Systemic Lupus Erythematosus and the Kidney

  • Brad H. Rovin
  • Daniel J. Birmingham
  • Tibor Nadasdy


Lupus nephritis (LN) is an immune complex glomerulonephritis that affects about half of patients with systemic lupus erythematosus (SLE). Patients who develop LN in the setting of SLE have a worse prognosis overall and can develop chronic or end-stage kidney disease. Effective therapies have been developed to treat LN, and while outcomes are better than in the past, complete remissions are still difficult to achieve, and the immunosuppressive therapies commonly used are associated with significant morbidity and mortality. Consequently the LN community is actively working to develop more effective, less toxic novel LN therapies. These new therapeutics are being designed based on an increasing knowledge of the pathogenesis of SLE, and in particular LN, and are guided by the types of kidney injuries seen in LN. This chapter reviews the diagnosis and management of LN as currently practiced and the targets of future management strategies based on the pathogenesis and pathology of LN.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Lupus Nephritis Lupus Nephritis Patient Proliferative Lupus Nephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Brad H. Rovin
    • 1
  • Daniel J. Birmingham
    • 2
  • Tibor Nadasdy
    • 3
  1. 1.Ohio State University College of MedicineColumbusUSA
  2. 2.Department of Internal Medicine, Division of NephrologyThe Ohio State UniversityColumbusUSA
  3. 3.Department of PathologyThe Ohio State UniversityColumbusUSA

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