Overview
- Focuses of this volume: chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermediates and their detoxification, and environmental agents that can promote tumor formation
- appeals to graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research
Part of the book series: Current Cancer Research (CUCR)
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Table of contents (18 chapters)
Keywords
About this book
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Editors and Affiliations
Bibliographic Information
Book Title: Chemical Carcinogenesis
Editors: Trevor M. Penning
Series Title: Current Cancer Research
DOI: https://doi.org/10.1007/978-1-61737-995-6
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Humana Press 2011
Hardcover ISBN: 978-1-61737-994-9Published: 03 March 2011
Softcover ISBN: 978-1-61779-729-3Published: 19 April 2013
eBook ISBN: 978-1-61737-995-6Published: 03 March 2011
Series ISSN: 2199-2584
Series E-ISSN: 2199-2592
Edition Number: 1
Number of Pages: XVI, 440
Topics: Cancer Research, Pharmacology/Toxicology