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The bio-inorganic chemistry of tungsten

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Metal Sites in Proteins and Models Redox Centres

Part of the book series: Structure & Bonding ((4143,volume 90))

Abstract

A steady flow of reports over the last seven years on the molecular characterization of tungsten-containing proteins from a wide range of microorganisms has drastically changed our appreciation of tungsten in redox enzymes. Biological tungsten is not an odd remnant of evolution but a widespread, versatile catalytic entity for the activation of the carbonyl group both in carbon dioxide and in a broad spectrum of aldehydes and carboxylic acids. This review starts off with an outline of the boundary conditions for the biological use of tungsten dictated by inorganic chemistry. Subsequently, the possibilities for spectroscopy on tungsten proteins are reviewed. The molecular properties of tungsten enzymes are described and are related to their physiology and their mechanism of action. Gaps in our current knowledge of the bio-inorganic chemistry of tungsten are identified, and possible directions of future research are indicated.

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Abbreviations

AOR:

aldehyde oxidoreductase

CAR:

carboxylic acid reductase

CEPT:

coupled electron-proton transfer

DMSOrd:

dimethyl sulfoxide reductase

ENDOR:

electron-nuclear double resonance

EPR:

electron paramagnetic resonance

ESEEM:

electron spin echo envelope modulation

ESR:

electron spin resonance

EXAFS:

extended X-ray absorption fine structure

FAD:

flavin adenine dinucleotide

FDH:

formate dehydrogenase

FMDH:

formylmethanofuran dehydrogenase

FMF:

formylmethanofuran

FOR:

formaldehyde oxidoreductase

GAP:

glyceraldehyde-3-phosphate

GAPOR:

glyceraldehyde-3-phosphate oxidoreductase

INEPT:

insensitive nucleus enhanced by polarization transfer

MCD:

magnetic circular dichroism

MFR:

methanofuran

NADH:

reduced nicotinamide-adenine dinucleotide

NMR:

nuclear magnetic resonance

OAT:

oxo-atom transfer

RR:

resonance Raman

RTP:

red tungsten protein

XANES:

X-ray absorption near edge structure

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Authors and Affiliations

  1. Department of Biochemistry, Wageningen Agricultural University, Germany

    W. R. Hagen & A. F. Arendsen

  2. Department of Molecular Spectroscopy, University of Nijmegen, The Netherlands

    W. R. Hagen

Authors
  1. W. R. Hagen
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  2. A. F. Arendsen
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Correspondence to W. R. Hagen .

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H. A. O. Hill P. J. Sadler A. J. Thomson

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Hagen, W.R., Arendsen, A.F. (1998). The bio-inorganic chemistry of tungsten. In: Hill, H.A.O., Sadler, P.J., Thomson, A.J. (eds) Metal Sites in Proteins and Models Redox Centres. Structure & Bonding, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-62888-6_6

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