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The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis

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Molecular Basis of Pancreas Development and Function

Part of the book series: Endocrine Updates ((ENDO,volume 11))

Abstract

The Hepatocyte Nuclear Factors Hepatocyte nuclear factors are a diverse class of transcription factors that were originally identified through their interaction with essential sequences for tissue-specific transcription of liver specific genes. These factors contain DNA-binding domains that have been conserved throughout evolution. Based on the structure of their functional domains, liver-enrichedtranscriptionfactors have been classified into six families. These include HNF-1 [HNF-1α and HNF-1β (vHNF-1)] genes, members of the homeodomaincontaining transcription factors; CCAAT/enhancer binding proteins (C/EBPs) that are basic leucine-zipper transcription factors; the winged helix proteins HNF-3 [HNF-3α, HNF-3β and HNF-γ], members of the HNF-3/forkhead(bZip) transcription factor family; the zinc finger orphan receptor HNF-4 family [HNF-4α and HNF-4β]; D-binding protein [DBP], a member of the proline acid-rich (PAR) subfamily of bZip transcription factors; and HNF-6, which contains two different DNA binding domains, a cut domain and a novel type of homeodomain.

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Authors and Affiliations

  1. The Rockefeller University, New York, NY, 10021, USA

    Markus Stoffel M.D., Ph.D.

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  1. Markus Stoffel M.D., Ph.D.
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  1. Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA

    Joel F. Habener M.D.

  2. Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York, NY

    Mehboob A. Hussain M.D.

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Stoffel, M. (2001). The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis. In: Habener, J.F., Hussain, M.A. (eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1669-9_15

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  • DOI: https://doi.org/10.1007/978-1-4615-1669-9_15

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