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Parathyroid Hormone and Calcitonin

  • Karen E. Kleeman
  • Charles R. Kleeman
Part of the Contemporary Endocrinology book series (COE, volume 2)

Abstract

In the course of reading and thinking a great deal about parathyroid hormone (PTH)—its purpose, its evolution, the effects of its excess and its deficiency—we have been led into speculation about the role of calcium in cellular economy. Increasingly we appreciate calcium’s critical role as a regulator in all kinds of cells and in organisms of all levels of complexity. Even the simplest organisms appear to employ calcium; it regulates chemotactic behavior1 and sporulation2 in bacteria; and it has been adapted to more and more uses in multicellular organisms. Cell aggregation, cell-cell communication, membrane integrity and permeability, microtubular assembly, cell division and growth, blood coagulation, hormone-response coupling, and electrical stimulus-response coupling, including muscle contraction and neurotransmitter release, all require calcium and are to some degree regulated by it.3

Keywords

Parathyroid Hormone Serum Calcium Adenylate Cyclase Parathyroid Gland Primary Hyperparathyroidism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ordal, G. W., 1977, Calcium ion regulates chemotactic behavior in bacteria, Nature (London) 270: 66–67.CrossRefGoogle Scholar
  2. 2.
    Golub, E. E., and Bronner, F., 1974, Bacterial calcium transport: Energy-dependent calcium uptake by membrane vesicles from Bacillus megaterium, J. Bacteriol. 119: 840–843.PubMedGoogle Scholar
  3. 3.
    Parfitt, A. M., and Kleerekoper, J., 1980, The divalent ion homeostatic system—Physiology and metabolism of calcium, phosphorus, magnesium, and bone, in: Clinical Disorders fo Fluid and Electrolyte Metabolism ( M. H. Maxwell and C. R. Kleeman, eds.), 3rd ed., pp. 269–398, McGraw–Hill, New York.Google Scholar
  4. 4.
    Kretsinger, R. H., 1979, The informational role of calcium in the cytosol, Adv. Cyclic Nucleotide Res. 11:1–26.Google Scholar
  5. 5.
    Loewenstein, W. R., and Rose, B., 1978, Calcium in functional intercellular communication and a thought on its behavior in intracellular communication, Ann. N.Y. Acad. Sci. 307: 285–307.PubMedCrossRefGoogle Scholar
  6. 6.
    Blaustein, M. P., Ratzlaff, R. W., and Kendrick, N. K., 1978, The regulation of intracellular calcium in presynaptic nerve terminals, Ann. N.Y. Acad. Sci. 307: 195–212.PubMedCrossRefGoogle Scholar
  7. 7.
    Martonosi, A. N., Chyn, T. L., and Schibeci, A., 1978, The calcium transport of sarcoplasmic reticulum, Ann. N.Y. Acad. Sci. 307: 148–159.PubMedCrossRefGoogle Scholar
  8. 8.
    Carafoli, G., and Crompton, M., 1978, The regulation of intracellular calcium by mitochondria, Ann. N.Y. Acad. Sci. 307: 269–284.PubMedCrossRefGoogle Scholar
  9. 9.
    Lehninger, A. L., Reynafarje, B., Vercesi, A., and Tew, W. P., 1978, Transport and accumulation of calcium in mitochondria, Ann. N.Y. Acad. Sci. 307: 160–176.PubMedCrossRefGoogle Scholar
  10. 10.
    Akerman, K. E. 0., 1978, Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane, Biochim. Biophys. Acta 502: 359–366.Google Scholar
  11. 11.
    Bockaert, J., Roy, C., and Jard, S., 1972, Oxytocin-sensitive adenylate cyclase in frog bladder epithelial cells: Role of calcium, nucleotides, and other factors in hormonal stimulation, J. Biol. Chem. 247: 7073–7081.PubMedGoogle Scholar
  12. 12.
    Campbell, B. J., Woodward, G., and Borberg, V., 1972, Calcium-mediated interactions between the antidiuretic hormone and renal plasma membranes, J. Biol. Chem. 247: 6167–6175.PubMedGoogle Scholar
  13. 13.
    Keutmann, H. T., Sauer, M. M., Hendy, G. N., O’Riordan, J. L. H., and Potts, J. T., Jr., 1978, Complete amino acid sequence of human parathyroid hormone, Biochemistry 17: 5723–5729.PubMedCrossRefGoogle Scholar
  14. 14.
    Brewer, H. B., Jr., 1972, Chemistry and conformation of bovine parathyroid hormone, in: Endocrinology 1971: Proceedings of the Third International Symposium ( S. Taylor, ed.), pp. 324–332, Heinemann Press, London.Google Scholar
  15. 15.
    Fiskin, M. A., Cohn, D. V., and Peterson, G. S., 1977, A model for the structure of bovine parathormone derived by dark field electron microscopy, J. Biol. Chem. 252: 8261–8268.PubMedGoogle Scholar
  16. 16.
    Habener, J. F., and Potts, J. T., Jr., 1979, Cleavage-associated enhancement of an antigenic site in the biologically active NH2-terminal region of parathyroid hormone, Endocrinology 105: 115–119.PubMedCrossRefGoogle Scholar
  17. 17.
    Mahaffey, J. E., Rosenblatt, M., Shepard, G. L., and Potts, J. T., Jr., 1979, Parathyroid hormone inhibitors: Determination of minimum sequence requirements, J. Biol. Chem. 254: 6496–6498.PubMedGoogle Scholar
  18. 18.
    Tregear, G. W., van Rietschoten, J., Greene, E., Keutmann, H. T., Niall, H. D., Parsons, J. A., and Potts, J. T., Jr., 1974, Principles and recent applications in the solid-phase synthesis of peptide hormones, in: Endocrinology 1973: Proceedings of the Fourth International Symposium ( S. Taylor, ed.), pp. 1–16, Heinemann Press, London.Google Scholar
  19. 19.
    Kronenberg, H. M., Roberts, B. E., Habener, J. F., Potts, J. T., Jr., and Rich, A., 1977, DNA complementary to parathyroid mRNA directs synthesis of pre-proparathyroid hormone in a linked transcription—translation system, Nature (London) 267: 804–807.CrossRefGoogle Scholar
  20. 20.
    Habener, J. F., and Kronenberg, H. M., 1978, Parathyroid hormone biosynthesis: Structure and function of biosynthetic precursors, Fed. Proc. 37: 2561–2566.PubMedGoogle Scholar
  21. 21.
    Palade, G., 1975, Intracellular aspects of the process of protein synthesis, Science 189: 347–358.PubMedCrossRefGoogle Scholar
  22. 22.
    Blobel, G., and Sabatini, D. P., 1971, Ribosome—membrane interaction in eukaryotic cells, Biomembranes 2: 193–195.CrossRefGoogle Scholar
  23. 23.
    Habener, J. F., Rosenblatt, M., Kemper, B., Kronenberg, H. M., Rich, A., and Potts, J. T., Jr., 1978, Pre-proparathyroid hormone: Amino acid sequence, chemical synthesis, and some biological studies of the precursor region, Proc. Natl. Acad. Sci. USA 75: 2616–2620.PubMedCrossRefGoogle Scholar
  24. 24.
    Habener, J. F., and Potts, J. T., Jr., 1979, Subcellular distributions of parathyroid hormone, hormonal precursors, and parathyroid secretory protein, Endocrinology 104: 265–275.PubMedCrossRefGoogle Scholar
  25. 25.
    Dorner, A. J., and Kemper, B., 1978, Conversion of pre-proparathyroid hormone to proparathyroid hormone by dog pancreatic microsomes, Biochemistry 17: 5550–5555.PubMedCrossRefGoogle Scholar
  26. 26.
    MacGregor, R. R., Hamilton, J. W., and Cohn, D. V., 1978, The mode of conversion of proparathormone to parathormone by a particulate converting enzymic activity of the parathyroid gland, J. Biol. Chem. 253: 2012–2017.PubMedGoogle Scholar
  27. 27.
    Mayer, G. P., and Hurst, J. G., 1978, Sigmoidal relationship between parathyroid hormone secretion rate and plasma calcium concentration in calves, Endocrinology 102: 1036–1042.PubMedCrossRefGoogle Scholar
  28. 28.
    Kleeman, K., and Kleeman, C. R., 1978, Parathyroid hormone and calcitonin, in: The Year in Endocrinology 1977 ( S. H. Ingbar, ed.), pp. 109–160, Plenum Medical, New York.Google Scholar
  29. 29.
    Smith, D. L., and Boime, I., 1977, Reversible calcium inhibition of the membrane-dependent cleavage of pre-placental lactogen in ascites cell-free extracts, FEBS Lett. 84: 115–118.PubMedCrossRefGoogle Scholar
  30. 30.
    Habener, J. F., Kemper, B. W., Potts, J. T., Jr., and Rich, A., 1974, Calcium-independent intracellular conversion of proparathyroid hormone to parathyroid hormone, Endocr. Res. Commun. 1: 239–246.CrossRefGoogle Scholar
  31. 31.
    Habener, J. F., and Potts, J. T., Jr., 1978, Biosynthesis of parathyroid hormone, N. Engl. J. Med. 299: 580–585, 635–644.CrossRefGoogle Scholar
  32. 32.
    Habener, J. F., Kemper, B., and Potts, J. T., Jr., 1975, Calcium-dependent intracellular degradation of parathyroid hormone: A possible mechanism for the regulation of hormone stores, Endocrinology 97: 431–441.PubMedCrossRefGoogle Scholar
  33. 33.
    Silverman, R., and Yalow, R. S., 1973, Heterogeneity of parathyroid hormone: Clinical and physiologic implications, J. Clin. Invest. 52: 1958–1971.PubMedCrossRefGoogle Scholar
  34. 34.
    Flueck, J. A., Di Bella, F. P., Edis, A. J., Kehrwald, J. M., and Arnaud, C. D., 1977, Immunoheterogeneity of parathyroid hormone in venous effluent serum from hyperfunctioning parathyroid glands, J. Clin. Invest. 60: 1367–1375.PubMedCrossRefGoogle Scholar
  35. 35.
    Di Bella, F. P., Gilkinson, J. B., Flueck, J., and Arnaud, C. D., 1978, Carboxyl-terminal fragments of human parathyroid hormone in parathyroid tumors: Unique new source of immunogens for the production of antisera potentially useful in the radioimmunoassay of parathyroid hormone in human serum, J. Clin. Endocrinol. Metab. 46: 604–612.PubMedCrossRefGoogle Scholar
  36. 36.
    Dambacher, M. A., Hunziker, W., Born, W., Moran, J., and Fischer, J. A., 1978, Circulating forms of immunoreactive parathyroid hormone (PTH) in control subjects and in patients with primary and secondary hyperparathyroidism, Acta Endocrinol. [Suppl.] (Copenhagen) 87 (Suppl. 215): 110–111.Google Scholar
  37. 37.
    Mayer, G. P., Keaton, J. A., Hurst, J. G., and Habener, J. F., 1979, Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood, Endocrinology 104: 1778–1783.PubMedCrossRefGoogle Scholar
  38. 38.
    Morrissey, J. J., and Cohn, D. V., 1979, Regulation of secretion of parathormone and secretory protein-I from separate intracellular pools by calcium, dibutyryl cyclic AMP, and (1)-isoproterenol, J. Cell Biol. 83: 93–102.CrossRefGoogle Scholar
  39. 39.
    Brown, G. M., Hurwitz, S., and Aurbach, G. D., 1976, Preparation of usable isolated bovine parathyroid cells, Endocrinology 99: 1582–1588.PubMedCrossRefGoogle Scholar
  40. 40.
    Brown, G. M., Brennan, M. F., Hurwitz, S., Windeck, R., Marx, S. J., Spiegel, A. M., Koehler, J. O., Gardner, D. G., and Aurbach, G. D., 1978, Dispersed cells prepared from human parathyroid glands: Distinct calcium sensitivity of adenomas vs. primary hyperplasia, J. Clin. Endocrinol. Metab. 46: 267–275.PubMedCrossRefGoogle Scholar
  41. 41.
    Blum, J. W., Mayer, G. P., and Potts, J. T., Jr., 1974, Parathyroid hormone response during spontaneous hypocalcemia and induced hypercalcemia in cows, Endocrinology 95: 84–92.PubMedCrossRefGoogle Scholar
  42. 42.
    Mayer, G. P., Habener, J. F., and Potts, J. T., Jr., 1976, Parathyroid hormone secretion in vivo: Demonstration of a calcium-independent nonsuppressible component of secretion, J. Clin. Invest. 57: 678–683.PubMedCrossRefGoogle Scholar
  43. 43.
    Neer, R. M., 1979, Calcium and inorganic phosphate homeostasis, in: Endocrinology, Volume 2 (L. J. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martini, J. T. Potts, Jr., D. H. Nelson, G. Steinberger, and A. I. Winegrad, eds.), pp. 699–692, Grune Stratton, New York.Google Scholar
  44. 44.
    Brown, E. M., Brennan, M. F., Broadus, A. E., Marx, S. J., Gardner, D. G., Spiegel, A. M., Downs, R. W., Jr., Attie, M. F., and Aurbach, G. D., 1979, Human parathyroid autografts: Comparison of function in vivo and in vitro, J. Clin. Endocrinol. Metab. 48: 648–654.PubMedCrossRefGoogle Scholar
  45. 45.
    Broadus, A. E., Deftos, L. J., and Banter, F. C., 1978, Effects of the intravenous administration of calcium on nephrogenous cyclic AMP: Use as a parathyroid suppression test, J. Clin. Endocrinol. Metab. 46: 477–487.PubMedCrossRefGoogle Scholar
  46. 46.
    Brown, E. M., Gardner, D. G., Windeck, R. A., and Aurbach, G. D., 1978, Relationship of intracellular 3’,5’-adenosine monophosphate accumulation to parathyroid hormone release from dispersed bovine parathyroid cells, Endocrinology 103: 2323–2332.PubMedCrossRefGoogle Scholar
  47. 47.
    Matsuzaki, S., and Dumont, J. E., 1972, Effect of calcium ion on horse parathyroid gland adenyl cyclase, Biochim. Biophys. Acta 284: 227–234.PubMedCrossRefGoogle Scholar
  48. 48.
    Rodriguez, H. J., Morrison, A., Slatopolsky, E., and Klahr, S., 1978, Adenylate cyclase of human parathyroid gland, J. Clin. Endocrinol. Metab. 47: 319–325.PubMedCrossRefGoogle Scholar
  49. 49.
    Ramp, W. K., Cooper, C. W., Ross, A. J., III, and Wells, S. A., Jr., 1979, Effects of calcium and cyclic nucleotides on rat calcitonin and parathyroid hormone secretion, Mol. Cell. Endocrinol. 14: 205–215.PubMedCrossRefGoogle Scholar
  50. 50.
    Tsuchiya, T., and Tamate, H., 1979, Ultrastructural localization of adenyl cyclase activity in sheep parathyroid gland, Acta Histochem. Cytochem. 12: 356–360.CrossRefGoogle Scholar
  51. 51.
    Gardner, D. G., Brown, E. M., Windeck, R., and Aurbach, G. D., 1979, Prostaglandin Fla inhibits 3’,5’-adenosine monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells, Endocrinology 104: 1–7.PubMedCrossRefGoogle Scholar
  52. 52.
    Gardner, D. G., Brown, E. M., Windeck, R., and Aurbach, G. D., 1978, PGE2 stimulation of cAMP accumulation and PTH release in dispersed bovine parathyroid cells, Endocrinology 103: 577–582.PubMedCrossRefGoogle Scholar
  53. 53.
    Licata, A. A., Au, W. Y., Vera, J., and Bartter, F. C., 1979, Effects of prostaglandin E1 on the metabolism in rat parathyroid gland in vitro, Biochim. Biophys. Acta 582: 59–66.PubMedCrossRefGoogle Scholar
  54. 54.
    Boquist, L., 1975, Occurrence of oxyphil cells in suppressed parathyroid glands, Cell Tissue Res. 163: 465–470.PubMedCrossRefGoogle Scholar
  55. 55.
    Carafoli, E., and Lehninger, A. L., 1971, A survey of the interaction of calcium ions with mitochondria from different tissues and species, Biochem. J. 122: 681–690.PubMedGoogle Scholar
  56. 56.
    Carafoli, E., 1979, The calcium cycle of mitochondria, FEBS Lett. 104: 1–5.PubMedCrossRefGoogle Scholar
  57. 57.
    Crompton, M., Moser, R., Ludi, H., and Carafoli, E., 1978, The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues, Eur. J. Biochem. 82: 25–31.PubMedCrossRefGoogle Scholar
  58. 58.
    Nicholls, D. G., 1978, Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart, Biochem. J. 170: 511–522.PubMedGoogle Scholar
  59. 59.
    Lee, N. H., and Shapiro, I. M., 1978, Cat+ transport by chondrocyte mitochondria of the epiphyseal growth plate, J. Membr. Biol. 41: 349–360.PubMedCrossRefGoogle Scholar
  60. 60.
    Glick, D. M., and Mockel, J., 1980, The disposition of calcium within parathyroid tissue, Norm. Metab. Res. 12: 475–480.CrossRefGoogle Scholar
  61. 61.
    Bruce, B. R., and Anderson, N. C., Jr., 1979, Hyperpolarization in mouse parathyroid cells by low calcium, Am. J. Physiol. 236: C15 - C21.PubMedGoogle Scholar
  62. 62.
    Petersen, O. H., 1976, Electrophysiology of mammalian gland cells, Physiol. Rev. 56: 535–577.PubMedGoogle Scholar
  63. 63.
    Heath, H., III, 1980, Biogenic amines and the secretion of parathyroid hormone and calcitonin, Endocr. Rev. 1:319–338.Google Scholar
  64. 64.
    Sherwood, L. M., and Abe, M., 1972, Adrenergic receptors and the release of parathyroid hormone, J. Clin. Invest. 51: 88a.Google Scholar
  65. 65.
    Brown, E. M., Hurwitz, S., and Aurbach, G. D., 1977, Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells, Endocrinology 100: 1696–1702.PubMedCrossRefGoogle Scholar
  66. 66.
    Brown, E. M., Gardner, D. G., Windeck, R. A., Hurwitz, S., Brennan, M. F., and Aurbach, G. D., 1979, 13-Adrenergically stimulated adenosine 3’,5’monophosphate accumulation in and parathyroid hormone release from dispersed human parathyroid cells, J. Clin. Endocrinol. Metab. 48: 618–626.Google Scholar
  67. 67.
    Mayer, G. P., Hurst, J. G., Barto, J. A., Keaton, J. A., and Moore, M. P., 1979, Effect of epinephrine on parathyroid hormone secretion in calves, Endocrinology 104: 1181–1187.PubMedCrossRefGoogle Scholar
  68. 68.
    Hanley, D. A., Takatsuki, K., Birnbaumer, M. E., Schneider, A. B., and Sherwood, L. M., 1980, In vitro perfusion for the study of parathyroid hormone secretion: The effects of extracellular calcium concentration and beta-adrenergic regulation on bovine parathyroid hormone secretion, Cal-cif. Tissue Int. 32: 19–27.CrossRefGoogle Scholar
  69. 69.
    Kukreja, S. C., Williams, O. A., Hargis, G. K., Bowser, E. N., Banerjee, P., Vora, N. M., and Henderson, W. J., 1979, Dual control of suppressibility of parathyroid hormone by calcium and by beta-adrenergic blockade, Miner. Electrolyte Metab. 2: 316–322.Google Scholar
  70. 70.
    Brown, E. M., Hurwitz, S. H., and Aurbach, G. D., 1978, Beta-adrenergic inhibition of adenosine 3’,5’-monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells, Endocrinology 103: 893–899.PubMedCrossRefGoogle Scholar
  71. 71.
    Blum, J. W., Guillebeau, A., Binswanger, V., Kunz, P., Da Prada, M., and Fischer, J. A., 1978, Effects of alpha-adrenergic stimulation and blockade on plasma parathyroid hormone concentrations in cows, Acta Endocrinol. (Copenhagen) 88: 535–544.Google Scholar
  72. 72.
    Harney, A. N., Kukreja, S. C., Hargis, G. K., Jonson, P. A., Bowser, E. N., and Williams, G. A., 1978, Effect of long-term administration of epinephrine and propranolol on serum calcium, parathyroid hormone, and calcitonin in the rat, Proc. Soc. Exp. Biol. Med. 159: 266–269.PubMedGoogle Scholar
  73. 73.
    Heath, H., III, 1980, Provocative tests of parathyroid and C cell function in adrenalectomized and chemically sympathectomized rats, Endocrinology 107: 977–981.Google Scholar
  74. 74.
    Blum, J. W., Bianca, W., Naf, F., Kunz, P., Fischer, J. A., and Da Prada, M., 1979, Plasma catecholamine and parathyroid hormone responses in cattle during treadmill exercise at simulated high altitude, Horm. Metab. Res. 11: 246–251.PubMedCrossRefGoogle Scholar
  75. 75.
    Wisneski, L. A., Croom, W. P., Silva, O. L., and Becker, K. L., 1978, Salmon calcitonin in hypercalcemia, Clin. Pharmacol. Ther. 24: 219–222.PubMedGoogle Scholar
  76. 76.
    Arnaud, C. D., Tsao, H. S., and Littledike, T., 1971, Radioimmunoassay of human parathyroid hormone in serum, J. Clin. Invest. 50: 21–34.PubMedCrossRefGoogle Scholar
  77. 77.
    Sinha, T. K., Miller, S., Fleming, J., Khairi, R., Edmondson, J., Johnston, C. C., Jr., and Bell, N. H., 1975, Demonstration of a diurnal variation in serum parathyroid hormone in primary and secondary hyperparathyroidism, J. Clin. Endocrinol. Metab. 41: 1009–1013.PubMedCrossRefGoogle Scholar
  78. 78.
    Kripke, D. F., Lavie, P., Parker, D., Huey, L., and Deftos, L. J., 1978, Plasma parathyroid hormone and calcium are related to sleep stage cycles, J. Clin. Endocrinol. Metab. 47: 1021–1027.PubMedCrossRefGoogle Scholar
  79. 79.
    Urist, M. R., 1976, Biogenesis of bone: Calcium and phosphorus in the skeleton and blood in vertebrate evolution, in: Handbook of Physiology, Section F, Volume VII ( G. D. Aurbach, ed.), pp. 183–213, American Physiological Society, Washington, D. C.Google Scholar
  80. 80.
    Wendelaar Bonga, S. E., and Greve, J. A. A., 1978, The relationship between prolactin cell activity, environmental calcium, and plasma calcium in the teleost Gasterosteus aculeatus: Observations on stanniectomized fish, Gen. Comp. Endocrinol. 36: 90–101.CrossRefGoogle Scholar
  81. 81.
    Pang, P. K. T., Schreibman, M. P., Balbontin, F., and Pang, R. K., 1978, Prolactin and pituitary control of calcium regulation in the killifish, Fundulus heteroclitus, Gen. Comp. Endocrinol. 36: 306–316.CrossRefGoogle Scholar
  82. 82.
    Maclntyre, I., Colston, K. W., Szelke, M., and Spanos, E., 1978, A survey of the hormonal factors that control calcium metabolism, Ann. N.Y. Acad. Sci. 307:345–355.Google Scholar
  83. 83.
    Mahajan, K. K., Robinson, C. J., and Horrobin, D. F., 1975, The role of prolactin in hypercalcemia, Br. J. Surg. 62: 161.PubMedGoogle Scholar
  84. 84.
    Parsons, J. A., Gray, D., Rafferty, B., and Zanelli, J. M., 1978, Evidence for a hypercalcemic factor in the fish pituitary immunologically related to mammalian parathyroid hormone, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 111–114, Excerpta Medica, Amsterdam.Google Scholar
  85. 85.
    Lee, S. W., Halstead, L. R., and Avioli, L. V., 1978, Hypothalamic hypocalcemic factors, Miner. Electrolyte Metab. 1: 247–252.Google Scholar
  86. 86.
    Kleeman, K., and Kleeman, C. R., 1979, Parathyroid hormone, in: Contemporary Endocrinology, Volume 1 ( S. H. Ingbar, ed.), pp. 305–339, Plenum Medical, New York.Google Scholar
  87. 87.
    Wecksler, W. R., Henry, H. L., and Norman, A. W., 1977, Studies on the mode of action of calciferol: Subcellular localization of 1,25-dihydroxyvitamin D3 in chicken parathyroid glands, Arch. Biochem. Biophys. 183: 168–175.PubMedCrossRefGoogle Scholar
  88. 88.
    Hughes, M. R., and Haussier, M. R., 1978, 1,25-Dihydroxyvitamin D3 receptors in parathyroid glands, J. Biol. Chem. 253: 1065–1073.Google Scholar
  89. 89.
    Stumpf, W. E., Sar, M., Reid, F. A., Tanaka, Y., and DeLuca, H. F., 1979, Target cells for 1,25 dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid, Science 206: 1188–1190.PubMedCrossRefGoogle Scholar
  90. 90.
    Finco, D., Olgaard, K., Rothstein, M., Schwartz, J., Korkor, A., Teitelbaum, S., Klahr, S., and Slatopolsky, E., 1980, Lack of a direct effect of 24,25 (OH)2D3 on PTH secretion in studies in vitro or in vivo, Proceedings of the 7th International Conference on Calcium-Regulating Hormones.Google Scholar
  91. 91.
    Care, A. D., Pickard, D. W., Papapoulos, S. E., O’Riordan, J. L. H., and Redel, J., 1978, Inhibitory effect of 25,26-dihydroxycholecalciferol on the rate of secretion of parathyroid hormone in goats, J. Endocrinol. 78: 303–304.PubMedCrossRefGoogle Scholar
  92. 92.
    Canterbury, J. M., Lerman, S., Claflin, A. J., Henry, H., Norman, A., and Reiss, E., 1978, Inhibition of parathyroid hormone secretion by 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in the dog, J. Clin. Invest. 61: 1375–1383.PubMedCrossRefGoogle Scholar
  93. 93.
    Dietel, M., Dorn, G., Montz, R., and Altenahr, E., 1979, Influence of vitamin D3 on parathyroid hormone secretion, adenosine 3’,5’-monophosphate release, and ultrastructure of parathyroid glands in organ cultures, Endocrinology 105: 237–245.PubMedCrossRefGoogle Scholar
  94. 94.
    Golden, P., Mazey, R., Greenwalt, A., Martin, K., and Slatopolsky, E., 1979, Vitamin D: A direct effect on the parathyroid gland, Miner. Electrolyte Metab. 2: 1–6.Google Scholar
  95. 95.
    Oldham, S. B., Smith, R., Hartenbower, D. K., Henry, H. L., Norman, A. W., and Coburn, J. W., 1979, The acute effects of 1,25-dihydroxycholecalciferol on serum immunoreactive parathryoid hormone in the dog, Endocrinology 104: 248–254.PubMedCrossRefGoogle Scholar
  96. 96.
    Oldham, S. B., Fischer, J. A., Shen, L. H., and Arnaud, C. D., 1974, Isolation and properties of a calcium-binding protein from porcine parathyroid gland, Biochemistry 13: 4790–4796.PubMedCrossRefGoogle Scholar
  97. 97.
    Oldham, S. B., Arnaud, C. D., and Jowsey, J., 1973, Influence of vitamin D on canine parathyroid glands, Clin. Res. 21: 254A.Google Scholar
  98. 98.
    Oldham, S. B., Mitnick, S. A., and Coburn, J. W., 1980, Intestinal and parathyroid calcium-binding proteins in the dog: Comparison of biochemical properties and responses to vitamin D, J. Biol. Chem. 255: 5789–5794.Google Scholar
  99. 99.
    Brown, E. M., Carroll, R. J., and Aurbach, G. D., 1977, Dopaminergic stimulation of cyclic AMP accumulation and parathyroid hormone release from dispersed bovine parathyroid cells, Proc. Natl. Acad. Sci. USA 74: 4210–4213.PubMedCrossRefGoogle Scholar
  100. 100.
    Williams, G. A., Longley, R. S., Hargis, G. K., Bowser, E. N., Kukreja, S. C., Johnson, P. A., Jackson, B. L., and Kawahara, W. J., 1979, Effect of histamine on parathyroid hormone, Clin. Res. 27: 704A.Google Scholar
  101. 101.
    Windeck, R., Brown, E. M., Gardner, D. G., and Aurbach, G. D., 1978, Effect of gastrointestinal hormones on isolated bovine parathyroid cells, Endocrinology 103: 2020–2026.PubMedCrossRefGoogle Scholar
  102. 102.
    Deftos, L. J., Lorenzi, M., Bohanon, N., Tsalakian, E., Schneider, V., and Gerich, J. E, 1976, Somatostatin does not suppress plasma parathyroid hormone, J. Clin. Endocrinol. Metab. 43: 205–207.PubMedCrossRefGoogle Scholar
  103. 103.
    Metz, S. A., Deftos, L. J., Baylink, D. J., and Robertson, R. P., 1978, Neuroendocrine modulation of calcitonin and parathyroid hormone in man, J. Clin. Endocrinol. Metab. 47: 151–159.PubMedCrossRefGoogle Scholar
  104. 104.
    Hargis, G. K., Williams, G. A., Reynolds, W. A., Chertow, B. S., Kukreja, S. C., Bowser, E. N., and Henderson, W. J., 1978, Effect of somatostatin on parathyroid hormone and calcitonin secretion, Endocrinology 102: 745–750.PubMedCrossRefGoogle Scholar
  105. 105.
    Williams, G. A., Hargis, G. K., Ensinck, J. W., Kukrega, S. C., Bowser, E. N., Chertow, B. S., and Henderson, W. J., 1979, Role of endogenous somatostatin in the secretion of parathyroid hormone and calcitonin, Metabolism 28: 950–954.PubMedCrossRefGoogle Scholar
  106. 106.
    Brown, E. M., Gardner, D. G., and Aurbach, G. D., 1980, Effects of the calcium ionophore A23187 on dispersed bovine parathyroid cells, Endocrinology 106: 133–138.PubMedCrossRefGoogle Scholar
  107. 107.
    Watterson, D. M., and Vicenzi, F. F. (eds.), 1980, Calmodulin and Cell Functions, Ann. N.Y. Acad. Sci. 356.Google Scholar
  108. 108.
    Satir, B. H., Garofalo, R. S., Gilligan, D. M., and Maihle, N.J., 1980, Possible functions of calmodulin in protozoa, Ann. N.Y. Acad. Sci. 356: 83–91.PubMedCrossRefGoogle Scholar
  109. 109. Oldham, S. B., Lipson, L. G., and Tiefjen, G. E., 1980, Evidence for calmodulin in parathyroid tissue, Proceedings of the 7th International Conference on Calcium-Regulating Hormones.Google Scholar
  110. 110.
    Martin, K. J., Hruska, K. A., Freitag, J. J., Klahr, S., and Slatopolsky, E., 1979, The peripheral metabolism of parathyroid hormone, N. Engl.J. Med. 301: 1092–1098.PubMedCrossRefGoogle Scholar
  111. 111.
    Neuman, M. W., Neuman, W. F., and Lane, K., 1979, Formation and serum disappearance of fragments of parathyroid hormone in the infused dog, Calcif. Tissue Int. 28: 79–81.PubMedCrossRefGoogle Scholar
  112. 112.
    Barret, P. Q., Teitelbaum, A., and Neuman, W. F., 1978, The heterogeneity of parathyroid hormone in rat plasma, Metab. Bone Dis. Relat. Res. 1: 263–267.CrossRefGoogle Scholar
  113. 113.
    Papapoulos, S. E., Hendy, G. N., Tomlinson, S., Lewin, I. G., and O’-Riordan, J. L. H., 1977, Clearance of exogenous parathyroid hormone in normal and uraemic man, Clin. Endocrinol. 7: 211–225.CrossRefGoogle Scholar
  114. 114.
    D’Amour, P., Segre, G. V., Roth, S. I., and Potts, J. T., Jr., 1979, Analysis of parathyroid hormone and its fragments in rat tissues, J. Clin. Invest. 63: 89–98.PubMedCrossRefGoogle Scholar
  115. 115.
    Hunziker, W. H., Blum, J. W., and Fischer, J. A., 1977, Plasma kinetics of exogenous bovine parathyroid hormone in calves, Pfluegers Arch. 371: 185–192.CrossRefGoogle Scholar
  116. 116.
    Segre, G. F., D’Amour, P., and Rosenblatt, M., 1978, Heterogeneity and metabolism of parathyroid hormone, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 329–332, Excerpta Medica, Amsterdam.Google Scholar
  117. 117.
    Rosenblatt, M., Segre, G. V., and Potts, J. T., Jr., 1977, Synthesis of a fragment of parathyroid hormone, bPTH-(28–48): An inhibitor of hormone cleavage in vivo, Biochemistry 16: 2811–2816.Google Scholar
  118. 118.
    Freitag, J. J., Martin, K. J., Conrades, M. B., and Slatopolsky, E., 1979, Metabolism of parathyroid hormone by fetal rat calvaria, Endocrinology 104: 510–515.PubMedCrossRefGoogle Scholar
  119. 119.
    Oldham, S. B., Finck, E. J., and Singer, F. R., 1978, Parathyroid hormone clearance in man, Metabolism 27: 993–1001.PubMedCrossRefGoogle Scholar
  120. 120.
    Barrett, P. Q., Teitelbaum, A., Neuman, W. F., and Neuman, M. W., 1978, The role of the liver in the peripheral metabolism of parathyroid hormone, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 324–328, Excerpta Medica, Amsterdam.Google Scholar
  121. 121.
    Canterbury, J. M., Bricker, L. A., Levey, J. S., Kozlovskis, P. L., Ruiz, E., Zull, J. E., and Reiss, E., 1975, Metabolism of bovine parathyroid hormone: Immunological and biological characteristic of fragments generated by liver perfusion, J. Clin. Invest. 55: 1245–1253.PubMedCrossRefGoogle Scholar
  122. 122.
    Martin, K. J., Hruska, K. A., Lewis, J., Anderson, C., and Slatopolsky, E., 1977, The renal handling of parathyroid hormone: Role of peritubular uptake and glomerular filtration, J. Clin. Invest. 60: 808–814.PubMedCrossRefGoogle Scholar
  123. 123.
    Freitag, J., Martin, K. J., Hruska, K. A., Anderson, C., Conrades, M., Ladenson, J., Klahr, S., and Slatopolsky, E., 1978, Impaired parathyroid hormone metabolism in patients with chronic renal failure, N. Engl. J. Med. 298: 29–32.PubMedCrossRefGoogle Scholar
  124. 124.
    Goltzman, D., Peytremann, A., Callahan, G. N., Segre, G. V., and Potts, J. T., Jr., 1976, Metabolism and biological activity of parathyroid hormone in renal cortical membranes, J. Clin. Invest. 57: 8–19.PubMedCrossRefGoogle Scholar
  125. 125.
    Goltzman, D., 1978. Examination of the requirement for metabolism of parathyroid hormone in skeletal tissue before biological action, Endocrinology 102: 1555–1562.PubMedCrossRefGoogle Scholar
  126. 126.
    Martin, K. J., Freitag, J. J., Conrades, M. B., Hruska, K. A., Klahr, S., and Slatopolsky, E., 1978, Selective uptake of the synthetic amino terminal fragment of bovine parathyroid hormone by isolated perfused bone, J. Clin. Invest. 62: 256–261.PubMedCrossRefGoogle Scholar
  127. 127.
    Parsons, J. A., and Robinson, G. J., 1968, A rapid indirect hypercaicemic action of parathyroid hormone demonstrated in isolated perfused bone in: Parathyroid Hormone and Thyrocalcitonin (R. V. Talmage and L. F. Belanger, eds.), pp. 329–331, Excerpta Medica, Amsterdam.Google Scholar
  128. 128.
    Mueller, W. J., Brubaker, R. L., Gay, C. V., and Boelkins, J. N., 1973, Mechanisms of bone resorption in laying hens, Fed. Proc. 32: 1951–1954.PubMedGoogle Scholar
  129. 129.
    Parsons, J. A., 1979, The physiology of parathyroid hormone, in: Endocrinology, Volume 2 (L. J. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martini, J. T. Potts, Jr., D. H. Nelson, E. Steinberger, and A. I. Winegrad, eds.), pp. 621–630, Grune Stratton, New York.Google Scholar
  130. 130.
    Wittle, L. W., and Dent, J. N., 1979, Effects of parathyroidectomy and of parathyroid extract on levels of calcium and phosphate in the blood and urine of the red-spotted newt, Gen. Comp. Endocrinol. 37: 428–439.PubMedCrossRefGoogle Scholar
  131. 131.
    Rader, J. I., Baylink, D. J., Hughes, M. R., Safilian, E. F., and Haussier, M. R., 1979, Calcium and phosphorus deficiency in rats: Effects on PTH and 1,25 dihydroxyvitamin D3, Am. J. Physiol. 236: E118 — E122.PubMedGoogle Scholar
  132. 132.
    Haldimann, B., Bonjour, J. P., and Fleisch, H., 1977, Role of parathyroid hormone in regulation of main calcium fluxes in rats, Am. J. Physiol. 232: E535 — E541.PubMedGoogle Scholar
  133. 133.
    Pitkin, R. M., 1979, Calcium metabolism during pregnancy and its effects on the fetus and newborn, Pediatr. Adolesc. Endocrinol. 5: 67–87.Google Scholar
  134. 134.
    Pitkin, R. M., Reynolds, W. A., Williams, G. A., and Hargis, G. K., 1979, Calcium metabolism in normal pregnancy: A longitudinal study, Am. J. Obstet. Gynecol. 133: 781–790.PubMedGoogle Scholar
  135. 135.
    Kumar, R., Cohen, W. R., Silva, P., and Epstein, F. H., 1979, Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation, J. Clin. Invest. 63: 342–344.PubMedCrossRefGoogle Scholar
  136. 136.
    Toverud, S. U., Becker, D. I., Boass, A., Cooper, C. W., Hirsch, P. F., Outjes, D. A., Peng, T.-C., and Ramp, W. K., 1978, Hormonal control of calcium metabolism in lactation, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 126–133, Excerpta Medica, Amsterdam.Google Scholar
  137. 137.
    Toverud, S. U., Cooper, C. W., and Munson, P. L., 1978, Calcium metabolism during lactation: Elevated blood levels of calcitonin, Endocrinology 103: 472–479.PubMedCrossRefGoogle Scholar
  138. 138.
    Peck, W. A., 1978, The specialization of bone cells, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 237–240, Excerpta Medica, Amsterdam.Google Scholar
  139. 139.
    Wong, G. L., 1979, Basal activities and hormone responsiveness of osteoclast-like and osteoblast-like bone cells are regulated by glucocorticoids, J. Biol. Chem. 254: 6337–6340.PubMedGoogle Scholar
  140. 140.
    Baud, C. A., and Boivin, G., 1978, Effects of hormones on osteocyte function and perilacunar wall structure, Clin. Orthop. Relat. Res. 136: 270–281.PubMedGoogle Scholar
  141. 141.
    Norimatsu, H., Vander Wiel, C. J., and Talmage, R. V., 1979, Morphological support of a role for cells lining bone surfaces in maintenance of plasma calcium concentration, Clin. Orthop. Relat. Res. 138: 254–262.PubMedGoogle Scholar
  142. 142.
    Holtrop, M. E., King, G. J., Cox, K. A., and Reit, B., 1979, Time-related changes in the ultrastructure of osteoclasts after injection of parathyroid hormone in young rats, Calcif. Tissue Int. 27: 29–135.CrossRefGoogle Scholar
  143. 143.
    Miller, S. C., 1978, Rapid activation of the medullary bone osteoclast cell surface by parathyroid hormone, J. Cell Biol. 76: 615–618.PubMedCrossRefGoogle Scholar
  144. 144.
    Vander Wiel, C., Matthews, J. L., and Talmage, R. V., 1978, Intracellular calcium localization in cells lining bone surfaces following parathyroid hormone injection, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), p. 355, Excerpta Medica, Amsterdam.Google Scholar
  145. 145.
    Parfitt, A. M., 1976, The actions of parathyroid hormone on bone: Relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. II. PTH and bone cells: Bone turnover and plasma calcium regulation, Metabolism 25: 904–955.Google Scholar
  146. 146.
    Baud, C. A., and Boivin, G., 1978, Effects of hormones on osteocyte function and perilacunar wall structure, Clin. Orthop. Relat. Res. 136: 270–281.PubMedGoogle Scholar
  147. 147.
    Burger, E. H., Matthews, J. L., and Doty, S. B., 1978, Intracellular calcium distribution in parathyroid-hormone treated fetal bones, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), p. 356, Excerpta Medica, Amsterdam.Google Scholar
  148. 148.
    Schulz, A., Bressel, M., and Delling, G., 1977, Activity of osteoclastic bone resorption in primary human hyperparathyroidism: A comparative electron microscopic and histomorphometric study, Calcif. Tissue Res. 22 (Suppl): 307–310.PubMedCrossRefGoogle Scholar
  149. 149.
    Krempien, B., Friedrich, G., Geger, G., and Ritz, E., 1977, Factors influencing the effect of parathyroid hormone on endosteal cell morphology, Calcif. Tissue Res. 22 (Suppl.): 164–168.PubMedCrossRefGoogle Scholar
  150. 150.
    Bonucci, E., Lo Cascio, V., Adami, S., Cominacini, L., Galvanini, G., and Scuro, A., 1978, The ultrastructure of bone cells and bone matrix in human primary hyperparathyroidism, Virchows Arch. A 379: 11–23.Google Scholar
  151. 151.
    Meunier, P. J., Bressot, C., and Edouard, C., 1978, Dynamics of bone remodeling in primary hyperparathyroidism: Histomorphometric data, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), p. 415, Excerpta Medica, Amsterdam.Google Scholar
  152. 152.
    Will, M. R., 1970, Fundamental physiologic role of parathyroid hormone in acid base homeostasis, Lancet 2: 802–804.CrossRefGoogle Scholar
  153. 153.
    Fraley, D. S., and Adler, S., 1979, An extrarenal role for parathyroid hormone in the disposal of acute acid loads in rats and dogs, Clin. Invest. 63: 985–997.CrossRefGoogle Scholar
  154. 154.
    Lechene, C. P., and Warner, R. R., 1977, Ultramicroanalysis: X-ray spectrometry by electron probe excitation, Annu. Rev. Biophys. Bioeng. 6: 57–85.PubMedCrossRefGoogle Scholar
  155. 155.
    Evers, C., Murer, H., and Kinne, R., 1978, Effect of parathyrin on the transport properties of isolated renal brush-border vesicles, Biochem. J. 172: 49–56.PubMedGoogle Scholar
  156. 156.
    Gmaj, P., Murer, H., and Kinne, R., 1979, Calcium ion transport across plasma membranes isolated from rat kidney cortex, Biochem. J. 178: 549–557.PubMedGoogle Scholar
  157. 157.
    Stoll, R., Kinne, R., and Murer, H., 1979, Effect of dietary phosphate intake on phosphate transport by isolated rat renal brush-border vesicles, Biochem. J. 180: 465–470.PubMedGoogle Scholar
  158. 158.
    Tenenhouse, H. S., and Scriver, C. R., 1979, Renal brushborder membrane adaptation to phosphorus deprivation in the Hyp/Y mouse, Nature (London) 281: 225–227.CrossRefGoogle Scholar
  159. 159.
    Suki, W. N., 1979, Calcium transport in the nephron, Am. J. Physiol. 237: F1 — F6.PubMedGoogle Scholar
  160. 160.
    Rouse, D., and Suki, W. N., 1978, Calcium transport in the superficial straight proximal tubule (SPT), Clin. Res. 26: 544A.Google Scholar
  161. 161.
    Shareghi, G. R., and Stoner, L. C., 1978, Calcium transport across segments of the rat distal nephron in vitro, Am. J. Physiol. 235: F367 — F375.Google Scholar
  162. 162.
    Greger, R., Lang, F., and Oberleithneu, H., 1978, Distal site of calcium reabsorption in the rat nephron, Pfluegers Arch. 374: 153–157.CrossRefGoogle Scholar
  163. 163.
    Agus, Z. S., Chiu, P. J. S., and Goldberg, M., 1977, Regulation of urinary calcium excretion in the rat, Am. J. Physiol. 232: F545 — F549.PubMedGoogle Scholar
  164. 164.
    Grabie, M., Lau, K., Agus, Z. S., Goldberg, M., and Goldfarb, S., 1978, Role of parathyroid hormone in the hypercalciuria of chronic phosphate depletion, Miner. Electrolyte Metab. 1: 279–287.Google Scholar
  165. 165.
    Costanzo, L. S., and Windhager, E. E., 1978, Calcium and sodium transport by the distal convoluted tubule of the rat, Am. J. Physiol. 235: F492 — F506.PubMedGoogle Scholar
  166. 166.
    Christensson, T., Hellstrom, K., and Wengle, B., 1977, Hypercalcemia and primary hyperparathyroidism, Arch. Intern. Med. 137: 1138–1141.PubMedCrossRefGoogle Scholar
  167. 167.
    Mohamadi, M., Bivins, L., and Becker, K. L., 1979, Effect of thiazides on serum calcium, Clin. Pharmacol. Ther. 26: 390–394.PubMedGoogle Scholar
  168. 168.
    Lechene, C., Colindres, R., and Knox, F. G., 1978, Electron probe microanalysis of the renal effect of parathyroid hormone, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 230–233, Excerpta Medica, Amsterdam.Google Scholar
  169. 169.
    Pastoriza-Munoz, E., Colindres, R. E., Lassiter, W. E., and Lechene, C., 1978, Effect of parathyroid hormone on phosphate reabsorption in rat distal convolution, Am. J. Physiol. 235: F321 — F330.PubMedGoogle Scholar
  170. 170.
    Sraer, J., Sraer, J. D., Chansel, D., Jueppner, H. J., Hesch, R. D., and Ardaillou, R., 1978, Evidence for glomerular receptors for parathyroid hormone, Am. J. Physiol. 235: F96 — F103.PubMedGoogle Scholar
  171. 171.
    Sraer, J., Ardaillou, R., Loreau, N., and Sraer, J. D., 1974, Evidence for parathyroid hormone sensitive adenylate cyclase in rat glomeruli, Mol. Cell. Endocrinol. 1: 285–294.CrossRefGoogle Scholar
  172. 172.
    Dousa, T. P., Barnes, L. D., Ong, S. H., and Steiner, A. L., 1977, Immunohistochemical localization of 3’,5’-cyclic AMP and 3’,5’-cyclic GMP in rat renal cortex: Effect of parathyroid hormone, Proc. Natl. Acad. Sci. USA 74: 3569–3573.PubMedCrossRefGoogle Scholar
  173. 173.
    Humes, H. D., Ichikawa, I., Troy, J. L., and Brenner, B. M., 1978, Evidence for a parathyroid-hormone dependent influence of calcium on the glomerular ultrafiltration coefficient, J. Clin. Invest. 61: 32–40.PubMedCrossRefGoogle Scholar
  174. 174.
    Ichikawa, I., Humes, H. D., Dousa, T. P., and Brenner, B. M., 1978, Influence of parathyroid hormone on glomerular ultrafiltration in the rat, Am. J. Physiol. 234: F393 — F401.PubMedGoogle Scholar
  175. 175.
    Lins, L.-E., 1979, Renal function in primary hyperparathyroidism and in non-hyperparathyroid hypercalcemia, Acta Med. Scand. 205: 607–613.PubMedCrossRefGoogle Scholar
  176. 176.
    Levine, B. S., Brautbar, N., and Coburn, J. W., 1978, Does vitamin D affect the renal handling of calcium and phosphorus? Miner. Electrolyte Metab. 1: 295–302.Google Scholar
  177. 177.
    Bernstein, D., Kleeman, C. R., Dowling, J. T., and Maxwell, M. H., 1959 The renal clearance of diffusible calcium associated with clinical and experimental alterations in parathyroid function, Clin. Res. 7:246.Google Scholar
  178. 178.
    Hugi, K., Bonjour, J.-P., and Fleisch, H., 1979, Renal handling of calcium: Influence of parathyroid hormone and 1,25-dihydroxy vitamin D3, Am. J. Physiol. 236: F349 — F356.PubMedGoogle Scholar
  179. 179.
    Forte, L. R., Nichols, R. A., and Anast, C. S., 1976, Renal adenylate cyclase and the interrelationship between parathyroid hormone and vitamin D in the regulation of urinary phosphate and adenosine cyclic 3’,5’-monophosphate excretion, J. Clin. Invest. 57: 559–568.PubMedCrossRefGoogle Scholar
  180. 180.
    Kakuta, S., Sato, C., Suda, T., Kimura, N., Araki, N., Ono, Y., and Nagata, N., 1978, Relationship between parathyroid hormone and adenosine 3’,5’monophosphate metabolism in the kidney of vitamin D-deficient rats, Biochim. Biophys. Acta 539: 173–180.PubMedCrossRefGoogle Scholar
  181. 181.
    Adams, N. D., Gray, R. W., and Lemann, J., Jr., 1979, The effects of oral CaCO3 loading and dietary calcium deprivation on plasma 1,25-dihydroxy vitamin D concentrations in healthy adults, J. Clin. Endocrinol. Metab. 48: 1008–1016.PubMedCrossRefGoogle Scholar
  182. 182.
    Gray, R. W., Caldas, A. E., Wilz, D. R., Lemann, J., Jr., Smith, G. A., and DeLuca, H. F., 1978, Metabolism and excretion of 3H-1,25-(OH)2-vitamin D3 in healthy adults, J. Clin. Endocrinol. Metab. 46: 756–765.PubMedCrossRefGoogle Scholar
  183. 183.
    Hughes, M. R., Brumbaugh, P. F., Haussier, M. R., Wergedal, J. E., and Baylink, D. T., 1975, Regulation of serum 1a,25-dihydroxy vitamin D3 by calcium and phosphate in the rat, Science 190: 578–580.PubMedCrossRefGoogle Scholar
  184. 184.
    Ribovich, M. L., and DeLuca, H. F., 1978, Adaptation of intestinal calcium absorption: Parathyroid hormone and vitamin D metabolism, Arch. Biochem. Biophys. 188: 157–163.PubMedCrossRefGoogle Scholar
  185. 185.
    Kaplan, R. A., Haussier, M. R., Deftos, L. J., Bone, H., and Pak, C. Y. C., 1977, The role of la,25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria, J. Clin. Invest. 59: 756–760.PubMedCrossRefGoogle Scholar
  186. 186.
    Bone, H. G., III, Zerwekh, J. E., Haussier, M. R., and Pak, C. Y. C., 1979, Effect of parathyroidectomy on serum la,25-dihydroxyvitamin D and intestinal calcium absorption in primary hyperparathyroidism, J. Clin. Endocrinol. Metab. 48: 877–879.PubMedCrossRefGoogle Scholar
  187. 187.
    Peacock, M., Heyburn, P. J., Barnett, M. J., Brown, W. B., Davies, A., and Taylor, G. A., 1980, Relative importance of plasma parathyroid hormone, calcium and phosphate in regulating 1,25(OH)2 vitamin D in primary hyperparathyroidism, Proceedings of the 7th International Conference on Calcium-Regulating Hormones.Google Scholar
  188. 188.
    Broadus, A. E., Horst, R. L., Lang, R., Littledike, E. T., and Rasmussen, H., 1980, The importance of circulating 1,25-dihydroxyvitamin D in the pathogenesis of hypercalciuria and renal-stone formation in primary hyperparathyroidism, N. Engl. J. Med. 302: 421–426.PubMedCrossRefGoogle Scholar
  189. 189.
    Malluche, H. H., Goldstein, D. A., and Massry, S. G., 1979, Osteomalacia and hyperparathyroid bone disease in patients with nephrotic syndrome, J. Clïn. Invest. 63: 494–500.PubMedCrossRefGoogle Scholar
  190. 190.
    Weisbrode, S. E., Capen, C. C., and Norman, A. W., 1978, Ultrastructural evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats fed a low-calcium diet, Am. J. Pathol. 92: 459–472.PubMedGoogle Scholar
  191. 191.
    Nissenson, R. A., and Arnaud, C., 1979, Properties of the parathyroid hormone receptor—adenylate cyclase system in chicken renal plasma membranes, J. Biol. Chem. 254: 1469–1475.PubMedGoogle Scholar
  192. 192.
    Segre, G. V., Rosenblatt, M., Reiner, B. L., Mahaffey, J. E., and Potts, J. T., Jr., 1979, Characterization of parathyroid hormone receptors in canine renal cortical plasma membranes using a radioiodinated sulfur-free hormone analogue, J. Biol. Chem. 254: 6980–6986.PubMedGoogle Scholar
  193. 193.
    Mohr, H., and Hesch, R. D., 1978, Parathormone degrading activity in basal lateral membranes of the bovine renal cortex, Acta Endocrinol. [Suppl.J(Copenhagen) 87(Suppl. 25 ): 107–108.Google Scholar
  194. 194.
    Mazzuoli, G. F., D’Erasmo, E., Scarda, A., Minisola, S., Mancini, D., and Aliberti, L. M., 1979, Significance of early increase in stable and radioactive plasma calcium after parathyroidectomy in primary hyperparathyroidism, Calcif. Tissue Int. 29: 185–191.PubMedCrossRefGoogle Scholar
  195. 195.
    Borle, A. B., and Uchikawa, T., 1978, Effects of parathyroid hormone on the distribution and transport of calcium in cultured kidney cells, Endocrinology 102: 1725–1732.PubMedCrossRefGoogle Scholar
  196. 196.
    Borie, A. B., and Uchikawa, T., 1979, Effects of adenosine 3’,5’-monophosphate, dibutyryl adenosine 3’,5’-monophosphate, aminophylline, and imidazole on renal cellular calcium metabolism, Endocrinology 104: 122–129.CrossRefGoogle Scholar
  197. 197.
    Dziak, R., and Stern, P. H., 1975, Calcium transport in isolated bone cells, Endocrinology 97: 1281–1287.PubMedCrossRefGoogle Scholar
  198. 198.
    Nagata, N., Ono, Y., and Kimura, N., 1977, Inhibition by cholera toxin of parathyroid hormone-induced calcium release from bone in culture, Biochem. Biophys. Res. Commun. 78: 819–826.Google Scholar
  199. 199.
    Kakuta, S., Suda, T., Sasak, S., Kimura, N., and Nagata, N., 1975, Effects of parathyroid hormone on the accumulation of cAMP in bone of vitamin D-deficient rats, Endocrinology 97: 1288–1293.PubMedCrossRefGoogle Scholar
  200. 200.
    Carnes, D. L., Anast, C. S., and Forte, L. R., 1978, Impaired renal adenylate cyclase response to parathyroid hormone in the calcium-deficient rat, Endocrinology 102:45-51.Google Scholar
  201. 201.
    Mears, D. C., 1971, Effects of parathyroid hormone and thyrocalcitonin on the membrane potential of osteoclasts, Endocrinology 88: 1021–1028.PubMedCrossRefGoogle Scholar
  202. 202.
    Dietrich, J. W., Mundy, G. R., and Raisz, L. G., 1979, Inhibition of bone resorption in tissue culture by membrane-stabilizing drugs, Endocrinology 104: 1644–1648.PubMedCrossRefGoogle Scholar
  203. 203.
    Baxter, J. D., and Funder, J. W., 1979, Hormone receptors, N. Engl. J. Med. 301: 1149–1161.PubMedCrossRefGoogle Scholar
  204. 204.
    Goltzman, D., Callahan, E. N., Tregear, G. M., and Potts, J. T., Jr., 1978, Influence of guanyl nucleotides on parathyroid hormone-stimulated adenylyl cyclase activity in renal cortical membranes, Endocrinology 103: 1352–1360.PubMedCrossRefGoogle Scholar
  205. 205.
    Drezner, M. K., and Burch, W. M., Jr., 1978, Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism, J. Clin. Invest. 62: 1222–1227.PubMedCrossRefGoogle Scholar
  206. 206.
    Levine, M., Downs, R., Singer, M., Marx, S., Aurbach, G., and Spiegel, A., 1980, Deficiency of guanine nucleotide regulatory protein: Postreceptor site of defect in pseudohypoparathyroidism, Proceedings of the 7th International Conference on Calcium-Regulating Hormones.Google Scholar
  207. 207.
    Walling, M., Marvaso, V., and Bernard, G. W., 1978, Stimulation of guanylate cyclase activity in cultured osteogenic murine calvarial mesenchymal cells by PTH, calcitonin and insulin, Biochem. Biophys. Res. Commun. 83: 521–527.PubMedCrossRefGoogle Scholar
  208. 208.
    Wrenn, R. W., Currie, M. G., and Biddulph, D. M., 1978, Influence of calcium, parathyroid hormone and ionophore A-23187 on cyclic nucleotide concentrations of isolated renal tubules, Mol. Cell. Endocrinol. 10: 263–276.PubMedCrossRefGoogle Scholar
  209. 209.
    Araki, N., Nagata, N., and Kimura, N., 1977, Effects of parathyroid hormone and prostaglandin E1 in vitro on release of cyclic AMP from kidney cortical tissue, Endocrinol. Jpn. 24: 581–587.PubMedCrossRefGoogle Scholar
  210. 210.
    Currie, M. G., and Biddulph, D. M., 1979, Metabolism of cyclic AMP in isolated renal tubules: Effects of prostaglandins and parathyroid hormone, Prostaglandins 17: 211–222.PubMedCrossRefGoogle Scholar
  211. 211.
    Biddulph, D. M., Currie, M. G., and Wrenn, R. W., 1979, Effects and interactions of parathyroid hormone and prostaglandins on adenosine 3’,5’monophosphate concentrations in isolated renal tubules, Endocrinology 104: 1164–1171.PubMedCrossRefGoogle Scholar
  212. 212.
    Marcus, R., and Orner, F. B., 1977, Cyclic AMP production in rat calvaria in vitro: Interaction of prostaglandins with parathyroid hormone, Endocrinology 101: 1570–1578.PubMedCrossRefGoogle Scholar
  213. 213.
    Goldring, S. R., Dayer, J.-M, and Krane, S. M., 1979, Regulation of hormone-induced cyclic AMP response to parathyroid hormone and prostaglandin E2 in cells cultured from human giant cell tumors of bone, Calcif. Tissue Int. 29: 193–200.PubMedCrossRefGoogle Scholar
  214. 214.
    Brown, G. M., Broadus, A. E., Brennan, M. F., Gardner, D. G., Marx, S. J., Spiegel, A. M., Downs, R. W., Jr., Attie, M., and Aurbach, G. D., 1979, Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism, J. Clin. Endocrinol. Metab.. 48: 604–610.PubMedCrossRefGoogle Scholar
  215. 215. Kukreja, S. C., Williams, G. A., Vora, N. M., Hargis, G. K., Bowser, E. N., and Henderson, W. J., 1980 Parathyroid hormone secretion in primary hyperparathyroidism: Retained control by calcium with impaired control by (3-adrenergic system, Miner. Electrolyte Metab..3:98–103.Google Scholar
  216. 216. Habener, J. F., 1978 Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro, J. Clin. Invest..62:436–450.Google Scholar
  217. 217.
    Caro, J. F., and Besarab, A., 1978, Propranolol therapy for hyperparathyroidism, Lancet 1: 827.PubMedCrossRefGoogle Scholar
  218. 218.
    Fournier, A., Coevoet, B., de Fremont. J. F., Gueris, J., Caillens, G., Des-plan, C., Calmette, C., and Moukhtar, M. S., 1978, Propranolol therapy for seconday hyperparathyroidism in uremia, Lancet 2: 50–51.PubMedCrossRefGoogle Scholar
  219. 219.
    Caro, J. F., Burke, J. F., Besarab, A., and Glennon, J. A., 1978, A possible role for propranolol in the treatment of renal osteodystrophy, Lancet 2: 451–454.PubMedCrossRefGoogle Scholar
  220. 220.
    Caro, J. F., Castro, J. H., and Glennon, J. A., 1979, Effect of long-term propranolol administration on parathyroid hormone and calcium concentration in primary hyperparathyroidism, Ann. Intern. Med. 91: 740–741.PubMedGoogle Scholar
  221. 221.
    Sherwood, J., Reinhard, D., and Garcia, M., 1979, Does cimetidine inhibit parathyroid hormone secretion?, N. Engl. J. Med. 300: 200–201.PubMedGoogle Scholar
  222. 222.
    Palmer, F. J., Sawyers, T. M., and Wierzbinski, S. J., 1980, Cimetidine and hyperparathyroidism, N. Engl. J. Med. 302: 692.PubMedGoogle Scholar
  223. 223.
    Jacob, A. I., Lanier, D., Jr., Canterbury, J., and Bourgoignie, J. J., 1980, Reduction by cimetidine of serum parathyroid hormone levels in uremic patients, N. Engl. J. Med. 302: 671–674.PubMedCrossRefGoogle Scholar
  224. 224.
    Christensson, T., 1978, Hyperparathyroidism and radiation therapy, Ann. Intern. Med. 89: 216–217.PubMedGoogle Scholar
  225. 225.
    Tisell, L.-E, Hansson, G., Lindberg, S., and Ragnhult, I., 1978, Occurrence of previous neck radiotherapy among patients with associated non-medullary thyroid carcinoma and parathyroid adenoma or hyperplasia, Acta Chir. Scand. 144: 7–11.PubMedGoogle Scholar
  226. 226.
    Russ, J. E., Scanlon, E. F., and Sener, S. F., 1979, Parathyroid adenomas following irradiation, Cancer 43: 1078–1083.PubMedCrossRefGoogle Scholar
  227. 227.
    Erkocak, E. V., and Taylor, S., 1978, Hyperparathyroidism after radiotherapy, Br. Med. J. 2: 327–328.PubMedCrossRefGoogle Scholar
  228. 228.
    Christensson, T., and Einarsson, K., 1977, Cholelithiasis in subjects with hypercalcemia and primary hyperparathyroidism detected in a health screening, Gut 18: 543–546.PubMedCrossRefGoogle Scholar
  229. 229.
    Linos, D. A., Van Heerden, J. A., Abboud, C. F., and Edis, A. J., 1978, Primary hyperparathyroidism and peptic ulcer disease, Arch. Surg. 113: 384–386.PubMedCrossRefGoogle Scholar
  230. McCarthy, D. M., Peikin, S. R., Lopatin, R. N., Long, B. W.,Spiegel, A., Marx, S., and Brennan, M., 1979, Hyperparathyroidism—A reversible cause of cimetidine-resistant gastric hypersecretion, Br. Med. J.1:1765–1766.Google Scholar
  231. 231.
    Christensson, T., 1977, Serum urate in subjects with hypercalcemic hyperparathyroidism, Clin. Chim. Acta 80: 529–533.PubMedCrossRefGoogle Scholar
  232. 232.
    Akgun, S., and Ertel, N. H., 1978, Hyperparathyroidism and coexisting diabetes mellitus, Arch. Intern. Med. 138: 1500–1502.PubMedCrossRefGoogle Scholar
  233. 233.
    Marx, S. J., Spiegel, A. M., Brown, E. M., and Aurbach, G. D., 1977, Family studies in patients with primary parathyroid hyperplasia, Am. J. Med. 62: 698–706.PubMedCrossRefGoogle Scholar
  234. 234.
    Marx, S. J., Spiegel, A. M., Brown, E. M., Koehler, J. O., Gardner, D. G., Brennan, M. F., and Aurbach, G. D., 1978, Divalent cation metabolism: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism, Am. J. Med. 635: 235–242.CrossRefGoogle Scholar
  235. 235.
    Marx, S. J., Spiegel, A. M., Brown, E. M., Windeck, R., Gardner, D. G., Downs, R. W., Jr., Attie, M., and Aurbach, G. D., 1978, Circulating parathyroid hormone activity: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism, J. Clin. Endocrinol. Metab. 47: 1190–1197.PubMedCrossRefGoogle Scholar
  236. 236.
    Massry, S. G., and Goldstein, D. A., 1978, Role of parathyroid hormone in uremic toxicity, Kidney Int. 13 (Suppl. 8): S39 - S42.Google Scholar
  237. 237.
    Cogan, M. G., Covey, C. M., Arieff, A. I., Wisniewski, A., and Clark, O. H., 1978, Central nervous system manifestations of hyperparathyroidism, Am. J. Med. 65: 963–970.PubMedCrossRefGoogle Scholar
  238. 238.
    Guisado, R., Arieff, A. I., and Massry, S. G., 1975, Changes in the electroencephalogram in acute uremia: Effects of parathyroid hormone and brain electrolytes, J. Clin. Invest. 55: 738–745.PubMedCrossRefGoogle Scholar
  239. 239.
    Goldstein, D. A., and Massry, S. G., 1978, Effect of parathyroid hormone administration and its withdrawal on brain calcium and electroencephalogram, Miner. Electrolyte Metab. 1: 84–91.Google Scholar
  240. 240.
    Cooper, J. D., Lazarowitz, V. C., and Arieff, A. I., 1978, Neurodiagnostic abnormalities in patients with acute renal failure, J. Clin. Invest. 61: 1448–1455.PubMedCrossRefGoogle Scholar
  241. 241.
    Goldstein, D. A., Chui, L. A., and Massry, S. G., 1978, Effect of parathyroid hormone and uremia on peripheral nerve calcium and motor nerve conduction velocity, J. Clin. Invest. 62: 88–93.PubMedCrossRefGoogle Scholar
  242. 242.
    Avram, M. M., Feinfeld, D. A., and Huatuco, A. H., 1978, Search for the uremic toxin: Decreased motor nerve conduction velocity and elevated parathyroid hormone in uremia, N. Engl. J. Med. 298: 1000–1003.PubMedCrossRefGoogle Scholar
  243. 243.
    Arieff, A. I., and Schmidt, R. W., 1978, Parathyroid hormone as a uremic neurotoxin, N. Engl. J. Med. 299: 362–363.CrossRefGoogle Scholar
  244. 244.
    Avram, M. M, Iancu, M., Morrow, P., Feinfeld, D., and Huatuco, A., 1979, Uremic syndrome in man: New evidence for parathormone as a multi-system neurotoxin, Clin. Nephrol. 11: 59–62.PubMedGoogle Scholar
  245. 245.
    Sauerwein, H. P., and Krediet, R. T., 1978, Parathyroid hormone as a uremic neurotoxin, N. Engl. J. Med. 29: 362.Google Scholar
  246. 246.
    diGiulio, S., Chkoff, N., Lhoste, F., Zingraff, J., and Drueke, T., 1978, Parathormone as a nerve poison in uremia, N. Engl. J. Med. 299: 1134–1135.Google Scholar
  247. 247.
    Massry, S. G., Goldstein, D. A., Procci, W. R., and Kletzky, O. A., 1977, Impotence in patients with uremia: A possible role for parathyroid hormone, Nephron 19: 305–310.PubMedCrossRefGoogle Scholar
  248. 248.
    Ladenson, J. H., Lewis, J. W., McDonald, J. M., Slatopolsky, E., and Boyd, J. C., 1978, Relationship of free and total calcium in hypercalcemic conditions, J. Clin. Endocrinol. Metab. 48: 393–397.CrossRefGoogle Scholar
  249. 249.
    Conceicao, S. C., Weightman, D., Smith, P. A., Luno, J., Wared, M. K., and Kerr, D. N. S., 1978, Serum ionised calcium concentration: Measurement versus calculation, Br. Med. J. 1: 1103–1105.PubMedCrossRefGoogle Scholar
  250. 250.
    Larsson, L., and Ohman, S., 1979, Serum calcium ion activity: Some aspects of methodological differences and intraindividual variation, Clin. Biochem. 12: 138–141.PubMedCrossRefGoogle Scholar
  251. 251.
    Parthemore, J. G., Roos, B. A., Parker, D. C., Kripke, D. F., Avioli, L. V., and Deftos, L. J., 1978, Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule, J. Clin. Endocrinol. Metab. 47: 284–289.PubMedCrossRefGoogle Scholar
  252. 252.
    Wallach, S., Cohn, S. H., Atkins, H. L., Ellis, K. J., Kohberger, R., Aioia, J. F., and Zanzi, I., 1977, Effect of salmon calcitonin on skeletal mass in osteoporosis, Curr. Ther. Res. 22: 556–572.Google Scholar
  253. 253.
    Christensen, M. S., 1979, Radioimmunoassay of human parathyroid hormone, Dan. Med. Bull. 26: 157–174.PubMedGoogle Scholar
  254. 254.
    Broadus, A. E., Deftos, L. J., and Bartter, F. C., 1978, Effects of the intravenous administration of calcium on nephrogenous cyclic AMP: Use as a parathyroid suppression test, J. Clin. Endocrinol. Metab. 46: 477–487.PubMedCrossRefGoogle Scholar
  255. 255.
    Chambers, D. J., Schafer, H., Laughorn, J. A., Jr., Johnstone, J., Zanelli, J. M., Parsons, J. A., Bitensky, L., and Chayen, J., 1978, Dose-related activation by PTH of specific enzymes in various regions of the kidney, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 216–220, Excerpta Medica, Amsterdam.Google Scholar
  256. 256.
    Chambers, D. J., Dunham, J., Zanelli, J. M., Parsons, J. A., Bitensky, L., and Chayen, J., 1978, A sensitive bioassay of parathyroid hormone in plasma, Clin. Endocrinol. 9: 375–379.CrossRefGoogle Scholar
  257. 257.
    Fenton, S., Somers, S., and Heath, D. A., 1978, Preliminary studies with the sensitive cytochemical assay for parathyroid hormone, Clin. Endocrinol. 9: 381–384.CrossRefGoogle Scholar
  258. 258.
    Karo, J. J., Maas, L. C., Kaine, H., and Gelzayed, E. A., 1978, Ultrasonography and parathyroid adenoma, J. Am. Med. Assoc. 239: 2163–2164.CrossRefGoogle Scholar
  259. 259.
    Crocker, E. F., Jellins, J., and Freund, J., 1979, Parathyroid lesions localized by radionuclide subtraction and ultrasound, Radiology 130: 215–217.PubMedGoogle Scholar
  260. 260.
    Shimshak, R. R., Schoenrock, G. J., Taekman, H. P., Cianci, P., and Chambers, R. F., 1979, Preoperative localization of a parathyroid adenoma using computed tomography and thyroid scanning, J. Comput. Assist. Tomogr. 3: 117–119.PubMedCrossRefGoogle Scholar
  261. 261.
    Fagerberg, G., 1978, Angiographic localization of parathyroid adenomas, Acta Radiol. Diagn. 19: 7–16.Google Scholar
  262. 262.
    Brote, L., Fagerberg, G., Gillquist, J., and Larson, L., 1978, Parathyroid localization in patients with previous neck surgery, Acta Chir. Scand. 144: 445–449.PubMedGoogle Scholar
  263. 263.
    Wang, C.-A., 1977, Parathyroid re-exploration: A clinical and pathological study of 112 cases, Ann. Surg. 186: 140–145.PubMedCrossRefGoogle Scholar
  264. 264.
    Sofianides, T., Chang, Y.-S., Leary, J. S., and Nichols, F. X., 1978, Localization of parathyroid adenomas by cervical esophagram. J. Clin. Endocrinol. Metab. 46: 587–592.PubMedCrossRefGoogle Scholar
  265. 265.
    Van Vroonhoven, T. J., and Muller, H. J., 1978, Causes of failure in the surgical treatment of primary hyperparathyroidism: Lessons from 51 successful reoperations, Br. J. Surg. 65: 297–300.PubMedCrossRefGoogle Scholar
  266. 266.
    Freaney, R., Casey, O. M., and Muldowney, F. P., 1978, The long-term effect of parathyroidectomy on renal function, Ir. J. Med. Sci. 147: 205–209.PubMedCrossRefGoogle Scholar
  267. 267.
    Attie, J. N., Wise, L., Mir, R., and Ackerman, L. V., 1978, The rationale against routine subtotal parathyroidectomy for primary hyperparathyroidism, Am. J. Surg. 136: 437–444.PubMedCrossRefGoogle Scholar
  268. 268.
    Harness, J. K., Ramsburg, S. R., Nishiyama, R. H., and Thompson, N. W., 1979, Multiple adenomas of the parathyroid: Do they exist?, Arch. Surg. 114: 468–474.PubMedCrossRefGoogle Scholar
  269. 269.
    Ljungberg, O., and Tibblin, S., 1979, Perioperative fat staining of frozen sections in primary hyperparathyroidism, Am. J. Pathol. 95: 633–645.PubMedGoogle Scholar
  270. 270.
    Wang, C.-A, and Rieder, S. V., 1978, A density test for the intraoperative differentiation of parathyroid hyperplasie from neoplasia, Ann. Surg. 187: 63–67.PubMedCrossRefGoogle Scholar
  271. 271.
    Akerstrom, G., Grimelius, L., Johansson, H., and Lundqvist, H., 1977, Estimation of the parenchymal cell content of the parathyroid gland using density-gradient columns, Acta Pathol. Microbiol. Scand. Sect. A 85: 555–557.Google Scholar
  272. 272.
    Ohman, V., Granberg, P.-O., and Lindell, B., 1978, Function of the parathyroid glands after total thyroidectomy, Surg. Gynecol. Obstet. 146: 773–778.PubMedGoogle Scholar
  273. 273.
    Brennan, M. F., Brown, E. M., Marx, S. J., Spiegel, A. M., Broadus A. E., Doppman, J. L., Webber, B., and Aurbach, G. D., 1978, Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma, N. Engl. J. Med. 299: 1057–1059.PubMedCrossRefGoogle Scholar
  274. 274.
    Penn, I., and Haase, G. M., 1979, Autotransplantation of parathyroid adenoma, N. Engl. J. Med. 300: 1489.PubMedGoogle Scholar
  275. 275.
    Brennan, M. F., Brown, E. M., Sears, H. F., and Aurbach G. D., 1978, Human parathyroid cryopreservation: In vitro testing of function by parathyroid hormone release, Ann. Surg. 187: 87–90.PubMedCrossRefGoogle Scholar
  276. 276.
    Brennan, M. F., Brown, E. M., Spiegel, A. M., Marx, S. J., Doppman, J. L., Jones, D. ‘C., and Aurbach, G. D., 1979, Autotransplantation of cryopreserved parathyroid tissue in man, Ann. Surg. 189: 139–142.Google Scholar
  277. 277.
    Taylor, C. M., Mawer, E. B., Wallace, J. E., St. John, J., Cochran, M., Russell, R. G. G., and Kanis, J. A., 1978, The absence of 24,25-dihydroxycholecalciferol in anephric patients, Clin. Sci. Mol. Med. 55: 541–547.Google Scholar
  278. 278.
    Slatopolsky, E., Rutherford, W. E., Hruska, K., Martin, K., and Klahr, S., 1978, How important is phosphate in the pathogenesis of renal osteodystrophy?, Arch. Intern. Med. 138: 848–852.PubMedGoogle Scholar
  279. 279.
    Massry, S. G., and Ritz, E., 1978, The pathogenesis of secondary hyperparathyroidism of renal failure: Is there a controversy?, Arch. Intern. Med. 138: 853–856.PubMedGoogle Scholar
  280. 280.
    Malluche, H. H., Werner, E., and Ritz, E., 1978, Intestinal absorption of calcium and whole body calcium retention in incipient and advanced renal failure, Miner. Electrolyte Metab. 1: 263–270.Google Scholar
  281. 281.
    Fiaschi, E., Maschio, G., D’Angelo, A., Bonucci, E., Tessitore, N., and Messa, P., 1978, Low protein diets and bone disease in chronic renal failure, Kidney Int. 13 (Suppl. 8): S79 — S82.Google Scholar
  282. 282.
    Bordier, P., Zingraff, J., Gueris, J., Jungers, P., Marie, P., Pechet, M., and Rasmussen, H., 1978, The effect of la(OH)D3 and la,25(OH)2D3 on the bone in patients with renal osteodystrophy, Am. J. Med. 64: 101–107.PubMedCrossRefGoogle Scholar
  283. 283.
    Chesney, R. W., Moorthy, A. V., Eisman, J. A., Jax, D. K., Mazess, R. B., and DeLuca, H. F., 1978, Increased growth after long-term oral la,25vitamin D3 in childhood renal osteodystrophy, N. Engl. J. Med. 298: 238–242.PubMedCrossRefGoogle Scholar
  284. 284.
    Berl, T., Berns, A. S., Huffer, W. E., Hammill, K., Alfrey, A. C., Arnaud, C. D., and Schrier, R. W., 1978, 1,25 dihydroxycholecalciferol effects in chronic dialysis, Ann. Intern. Med. 88: 774–780.Google Scholar
  285. 285.
    Madsen, S., and Olgaard, K., 1978, Long-term trial of 1-alpha-hydroxycholecalciferol in adults with chronic renal failure, Eur. J. Ctim Pharmacol. 13: 401–408.CrossRefGoogle Scholar
  286. 286.
    Goldstein, D. A., Malluche, H. H., and Massry, S. G., 1979, Management of renal osteodystrophy with 1,25(OH)2D3. I. Effects on clinical, radiographic and biochemical parameters, Miner. Electrolyte Metab. 2: 35–47.Google Scholar
  287. 287.
    Malluche, H. H., Goldstein, D. A., and Massry, S. G., 1979, Management of renal osteodystrophy with 1,25(OH)2D3. II. Effects on histopathology of bone: Evidence for healing of osteomalacia, Miner. Electrolyte Metab. 2: 48–55.Google Scholar
  288. 288.
    Binswanger, U., Fischer, J. A., Iselin, H., Oswald, N., Keusch, G., Frei, D., and Willimann, P., 1979, 1,25-dihydroxycholecalciferol treatment of clinically asymptomatic renal osteodystrophy, Miner. Electrolyte Metab. 2: 103–115.Google Scholar
  289. 289.
    Christiansen, L., Rodbro, P., Christensen, M. S., Hartnack, B., and Trans-bol, I., 1978, Deterioration of renal function during treatment of chronic renal failure with 1,25-dihydroxycholecalciferol, Lancet 2: 700–703.PubMedCrossRefGoogle Scholar
  290. 290.
    Feest, T. G., Ward, M. K., Ellis, H. A., Conceicao, S., Pierides, A. M., Aird, E., Simpson, W., Cook, D. B., and Kerr, D. N. S., 1977, Renal bone disease—What is it and why does it happen?, Clin. Endocrinol. 7 (Suppl.): 19s - 23s.CrossRefGoogle Scholar
  291. 291.
    Alvarez-Ude, F., Feest, T. G., Ward, M. K., Pierides, A. M., Ellis, H. A., Peart, K. M., Simpson, W., Weightman, D., and Kerr, D. N. S., 1978, Hemodialysis bone disease: Correlation between clinical, histologic, and other findings, Kidney Int. 14: 68–73.PubMedCrossRefGoogle Scholar
  292. 292.
    Coburn, J. W., personal communication.Google Scholar
  293. 293.
    Nielsen, H. E., Christensen, C. K., and Olsen, K. J., 1979, Serum calcitonin in patients with chronic renal disease, Acta Med. Scand. 205: 615–618.PubMedCrossRefGoogle Scholar
  294. 294.
    Heynen, G., Kanis, J. A., Oliver, D., Ledingham, J. G. G., and Russel, R. G. G., 1976, Evidence that endogenous calcitonin protects against renal bone disease, Lancet 2: 1322–1325.CrossRefGoogle Scholar
  295. 295.
    Feletti, C., and Bonomini, V., 1979, Effect of calcitonin on bone lesions in chronic dialysis patients, Nephron 24: 85–88.PubMedCrossRefGoogle Scholar
  296. 296.
    Zucchelli, P., Fusaroli, M., Fabbri, L., Pavlica, P., Casanoa, S., Viglietta, G., and Sasdelli, M., 1978, Treatment of ectopic calcification in ureia, Kidney Int. 13:(Suppl. 8):S-86–S90.Google Scholar
  297. 297.
    Breslau, N. A., and Pak, C. Y. C., 1979, Hypoparathyroidism, Metabolism 28: 1261–1276.PubMedCrossRefGoogle Scholar
  298. 298.
    Nusynowitz, M. L., and Klein, M. H., 1973, Pseudoidiopathic hypoparathyroidism: Hypoparathyroidism with ineffective parathyroid hormone, Am. J. Med. 55: 677–686.PubMedCrossRefGoogle Scholar
  299. 299.
    Lewin, I. G., Papapoulos, S. E., Tomlinson, S., Hendy, G. N., and D’Riordan, J. L. H., 1978, Studies of hypoparathyroidism and pseudohypoparathyroidism, Q. J. Med. 47: 533–548.Google Scholar
  300. Graham, K., Williams, B. O., and Rowe, M. J., 1979, Idiopathic hypoparathyroidism: A cause of fits in the elderly, Br. Med. J .1:1460–1461.Google Scholar
  301. 301.
    Slyter, H., 1979, Idiopathic hypoparathyroidism presenting as dementia, Neurology 29: 393–394.PubMedCrossRefGoogle Scholar
  302. 302.
    Preskorn, S. H., and Reveley, A., 1978, Pseudohypoparathyroidism and Capgnas’ syndrome, Br. J. Psychiatry 133: 34–37.PubMedCrossRefGoogle Scholar
  303. 303.
    Parfitt, A. M., 1979, Surgical, idiopathic, and other varieties of parathyroid hormone-deficient hypoparathyroidism, in: Endocrinology, Volume 2 ( L. J. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martin, J. T. Potts, Jr., D. H. Nelson, E. Steinberger, and A. I.Winegrad, eds.), pp. 755–768, Grune Stratton, New York.Google Scholar
  304. 304.
    Nyland, H., and Skre, H., 1977, Cerebral calcinosis with late onset encephalopathy: unusual type of pseudo-pseudohypoparathyroidism, Acta Neurol. Scand. 56: 309–325.PubMedCrossRefGoogle Scholar
  305. 305.
    Werder, E. A., Fischer, J. A., Illig, R., Kind, H. P., Bernasconi, S., Fanconi, A., and Brader, A., 1978, Pseudohypoparathyroidism and idiopathic hypoparathyroidism: Relationship between serum calcium and parathyroid hormone levels and urinary cyclic adenosine-3’,5’-monophosphate response to parathyroid extract, J. Clin. Endocrinol. Metab. 46: 872–879.PubMedCrossRefGoogle Scholar
  306. 306.
    Parfitt, A. M., 1979, Testing for hypoparathyroidism, N. Engl. J. Med. 300: 11–63.Google Scholar
  307. 307.
    Rude, R. K., Oldham, S. B., Sharp, C. F., Jr., and Singer, F. R., 1978, Parathyroid hormone secretion in magnesium deficiency, J. Clin. Endocrinol. Metab. 47: 800–806.PubMedCrossRefGoogle Scholar
  308. 308.
    Mennes, P., Rosenbaum, R., Martin, K., and Slatopolsky, E., 1978, Hypomagnesemia and impaired parathyroid hormone secretion in chronic renal disease. Ann. Intern. Med. 88: 206–209.PubMedGoogle Scholar
  309. 309.
    Yamada, K., Tamura, Y., Yamamoto, M., and Kumagai, A., 1978, Effect of calcium administration on renal responsiveness to parathyroid hormone in pseudohypoparathyroidism type I and II in comparison with normals, idiopathic and surgical hypoparathyroidism, Endocrinol. Jpn. 26: 147–157.CrossRefGoogle Scholar
  310. 310.
    Frame, B., Hanson, C. A., Frost, H. M., Block, M., and Arnstein, A. R., 1972, Renal resistance to parathyroid hormone with osteitis fibrosa: “Pseudohypohyperparathyroidism,” Am. J. Med. 52: 311–321.PubMedCrossRefGoogle Scholar
  311. 311.
    Duck, S. C., Rosenberg, E. M., Ratzan, S. K., and Haymond, M. W., 1978, Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP, J. Clin. Endocrinol. Metab. 47: 640–646.PubMedCrossRefGoogle Scholar
  312. 312.
    Metz, S. A., Baylink, D. J., Hughes, M. R., Haussier, M. R., and Robertson, R. P., 1977, Selective deficiency of 1,25-dihydroxycholecalciferol: A case of isolated skeletal resistance to parathyroid hormone, N. Engl. J. Med. 297: 1084–1090.PubMedCrossRefGoogle Scholar
  313. 313.
    Parfitt, A. M., 1978, Tubular reabsorption of calcium in pseudohypoparathyroidism, in: Endocrinology of Calcium Metabolism(D. H. Copp and R. V. Talmage, eds.), p. 409, Excerpta Medica, Amsterdam.Google Scholar
  314. 314.
    Potts, J. T., Jr., 1979, Pseudohypoparathyroidism, in: Endocrinology ( L. T. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martin, J. T. Potts, Jr., D. H. Nelson, E. Steinberger, and A. I. Winegrad, eds.), pp. 769–776, Grune Stratton, New York.Google Scholar
  315. 315.
    Eisenberg, E., 1965, Effect of serum calcium level and parathyroid extract on phosphate and calcium excretion in hypoparathyroid patients, J. Clin. Invest. 44: 942–946.PubMedCrossRefGoogle Scholar
  316. 316.
    Breslau, N., and Moses, A., 1977, Studies on renal calcium reabsorption in patients with pseudo-and pseudopseudohypoparathyroidism, Endocrine Society Meeting, Chicago.Google Scholar
  317. 317.
    Baran, D. T., Klahr, S., Slatopolsky, E., and Avioli, L. V., 1979, Effect of acetazolamide on calcium and phosphate metabolism in type I pseudo-hypoparathyroidism: Interaction with parathyroid hormone, J. Clin. Endocrinol. Metab. 48: 766–770.PubMedCrossRefGoogle Scholar
  318. 318.
    Lawayin, S., Norman, D. A., Zerwekh, J. E., Breslau, N. A., and Pak, C. Y. C., 1979. A patient with pseudohypoparathyroidism with increased serum calcium and 1a,25-dihydroxyvitamin D after exogenous parathyroid hormone administration, J. Clin. Endocrinol. Metab. 49: 783–786.CrossRefGoogle Scholar
  319. 319.
    Carlson, H. E., Brickman, A. S., and Bottazzo, G. F., 1977, Prolactin deficiency in pseudohypoparathyroidism, N. Engl. J. Med. 296: 140–144.Google Scholar
  320. 320.
    Wolfsdorf, J. T., Rosenfield, R. L., Fang, V. S., Kobayashi, R., Razdan, A. K., and Kim, M. H., 1978, Partial gonadotrophin resistance in pseudohypoparathyroidism, Acta Endocrinol. (Copenhagen) 88: 321–328.Google Scholar
  321. 321.
    Parfitt, A. M., 1978, Adult hypoparathyroidism treatment with calcifediol, Arch. Intern. Med. 138: 874–881.PubMedGoogle Scholar
  322. 322.
    Kind, H. P., Handysides, A., Kooh, S. W., and Fraser, D., 1977, Vitamin D therapy in hypoparathyroidism and pseudohypoparathyroidism: Weight-related dosages for initiation of therapy and maintenance therapy, J. Pediatr. 91: 1006–1010.PubMedCrossRefGoogle Scholar
  323. 323.
    Porter, R. H., Cox, B. G., Heaney, D., Hostetter, T. H., Stinebaugh, B. J., and Suki, W. N., 1978, Treatment of hypoparathyroid patients with chlorthalidone, N. Engl. J. Med. 298: 577–581.PubMedCrossRefGoogle Scholar
  324. 324.
    Copp, D. H., 1979, Calcitonin: Comparative endocrinology, in: Endocrinology, Volume 2 (L. J. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martin, J. T. Potts, Jr., D. H. Nelson, E. Steinberger, and A. I. Winegrad, eds.), pp. 637–640, Grune Stratton, New York.Google Scholar
  325. 325.
    Fontaine, J., 1979, Multistep migration of calcitonin cell precursors during ontogeny of the mouse pharynx, Gen. Comp. Endocrinol. 37: 81–92.PubMedCrossRefGoogle Scholar
  326. 326.
    Kameda, Y., 1971, The occurrence and distribution of the parafollicular cells in the thyroid, parathyroid -IV and thymus -IV in some mammals, Arch. Histol. Jpn. 33: 283–299.PubMedCrossRefGoogle Scholar
  327. 327.
    Galante, L., Gudmundsson, T. V., Matthews, E. W., Tse, A., Williams, E. D., Woodhouse, N. J. Y., and Maclntyre, I., 1968, Thymic and parathyroid origin of calcitonin in man, Lancet 2: 537–538.PubMedCrossRefGoogle Scholar
  328. 328.
    Silva, O. L., Wisneski, L. A., Cyrus, J., Snider, R. H., Moore, C. F., and Becker, K. L., 1978, Calcitonin in thyroidectomized patients, Am. J. Med. Sci. 275: 159–164.PubMedCrossRefGoogle Scholar
  329. 329.
    Merle, M., Lefevre, G., and Milhaud, G., 1979, Predicted secondary structure of calcitonin in relation to the biological activity, Biochem. Biophys. Res. Commun. 87: 455–460.PubMedCrossRefGoogle Scholar
  330. 330.
    Heath, H., III, and Sizemore, G. W., 1979, Immunochemical heterogeneity of calcitonin in tumor, tumor venous effluent, and peripheral blood of patients with medullary thyroid carcinoma, J. Lab. Clin. Med. 93: 390–401.PubMedGoogle Scholar
  331. 331.
    Pont, A., 1979, Secretion and metabolism of calcitonin in man, in: Endocrinology, Volume 2 (L. J. DeGroot, G. F. Cahill, Jr., W. D. Odell, L. Martin, J. T. Potts, Jr., D. H. Nelson, E. Steinberger, and A. I. Winegrad, eds.), pp. 641–645, Grune Stratton, New York.Google Scholar
  332. 332.
    Baylin, S. E., Bailey, A. J., Hsu, T.-H., and Foster, G. V., 1977, Degradation of human calcitonin in human plasma, Metabolism 26: 1345–1354.Google Scholar
  333. 333.
    Parthemore, J. G., and Deftos, L. G., 1975, The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction, J. Clin. Invest. 56: 835–841.PubMedCrossRefGoogle Scholar
  334. 334.
    Heath, H., III, and Sizemore, G. W., 1977, Plasma calcitonin in normal man, J. Clin. Invest. 60: 1135–1140.PubMedCrossRefGoogle Scholar
  335. 335.
    Hillyard, C. J., Cooke, T. J. C., Coombes, R. C., Evans, I. M. A., and Maclntyre, I., 1977, Normal plasma calcitonin: Circadian variation and response to stimuli, Clin. Endocrinol. 6: 291–298.CrossRefGoogle Scholar
  336. 336.
    Deftos, L. J., and O’Riordan, J. L. H., 1978, Problems in radioassays of the calcitropic hormones, in: Endocrinology of Calcium Metabolism ( D. H. Copp and R. V. Talmage, eds.), pp. 345–348, Excerpta Medica, Amsterdam.Google Scholar
  337. 337.
    Becker, K. L., Bivins, L. E., Radfor, R. H., Snider, R. H., Moore, C. F., and Silva, O. L., 1978, Study of calcitonin heterogeneity using a radio-receptor assay, Horm. Metab. Res. 10: 457–458.PubMedCrossRefGoogle Scholar
  338. 338.
    Loreau, N., Lajotte, C., Wahbe, F., and Ardaillou, R., 1978, Effects of guanyl nucleotides on calcitonin-sensitive adenylate cyclase and calcitonin binding in rat renal cortex, J. Endocrinol. 76: 533–545.PubMedCrossRefGoogle Scholar
  339. 339.
    Hillyard, C.J., Stevenson, J. C., and Maclntyre, I., 1978, Relative deficiency of plasma calcitonin in normal women, Lancet 1: 961–962.PubMedCrossRefGoogle Scholar
  340. 340.
    Mulder, H., Hackeng, W. H. L., and Silberbusch, J., 1979, Racial difference in serum calcitonin, Lancet 2: 154.PubMedCrossRefGoogle Scholar
  341. 341.
    Vora, N. M., Williams, G. A., Hargis, G. K., Bowser, E. N., Kawahara, W., Jackson, B. L., Henderson, W. J., and Kukreja, S. C., 1978, Comparative effect of calcium and of the adrenergic system on calcitonin secretion in man, J. Clin. Endocrinol. Metab. 46: 567–571.PubMedCrossRefGoogle Scholar
  342. 342.
    Austin, L. A., Heath, H., III, and Go, V. L. W., 1979, Regulation of calcitonin secretion in normal man by changes of serum calcium within the physiologic range, J. Clin. Invest. 64: 1721–1724.PubMedCrossRefGoogle Scholar
  343. 343.
    Sizemore, G. W., Go, V. L. W., Kaplan, E. L., Sanzenbacher, L. J., Holtermuller, K. H., and Arnaud, C. D., 1973, Relations of calcitonin and gastrin in the Zollinger—Ellison syndrome and medullary carcinoma of the thyroid, N. Engl. J. Med. 288: 641–644.PubMedCrossRefGoogle Scholar
  344. 344.
    Owyang, C., Heath, H., III, Sizemore, G. W., and Go, V. L. W., 1978, Comparison of the effects of pentagastrin and meal-stimulated gastrin on plasma calcitonin in normal man, Dig. Dis. 23: 1084–1088.CrossRefGoogle Scholar
  345. 345.
    Van Noorden, S., Polak, J. M., and Pearse, A. G., 1977, Single cellular origin of somatostatin and calcitonin in the rat thyroid gland, Histochemistry 53: 243–247.PubMedCrossRefGoogle Scholar
  346. 346.
    Buffa, R., Chayvialle, J. A., Fontana, P., Uselli, L., Capella, C., and Solcia, E., 1979, Parafollicular cells of rabbit thyroid store both calcitonin and somatostatin and resemble gut D cells ultrastructurally, Histochemistry 62: 281–288.PubMedCrossRefGoogle Scholar
  347. 347.
    Capella, C., Bordi, C., Monga, G., Buffa, R., Fontana, P., Bonfanti, S., Bussolati, G., and Solcia, E., 1978, Multiple endocrine cell types in thyroid medullary carcinoma, Virchows Arch. A 377: 111–128.Google Scholar
  348. 348.
    Linehan, W. M., Cooper, C. W., Bolman, R. M., III, and Wells, S. A., Jr., 1979, Inhibition of in vivo secretion of calcitonin in the pig by somatostatin and calcitonin in the rat thyroid gland, Histochemistry 53: 243–247.Google Scholar
  349. 349.
    Hargis, G. K., Williams, G. A., Reynolds, W. A., Chertow, B. S., Kukreja, S. C., Bowser, E. N., and Henderson, W. J., 1978, Effect of somatostatin on parathyroid hormone and calcitonin secretion, Endocrinology 102: 745–750.PubMedCrossRefGoogle Scholar
  350. 350.
    Gordin, A., Lamberg, B.-A., Pelkonen, R., and Almquist, S., 1978, Somatostatin inhibits the pentagastrin-induced release of serum calcitonin in medullary carcinoma of the thyroid, Clin. Endocrinol. 8: 289–293.CrossRefGoogle Scholar
  351. 351.
    Peng, T-C., Cooper, C. W., Garner, S. C., and Bolpert, E. M., 1978, Hypercalcitoninism and C-cell hyperplasia in rats with goiters produced by a low iodine diet or propylthiouracil, J. Pharmacol. Exp. Ther. 206: 710–717.PubMedGoogle Scholar
  352. 352.
    Didoklar, M. S., and Moore, G. E., 1974, Hormone-dependent medullary carcinoma of the thyroid, Am. J. Surg. 128: 100–102.CrossRefGoogle Scholar
  353. 353.
    Wells, S. A., Cooper, C. W., and Ontjos, D. A., 1975, Stimulation of thyrocalcitonin secretion by ethanol in patients with medullary thyroid carcinoma—an effect apparently not mediated by gastrin, Metabolism 24: 1215–1219.PubMedCrossRefGoogle Scholar
  354. 354.
    Kanis, J. A., Adams, N. D., Cecchettin, M., Luizetto, G., Gaspar, S., and Heymen, G., 1979, Ethanol induced secretion of calcitonin in chronic renal disease, Clin. Endocrinol. 10: 155–161.CrossRefGoogle Scholar
  355. 355.
    Baylin, S. B., Hsu, T.-H., Stevens, S. A., Kallman, C. H., Trump, D. L., and Beaven, M. A., 1979, The effects of L-dopa on in vitro and in vivo calcitonin release from medullary carcinoma of the thyroid, J. Clin. Endocrinol. Metab. 48: 408–414.PubMedCrossRefGoogle Scholar
  356. 356.
    Cooper, C. W., Ramp, W. K., Becker, D. I., and Ontjes, D. A., 1977, In vitro secretion of immunoreactive rat thyrocalcitonin, Endocrinology 101: 304–311.PubMedCrossRefGoogle Scholar
  357. 357.
    Vora, N. M., Williams, G. A., Hargis, G. K., Bowser, E. N., Kawahara, W., Jackson, B. L., Henderson, W. J., and Kukrega, S. C., 1978, Comparative effect of calcium and of the adrenergic system on calcitonin secretion in man, J. Clin. Endocrinol. Metab. 46: 567–571.PubMedCrossRefGoogle Scholar
  358. 358.
    Milhaud, G., Rankin, J. C., Bolis, L., and Benson, A. A., 1977, Calcitonin: Its hormonal action on the gill, Proc. Natl. Acad. Sci. USA 74: 4693–4696.PubMedCrossRefGoogle Scholar
  359. 359.
    Sasayama, Y., 1978, Effects of implantation of the ultimobranchial glands and the administration of synthetic salmon calcitonin on serum Ca concentrations in ultimobranchialectomized bullfrog tadpoles, Gen. Comp. Endocrinol. 34: 229–233.PubMedCrossRefGoogle Scholar
  360. 360.
    Kalu, D. N., 1978, Acute effect of calcitonin deficiency on plasma calcium in fasted young rats, Harm. Metab. Res. 10: 72–75.CrossRefGoogle Scholar
  361. 361.
    Robertson, R. P., and Baylink, D. J., 1977, Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats, Prostaglandins 13: 1141–145.PubMedCrossRefGoogle Scholar
  362. Kalu, D. N., 1977, Acute and longterm effects of thyroidectomy on plasma calcium in rats, Endocrinology 101:1665–1669.Google Scholar
  363. 363.
    Grubb, S. A., Markham, T. C., and Talmage, R. V., 1977, Effect of salmon calcitonin infusion on plasma concentrations of recently administered 45Ca, Calcif. Tissue Res. 24: 201–208.PubMedCrossRefGoogle Scholar
  364. 364.
    Norimatsu, H., Vander Wiel, C. J., and Talmage, R. V., 1979, Electron microscopic study of the effects of calcitonin on bone cells and their extracellular milieu, Clin. Orthop. Relat. Res. 139: 250–258.PubMedGoogle Scholar
  365. 365.
    Cutler, G. B., Jr., Habener, J. F., and Potts, J. T., Jr., 1977, Biosynthesis and secretion of calcitonin by avian ultimobranchial glands, Endocrinology 100: 537–548.PubMedCrossRefGoogle Scholar
  366. 366.
    Jowsey, J., Riggs, B. L., Kelly, P. J., and Hoffman, D. L., 1978, Calcium and salmon calcitonin in treatment of osteoporosis, J. Clin. Endocrinol. Me-tab. 47 :633–639.Google Scholar
  367. 367.
    Lambert, P. W., Heath, H., III, and Sizemore, G. W., 1979, Pre-and postoperative studies of plasma calcitonin in primary hyperparathyroidism, J. Clin. Invest. 63 :602–608.Google Scholar
  368. 368.
    Talmage, R. V., Doppelt, S. H., and Cooper, C. W., 1975, Relationship of blood concentrations of calcium, phosphate, gastrin and calcitonin to the onset of feeding in the rat, Proc. Soc. Exp. Biol. Med. 149: 855–859.PubMedGoogle Scholar
  369. 369.
    Talmage, R. V., Vander Wiel, C. J., Decker, S. A., and Grubb, S. A., 1979, Changes produced in postprandial urinary calcium excretion by thyroidectomy and calcitonin administration in rats on different calcium regimens, Endocrinology 105: 459–464.PubMedCrossRefGoogle Scholar
  370. Cooper, C. W., Obie, J. F., Toverud, S. U., and Munson, P. L., 1977, Elevated serum calcitonin and serum calcium during suckling in the baby rat, Endocrinology 101:1657–1664.Google Scholar
  371. 371.
    Parthemore, J. G., and Deftos, L. J., 1979, Calcitonin secretion in primary hyperparathyroidism, J. Clin. Endocrinol. Metab. 49: 223–226.PubMedCrossRefGoogle Scholar
  372. 372.
    Shamonki, I. M., Frumar, A. M., Tataryn, J. V., Meldrum, D. R., Davidson, B. H., Parthemore, J. G., Judd, H. L., and Deftos, L. J., 1980, Age-related changes of calcitonin secretion in females, J. Clin. Endocrinol. Metab. 50: 437–439.PubMedCrossRefGoogle Scholar
  373. 373.
    Milhaud, G., Benezich-Lefevre, M., and Mouktar, M. S., 1978, Deficiency of calcitonin in age-related osteoporosis, Biomed. Exp. 29: 272–276.Google Scholar
  374. 374.
    Samaan, N. A., Anderson, G. D., and Adam-Mayne, M. E., 1975, Immunoreactive calcitonin in the mother, neonate, child and adult, Am. J. Obstet. Gynecol. 121: 622–625.PubMedGoogle Scholar
  375. 375.
    Freed, W. J., Perlow, M. J., and Wyatt, R. J., 1979, Calcitonin: Inhibitory effect on eating in rats, Science 206: 850–852.PubMedCrossRefGoogle Scholar
  376. 376.
    Bolman, R. M., III, Cooper, C. W., Garner, S. C., Munson, P. L., and Wells, S. A., Jr., 1977, Stimulation of gastrin secretion in the pig by parathyroid hormone and its inhibition by thyrocalcitonin, Endocrinology 100: 1014–1021.PubMedCrossRefGoogle Scholar
  377. 377.
    Ito, H., Sakurada, T., and Orimo, H., 1977, Role of endogenous calcitonin in the secretion of gastrin and gastric acid in rats, Horm. Metab. Res. 9: 89–92.PubMedCrossRefGoogle Scholar
  378. 378.
    Cantalamessa, L., Catania, A., Reschini, E., and Peracchi, M., 1978, Inhibitory effect of calcitonin on growth hormone and insulin secretion in man, Metabolism 27: 987–992.PubMedCrossRefGoogle Scholar
  379. 379.
    Walling, M. W., Brasitus, T. A., and Kimberg, D. V., 1977, Effects of calcitonin and substance P on the transport of Ca, Na, and Cl across rat ileum in vitro, Gastroenterology 73: 89–94.PubMedGoogle Scholar
  380. 380.
    Gray, T. K., Brannan, P., Juan, D., Morawski, S. G., and Fordtran, J. S., 1976, Ion transport changes during calcitonin-induced intestinal secretion in man, Gastroenterology 71: 392–398.PubMedGoogle Scholar
  381. 381.
    Kisloff,B. and Moore, E. W., 1977, Effects of intravenous calcitonin on water, electrolyte, and calcium movement across in vivo rabbit jejunum and ileum, Gastroenterology 72:462–468.Google Scholar
  382. 382.
    Clark, M. B., Boyd, G. W., Byfield, P. G. H., and Foster, G. V., 1969, A radioimmunoassay for human calcitonin, Lancet 2: 74–77.PubMedCrossRefGoogle Scholar
  383. 383.
    Goltzman, D., Potts, J. T., Jr., Ridgway, E. C., and Maloof, F., 1974, Calcitonin as a tumor marker, N. Engl. J. Med. 290: 1035–1039.PubMedCrossRefGoogle Scholar
  384. 384.
    Becker, K. L., Snider, R. H., Silva, O. L., and Moore, C. F., 1978, Calcitonin heterogeneity in lung cancer and medullary thyroid cancer, Acta Endocrinol. (Copenhagen) 89: 89–99.Google Scholar
  385. 385.
    Galmiche, J. P., Colin, R., DuBois, P. M., Chayvialle, J. A., Descos, F., Paulin, C., and Geffroy, Y., 1978, Calcitonin secretion by a pancreatic somatostatinoma, N. Engl. J. Med. 299:12–52.Google Scholar
  386. 386.
    Kalager, T., Gluck, E., Heimann, P., and Myking, 0., 1977, Pheochromocytoma with ectopic calcitonin production and parathyroid cyst, Br. Med. J. 2: 21.PubMedCrossRefGoogle Scholar
  387. 387.
    Dayal, Y., Tashjian, A. H., and Wolfe, H. J., 1979, Immunocytochemical localization of calcitonin-producing cells in a stroma] carcinoid with amyloid stroma, Cancer 43: 1331–1338.PubMedCrossRefGoogle Scholar
  388. 388.
    Rousseau, J. J., Franck, G., Grisar, T., Reznik, M., Heynen, G., and Salmon, J., 1978, Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin, Eur. J. Cancer 14: 133–140.PubMedCrossRefGoogle Scholar
  389. 389.
    White, M. C., and Hickson, B. R., 1979, Multiple paragangliomata secreting catecholamines and calcitonin with intermittent hypercalcemia, J. R. Soc. Med. 72: 532–538.PubMedGoogle Scholar
  390. 390.
    Silva, O. L., Becker, K. L., Primack, A., Doppman, J., and Snider, R. H., 1974, Ectopic secretion of calcitonin by oat-cell carcinoma, N. Engl. J. Med. 290: 1122–1124.PubMedCrossRefGoogle Scholar
  391. 391.
    Hansen, M., Hansen, H. H., and Tryding, N., 1978, Small cell carcinoma of the lung: Serum calcitonin and serum histaminase (diamine oxidase) at basal levels and stimulated by pentagastrin, Acta Med. Scand. 204: 257–261.PubMedCrossRefGoogle Scholar
  392. 392.
    Hansen, M., Rehfeld, J. F., and Stadil, F., 1979, Small cell carcinoma of the lung: Relation of calcitonin to bone marrow metastases, parathormone and gastrin, Acta Med. Scand. 206: 215–218.PubMedCrossRefGoogle Scholar
  393. 393.
    Silva, O. L., Broder, L. E., Doppman, J. L., Snider, R. H., Moore, C. F., Cohen, M. H., and Becker, K. L., 1979, Calcitonin in non thyroidal cancer, J. Clin. Endocrinol. Metab. 49: 438–444.CrossRefGoogle Scholar
  394. 394.
    Silva, O. L., Broder, L. E., Doppman, J. L., Snider, R. H., Moore, C. F., Cohen, M. H., and Becker, K. L., 1979, Calcitonin as a marker for bronchogenic carcinoma, Cancer 44: 680–684.PubMedCrossRefGoogle Scholar
  395. 395.
    Baylin, S. B., Weisburger, W. R., Eggleston, J. C., Mendelsohn, G., Beaven, M. A., Abeloff, M. D., and Ettinger, D. S., 1978, Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung, N. Engl. J. Med. 299: 105–110.PubMedCrossRefGoogle Scholar
  396. 396.
    Martin, T. J., 1979, Treatment of Paget’s disease with the calcitonins, Aust. N.Z. J. Med. 9: 36–43.PubMedCrossRefGoogle Scholar
  397. 397.
    Wooton, R., Reeve, J., Spellacy, E., and Tellez-Yudilevich, M., 1978, Skeletal blood flow in Paget’s disease and its response to calcitonin therapy, Clin. Sci. Mol. Med. 54: 69–74.Google Scholar
  398. 398.
    Henley, J. W., Croxson, R. S., and Ibbertson, H. K., 1979, The cardiovascular system in Paget’s disease of bone and the response to therapy with calcitonin and diphosphonate, Aust. N.Z. J. Med. 9: 390–397.PubMedCrossRefGoogle Scholar
  399. 399.
    Hosking, D. J., Denton, L. B., Cadge, B., and Martin, T. J., 1979, Functional significance of antibody formation after long-term salmon calcitonin therapy, Clin. Endocrinol. 10: 243–252.CrossRefGoogle Scholar
  400. 400.
    Rojanasathit, S., Rosenberg, E., and Haddad, J. G., Jr., 1974, Paget’s bone disease: Response to human calcitonin in patients resistant to salmon calcitonin, Lancet 2: 1412–1415.PubMedCrossRefGoogle Scholar
  401. 401.
    Nilsson, O., Almqvist, S., and Karlberg, B. E., 1978, Salmon calcitonin in the acute treatment of moderate and severe hypercalcemia in man, Acta Med. Scand. 204: 249–252.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Karen E. Kleeman
    • 1
  • Charles R. Kleeman
    • 2
  1. 1.Department of Psychiatry and Biobehavioral ScienceUCLA Neuropsychiatric Institute and School of MedicineLos AngelesUSA
  2. 2.Division of Nephrology, Department of MedicineUCLA Center for the Health Sciences and School of MedicineLos AngelesUSA

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