Overview
- Editors:
-
-
Nagy A. Habib
-
Imperial College School of Medicine, Hammersmith Hospital, London, UK
Access this book
Other ways to access
Table of contents (41 chapters)
-
-
The Clinical Problem
-
- Susan J. Cleator, Pat Price
Pages 3-10
-
Vectors
-
-
- Yasuhiro Takeuchi, Massimo Pizzato
Pages 23-35
-
- Paul L. Hallenbeck, Susan C. Stevenson
Pages 37-46
-
-
- David Bermudes, Brooks Low, John Pawelek
Pages 57-63
-
-
- Nina Krauzewicz, Beverly E. Griffin
Pages 73-82
-
- Leila Zarif, Raphael J. Mannino
Pages 83-93
-
- Stephen Coe, Michael Harron, Marc Winslet, Geoffrey Goldspink
Pages 95-111
-
Cell Cycle Control
-
- Yaw Ohene-Abuakwa, Massimo Pignatelli
Pages 115-126
-
- Vivien J. Tannoch, Phil W. Hinds, Li-Huei Tsai
Pages 127-140
-
Apoptosis
-
- Gen Sheng Wu, Kunghong Kim, Wafik S. El-Deiry
Pages 143-151
-
- Alexandra Pietersen, Mathieu H. M. Noteborn
Pages 153-161
-
- Anu-Maaria Sandmair, Matti Vapalahti, Seppo Ylä-Herttuala
Pages 163-170
-
- M. C. Hung, Hortobagyi G. N., N. T. Ueno
Pages 171-180
-
Tumout Suppressor Genes
-
-
- Ragai R. Mitry, Marc R. Mansour, Roman Havlik, Nagy A. Habib
Pages 193-205
-
- Junzo Kigawa, Naoki Terakawa
Pages 207-214
About this book
With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.
Editors and Affiliations
-
Imperial College School of Medicine, Hammersmith Hospital, London, UK
Nagy A. Habib