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Computer-Assisted Interpretation of Cancer-Predisposing Variants

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Hereditary Gastric and Breast Cancer Syndrome

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Abstract

The increasing scope of genomic profiling in cancer care has led to a specific issue related to the interpretation of genetic variants as benign or pathogenic in clinical settings for adequate patient management. In the last few years, several bioinformatic tools have been developed in order to assist the decision-making process during the evaluation of mutations in cancer-predisposing genes and the actionability of druggable variants [1–3].

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Author information

Authors and Affiliations

  1. Department of Onco-Hematology, Università degli Studi di Milano, Milan, Italy

    Emanuele Bonetti & Gianluca Vozza

  2. Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy

    Emanuele Bonetti, Gianluca Vozza & Luca Mazzarella

Authors
  1. Emanuele Bonetti
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  2. Gianluca Vozza
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  3. Luca Mazzarella
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Corresponding author

Correspondence to Luca Mazzarella .

Editor information

Editors and Affiliations

  1. European Institute of Oncology, University of Milan, Milan, Italy

    Giovanni Corso

  2. European Institute of Oncology, University of Milan, Milan, Italy

    Paolo Veronesi

  3. University of Siena, Siena, Italy

    Franco Roviello

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Bonetti, E., Vozza, G., Mazzarella, L. (2023). Computer-Assisted Interpretation of Cancer-Predisposing Variants. In: Corso, G., Veronesi, P., Roviello, F. (eds) Hereditary Gastric and Breast Cancer Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-031-21317-5_8

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