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The Interplay between Pro-Death and Pro-Survival Signaling Pathways in Myocardial Ischemia/Reperfusion Injury: Apoptosis Meets Autophagy

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Abstract

Introduction

Programmed cell death of cardiac myocytes occurs following a bout of ischemia/reperfusion (I/R), which results in reduced function of the heart. Numerous studies, including in vivo, have shown that cell death occurs via necrosis and apoptosis following I/R. Recently, autophagy has emerged as a powerful mediator of programmed cell death, either opposing or enhancing apoptosis, or acting as an alternative form of programmed cell death distinct from apoptosis.

Aim

Here we review the apoptotic and autophagic signaling pathways, their influences on each other, and we discuss the relevance of autophagy in the heart.

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  1. Department of Molecular and Experimental Medicine MEM-220, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, San Diego, CA, 92037, USA

    Anne Hamacher-Brady, Nathan Ryan Brady & Roberta Anne Gottlieb

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Correspondence to Roberta Anne Gottlieb.

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This work was supported by NIH grants R01-AG21568 and R01-HL60590 (to R.A.G.) and the Stein endowment fund. This is MS# 18245 of The Scripps Research Institute.

Anne Hamacher-Brady and Nathan Ryan Brady contributed equally.

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Hamacher-Brady, A., Brady, N.R. & Gottlieb, R.A. The Interplay between Pro-Death and Pro-Survival Signaling Pathways in Myocardial Ischemia/Reperfusion Injury: Apoptosis Meets Autophagy. Cardiovasc Drugs Ther 20, 445–462 (2006). https://doi.org/10.1007/s10557-006-0583-7

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