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Immunological Detection of Radiation Damage in DNA

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Photochemical and Photobiological Reviews

Abstract

Antibodies specific for photoproducts in nucleic acid offer many distinct advantages in detecting and estimating damage and repair in deoxyribonucleic acid (DNA). Sensitive immunoassays often facilitate the investigation of intact DNA irradiated at doses within the range affecting biological activities. When combined with techniques that allow visualization, antibodies can also be used to monitor the production and elimination of lesions in the DNA of cells and tissue sections in situ.

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Authors and Affiliations

  1. Department of Biochemistry, Brandeis University, Waltham, 02154, Massachusetts, USA

    Helen Van Vunakis

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  1. Helen Van Vunakis
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  1. Stanford University School of Medicine, USA

    Kendric C. Smith

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© 1980 Plenum Press, New York

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Van Vunakis, H. (1980). Immunological Detection of Radiation Damage in DNA. In: Smith, K.C. (eds) Photochemical and Photobiological Reviews. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3641-9_8

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  • DOI: https://doi.org/10.1007/978-1-4684-3641-9_8

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