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Secondary-Metabolite Biosynthesis and Metabolism

  • Book
  • © 1992

Overview

Editors:
  1. Richard J. Petroski

    1. Agricultural Research Service, United States Department of Agriculture, Peoria, USA

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  2. Susan P. McCormick

    1. Agricultural Research Service, United States Department of Agriculture, Peoria, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Environmental Science Research (ESRH, volume 44)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xi
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  2. Antibiotics

    1. Front Matter

      Pages 1-1
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    2. Polyketide Synthases: Enzyme Complexes and Multifunctional Proteins Directing the Biosynthesis of Bacterial Metabolites from Fatty Acids

      • C. Richard Hutchinson, Heinrich Decker, Pat Guilfoile, Ben Shen, Richard Summers, Evelyn Wendt-Pienkowski et al.
      Pages 3-10

    3. Exploring the Intricate Details of Antibiotic Biosynthesis

      • Steven J. Gould
      Pages 11-25

    4. Intact Incorporation of Partially Assembled Intermediates into Acetate-Derived Polyketide Antibiotics

      • Zhe Li, Fionna M. Martin, Paul B. Reese, Yuko Yoshizawa, John C. Vederas
      Pages 27-39

    5. Biosynthetic Studies on Antibiotics

      • Kenneth L. Rinehart, William C. Snyder, Andrew L. Staley, Raymond C. M. Lau
      Pages 41-60

    6. Methylation Pathways in Antibiotic Producing Streptomycetes

      • Marilyn K. Speedie, James J. Zulty, Bonnie M. Fox, Kimberlee K. Wallace
      Pages 61-76

    7. Diversions of the Shikimate Pathway — The Biosynthesis of Cyclohexanecarboxylic Acid

      • H. G. Floss, H. Cho, R. Casati, K. A. Reynolds, E. Kennedy, B. S. Moore et al.
      Pages 77-88

    8. Investigations of the Biosynthesis of Aristeromycin

      • Ronald J. Parry
      Pages 89-104

    9. The Biosynthesis of Virginiamycins M1 and M2

      • David G. I. Kingston
      Pages 105-117

  3. Natural Toxins

    1. Front Matter

      Pages 119-119
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    2. The Biosynthesis of Nicotine and Related Alkaloids in Intact Plants, Isolated Plant Parts, Tissue Cultures, and Cell-Free Systems

      • Edward Leete
      Pages 121-139

    3. Examination of Tetrahydro- and Dihydrobisfuran Formation in Aflatoxin Biosynthesis: From Whole Cells to Purified Enzymes

      • Craig A. Townsend, Sean M. McGuire, Susan W. Brobst, Todd L. Graybill, Kollol Pal, Clifton E. Barry III
      Pages 141-154

  4. Herbicides, Phytoalexins and Microbial Metabolites

    1. Front Matter

      Pages 155-155
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    2. Microorganisms: A Remarkable Source of Diverse Chemical Structures for Herbicide Discovery

      • Barbara G. Isaac, Stephen W. Ayer, Richard J. Stonard
      Pages 157-187

    3. Induction of Secondary Metabolite-Phytoalexin Formation in Plant Cell Suspension Cultures

      • Peter Heinstein, Mark Horn, David Davis, Philip S. Low
      Pages 189-195

    4. Applications of Whole Cell Fungal Systems as Models of Mammalian Xenobiotic/Drug Metabolism

      • P. J. Davis, W. Yang, M. Hezari, J. Campos, C. G. Reddy
      Pages 197-207

    5. The Structural Analysis of the Components of Alginic Acid and the Effects of Their Metal Ion Complexation as Determined by NMR

      • John M. Beale Jr., Cora A. Steginsky, Blain M. Mamiya
      Pages 209-225

  5. Isoprenoid Pathway: Biosynthesis and Metabolism

    1. Front Matter

      Pages 227-227
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    2. Problems and Perspectives in the Study of Metabolic Turnover of Plant Secondary Metabolites

      • Charles Mihaliak, Jonathan Gershenzon, Rodney Croteau
      Pages 229-238
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Keywords

About this book

This book was developed from the proceedings of the American Chemical Society, Division of Agricultural & Food Chemistry, subdivision of Natural Products Symposium "Biosynthesis and Metabolism of Secondary Natural Products" held in Atlanta, Georgia, April 1991. The objective of the conference was to bring together people from apparently diverse fields, ranging from biotechnology, metabolism, mechanistic organic chemistry, enzymology, fermentation, and biosynthesis, but who share a common interest in either the biosynthesis or the metabolism of natural products. It is our intention to help bridge the gap between the fields of mechanistic bio-organic chemistry and biotechnology. Our thanks go to Dr. Henry Yokoyama, co-organizer of the symposium, the authors who so kindly contributed chapters, the conference participants, and to those who assisted in the peer review process. We also thank the financial supporters of the symposium: ACS/AGFD, NIH General Medical Sciences, and the agricultural, pharmaceutical, biotechnology, and chromatography companies. A full list of the supporting corporations and institutions is given on the following page. Pharma-Tech and P.C., Inc. are manufacturers of instrumentation for high-speed countercurrent chromatography. We thank the Agricultural Research Service and the U. S. Department of Agriculture for granting me permission to co-organize the conference and for us to complete the book. Richard J. Petroski Susan P. McCormick USDA, ARS, National Center for Agricultural Utilization Research Peoria, IL 61604 June 10, 1992 vii CONTENTS ANTIBIOTICS Polyketide Synthetases: Enzyme Complexes and Multifunctional Proteins Directing the Biosynthesis of Bacterial Metabolites from Fatty Acids. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 . . . . . . . . . . .

Editors and Affiliations

  • Agricultural Research Service, United States Department of Agriculture, Peoria, USA

    Richard J. Petroski, Susan P. McCormick

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