Overview
- Discusses the genetic basis and pathology of hereditary gastric and breast cancer syndromes
- Is intended to provide the basis for evaluating and improving guidelines for CDH1 genetic testing
- Combines expertise from epidemiology, cancer biology, pathology, genetics, and oncology
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Table of contents (26 chapters)
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Front Matter
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Genetics
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Front Matter
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Surgery
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Front Matter
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Keywords
About this book
In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well.
Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer.
This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
Editors and Affiliations
About the editors
Giovanni Corso MD, PhD
Breast surgeon at the European Institute of Oncology in Milan, Italy, and senior researcher at the University of Milan, Italy. Elected president of the European Cancer Prevention Organization (ECPO), and next editor-in-chief of the European Journal of Cancer Prevention.
Paolo Veronesi, MDDirector of the Breast Surgery Division at the European Institute of Oncology in Milan, Italy, and full professor in surgery at the University of Milan, Italy. President of the Umberto Veronesi Foundation (FUV).
Franco Roviello, MD
Director of the Surgical Oncology Unit at the Hospital “Le Scotte” in Siena, Italy, and full professor in surgery at the University of Siena, Italy. President of the Italian Society of Surgical Oncology (SICO).
Bibliographic Information
Book Title: Hereditary Gastric and Breast Cancer Syndrome
Book Subtitle: CDH1: One Genotype with Multiple Phenotypes
Editors: Giovanni Corso, Paolo Veronesi, Franco Roviello
DOI: https://doi.org/10.1007/978-3-031-21317-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-21316-8Published: 18 March 2023
Softcover ISBN: 978-3-031-21319-9Published: 19 March 2024
eBook ISBN: 978-3-031-21317-5Published: 17 March 2023
Edition Number: 1
Number of Pages: XV, 422
Number of Illustrations: 1 b/w illustrations, 57 illustrations in colour
Topics: Cancer Research, Genetics and Genomics, Oncology, Oncology