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Antimicrobial Peptides, An Alternative Antimicrobial Agent Against Multi-drug-Resistant Microbes: Source, Application, and Potential

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Advancements in Materials Science and Technology Led by Women

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 165))

Abstract

Pathogenic microorganisms are often associated with infectious diseases in humans, plants, or animals. Over the past 100 years, antibiotics have been often used to combat the infections caused by these pathogenic microorganisms. The frequent and overuse of antibiotics has led to the rapid emergence of multi-drug-resistant microorganisms. There has been a worldwide quest for a new antibacterial agent. In recent years, antimicrobial peptides (AMPs), produced naturally by bacteria, insects, amphibians, and mammals, have gained attention as an alternative antimicrobial agent against multi-drug resistant microbes. Contrary to conventional antibiotics, which typically work by targeting a specific high-affinity antimicrobial target and may lead to the development of resistance in microorganisms, AMPs exert various antimicrobial activities that may offer a strategy to stop bacterial resistance. In addition, AMPs have a wide range of applications as they are effective in eradicating microorganisms and are non-toxic or harmful to humans and the environment. This paper reviews the sources, application, and potential of AMPs against multi-drug-resistant microorganisms and their risks to humankind.

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Acknowledgements

This research was supported by the Malaysia Ministry of Higher Education under the Fundamental Research Grant scheme (FRGS/1/2020/STG01/UNIKL/02/1).

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Authors and Affiliations

  1. Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988, Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia

    Nur Husna Hafiza Lyana Ramzah & Leong Chean Ring

  2. Institute of Medical Science Technology, Universiti Kuala Lumpur, A1-1, Jalan TKS 1, Taman Kajang Sentral, 43000, Kajang, Selangor, Malaysia

    Tong Woei Yenn

  3. Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia

    Wing-Hin Lee & Ching-Yee Loo

  4. School of Distance Education, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia

    Wen-Nee Tan

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  1. Nur Husna Hafiza Lyana Ramzah
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  2. Tong Woei Yenn
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  3. Wing-Hin Lee
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  4. Ching-Yee Loo
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  5. Wen-Nee Tan
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  6. Leong Chean Ring
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Corresponding author

Correspondence to Leong Chean Ring .

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Editors and Affiliations

  1. Centre for Women Advancement and Leadership, Universiti Kuala Lumpur, Malaysian Institute of Marine Engineering Technology, Lumut, Perak, Malaysia

    Azman Ismail

  2. Faculty of Information Management, Universiti Teknologi MARA, Machang, Kelantan, Malaysia

    Fatin Nur Zulkipli

  3. Centre for Women Advancement and Leadership, Universiti Kuala Lumpur, Malaysian Institute of Information Technology, Kuala Lumpur, Malaysia

    Husna Sarirah Husin

  4. Faculty of Mechanical Engineering, Esslingen University of Applied Sciences, Esslingen, Germany

    Andreas Öchsner

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Ramzah, N.H.H.L., Yenn, T.W., Lee, WH., Loo, CY., Tan, WN., Ring, L.C. (2023). Antimicrobial Peptides, An Alternative Antimicrobial Agent Against Multi-drug-Resistant Microbes: Source, Application, and Potential. In: Ismail, A., Nur Zulkipli, F., Husin, H.S., Öchsner, A. (eds) Advancements in Materials Science and Technology Led by Women. Advanced Structured Materials, vol 165. Springer, Cham. https://doi.org/10.1007/978-3-031-21959-7_17

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