Overview
- Systematically providing readers with cutting-edge developments in Treg research
- Introducing the biology of Treg cells and their functions in diseases
- Discussing the manipulation of Treg in clinical therapy
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1278)
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About this book
This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters.
The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.
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Keywords
Table of contents (15 chapters)
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Front Matter
Editors and Affiliations
About the editor
Dr. Song-Guo Zheng is Ronald L. Whisler Chair in Immunology and Rheumatology, Professor of Internal Medicine of Ohio State University College of Medicine, USA. He is also the director of the Department of Clinical Immunology, Third Hospital affiliated to Sun Yat-sen University, China. He serves as the EiC of American Journal of Clinical and Experimental Immunology, Associate Editor of Frontiers in Immunology, and the editorial board member of several international peer-reviewed journals, such as Cytokine & Growth Factor Reviews and Cellular and Molecular Immunology. Dr. Zheng’s research group is investigating the properties of regulatory T cells (Tregs), and their role in the maintenance of immune tolerance and prevention of autoimmune diseases. He has published over 100 articles on international journals in this field.
Bibliographic Information
Book Title: T Regulatory Cells in Human Health and Diseases
Editors: Song-Guo Zheng
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-15-6407-9
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
Hardcover ISBN: 978-981-15-6406-2Published: 02 February 2021
Softcover ISBN: 978-981-15-6409-3Published: 03 February 2022
eBook ISBN: 978-981-15-6407-9Published: 01 February 2021
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: X, 302
Number of Illustrations: 4 b/w illustrations, 31 illustrations in colour
Topics: Immunology, Molecular Medicine, Cell Biology