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Molecular Basis of Pancreas Development and Function

  • Joel F. Habener
  • Mehboob A. Hussain

Part of the Endocrine Updates book series (ENDO, volume 11)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ole D. Madsen, Palle Serup, Jan Jensen, Helle V. Petersen, R. Scott Heller
    Pages 1-17
  3. R. Paul Robertson, Jamie Harmon, Yoshito Tananka, Giovanni Sacchi, Phuong Oanh T. Tran, Catherine Gleason et al.
    Pages 47-66
  4. Susumu Seino, Takashi Miki, Hideki Yano
    Pages 91-107
  5. Paolo Meda, Domenico Bosco
    Pages 143-163
  6. Raphael Scharfmann, Paul Czernichow
    Pages 165-175
  7. Thomas S. Maldonado, Christopher A. Crisera, Alan S. Kadison, Michael T. Longaker, George K. Gittes
    Pages 177-195
  8. Ulf Ahlgren, Helena Edlund
    Pages 197-212
  9. Jan Jensen, Luis Emilio Flores, R. Scott Heller, Palle Serup, Ole D. Madsen
    Pages 213-227
  10. Xunlei Zhou, Peter Gruss
    Pages 239-254
  11. Kevin Gerrish, Susan Samaras, Michelle A. Cissell, Christopher V.E. Wright, Roland Stein
    Pages 275-287
  12. Susan Bonner-Weir, Gordon C. Weir
    Pages 289-297
  13. Rohit N. Kulkarni, C. Ronald Kahn
    Pages 299-323
  14. Julie C. Evans, Timothy M. Frayling, Andrew T. Hattersley
    Pages 325-336
  15. Bernard Thorens
    Pages 337-350
  16. Alberto Hayek, Gillian M. Beattie, Fred Levine
    Pages 373-400
  17. Back Matter
    Pages 401-412

About this book

Introduction

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.

Keywords

Pancreas Pancreatic Islets biology diabetes diabetes mellitus growth growth factor homeostasis hormone insulin insulin resistance pathophysiology physiology protein

Editors and affiliations

  • Joel F. Habener
    • 1
  • Mehboob A. Hussain
    • 2
  1. 1.Laboratory of Molecular Endocrinology, Howard Hughes Medical InstituteMassachusetts General HospitalBoston
  2. 2.Department of Medicine, Clinical and Molecular EndocrinologyNew York University Medical CenterNew York

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1669-9
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5669-1
  • Online ISBN 978-1-4615-1669-9
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site