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Cross Talk Between Apoptosis and Autophagy in Regulating the Progression of Heart Disease

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Biochemistry of Apoptosis and Autophagy

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 18))

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Abstract

Apoptosis, the programmed cell death is prominent in multiple cardiac pathologies eventually resulting in heart failure. Autophagy, on the other hand plays an important role in recycling nutrients by causing the degradation of intracellular components not required by the cardiomyocytes, during cellular stress. Both apoptosis and autophagy play significant roles in cardiac development and disease. Absence of apoptosis in the developing embryo results in various congenital heart defects; however, excessive apoptosis in heart has been linked to negative ventricular remodeling. Similarly, desired levels of cellular proteins are maintained by basal levels of autophagy, and abnormal changes in the autophagic pathway have detrimental effects on myocytes. Though the mechanisms of each of these pathways differ, there is some dialogue that is always active amongst these two processes through common signaling pathways. Therefore, the interaction of proteins specific to autophagy with the apoptotic proteins might result in activation or inactivation of the process. This chapter summarizes mechanisms of both the pathways in cardiomyocytes and the molecules that link these pathways to regulate cell death.

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Authors and Affiliations

  1. Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, St. Boniface Hospital Albrechtsen Research Centre, Institute of Cardiovascular Sciences, Max Rady College of Medicine, University of Manitoba, 351 Tache Avenue, R226, Winnipeg, R-3028-2, Canada

    Niketa Sareen, Lorrie A. Kirshenbaum & Sanjiv Dhingra

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  1. Niketa Sareen
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  2. Lorrie A. Kirshenbaum
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  3. Sanjiv Dhingra
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Correspondence to Sanjiv Dhingra .

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  1. University of Manitoba, Winnipeg, MB, Canada

    Lorrie A. Kirshenbaum

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Sareen, N., Kirshenbaum, L.A., Dhingra, S. (2022). Cross Talk Between Apoptosis and Autophagy in Regulating the Progression of Heart Disease. In: Kirshenbaum, L.A. (eds) Biochemistry of Apoptosis and Autophagy. Advances in Biochemistry in Health and Disease, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-78799-8_6

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