin CL, Fiallo A, Glenn AS, Patel A, Williams L, Seki Y, Katz EB, Charron MJ. Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome. PLoS One. 2013;8:e63021.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vujkovic M, de Vries JH, Lindemans J, Macklon NS, van der Spek PJ, Steegers EA, Steegers-Theunissen RP. The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertil Steril. 2010;94:2096–101.

    Article  PubMed  Google Scholar 

  • Wang Y, Walsh SW. Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia. Placenta. 2001;22:206–122.

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Ding H, Ryan L, Xu X. Association between air pollution and low birth weight: a community-based study. Environ Health Perspect. 1997;105:514–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Chen L, Li D, Yin Y, Wang X, Li P, Dangott LJ, Hu W, Wu G. Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs. J Nutr. 2008;138:60–6.

    Article  CAS  PubMed  Google Scholar 

  • Wang Z, Fu C, Yu S. Green tea polyphenols added to IVM and IVC media affect transcript abundance, apoptosis, and pregnancy rates in bovine embryos. Theriogenology. 2013;79:186–92.

    Article  CAS  PubMed  Google Scholar 

  • Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF Jr, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state—impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med. 2003;41:1455–61.

    CAS  PubMed  Google Scholar 

  • Weldy CS, Liu Y, Chang YC, Medvedev IO, Fox JR, Larson TV, Chien WM, Chin MT. In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice. Part Fibre Toxicol. 2013;10:59.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wells PG, McCallum GP, Chen CS, Henderson JT, Lee CJ, Perstin J, Preston TJ, Wiley MJ, Wong AW. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicol Sci. 2009;108:4–18.

    Article  CAS  PubMed  Google Scholar 

  • Westbrook DG, Anderson PG, Pinkerton KE, Ballinger SW. Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates. Cardiovasc Toxicol. 2010;10:216–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wigle DT, Arbuckle TE, Turner MC, Bérubé A, Yang Q, Liu S, Krewski D. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 2008;11:373–517.

    Article  CAS  PubMed  Google Scholar 

  • Wong CM, Vichit-Vadakan N, Vajanapoom N, Ostro B, Thach TQ, Chau PY, Chan EK, et al. Part 5. Public health and air pollution in Asia (PAPA): a combined analysis of four studies of air pollution and mortality. Res Rep Health Eff Inst. 2010:377–418.

    Google Scholar 

  • World Health Organization. Low birth weight: a tabulation of available information, WHO/MCH/92.2. Geneva: World Health Organization; 1992.

    Google Scholar 

  • World Health Organization. Low birthweight: country, regional and global estimates. New York: United Nations Children’s Fund & World Health Organization; 2004.

    Google Scholar 

  • Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489–92.

    Article  CAS  PubMed  Google Scholar 

  • Wu Y, Wang F, Reece EA, Yang P. Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis. Am J Obstet Gynecol. 2015;212(6):802.e1–8.el.

    Article  CAS  Google Scholar 

  • Xia W, Hu J, Zhang B, Li Y, Wise JP Sr, Bassig BA, Zhou A, et al. A case-control study of maternal exposure to chromium and infant low birth weight in China. Chemosphere. 2016;144:1484–9.

    Article  CAS  PubMed  Google Scholar 

  • Yessoufou A, Gbenou J, Grissa O, Hichami A, Simonin AM, Tabka Z, Moudachirou M, et al. Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation. BMC Complement Altern Med. 2013;13:77.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ying CJ, Sun XF, Zhang SL, Zhang XP, Mao LM, Zuo XZ, Yao P. ROS-related enzyme expressions in endothelial cells regulated by tea polyphenols. Biomed Environ Sci. 2004;17:33–9.

    PubMed  Google Scholar 

  • Yurdakök K. Environmental pollution and the fetus. J Pediatr Neonat Individual Med. 2012;1:33–42.

    Google Scholar 

  • Zagré NM, Desplats G, Adou P, Mamadoultaibou A, Aguayo VM. Prenatal multiple micronutrient supplementation has greater impact on birthweight than supplementation with iron and folic acid: a cluster-randomized, double-blind, controlled programmatic study in rural Niger. Food Nutr Bull. 2007;28:317–27.

    Article  PubMed  Google Scholar 

  • Zhang C, Schulze MB, Solomon CG, Hu FB. A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitus. Diabetologia. 2006;49:2604–13.

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Li X, Jing Y, Fang X, Zhang X, Lei B, Yu Y. Transplacental transfer of polycyclic aromatic hydrocarbons in paired samples of maternal serum, umbilical cord serum, and placenta in Shanghai, China. Environ Pollut. 2017;222:267–75.

    Article  CAS  PubMed  Google Scholar 

  • Zhong J, Reece EA, Yang P. Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects. Biochem Biophys Res Commun. 2015;467:179–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou J, Miao H, Li X, Hu Y, Sun H, Hou Y. Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt. Inflamm Res. 2017;66:177–85.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

I am thankful and delighted to invaluable support of my research in the field of Free Radical Biology by Dr. Catherine Garrel, and I am very honoured to work with her staff at “Unité de Biochimie Hormonale et Nutritionnelle” (Centre Hospitalier Universitaire de Grenoble, Département de Biologie-Toxicologie-Pharmacologie, Grenoble, France).

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  1. National Institute for Agricultural Research, 78350, Jouy-en-Josas, France

    Kaïs Hussain Al-Gubory

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Correspondence to Kaïs Hussain Al-Gubory .

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  1. National Institute for Agricultural Research, Jouy-en-Josas, France

    Kaïs Hussain Al-Gubory

  2. Department of Pharmacology and Therapeut, Faculty of Medicine, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Al-Gubory, K.H. (2017). Plant Antioxidants in the Prevention of Early Life Programming Diseases. In: Al-Gubory, K., Laher, I. (eds) Nutritional Antioxidant Therapies: Treatments and Perspectives. Springer, Cham. https://doi.org/10.1007/978-3-319-67625-8_7

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