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Synthetic Bioinorganic Chemistry: Scorpionates Turn 50

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50 Years of Structure and Bonding – The Anniversary Volume

Part of the book series: Structure and Bonding ((STRUCTURE,volume 172))

Abstract

The coordination chemistry of scorpionates, anionic tripodal boron-centered ligands that readily bind to virtually all main group, transition, and f-block metals, has had a profound effect in the development of synthetic bioinorganic chemistry during the past 50 years. Highlighted in this article are some of the most meaningful results published in the area, primarily in the preparation of structural and functional model compounds for the active sites in metalloproteins and metalloenzymes, a theme that encompasses topics as diverse as nitrogen fixation and heavy metal poisoning. It has also been 50 years since the genesis of Structure and Bonding, so let this account also be a celebration of the many contributions that the staunch serial has had on the entire field of inorganic chemistry during the past half century.

The original version of this chapter was revised: Figure 10 of this chapter was displayed incorrect. The erratum to this chapter is available at DOI: 10.1007/430_2016_213.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/430_2016_213

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Abbreviations

Ad:

Adamantyl

ALAD:

5-Aminolevulinate dehydratase

Bp:

Bis(pyrazolyl)borate

But :

Tert-butyl

CA:

Carbonic anhydrase

Cp2Co:

Bis(cyclopentadienyl)cobalt (cobaltocene)

Cys:

Cysteine

DMSO:

Dimethyl sulfoxide

Et:

Ethyl

His:

Histidine

HSAB:

Hard and soft acids and bases

Im:

Imidazol-2-ylidene

IR:

Infrared

LADH:

Liver alcohol dehydrogenase

Me:

Methyl

Mes:

Mesityl (2,4,6-trimethylphenyl)

MRI:

Magnetic resonance imaging

NHC:

N-Heterocyclic carbene

NHSe:

N-Heterocyclic selone

NHT:

N-Heterocyclic thione

Ph:

Phenyl

Pri :

Isopropyl

THF:

Tetrahydrofuran

TmR :

Tris(mercaptoimidazolyl)borate

ToR :

Tris(oxoimidazolyl)borate

TpRR′ :

Tris(pyrazolyl)borate

TseR :

Tris(selenoimidazolyl)borate

TtR :

Tris(thioether)borate

TtzRR′ :

Tris(triazolyl)borate

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Acknowledgments

Insightful discussions with Professors Joshua Telser (Roosevelt University), Brian Hoffman (Northwestern University), and Bill Jensen (University of Cincinnati) regarding the first public use of the term “bioinorganic” are sincerely appreciated. The National Science Foundation (Award No. CHE-0911407) and The University of North Carolina at Charlotte are gratefully acknowledged for support of our research in synthetic bioinorganic chemistry since 1996.

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  1. Department of Chemistry, The University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC, 28223, USA

    Daniel Rabinovich

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    D. Michael P. Mingos

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Rabinovich, D. (2016). Synthetic Bioinorganic Chemistry: Scorpionates Turn 50. In: Mingos, D. (eds) 50 Years of Structure and Bonding – The Anniversary Volume. Structure and Bonding, vol 172. Springer, Cham. https://doi.org/10.1007/430_2015_212

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