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Cancer Gene Therapy pp 207–214Cite as

Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 465))

Summary

Given the lack of effective conventional therapy, those patients with recurrent or refractory ovarian cancer should be considered for currently approved investigational gene therapy protocols. Several studies have shown a potential modality of p53 gene transfer in cancer gene therapy. We also developed a new recombinant adenovirus carrying a wild-type p53 gene (AxCAp53). Although the efficacy of AxCAp53 to suppression of cell growth was not sufficient, AxCAp53 increased sensitivity to CDDP in ovarian cancer cells with deletion of the p53 gene. The combination of CDDP and AxCAp53 may be a potential strategy for the therapy of CDDP resistant ovarian cancer.

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishimachi, Yonago, 6838504, Japan

    Junzo Kigawa & Naoki Terakawa

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  1. Junzo Kigawa
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  2. Naoki Terakawa
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Editors and Affiliations

  1. Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Nagy A. Habib

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© 2002 Kluwer Academic Publishers

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Kigawa, J., Terakawa, N. (2002). Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_19

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  • DOI: https://doi.org/10.1007/0-306-46817-4_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-46191-0

  • Online ISBN: 978-0-306-46817-9

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