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Plasma kinetics of exogenous bovine parathyroid hormone in calves

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Summary

The metabolism of purified bovine parathyroid hormone-(1-84) [bPTH-(1-84)] administered i.v. by constant infusions or rapid injections was investigated in 11 normocalcemic calves. Plasma kinetics of bPTH-(1-84) were derived with a radioimmunoassay system which recognised the intact hormone but no fragments. The metabolic clearance rates ranged from 9.1–22.9 ml/min/kg. The disappearance of the intact hormone and the reversible appearance of its NH2-and COOH-terminal fragments was investigated with additional and specific radioimmunoassay systems. At 2 min after the i.v. injection of bPTH-(1-84) a NH2-terminal fragment (M∼3500) was recognised and at 4 and 20 min COOH-terminal fragments (M∼7000 and 3500, respectively) were detected. The survival time in the circulation of the intact hormone and of its fragments was comparable. In conclusion, bovine bPTH-(1-84) and its NH2- and COOH-terminal fragments are metabolised in normocalcemic calves within minutes.

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Authors and Affiliations

  1. Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zürich, Forchstrasse 340, CH-8008, Zürich, Switzerland

    Willi H. Hunziker & Jan A. Fischer

  2. Institute of Animal Production, Federal Institute of Technology, CH-8006, Zürich, Switzerland

    Jürg W. Blum

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  1. Willi H. Hunziker
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  2. Jürg W. Blum
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  3. Jan A. Fischer
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Hunziker, W.H., Blum, J.W. & Fischer, J.A. Plasma kinetics of exogenous bovine parathyroid hormone in calves. Pflugers Arch. 371, 185–192 (1977). https://doi.org/10.1007/BF00586257

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  • DOI: https://doi.org/10.1007/BF00586257

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