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Small Leucine-Rich Proteoglycans (SLRPs) and Biomineralization

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Extracellular Matrix Biomineralization of Dental Tissue Structures

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 10))

Abstract

Small leucine-rich proteoglycans (SLRPs) represent the largest family of proteoglycans consisting of 18–19 members. They play diverse structural and biological roles by interacting with extracellular matrix components, growth factors, and cell surface receptors. One of the well-studied features of SLRPs is their structural control of collagen fibrillogenesis. Since fibrillar collagens are the structural basis for mineralization in bone, dentin, and cementum, such interactions may inhibit and/or facilitate mineralization. The ability to modulate specific growth factors can be used for effective mineralized tissue engineering. In this chapter, we will provide an overview of the basic structural and genomic features of SLRPs, their roles in collagen mineralization, cell signaling, and potential utility for mineralized tissue regeneration.

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Acknowledgments

Fundings—Boston University Henry Goldman School of Dental Medicine (YM), NIH/NIDCR R03DE028035 and NIH CTSA – NCTraCs 550KR211924 (PM) and the University of North Carolina at Chapel Hill Adams School of Dentistry (MY).

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA

    Yoshiyuki Mochida

  2. Division of Comprehensive Oral Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA

    Patricia Miguez

  3. Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA

    Mitsuo Yamauchi

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  1. Yoshiyuki Mochida
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  3. Mitsuo Yamauchi
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Correspondence to Mitsuo Yamauchi .

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  1. Faculty of Fundamental and Biomedical Sciences, Paris Cite University INSERM UMR-S 1124, Paris, France

    Michel Goldberg

  2. Department of Orofacial Sciences, UCSF School of Dentistry, University of California, San Francisco, USA

    Pamela Den Besten

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Mochida, Y., Miguez, P., Yamauchi, M. (2021). Small Leucine-Rich Proteoglycans (SLRPs) and Biomineralization. In: Goldberg, M., Den Besten, P. (eds) Extracellular Matrix Biomineralization of Dental Tissue Structures. Biology of Extracellular Matrix, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-030-76283-4_6

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