Overview
- Editors:
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Dean H. Lockwood
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Department of Clinical Research, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, USA
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Thomas C. Heffner
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Neuroscience Therapeutics, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, USA
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About this book
Obesity is a serious medical problem that affects millions of people, especially in Western societies. Although long considered a complicating factor in a variety of diseases, there is now widespread agreement that obesity itself should be classified and treated as a disease and that it has important conse quences for personal health, quality of life and cost to society. Understanding obesity and the means of treating it have been hampered in the past. There have been misperceptions that obesity is a behavioral disorder and that its treatments provides only cosmetic benefits. Pharmacologic approaches to treatment have suffered from problems of limited efficacy, reduced activity upon chronic use, and serious side effects, including abuse liability, cardiac disease, hypertension, and respiratory complications. Finally, there has been a proliferation of consumer and natural products with unproven benefits. This book attempts to address both the problems associated with obesity and the approaches to treating it. In the first section devoted to pathology, Drs. DIGIROLAMO, HARP, and STEVENS elaborate in Chap. 1 on how obesity and its medical complications develop. As described by Dr. PI-SUNYER in Chap. 2, obesity is a disease seen most often in affluent Western societies and is associated with the aforemen tioned medical problems, as well as Type II diabetes mellitus and gallbladder disease. Drs. CHAGNON, PERUSSE, and BOUCHARD review the human genetics of obesity in Chap. 3, and Drs.
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Table of contents (18 chapters)
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Front Matter
Pages I-XXIII
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Pathology
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- M. DiGirolamo, J. Harp, J. Stevens
Pages 3-28
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- Y. C. Chagnon, L. Pérusse, C. Bouchard
Pages 57-89
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- J. W. Kolaczynski, B. J. Goldstein
Pages 91-119
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- M. D. Hirvonen, R. E. Keesey
Pages 133-151
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Pharmacological and Other Treatments
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Front Matter
Pages 153-153
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- J. C. G. Halford, J. E. Blundell
Pages 155-176
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- L. A. Campfield, F. J. Smith
Pages 177-194
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- D. M. Smith, W. J. Pories, K. G. MacDonald Jr
Pages 259-291
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Pharmacological Targets
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Front Matter
Pages 293-293
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- J. F. Caro, M. E. Trautmann
Pages 295-311
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Strategies for Indentifying Future Targets
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Front Matter
Pages 401-401
Editors and Affiliations
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Department of Clinical Research, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, USA
Dean H. Lockwood
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Neuroscience Therapeutics, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, USA
Thomas C. Heffner