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Chemical Carcinogenesis pp 297–319Cite as

Base-Excision Repair: Role of DNA Polymerase β in Late-Stage Base Excision Repair

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Abstract

The cellular DNA repair pathway known as base-excision repair is responsible for removing toxic base lesions and strand breaks from genomic and mitochondrial DNA. The base-excision repair pathway is conserved in organisms throughout nature, but there are many variations probably reflecting the broad range of genotoxic stresses encountered and the gene expression status of the organism. There has been remarkable progress in recent years toward deciphering the various types of base lesions and the multiple steps and subpathways involved in the overall base excision pathway. This progress is reviewed here, and a detailed discussion of current research on the long-patch base-excision repair subpathway is presented.

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  1. Laboratory of Structural Biology, NIEHS/National Institutes of Health, Research Triangle Park, NC, USA

    Samuel H. Wilson

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  1. Kenjiro Asagoshi
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  1. School of Medicine, Dept. Pharmacology, University of Pennsylvania, Hamilton Walk 3260, Philadelphia, 19104, Pennsylvania, USA

    Trevor M. Penning

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Asagoshi, K., Wilson, S.H. (2011). Base-Excision Repair: Role of DNA Polymerase β in Late-Stage Base Excision Repair. In: Penning, T. (eds) Chemical Carcinogenesis. Current Cancer Research. Humana Press. https://doi.org/10.1007/978-1-61737-995-6_14

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