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Renal Involvement in the Antiphospholipid Syndrome (APS)—APS Nephropathy

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Abstract

Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently. The most well-recognized renal manifestations of APS are the renal artery thrombosis/stenosis, renal infarction, hypertension, renal vein thrombosis, end-stage renal disease, increased allograft vascular thrombosis, some types of glomerular disease, and a small-vessel vaso-occlusive nephropathy, recently defined as APS nephropathy. APS nephropathy was first described in primary APS patients, characterized by acute thrombotic lesions in glomeruli and/or arterioles (thrombotic microangiopathy) and chronic vascular lesions such as fibrous intimal hyperplasia of arterioles and interlobular arteries, organized thrombi with or without recanalization, and fibrous arterial and arteriolar occlusions or focal cortical atrophy. APS nephropathy was also detected in further studies including patients with systemic lupus erythematosus (SLE)-related APS and SLE/non-APS patients with positive antiphospholipid antibodies, independently of lupus nephritis. The same histologic lesions, especially thrombotic mictroangiopathy, were also observed in patients with catastrophic APS. The most frequent clinical and laboratory characteristics of APS nephropathy in all the above groups of patients are hypertension (often severe), proteinuria (ranging from mild to nephrotic range), hematuria, and acute or chronic renal insufficiency.

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References

  1. Wilson WA, Gharavi AE, Koike T et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42:1309–1311

    Article  PubMed  CAS  Google Scholar 

  2. Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306

    Article  PubMed  CAS  Google Scholar 

  3. Hughes GR (1993) The antiphospholipid syndrome: ten years on. Lancet 341:342–344

    Article  Google Scholar 

  4. Asherson RA, Kant KS (1988) A “primary” antiphospholipid syndrome. J Rheumatol 15:1742–1746

    PubMed  CAS  Google Scholar 

  5. Cervera R, Piette JC, Font J et al (2002) Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 46:1019–1027

    Article  PubMed  Google Scholar 

  6. Love PE, Santoro SA (1990) Antiphospholipid antibodies: anticardiolipin and lupus anticoagulant in systemic lupus erythematosus (SLE) and non-SLE disorders. Ann Intern Med J 112:682–689

    CAS  Google Scholar 

  7. Harris EN, Gharavi AE, Asherson RA, Boey ML, Hughes GR (1984) Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol 2:47–51

    PubMed  CAS  Google Scholar 

  8. Ostuni PA, Lazzarin P, Pengo V et al (1990) Renal artery thrombosis and hypertension in a 13 year old girl with antiphospholipid syndrome. Ann Rheum Dis 49:184–187

    Article  PubMed  CAS  Google Scholar 

  9. Asherson RA, Noble GE, Hughes GRV (1991) Hypertension and renal stenosis in the primary antiphospholipid syndrome. J Rheumatol 18:1413–1415

    PubMed  CAS  Google Scholar 

  10. Ames PR, Cianciaruso B, Belizzi V et al (1992) Bilateral renal artery occlusion in a patient with the primary antiphospholipid syndrome: thrombosis, vasculitis or both? J Rheumatol 10:1802–1806

    Google Scholar 

  11. Rossi E, Sani C, Zini M, Casoli MC, Restori G (1992) Anticardiolipin antibodies and renovascular hypertension. Ann Rheum Dis 51:1180–1181

    Article  PubMed  CAS  Google Scholar 

  12. Mandreoli M, Zuccala A, Zucchelli P (1992) Fibromuscular dysplasia of the renal arteries associated with antiphospholipid autoantibodies: two cases reports. Am J Kidney Dis 20:500–503

    PubMed  CAS  Google Scholar 

  13. Mandreoli M, Zucchelli P (1993) Renal vascular disease in patients with primary antiphospholipid autoantibodies. Nephrol Dial Transplant 8:1277–1280

    PubMed  CAS  Google Scholar 

  14. Poux JM, Boudet R, Lacroix P et al (1996) Renal infarction and thrombosis of the infrarenal aorta in 35 year-old man with primary antiphospholipid syndrome. Am J Kidney Dis 27:721–725

    Article  PubMed  CAS  Google Scholar 

  15. Godfrey T, Khamashta MA, Hughes GRV (2000) Antiphospholipid syndrome and renal artery stenosis. QJM 93:127–129

    Article  PubMed  CAS  Google Scholar 

  16. Sangle SR, D’ Cruz DP, Jan W et al (2003) Renal artery stenosis in the antiphospholipid syndrome (Hughes) syndrome and hypertension. Ann Rheum Dis 62:999–1002

    Article  PubMed  CAS  Google Scholar 

  17. Remondino GI, Mysler E, Pissano MN et al (2000) A reversible bilateral renal artery stenosis in association with antiphopsholipid syndrome. Lupus 9:65–67

    Article  PubMed  CAS  Google Scholar 

  18. Sangle SR, D’ Cruz DP, Abbs IC, Khamashta MA, Hughes GR (2005) Renal artery stenosis in hypertensive patients with antiphospholipid syndrome (Hughes syndrome): outcome following anticoagulation. Rheumatology (Oxford) 44:372–377

    Article  CAS  Google Scholar 

  19. Rysana R, Zabka J, Peregin JH, Tesar V, Merta M, Rychlik I (1998) Acute renal failure due to bilateral renal artery thrombosis associated with primary antiphospholipid syndrome. Nephrol Dial Transplant 13:2645–2647

    Article  Google Scholar 

  20. Aizawa K, Nakamura T, Sumino H et al (2000) Renovascular hypertension observed in a patient with antiphospholipid-antibody syndrome. Jpn Circ J 64:541–543

    Article  PubMed  CAS  Google Scholar 

  21. Peribasekar S, Chawla K, Rosner F, Depestre M (1995) Complete recovery from renal infarcts in a patient with mixed connective tissue disease. Am J Kidney Dis 26:649–653

    Article  Google Scholar 

  22. Sonpal GM, Sharma A, Miller A (1993) Primary antiphospholipid antibody syndrome, renal infarction and hypertension. J Rheumatol 20:1221–1223

    PubMed  CAS  Google Scholar 

  23. Hughes G (1984) Connective tissue diseases and the skin. The 1983 Posser–White Oration. Clin Exp Dermatol 9:535–544

    Article  PubMed  CAS  Google Scholar 

  24. Hughes GRV, Harris EN, Gharavi AE (1987) The anticardiolipin syndrome. J Rheumatol 13:486–489

    Google Scholar 

  25. Asherson RA, Lanham JG, Hull RG et al (1984) Renal vein thrombosis in systemic lupus associated with the lupus anticoagulant. Clin Exp Rheumatol 2:47–51

    PubMed  Google Scholar 

  26. Jouquan J, Pennec Y, Mottier D et al (1986) Accelerated hypertension associated with lupus anticoagulant and false positive VDRL in systemic lupus erythematosus. Arthritis Rheum 29:147

    Article  PubMed  CAS  Google Scholar 

  27. Cacoub P, Piette JC, Beaufilis H et al (1992) Malignant hypertension in the antiphospholipid syndrome (APS) without lupus nephritis (abst). Arthritis Rheum 35:S360

    Google Scholar 

  28. Kincaid-Smith P, Fairley KF, Kloss M (1988) Lupus anticoagulant associated with renal thrombotic microangiopathy and pregnancy-related renal failure. Q J Med 68:795–815

    PubMed  CAS  Google Scholar 

  29. Julkunen H, Kaaja R, Jouhikainen T et al (1991) Malignant hypertension and antiphospholipid antibodies as presenting features of SLE in a young woman using oral contraceptives. Br J Rheumatol 30:471–472

    Article  PubMed  CAS  Google Scholar 

  30. Nochy D, Daugas E, Droz D et al (1999) The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol 10:507–518

    PubMed  CAS  Google Scholar 

  31. Daugas E, Nochy D, Huong du LT et al (2002) Antiphospholipid syndrome nephropathy in systemic lupus erythematosus. J Am Soc Nephrol 13:42–52

    Article  PubMed  Google Scholar 

  32. Tektonidou MG, Sotsiou F, Nakopoulou L, Vlachoyiannopoulos PG, Moutsopoulos HM (2004) Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome. Arthritis Rheum 50:2569–2579

    Article  PubMed  Google Scholar 

  33. Tektonidou MG, Sotsiou F, Moutsopoulos HM (2008) Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary and systemic lupus erythematosus-related APS. J Rheumatol 35:1983–1988

    PubMed  CAS  Google Scholar 

  34. Dayal NA, Isenberg DA (2003) End stage renal failure in primary antiphospholipid syndrome-case report and review of literature. Rheumatology (Oxford) 42:1128–1129

    Article  CAS  Google Scholar 

  35. Asherson MA, Khamashta MA, Hughes GRV (1993) Hypertension and the antiphospholipid antibodies. Clin Exp Rheumatol 11:465–467

    PubMed  CAS  Google Scholar 

  36. Glueck HI, Kant KS, Weiss MA, Pollak VE, Miller MA, Coots M (1985) Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med 145:1389–1395

    Article  PubMed  CAS  Google Scholar 

  37. D’Cruz DP (2005) Renal manifestations of the antiphospholipid syndrome. Lupus 14:45–48

    Article  PubMed  CAS  Google Scholar 

  38. Lai NS, Lan JL (1997) Renal vein thrombosis in Chinese patients with systemic lupus erythematosus. Ann Rheum Dis 56:562–564

    Article  PubMed  CAS  Google Scholar 

  39. Mintz G, Acevedo-Vazquez E, Guttierrez-Espinosa G et al (1984) Renal vein thrombosis and inferior vena cava thrombosis in systemic lupus erythematosus. Arthritis Rheum 27:539–544

    Article  PubMed  CAS  Google Scholar 

  40. Piette JC, Cacoub P, Wechsler B (1994) Renal manifestations of the antiphospholipid syndrome. Semin Arthritis Rheum 23:357–366

    Article  PubMed  CAS  Google Scholar 

  41. Garcia-Martin F, De Arriba G, Carrascosa T et al (1991) Anticardiolipin antibodies and lupus anticoagulant in end stage renal disease. Nephrol Dial Transplant 6:543–547

    PubMed  CAS  Google Scholar 

  42. Quereda C, Pardo A, Lamas S et al (1988) Lupus-like in vitro anticoagulant activity in end-stage renal disease. Nephron 49:39–44

    Article  PubMed  CAS  Google Scholar 

  43. Gronhagen-Riska C, Teppo AM, Healntera A et al (1990) Raised concentrations of antibodies to cardiolipin in patients receiving dialysis. BMJ 300:1696–1697

    PubMed  CAS  Google Scholar 

  44. Brunet P, Aillaud MF, SanMarco M et al (1995) Antiphospholipid in hemodialysis patients: relationship between lupus anticoagulant and thrombosis. Kidney Int 58:794–800

    Article  Google Scholar 

  45. Pieto LN, Suki WN (1994) Frequent hemodialysis graft thrombosis: association with antiphospholipid antibodies. Am J Kidney Dis 23:587–590

    Google Scholar 

  46. Sitter T, Spannagl M, Schiff H (1992) Anticardiolipin antibodies and lupus anticoagulant in patients treated with different methods of renal replacement therapy in comparison to patients with systemic lupus erythematosus. Ann Hematol 65:79–82

    Article  PubMed  CAS  Google Scholar 

  47. Fastenau DR, Wagenknecht DR, McIntyre JA (1999) Increased incidence of antiphospholipid antibodies in left ventricular assist system recipients. Ann Thorac Surg 68:137–142

    Article  PubMed  CAS  Google Scholar 

  48. Uhtman I, Khamashta M (2006) Antiphospholipid syndrome and the kidneys. Semin Arthritis Rheum 35:360–367

    Article  CAS  Google Scholar 

  49. Fabrizi F, Sangiorgio R, Pontoriero G et al (1999) Antiphospholipid (aPL) antibodies in end stage renal disease. J Nephrol 12:89–94

    PubMed  CAS  Google Scholar 

  50. Chew SL, Lins RL, Daelemans R, Zachee P, De Clerck LS, Vermylen J (1992) Are antiphospholipid antibodies clinically relevant in dialysis patients. Nephrol Dial Transpalnt 7:1194–1198

    CAS  Google Scholar 

  51. Haviv YS (2000) Association of anticardiolipin antibodies with vascular access occlusion in hemodialysis patients: cause or effect. Nephron 86:447–454

    Article  PubMed  CAS  Google Scholar 

  52. Prakash R, Miller CC, Suki W (1995) Anticardiolipin antibody in patients on maintenance hemodialysis and its association with recurrent arteriovenous graft thrombosis. Am J Kidney Dis 26:347–352

    Article  PubMed  CAS  Google Scholar 

  53. Lesar CJ, Merrick HW, Smith MR (1999) Thrombotic complications resulting from hypercoaguable states in chronic hemodialysis vascular access. J Am Coll Sur 189:73–79

    Article  CAS  Google Scholar 

  54. Stone JH, Amend WJ, Criswell LA (1998) Outcome of renal transplantation in ninety-seven cyclosporine -era patients with systemic lupus erythematosus and matched controls. Arthritis Rheum 41:1438–1445

    Article  PubMed  CAS  Google Scholar 

  55. Radhakrishnan J, Williams GS, Appel GB et al (1994) Renal transplantation in anticardiolipin anrtibody-positive lupus erythematosus patients. Am J Kidney Dis 23:286–289

    PubMed  CAS  Google Scholar 

  56. Stone JH, Amend WJC, Criswell LA (1999) Antiphospholipid antibody syndrome in renal transplantation: occurrence of clinical events in 96 consecutive patients with systemic lupus erythematosus. Am J Kidney Dis 34:1040–1047

    Article  PubMed  CAS  Google Scholar 

  57. Nied Prieto L, Suki NW (1994) Frequent hemodialysis graft thrombosis: association with antiphospholipid antibodies. Am J Kidney Dis 23:587–590

    Google Scholar 

  58. Ducloux D, Pellet E, Fournier V, Rebibou JM, Bresson-Vautrin C, Racadot E et al (1999) Prevalence and clinical significance of antiphospholipid antibodies in renal transplant recipients. Transplantation 67:90–93

    Article  PubMed  CAS  Google Scholar 

  59. Moroni G, Tantardini F, Galleli B, Quaglini S, Banfi G, Poli F et al (2005) The long-term prognosis of renal transplantation in patients with lupus nephritis. Am J Kidney Dis 45:901–911

    Article  Google Scholar 

  60. Wagenknecht DR, Becker DG, LeFor WM, McIntyre JA (1999) Antiphospholipid antibodies are a risk factor for early renal allograft failure. Transplantation 68:241–246

    Article  PubMed  CAS  Google Scholar 

  61. Montragon-Ramirez G, Bochcchio T, Garcia-Torres R et al (1994) Recurrent renal thrombotic angioplasty after kidney transplantation in two patients with primary antiphospholipid syndrome (PAPS). Clin Transplant 8:93–96

    Google Scholar 

  62. Vaidya S, Wang CC, Gugliuzza C et al (1998) Relative risk of post-transplant renal thrombosis in patients with antiphospholipid antibodies. Clin Transplant 12:439–444

    PubMed  CAS  Google Scholar 

  63. Vaidya S, Gugliuzza K, Daller J (2004) Efficacy of anticoagulation therapy in end-stage renal disease patients with antiphospholipid antibody syndrome. Transplantation 77:1046–1049

    Article  PubMed  CAS  Google Scholar 

  64. Kleinknecht D, Bobrie G, Meyer O, Noel LH, Callard P, Ramdane M (1989) Recurrent thrombosis and renal vascular disease in patients with a lupus anticoagulant. Nephrol Dial Transplant 4:854–858

    PubMed  CAS  Google Scholar 

  65. Becquemont L, Thervent E, Rondeau E, Lacave R, Mougenot B, Sraer JD (1990) Systemic and renal fibrinolytic activity in a patient with anticardiolipin syndrome and renal thrombotic microangiopathy. Am J Nephrol 10:254–258

    Article  PubMed  CAS  Google Scholar 

  66. D’Agati V, Kunis C, Williams G, Appel GB (1990) Anti-cardiolipin antibody and renal disease: a report of three cases. J Am Soc Nephrol 1:777–784

    PubMed  CAS  Google Scholar 

  67. Amigo MC, Garcia-Torres R, Robles M, Biochicchio T, Reyes PA (1992) Renal involvement in primary antiphospholipid syndrome. J Rheumatol 19:1181–1185

    PubMed  CAS  Google Scholar 

  68. Magil AB, McFadden D, Rae A (1986) Lupus glomerulonephritis with thrombotic microangiopathy. Hum Pathol 17:192–194

    Article  PubMed  CAS  Google Scholar 

  69. Domrongkitchaiporn S, Cameron EJ, Jetha N, Kassen BO, Sutton RA (1994) Renal microangiopathy in the primary antiphospholipid syndrome: a case report with literature review. Nephron 68:128–132

    Article  PubMed  CAS  Google Scholar 

  70. Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller MA, Hess EV (1981) Glomerular thrombosis in systemic lupus erythematosus. Prevalence and significance. Medicine 60:71–86

    Article  PubMed  CAS  Google Scholar 

  71. Glueck HI, Kant KS, Weiss MA, Pollak VE, Miller MA, Coots M (1985) Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med 145:1389–1395

    Article  PubMed  CAS  Google Scholar 

  72. Frampton G, Hicks J, Cameron JS (1991) Significance of anti-phospholipid antibodies in patients with lupus nephritis. Kidney Int 39:1225–1231

    Article  PubMed  CAS  Google Scholar 

  73. Farrugia E, Torres VE, Gastineau D, Michet CJ, Holley KE (1992) Lupus anticoagulant in systemic lupus erythematosus: a clinical and renal pathological study. Am J Kidney Dis 20:463–471

    PubMed  CAS  Google Scholar 

  74. Hughson MD, Nadasdy T, McCarty GA, Sholer C, Min KW, Silva F (1992) Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis 20:150–158

    PubMed  CAS  Google Scholar 

  75. Bridoux F, Vrtovsnik F, Noel C, Saunier P, Mougenot B, Lemaitre V, Dracon M, Lelievre G, Vanhille P (1998) Renal thrombotic microangiopathy in systemic lupus erythematosus: clinical correlations and long-term renal survival. Nephrol Dial Transplant 13:298–304

    Article  PubMed  CAS  Google Scholar 

  76. Perez RE, McClendon JR, Lie JT (1992) Primary antiphospholipid syndrome with multiorgan arterial and venous thrombosis. J Rheumatol 19:1289–1292

    PubMed  CAS  Google Scholar 

  77. Lie JT (1996) Pathology of the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y (eds) The Antiphospholipid syndrome. CRC, Boca Raton, FL, pp 89–104

    Google Scholar 

  78. Salmon JE, de Groot PG (2008) Pathogenetic role of antiphospholipid antibodies. Lupus 17:405–411

    Article  PubMed  CAS  Google Scholar 

  79. Salmon JE, Girardi G, Lockshin MD (2007) The antiphospholipid syndrome as a disorder initiated by inflammation: implications for the therapy of pregnant patients. Nat Clin Pract Rheumatol 3:140–147

    Article  PubMed  CAS  Google Scholar 

  80. Oku K, Atsumi T, Bohgaki M et al (2008) Complement activation in patients with primary antiphospholipid syndrome. Ann Rheum Dis (in press) July 14

  81. Olguin L, Calleja C, Hernandez C et al (2003) Primary antiphospholid antiphospholipid syndrome nephropathy despite anticoagulant therapy. Arthritis Rheum 48(suppl):S359

    Google Scholar 

  82. Hamidou MA, Moreau A, Jego P et al (1995) Captopril and aspirin in the treatment of renal microangiopathy in primary antiphospholipid syndrome. Am J Kidney Dis 25:486–488

    Article  PubMed  CAS  Google Scholar 

  83. Korkmaz C, Kabukcuoglu S, Isiksoy S et al (2003) Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy. Lupus 12:760–765

    Article  PubMed  CAS  Google Scholar 

  84. Wilkowski M, Arroyo R, McCabe K (1990) Glomerulonephritis in a patient with anticardiolipin antibody. Am J Kidney Dis 15:184–186

    PubMed  CAS  Google Scholar 

  85. Saracino A, Ramunni A, Pannarale G et al (2005) Kidney disease associated with primary antiphospholipid ssyndrome: clinical signs and histopathological features in an experience of five cases. Clin Nephrol 63:471–476

    PubMed  CAS  Google Scholar 

  86. Fakhouri F, Noel LH, Zuber J et al (2003) The expanding spectrum of renal diseases associated with antiphospholipid syndrome. Am J Kidney Dis 41:1205–1211

    Article  PubMed  Google Scholar 

  87. Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller MA, Hess EV (1981) Glomerular thrombosis in systemic lupus erythematosus. Prevalence and significance. Medicine 60:71–86

    Article  PubMed  CAS  Google Scholar 

  88. Leaker B, McGregor A, Griffiths M, Snaith M, Neild GH, Isenberg D (1991) Insidious loss of renal function in patients with anticardiolipin antibodies and absence of overt nephritis. Br J Rheumatol 30:422–425

    Article  PubMed  CAS  Google Scholar 

  89. Mayer SA, Aledort LM (2005) Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies. Mt Sinai J Med 72:166–175

    PubMed  Google Scholar 

  90. Cecere FA, Yoshinoya S, Pope RM (1981) Fatal thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus. Relationship to circulating immune complexes. Arthritis Rheum 24:550–553

    Article  PubMed  CAS  Google Scholar 

  91. Bandari S, Harnden P, Brownjohn AM, Turney JH (1998) Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. QJM 91:401–409

    Article  Google Scholar 

  92. Moroni G, Ventura D, Riva P et al (2004) Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis. Am J Kidney Dis 43:28–36

    Article  PubMed  CAS  Google Scholar 

  93. Banfi G, Bertani T, Boeri V, Faraggiana T, Mazzucco G, Monga G et al (1991) Renal vascular lesions as a marker for poor prognosis in patients with lupus nephritis. Am J Kidney Dis 18:240–248

    PubMed  CAS  Google Scholar 

  94. Miranda JM, Garcia-Torres R, Jara LJ et al (1994) Renal biopsy in systemic lupus erythematosus: significance of glomerular thrombosis. Analysis of 108 cases. Lupus 3:25–29

    Article  PubMed  CAS  Google Scholar 

  95. Asherson RA (1992) The catastrophic antiphospholipid syndrome. J Rheumatol 19:508–512

    PubMed  CAS  Google Scholar 

  96. Bucciarelli S, Espinosa G, Cervera R et al (2006) European Forum on Antiphospholipid Antibodies. Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients. Arthritis Rheum 54:2568–2576

    Article  PubMed  Google Scholar 

  97. Erkan D, Cervera R, Asherson RA (2003) Catastrophic antiphospholipid syndrome. Where do we stand. Arthritis Rheum 48:3320–3327

    Article  PubMed  Google Scholar 

  98. Inam S, Sidki K, Al-Marshedy AR, Judzewitsch R (1991) Addison’s disease, hypertension, renal and hepatic microthrombosis in “primary” antiphospholipid syndrome. Postgrad Med J 66:385–388

    Article  Google Scholar 

  99. Perez RE, McClendon JR, Lie JT (1992) Primary antiphospholipid syndrome with multiorgan arterial and venous thromboses. J Rheumatol 19:1289–1292

    PubMed  CAS  Google Scholar 

  100. Lacueva J, Enriquez R, Cabezuelo JB, Arenas MD, Teruel A, Gonzalez C (1993) Acute renal failure as first clinical manifestation of the primary antiphospholipid syndrome. Nephron 64:479–480

    Article  PubMed  CAS  Google Scholar 

  101. Peddi VR, Kant KS (1995) Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency. J Am Soc Nephrol 5:1882–1887

    PubMed  CAS  Google Scholar 

  102. Tsirpanlis G, Moustakas G, Sakka E, Triantafyllis G, Sotsiou F, Liapis H et al (2005) Catastrophic antiphospholipid syndrome in a 14-year-old child. Pediatr Nephrol 20:519–521

    Article  PubMed  Google Scholar 

  103. Sharma J, Karthik S, Rao S, Phadke K, Crasta J, Garg I (2005) Catastrophic antiphospholipid syndrome. Pediatr Nephrol 20:998–999

    Article  PubMed  Google Scholar 

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  1. Department of Pathophysiology, School of Medicine, National University of Athens, 75 M. Asias str., 115 27, Athens, Greece

    Maria G. Tektonidou

  2. Rheumatology Department, Euroclinic Hospital, Athens, Greece

    Maria G. Tektonidou

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Tektonidou, M.G. Renal Involvement in the Antiphospholipid Syndrome (APS)—APS Nephropathy. Clinic Rev Allerg Immunol 36, 131–140 (2009). https://doi.org/10.1007/s12016-008-8112-z

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