Overview
- Editors:
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Miral Dizdaroglu
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National Institute of Standards and Technology, Gaithersburg, USA
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Ali Esat Karakaya
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Gazi University, Ankara, Turkey
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Table of contents (35 chapters)
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- Steven Akman, Regen Drouin, Gerald Holmquist, Henry Rodriguez
Pages 1-17
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- Okezie I. Aruoma, Andrew Jenner, Barry Halliwell
Pages 19-26
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- Vilhelm A. Bohr, Adabalayam Balajee, Robert Brosh, Jan Nehlin, Amrita Machwe, Michele Evans et al.
Pages 27-34
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- Serge Boiteux, J. Pablo Radicella
Pages 35-45
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- J. Cadet, M. Bardet, M. Berger, T. Berthod, T. Delatour, C. D’Ham et al.
Pages 47-58
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- Bruce Demple, Elisabeth Bailey, Richard A. O. Bennett, Yuji Masuda, Donny Wong, Yong-jie Xu
Pages 59-66
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- Paul W. Doetsch, Anand Viswanathan, Wei Zhou, Jiang Liu
Pages 97-110
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- Errol C. Friedberg, William J. Feaver, Wenya Huang, Michael S. Reagan, Simon H. Reed, Zhaoyang You et al.
Pages 111-123
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- Matthew B. Grisham, David Jourd’heuil, David A. Wink
Pages 125-134
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- Arthur P. Grollman, Dmitry O. Zharkov
Pages 135-148
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- Lawrence Grossman, Genevieve Matanoski, Evan Farmer, Mohammad Hedyati, Sugita Ray, Bruce Trock et al.
Pages 149-167
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- Philip C. Hanawalt, Graciela Spivak
Pages 169-179
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- Ali E. Karakaya, Semra Sardas, Sema Burgaz
Pages 181-191
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- Kazimierz S. Kasprzak, Wojciech Bal, Dale W. Porter, Karol Bialkowski
Pages 193-208
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- Yoke W. Kow, Lois E. Rabow
Pages 209-219
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- Hans E. Krokan, Frank Skorpen, Marit Otterlei, Sangeeta Bharati, Kristin Steinsbekk, Hilde Nilsen et al.
Pages 221-236
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- Jacques Laval, Cécile Bauche, Juan Jurado, Franck Paillard, Murat Saparbaev, Olga Sidorkina
Pages 237-250
About this book
Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistence of human cells to DNA-damaging agents. This volume covers the most recent devlopments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology.
Editors and Affiliations
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National Institute of Standards and Technology, Gaithersburg, USA
Miral Dizdaroglu
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Gazi University, Ankara, Turkey
Ali Esat Karakaya