Abstract
Antibodies specific for nucleic acids have been obtained by immunizing rabbits with conjugates composed of bases, nucleosides or nucleotides covalently linked to proteins or polyamino acids. The chemical methods used to prepare such immunogens have been reviewed (Levine and Stollar, 1967) and the characteristics of some of these antibodies are considered in this volume.
Aided by grants from the NIH (AI-01940 and AI-02792) and the Charles Simon Memorial Grant for Cancer Research from the American Cancer Society (E.222). L. L. is an American Cancer Society Professor of Biochemistry and H. V. V. is a recipient of a Public Health Service Research Career Award K6-AI-2372. Publication No. 564 from the Graduate Department of Biochemistry, Brandeis University.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Chen, Jr., P. S., T. Y. Toribara, and H. Warner (1956). Microdetermination of Phosphorus. Analytical Chemistry, 28:1756–1758.
Erlanger, B. F., and S. M. Beiser (1964). Antibodies specific for ribonucleosides and ribonucleotides and their reaction with DNA. Proc. Natl. Acad. Sci. U. S., 52:68–74.
Halloran, M. J., and C. W. Parker (1966). The production of antibodies to mononucleotides, oligonucleotides and DNA. J. Immunol., 96:379–385.
Landsteiner, K. (1936). The specificity of serological reactions (Harvard University Press, Cambridge, Mass.).
Levine, L., and D. Stollar (1967). Nucleic acid immune systems in “Progress in Allergy.” Vol. 12 in press, (S. Karger, Basel, Switzerland).
Panijel, J., C. Souleil, and P. Cayeux (1966). Immunochemical characterization of polyribonucleotides. Science, 132:773–775.
Plescia, O. J., W. Braun, and N. C. Palczuk (1964). Production of antibodies to denatured deoxyribonucleic acid (DNA). Proc. Natl. Acad. Sci. U. S., 52: 279–285.
Sela, M., H. Ungar-Waron, and Y. Shechter (1964). Uridine specific antibodies obtained with synthetic antigens. Proc. Natl. Acad. Sci. U. S., 52:285–292.
Simon, M. I., and H. Van Vunakis (1962). The photodynamic reaction of methylene blue (MB) with deoxyribonucleic acid (DNA). J. Mol. Biol., 4:488–499.
Van Vunakis, H., E. Seaman, L. Kahan, J. W. Kappler, and L. Levine (1966). Formation of an adduct with tris (hydroxymethyl) aminomethane during the photooxidation of deoxyribonucleic acid and guanine derivatives. Biochemistry, 5:3986–3991.
Wasserman, E., and L. Levine (1960). Quantitative micro complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J. Immunol., 87:290–295.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1968 Springer-Verlag New York Inc.
About this paper
Cite this paper
Van Vunakis, H., Seaman, E., Levine, L. (1968). Antibodies to the Terminal Moieties of Guanine Mononucleotides and Guanine-Containing Dinucleotides. In: Plescia, O.J., Braun, W. (eds) Nucleic Acids in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87668-4_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-87668-4_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-87670-7
Online ISBN: 978-3-642-87668-4
eBook Packages: Springer Book Archive