Abstract
Study of the bioconversion of primary metabolites to antibiotics can provide a diverse array of novel information. The usual approach is to determine the pathway of carbon during the bioconversion and propose intermediates for further study. However, investigations employing multi-labeled intermediates (e.g., [13C6]glucose) can also provide information on the intermediary metabolism of the producing organism. Moreover, the organism can produce novel (often unrelated) antibiotics or other metabolites of structural interest during the biosynthetic fermentation.
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Rinehart, K.L., Snyder, W.C., Staley, A.L., Lau, R.C.M. (1992). Biosynthetic Studies on Antibiotics. In: Petroski, R.J., McCormick, S.P. (eds) Secondary-Metabolite Biosynthesis and Metabolism. Environmental Science Research, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3012-1_4
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DOI: https://doi.org/10.1007/978-1-4615-3012-1_4
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