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Human α-fetoprotein Transcriptional Regulatory Sequences

Application to Gene Therapy
Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 465)

Summary/Conclusion

The AFP regulatory sequences are among the best known tumor-specific transcriptional regulators. A number of groups have demonstrated that a variety of genes can be expressed in an HCC-specific manner under the control of the AFP regulatory sequences in vitro and in vivo. It would appear that, with the development of a suitable delivery system, HCC-directed gene therapy using the AFP regulatory sequences holds a promising future.

Keywords

lacZ Gene Herpes Simplex Virus Thymidine Kinase Cytosine Deaminase Gene Simplex Virus Thymidine Kinase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyUniversity of CalgaryCalgaryCanada

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