Abstract
The increase in progressive kidney disease, resulting in a constantly rising prevalence of endstage renal disease (ESRD), urgently warrants the development of more effective strategies to diagnose, prevent, and intervene in renal disease. Histological information obtained by renal biopsies (RBx) is a cornerstone of the current management of kidney disease. Renal tissue can provide critical information on the disease process not available by nontissue-based approaches. However, insight gained by conventional histopathology remains limited and additional strategies to define renal disease on a molecular level are required. The sequencing of the human genome, together with recent advances in genome-wide profiling techniques, has provided the framework for a comprehensive analysis of renal disease-associated transcriptional programs. In this review, strategies to apply these technological advances towards the analysis of RBx will be described, with special emphasis on their potential impact on clinical management, but also on their inherent limitations. Finally, an outlook towards the emerging proteomic studies of renal disease will be given.
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References
S Nakai T Shinzato Y Nagura I Masakane T Kitaoka T Shinoda et al. (2004) ArticleTitlePatient Registration Committee, Japanese Society for Dialysis Therapy, Tokyo. An overview of regular dialysis treatment in Japan (as of 31 December 2001) Ther Apher Dial 8 3–32 Occurrence Handle15128016 Occurrence Handle10.1111/j.1526-0968.2004.00180.x
RS Barsoum (2006) ArticleTitleChronic kidney disease in the developing world N Engl J Med 354 997–9 Occurrence Handle16525136 Occurrence Handle1:CAS:528:DC%2BD28XitV2rsLk%3D Occurrence Handle10.1056/NEJMp058318
MP Madaio (1990) ArticleTitleRenal biopsy Kidney Int 38 529–43 Occurrence Handle2232496 Occurrence Handle1:STN:280:DyaK3M%2FktVemsg%3D%3D
DA Alcorta K Prakash I Waga H Sasai W Munger JC Jennette et al. (2000) ArticleTitleFuture molecular approaches to the diagnosis and treatment of glomerular disease Semin Nephrol 20 20–31 Occurrence Handle10651215 Occurrence Handle1:CAS:528:DC%2BD3cXptFKntw%3D%3D
M Kretzler CD Cohen P Doran A Henger S Madden EF Grone et al. (2002) ArticleTitleRepuncturing the renal biopsy: strategies for molecular diagnosis in nephrology J Am Soc Nephrol 13 1961–72 Occurrence Handle12089394 Occurrence Handle10.1097/01.ASN.0000020390.29418.70
CD Cohen K Frach D Schlondorff M Kretzler (2002) ArticleTitleQuantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application Kidney Int 61 133–40 Occurrence Handle11786093 Occurrence Handle1:CAS:528:DC%2BD38XlslGmsg%3D%3D Occurrence Handle10.1046/j.1523-1755.2002.00113.x
MC Roos-van Groningen M Eikmans HJ Baelde E De Heer JA Bruijn (2004) ArticleTitleImprovement of extraction and processing of RNA from renal biopsies Kidney Int 65 97–105 Occurrence Handle14675040 Occurrence Handle1:CAS:528:DC%2BD2cXmt1WjsA%3D%3D Occurrence Handle10.1111/j.1523-1755.2004.00366.x
D Suzuki M Miyazaki R Naka T Koji M Yagame K Jinde et al. (1995) ArticleTitleIn situ hybridization of interleukin 6 in diabetic nephropathy Diabetes 44 1233–8 Occurrence Handle7556963 Occurrence Handle1:CAS:528:DyaK2MXotlGgsr0%3D
D Suzuki M Miyazaki K Jinde T Koji M Yagame M Endoh et al. (1997) ArticleTitleIn situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-1 and type IV collagen in diabetic nephropathy Kidney Int 52 111–9 Occurrence Handle9211353 Occurrence Handle1:STN:280:DyaK2szlsFWmug%3D%3D
M Toyoda D Suzuki M Honma G Uehara T Sakai T Umezono et al. (2004) ArticleTitleHigh expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy Kidney Int 66 1107–14 Occurrence Handle15327405 Occurrence Handle1:CAS:528:DC%2BD2cXnvVCrtLY%3D Occurrence Handle10.1111/j.1523-1755.2004.00798.x
AM Wang MV Doyle DF Mark (1989) ArticleTitleQuantitation of mRNA by the polymerase chain reaction Proc Natl Acad Sci USA 86 9717–21 Occurrence Handle2481313 Occurrence Handle1:CAS:528:DyaK3cXhtFGjt7w%3D Occurrence Handle10.1073/pnas.86.24.9717
EP Peten LJ Striker MA Carome SJ Elliott CW Yang GE Striker (1992) ArticleTitleThe contribution of increased collagen synthesis to human glomerulosclerosis: a quantitative analysis of alpha 2IV collagen mRNA expression by competitive polymerase chain reaction J Exp Med 176 1571–6 Occurrence Handle1281210 Occurrence Handle1:CAS:528:DyaK38XmtFSit78%3D Occurrence Handle10.1084/jem.176.6.1571
C Esposito LJ Striker A Patel E Peten ZH Liu H Sakai et al. (1996) ArticleTitleMolecular analysis of glomerular diseases in renal biopsies: initial results of a collaborative international study. The International Study Group for Molecular Study of Kidney Biopsies Proc Assoc Am Physicians 108 209–17 Occurrence Handle8774054 Occurrence Handle1:CAS:528:DyaK28Xkt1Kltrw%3D
M Iwano Y Akai Y Fujii Y Dohi N Matsumura K Dohi (1994) ArticleTitleIntraglomerular expression of transforming growth factor-beta 1 (TGF-beta 1) mRNA in patients with glomerulonephritis: quantitative analysis by competitive polymerase chain reaction Clin Exp Immunol 97 309–14 Occurrence Handle8050182 Occurrence Handle1:CAS:528:DyaK2cXlslKrs7c%3D Occurrence Handle10.1111/j.1365-2249.1994.tb06086.x
M Iwano A Kubo T Nishino H Sato H Nishioka Y Akai et al. (1996) ArticleTitleQuantification of glomerular TGF-beta 1 mRNA in patients with diabetes mellitus Kidney Int 49 1120–6 Occurrence Handle8691733 Occurrence Handle1:STN:280:DyaK283lsFWmtg%3D%3D
CW Yang S Hsueh MS Wu PC Lai JY Huang CH Wu et al. (1997) ArticleTitleGlomerular transforming growth factor-beta 1 mRNA as a marker of glomerulosclerosis – application in renal biopsies Nephron 77 290–7 Occurrence Handle9375822 Occurrence Handle1:CAS:528:DyaK2sXntVajurs%3D Occurrence Handle10.1159/000134601
N Yano M Endoh Y Nomoto H Sakai K Fadden A Rifai (1997) ArticleTitlePhenotypic characterization of cytokine expression in patients with IgA nephropathy J Clin Immunol 17 396–403 Occurrence Handle9327339 Occurrence Handle1:CAS:528:DyaK2sXmslCis7g%3D Occurrence Handle10.1023/A:1027368308453
CS Lim S Zheng YS Kim C Ahn JS Han S Kim et al. (2001) ArticleTitleTh1/Th2 predominance and proinflammatory cytokines determine the clinicopathological severity of IgA nephropathy Nephrol Dial Transplant 16 269–75 Occurrence Handle11158399 Occurrence Handle1:CAS:528:DC%2BD3MXhtlKntrY%3D Occurrence Handle10.1093/ndt/16.2.269
S Mizuiri H Hemmi H Kumanomidou M Iwamoto M Miyagi K Sakai et al. (2001) ArticleTitleAngiotensin-converting enzyme (ACE) I/D genotype and renal ACE gene expression Kidney Int 60 1124–30 Occurrence Handle11532108 Occurrence Handle1:CAS:528:DC%2BD3MXmvFKjtbo%3D Occurrence Handle10.1046/j.1523-1755.2001.0600031124.x
J Wagner S Volk CC Haufe A Ciechanowicz M Paul E Ritz (1995) ArticleTitleRenin gene expression in human kidney biopsies from patients with glomerulonephritis or graft rejection J Am Soc Nephrol 5 1469–75 Occurrence Handle7703385 Occurrence Handle1:STN:280:DyaK2M3hvVSmtQ%3D%3D
JP Briggs K Todd-Turla JB Schnermann PD Killen (1993) ArticleTitleApproach to the molecular basis of nephron heterogeneity: application of reverse transcription-polymerase chain reaction to dissected tubule segments Semin Nephrol 13 2–12 Occurrence Handle7679518 Occurrence Handle1:CAS:528:DyaK3sXkt1Whtbw%3D
UE Gibson CA Heid PM Williams (1996) ArticleTitleA novel method for real time quantitative RT-PCR Genome Res 6 995–1001 Occurrence Handle8908519 Occurrence Handle1:CAS:528:DyaK28XmsVWru7s%3D
CA Heid J Stevens KJ Livak PM Williams (1996) ArticleTitleReal time quantitative PCR Genome Res 6 986–94 Occurrence Handle8908518 Occurrence Handle1:CAS:528:DyaK28XmsVWru7w%3D
Y Kohda H Murakami OW Moe RA Star (2000) ArticleTitleAnalysis of segmental renal gene expression by laser capture microdissection Kidney Int 57 321–31 Occurrence Handle10620215 Occurrence Handle1:STN:280:DC%2BD3c%2FoslWmtA%3D%3D Occurrence Handle10.1046/j.1523-1755.2000.00824.x
H Murakami L Liotta Star RA. IF-LCM (2000) ArticleTitleLaser capture microdissection of immunofluorescently defined cells for mRNA analysis (rapid communication) Kidney Int 58 1346–53 Occurrence Handle10972700 Occurrence Handle1:CAS:528:DC%2BD3cXmslehurs%3D Occurrence Handle10.1046/j.1523-1755.2000.00295.x
M Kretzler VP Teixeira PG Unschuld CD Cohen R Wanke I Edenhofer et al. (2001) ArticleTitleIntegrin-linked kinase as a candidate downstream effector in proteinuria FASEB J 15 1843–5 Occurrence Handle11481249 Occurrence Handle1:CAS:528:DC%2BD3MXmsFejsL0%3D
B Schroppel S Huber M Horster D Schlondorff M Kretzler (1998) ArticleTitleAnalysis of mouse glomerular podocyte mRNA by single-cell reverse transcription-polymerase chain reaction Kidney Int 53 119–24 Occurrence Handle9453007 Occurrence Handle1:CAS:528:DyaK1cXnsFCjtQ%3D%3D Occurrence Handle10.1046/j.1523-1755.1998.00742.x
CD Cohen HJ Grone EF Grone PJ Nelson D Schlondorff M Kretzler (2002) ArticleTitleLaser microdissection and gene expression analysis on formaldehyde-fixed archival tissue Kidney Int 61 125–32 Occurrence Handle11786092 Occurrence Handle1:CAS:528:DC%2BD38XlslGnuw%3D%3D Occurrence Handle10.1046/j.1523-1755.2002.00112.x
H Schmid CD Cohen A Henger S Irrgang D Schlondorff M Kretzler (2003) ArticleTitleValidation of endogenous controls for gene expression analysis in microdissected human renal biopsies Kidney Int 64 356–60 Occurrence Handle12787429 Occurrence Handle1:CAS:528:DC%2BD3sXlsFeks7g%3D Occurrence Handle10.1046/j.1523-1755.2003.00074.x
CD Cohen N Calvaresi S Armelloni H Schmid A Henger U Ott et al. (2005) ArticleTitleCD20-positive infiltrates in human membranous glomerulonephritis J Nephrol 18 328–33 Occurrence Handle16013025
H Schmid H Nitschko J Gerth V Kliem A Henger CD Cohen et al. (2005) ArticleTitlePolyomavirus DNA and RNA detection in renal allograft biopsies: results from a European multicenter study Transplantation 80 600–4 Occurrence Handle16177632 Occurrence Handle1:CAS:528:DC%2BD2MXhtVajs7nE Occurrence Handle10.1097/01.tp.0000173385.45918.39
H Schmid A Henger CD Cohen K Frach HJ Grone D Schlondorff et al. (2003) ArticleTitleGene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases J Am Soc Nephrol 14 2958–66 Occurrence Handle14569107 Occurrence Handle1:CAS:528:DC%2BD3sXotFWnsbc%3D Occurrence Handle10.1097/01.ASN.0000090745.85482.06
K Okubo N Hori R Matoba T Niiyama A Fukushima Y Kojima et al. (1992) ArticleTitleLarge scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression Nat Genet 2 173–9 Occurrence Handle1345164 Occurrence Handle1:CAS:528:DyaK3sXjtlKmsA%3D%3D Occurrence Handle10.1038/ng1192-173
Y Yasuda T Miyata M Nangaku Y Iida K Maeda K Kurokawa et al. (1998) ArticleTitleFunctional quantitative analysis of the genome in cultured human mesangial cells Kidney Int 53 154–8 Occurrence Handle9453012 Occurrence Handle1:CAS:528:DyaK1cXnsFCisA%3D%3D Occurrence Handle10.1046/j.1523-1755.1998.00751.x
T Miyata M Nangaku D Suzuki R Inagi K Uragami H Sakai et al. (1998) ArticleTitleA mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy J Clin Invest 102 828–36 Occurrence Handle9710452 Occurrence Handle1:CAS:528:DyaK1cXlsFaqs7s%3D
T Wada T Miyata R Inagi M Nangaku M Wagatsuma D Suzuki et al. (2001) ArticleTitleCloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells J Am Soc Nephrol 12 2601–8 Occurrence Handle11729228 Occurrence Handle1:CAS:528:DC%2BD38XktF2m
M Takenaka E Imai T Kaneko T Ito T Moriyama A Yamauchi et al. (1998) ArticleTitleIsolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles predominantly expressed Kidney Int 53 562–72 Occurrence Handle9507200 Occurrence Handle1:CAS:528:DyaK1cXhs1Sis70%3D Occurrence Handle10.1046/j.1523-1755.1998.00808.x
M Takenaka E Imai Y Nagasawa Y Matsuoka T Moriyama T Kaneko et al. (2000) ArticleTitleGene expression profiles of the collecting duct in the mouse renal inner medulla Kidney Int 57 19–24 Occurrence Handle10620183 Occurrence Handle1:CAS:528:DC%2BD3cXivFOltbg%3D Occurrence Handle10.1046/j.1523-1755.2000.00834.x
VE Velculescu L Zhang B Vogelstein KW Kinzler (1995) ArticleTitleSerial analysis of gene expression Science 270 484–7 Occurrence Handle7570003 Occurrence Handle1:CAS:528:DyaK2MXovVersb8%3D
B Virlon L Cheval JM Buhler E Billon A Doucet JM Elalouf (1999) ArticleTitleSerial microanalysis of renal transcriptomes Proc Natl Acad Sci USA 96 15 286–91 Occurrence Handle1:CAS:528:DC%2BD3cXhtFeitQ%3D%3D Occurrence Handle10.1073/pnas.96.26.15286
D Chabardes-Garonne A Mejean JC Aude L Cheval A Di Stefano MC Gaillard et al. (2003) ArticleTitleA panoramic view of gene expression in the human kidney Proc Natl Acad Sci USA 100 13 710–5 Occurrence Handle1:CAS:528:DC%2BD3sXptFOiuro%3D Occurrence Handle10.1073/pnas.2234604100
MA El-Meanawy JR Schelling F Pozuelo MM Churpek EK Ficker S Iyengar et al. (2000) ArticleTitleUse of serial analysis of gene expression to generate kidney expression libraries Am J Physiol Renal Physiol 279 F383–92 Occurrence Handle10919859 Occurrence Handle1:STN:280:DC%2BD3cvis1ykuw%3D%3D
F Schwartz A Duka E Triantafyllidi C Johns I Duka J Cui et al. (2003) ArticleTitleSerial analysis of gene expression in mouse kidney following angiotensin II administration Physiol Genomics 16 90–8 Occurrence Handle14570981 Occurrence Handle1:CAS:528:DC%2BD2cXjslyntb0%3D Occurrence Handle10.1152/physiolgenomics.00108.2003
M Kretzler G Fan D Rose LJ Arend JP Briggs LB Holzman (1996) ArticleTitleNovel mouse embryonic renal marker gene products differentially expressed during kidney development Am J Physiol 271 F770–7 Occurrence Handle8853441 Occurrence Handle1:CAS:528:DyaK28XmtFeisLo%3D
A Haltia M Solin P Luimula M Kretzler H Holthofer (1999) ArticleTitlemRNA Differential display analysis of nephrotic kidney glomeruli Exp Nephrol 7 52–8 Occurrence Handle9892814 Occurrence Handle1:CAS:528:DyaK1MXht1GrsLY%3D Occurrence Handle10.1159/000020584
M Schena D Shalon RW Davis PO Brown (1995) ArticleTitleQuantitative monitoring of gene expression patterns with a complementary DNA microarray Science 270 467–70 Occurrence Handle7569999 Occurrence Handle1:CAS:528:DyaK2MXovVersLk%3D
TL Ferea D Botstein PO Brown RF Rosenzweig (1999) ArticleTitleSystematic changes in gene expression patterns following adaptive evolution in yeast Proc Natl Acad Sci USA 96 9721–6 Occurrence Handle10449761 Occurrence Handle1:CAS:528:DyaK1MXlsVymtrY%3D Occurrence Handle10.1073/pnas.96.17.9721
J DeRisi L Penland PO Brown ML Bittner PS Meltzer M Ray et al. (1996) ArticleTitleUse of a cDNA microarray to analyse gene expression patterns in human cancer Nat Genet 14 457–60 Occurrence Handle8944026 Occurrence Handle1:CAS:528:DyaK28XntlGgtLo%3D Occurrence Handle10.1038/ng1296-457
AA Alizadeh MB Eisen RE Davis C Ma IS Lossos A Rosenwald et al. (2000) ArticleTitleDistinct types of diffuse large B-cell lymphoma identified by gene expression profiling Nature 403 503–11 Occurrence Handle10676951 Occurrence Handle1:CAS:528:DC%2BD3cXht1Shtrg%3D Occurrence Handle10.1038/35000501
N Yano M Endoh K Fadden H Yamashita A Kane H Sakai et al. (2000) ArticleTitleComprehensive gene expression profile of the adult human renal cortex: analysis by cDNA array hybridization Kidney Int 57 1452–9 Occurrence Handle10760081 Occurrence Handle1:CAS:528:DC%2BD3cXjtVOrt7s%3D Occurrence Handle10.1046/j.1523-1755.2000.00990.x
N Yano M Endoh K Fadden H Yamashita H Sakai K Kurokawa et al. (2000) ArticleTitleGenomic repertoire of human mesangial cells: comprehensive analysis of gene expression by cDNA array hybridization Nephrology 5 215–23 Occurrence Handle1:CAS:528:DC%2BD3MXhs1Sks7c%3D Occurrence Handle10.1046/j.1440-1797.2000.00008.x
J Wada H Zhang Y Tsuchiyama K Hiragushi K Hida K Shikata et al. (2001) ArticleTitleGene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis Kidney Int 59 1363–73 Occurrence Handle11260397 Occurrence Handle1:CAS:528:DC%2BD3MXjtVOhtLw%3D Occurrence Handle10.1046/j.1523-1755.2001.0590041363.x
T Yoshida SS Tang LL Hsiao RV Jensen JR Ingelfinger SR Gullans (2002) ArticleTitleGlobal analysis of gene expression in renal ischemia-reperfusion in the mouse Biochem Biophys Res Commun 291 787–94 Occurrence Handle11866434 Occurrence Handle1:CAS:528:DC%2BD38XhsFWjsLk%3D Occurrence Handle10.1006/bbrc.2002.6535
NE Kieran PP Doran SB Connolly MC Greenan DF Higgins M Leonard et al. (2003) ArticleTitleModification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog Kidney Int 64 480–92 Occurrence Handle12846743 Occurrence Handle1:CAS:528:DC%2BD3sXmsFyku78%3D Occurrence Handle10.1046/j.1523-1755.2003.00106.x
DF Higgins DW Lappin NE Kieran HJ Anders RW Watson F Strutz et al. (2003) ArticleTitleDNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition Kidney Int 64 2079–91 Occurrence Handle14633130 Occurrence Handle1:CAS:528:DC%2BD3sXpvFOqs7Y%3D Occurrence Handle10.1046/j.1523-1755.2003.00306.x
DM Sadlier SB Connolly NE Kieran S Roxburgh DP Brazil L Kairaitis et al. (2004) ArticleTitleSequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy J Biol Chem 279 29 670–80 Occurrence Handle1:CAS:528:DC%2BD2cXlsVCltro%3D Occurrence Handle10.1074/jbc.M313408200
Y Yasuda A Boucherot H Schmid F Eichinger A Henger CD Cohen et al. (2005) ArticleTitleConserved expression signatures in murine and human disease imply a shared transcriptome regulated in renal failure Nephron News 09/05 110
Y Yasuda Y Hiki S Sugiyama A Nishimoto T Shinzato K Maeda (2000) ArticleTitleComprehensive gene expression profiling analysis in minimal change nephrotic syndrome (MCNS) using cDNA array: a novel approach to the mechanism of proteinurea (abstract) J Am Soc Nephrol 11 102
JJ Yang GA Preston DA Alcorta I Waga WE Munger SL Hogan et al. (2002) ArticleTitleExpression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA) Kidney Int 62 1638–49 Occurrence Handle12371964 Occurrence Handle1:CAS:528:DC%2BD38Xos1ektro%3D Occurrence Handle10.1046/j.1523-1755.2002.00619.x
GA Preston I Waga DA Alcorta H Sasai WE Munger P Sullivan et al. (2004) ArticleTitleGene expression profiles of circulating leukocytes correlate with renal disease activity in IgA nephropathy Kidney Int 65 420–30 Occurrence Handle14717912 Occurrence Handle1:CAS:528:DC%2BD2cXhsVSnsL0%3D Occurrence Handle10.1111/j.1523-1755.2004.00398.x
M Takahashi DR Rhodes KA Furge H Kanayama S Kagawa BB Haab et al. (2001) ArticleTitleGene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification Proc Natl Acad Sci U S A 98 9754–9 Occurrence Handle11493696 Occurrence Handle1:CAS:528:DC%2BD3MXmtlCms74%3D Occurrence Handle10.1073/pnas.171209998
E Akalin RC Hendrix RG Polavarapu TC Pearson JF Neylan CP Larsen et al. (2001) ArticleTitleGene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology Transplantation 72 948–53 Occurrence Handle11571464 Occurrence Handle1:CAS:528:DC%2BD3MXns1Kjurg%3D Occurrence Handle10.1097/00007890-200109150-00034
M Sarwal MS Chua N Kambham SC Hsieh T Satterwhite M Masek et al. (2003) ArticleTitleMolecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling N Engl J Med 349 125–38 Occurrence Handle12853585 Occurrence Handle1:CAS:528:DC%2BD3sXltlOktbc%3D Occurrence Handle10.1056/NEJMoa035588
HJ Baelde M Eikmans PP Doran DW Lappin E De Heer JA Bruijn (2004) ArticleTitleGene expression profiling in glomeruli from human kidneys with diabetic nephropathy Am J Kidney Dis 43 636–50 Occurrence Handle15042541 Occurrence Handle1:CAS:528:DC%2BD2cXjsFegt7s%3D Occurrence Handle10.1053/j.ajkd.2003.12.028
K Schwab DP Witte BJ Aronow P Devarajan SS Potter LT Patterson (2004) ArticleTitleMicroarray analysis of focal segmental glomerulosclerosis Am J Nephrol 24 438–47 Occurrence Handle15308877 Occurrence Handle10.1159/000080188
KS Peterson JF Huang J Zhu V D’Agati X Liu N Miller et al. (2004) ArticleTitleCharacterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli J Clin Invest 113 1722–33 Occurrence Handle15199407 Occurrence Handle1:CAS:528:DC%2BD2cXkvFyjsb4%3D Occurrence Handle10.1172/JCI200419139
F Kamme R Salunga J Yu DT Tran J Zhu L Luo et al. (2003) ArticleTitleSingle-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity J Neurosci 23 3607–15 Occurrence Handle12736331 Occurrence Handle1:CAS:528:DC%2BD3sXjslGntbg%3D
A Henger M Kretzler P Doran M Bonrouhi H Schmid E Kiss et al. (2004) ArticleTitleGene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression Kidney Int 65 904–17 Occurrence Handle14871410 Occurrence Handle1:CAS:528:DC%2BD2cXitleksLg%3D Occurrence Handle10.1111/j.1523-1755.2004.00499.x
Y Yasuda H Schmid A Boucherot F Eichinger B Brunner DM Sadlier et al. (2005) ArticleTitleGenome-wide transcriptomic analysis identifies gene expression signature of NF-κB pathway activation in progressive human diabetic nephropathy Nephrol Dial Transplant 20 IssueIDSuppl 5 v371
J Peng SPJ Gygi (2001) ArticleTitleProteomics: the move to mixtures Rapid Commun Mass Spectrom 36 1083–91 Occurrence Handle1:CAS:528:DC%2BD3MXotFOqt7Y%3D
K Tanaka H Waki Y Ido S Akita T Yoshida (1988) ArticleTitleProtein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry Rapid Commun Mass Spectrom 2 151–3 Occurrence Handle1:CAS:528:DyaK3cXjtVSgug%3D%3D Occurrence Handle10.1002/rcm.1290020802
Y Hiki H Odani M Takahashi Y Yasuda A Nishimoto H Iwase et al. (2001) ArticleTitleMass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy Kidney Int 59 1077–85 Occurrence Handle11231363 Occurrence Handle1:CAS:528:DC%2BD3MXitlOmtr8%3D Occurrence Handle10.1046/j.1523-1755.2001.0590031077.x
AC Allen EM Bailey PE Brenchley KS Buck J Barratt Feehally J. Mesangial (2001) ArticleTitleIgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients Kidney Int 60 969–73 Occurrence Handle11532091 Occurrence Handle1:CAS:528:DC%2BD3MXmvFKjt7Y%3D Occurrence Handle10.1046/j.1523-1755.2001.060003969.x
Y Yasuda A Horie H Odani H Iwase Y Hiki (2004) ArticleTitleApplication of mass spectrometry to IgA nephropathy: structural and biological analyses of underglycosylated IgA1 molecules Contrib Nephrol 141 170–88 Occurrence Handle14650232 Occurrence Handle1:CAS:528:DC%2BD2cXptVyg Occurrence Handle10.1159/000074598
V Thongboonkerd MT Barati KR McLeish C Benarafa E Remold-O'Donnell S Zheng et al. (2004) ArticleTitleAlterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis J Am Soc Nephrol 15 650–62 Occurrence Handle14978167 Occurrence Handle1:CAS:528:DC%2BD2cXhtlShu78%3D Occurrence Handle10.1097/01.ASN.0000115334.65095.9B
EM Weissinger S Wittke T Kaiser H Haller S Bartel R Krebs et al. (2004) ArticleTitleProteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes Kidney Int 65 2426–34 Occurrence Handle15149356 Occurrence Handle1:CAS:528:DC%2BD2cXltFKgt7o%3D Occurrence Handle10.1111/j.1523-1755.2004.00659.x
M Haubitz S Wittke EM Weissinger M Walden HD Rupprecht J Floege et al. (2005) ArticleTitleUrine protein patterns can serve as diagnostic tools in patients with IgA nephropathy Kidney Int 67 2313–20 Occurrence Handle15882273 Occurrence Handle1:CAS:528:DC%2BD2MXlsFyjtbc%3D Occurrence Handle10.1111/j.1523-1755.2005.00335.x
S Wittke M Haubitz M Walden F Rohde A Schwarz M Mengel et al. (2005) ArticleTitleDetection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients Am J Transplant 5 2479–88 Occurrence Handle16162198 Occurrence Handle1:CAS:528:DC%2BD2MXhtFeqsL3F Occurrence Handle10.1111/j.1600-6143.2005.01053.x
Y Yoshida K Miyazaki J Kamiie M Sato S Okuizumi A Kenmochi et al. (2005) ArticleTitleTwo-dimensional electrophoretic profiling of normal human kidney glomerulus proteome and construction of an extensible markup language (XML)-based database Proteomics 5 1083–96 Occurrence Handle15668994 Occurrence Handle1:CAS:528:DC%2BD2MXivVGgt7Y%3D Occurrence Handle10.1002/pmic.200401075
BJ Xu Y Shyr X Liang LJ Ma EM Donnert JD Roberts et al. (2005) ArticleTitleProteomic patterns and prediction of glomerulosclerosis and its mechanisms J Am Soc Nephrol 16 2967–75 Occurrence Handle16079267 Occurrence Handle1:CAS:528:DC%2BD2MXhtFegtLnP Occurrence Handle10.1681/ASN.2005030262
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Yasuda, Y., Cohen, C., Henger, A. et al. Gene expression profiling analysis in nephrology: towards molecular definition of renal disease. Clin Exp Nephrol 10, 91–98 (2006). https://doi.org/10.1007/s10157-006-0421-z
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DOI: https://doi.org/10.1007/s10157-006-0421-z