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  • Conference proceedings
  • Open Access
  • © 2015

Innovative Medicine

Basic Research and Development

  • Covers the basic, translational, and new technology of medical research

  • Broadens the understanding of innovative medicine

  • Is written by leading scientists in medical research

  • Includes supplementary material:

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)

Table of contents (27 papers)

  1. Front Matter

    Pages i-ix
  2. Basic Research for Innovative Medicine

    1. Front Matter

      Pages 1-1
    2. Diverting Glycolysis to Combat Oxidative Stress

      • Edouard Mullarky, Lewis C. Cantley
      Pages 3-23Open Access
    3. Metabolic Regulation by Nuclear Receptors

      • Sihao Liu, Michael Downes, Ronald M. Evans
      Pages 25-37Open Access
    4. Fighting Fire with Fire in Cancer

      • Thorsten Berger, Mary E. Saunders, Tak W. Mak
      Pages 39-49Open Access
    5. Roles of E-cadherin in Hepatocarcinogenesis

      • Shin Maeda, Hayato Nakagawa
      Pages 71-77Open Access
    6. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors

      • Miki Nishio, Hiroki Goto, Miki Suzuki, Aya Fujimoto, Koshi Mimori, Akira Suzuki
      Pages 79-94Open Access
    7. Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation

      • Akira Shibuya, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka
      Pages 95-107Open Access
    8. Doxycycline-Inducible Autoimmune Blistering Skin Disease Model

      • Wataru Nishie, Hiroshi Shimizu
      Pages 109-117Open Access
    9. T Cell Senescence and Autoimmunity

      • Nagahiro Minato
      Pages 119-128Open Access
  3. Translational Research for Innovative Medicine

    1. Front Matter

      Pages 129-129
    2. IL-6: A New Era for the Treatment of Autoimmune Inflammatory Diseases

      • Tadamitsu Kishimoto, Sujin Kang, Toshio Tanaka
      Pages 131-147Open Access
    3. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies

      • Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh, Miyako Tanaka
      Pages 149-156Open Access
    4. Translational Research of Leptin in Lipodystrophy and Its Related Diseases

      • Ken Ebihara, Kazuwa Nakao
      Pages 165-175Open Access
    5. Clarity and Challenges in Tissue Fibrosis

      • Scott L. Friedman
      Pages 187-194Open Access
    6. TRP Channels: Their Function and Potentiality as Drug Targets

      • Motohiro Nishida, Koichiro Kuwahara, Daisuke Kozai, Reiko Sakaguchi, Yasuo Mori
      Pages 195-218Open Access

About this book

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.


  • Cancer
  • Clinical application
  • Metabolism
  • Stem cell
  • Translational research

Editors and Affiliations

  • Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Kazuwa Nakao

  • Department of Immunology & Cell Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Nagahiro Minato

  • Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Shinji Uemoto

Bibliographic Information

  • Book Title: Innovative Medicine

  • Book Subtitle: Basic Research and Development

  • Editors: Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto

  • DOI:

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2015

  • License: CC BY-NC

  • Hardcover ISBN: 978-4-431-55650-3Published: 28 October 2015

  • Softcover ISBN: 978-4-431-56246-7Published: 23 August 2016

  • eBook ISBN: 978-4-431-55651-0Published: 13 October 2015

  • Edition Number: 1

  • Number of Pages: IX, 339

  • Topics: Biomedical Research, Immunology, Cell Biology

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)