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Oncologic Impact of Anastomotic Leakage Following Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Anastomotic leakage (AL) is a major complication of surgery for colorectal cancer (CRC), and is associated with increased morbidity and mortality; However, there are conflicting results on the impact of AL on long-term oncologic outcomes.

Objective

The aim of this meta-analysis was to assess the oncologic outcomes of AL following restorative surgery for CRC.

Methods

Multiple comprehensive databases, including PubMed, EMBASE, and The Cochrane Library, were searched for studies that assessed the oncologic effects of AL following surgery for CRC. The included studies evaluated local and distant recurrence, overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Outcome data were pooled, and overall effect size was calculated using random effects models.

Results

Thirty-four nonrandomized studies including 78,434 patients met the inclusion criteria. The results show that AL was associated with increased local recurrence (relative risk [RR] 1.90, 95% confidence interval [CI] 1.48–2.44, I 2 = 78%) and reduced OS (RR 1.36, 95% CI 1.24–1.50, I 2 = 74%), CSS (RR 1.41, 95% CI 1.19–1.68, I 2 = 56%), and DFS (RR 1.40, 95% CI 1.20–1.63, I 2 = 86%). AL had no significant effect on distant recurrence (RR 1.20, 95% CI 0.94–1.53, I 2 = 61%).

Conclusions

AL after restorative surgery for CRC is associated with increased local recurrence and reduced long-term survival, including OS, CSS, and DFS.

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Disclosure

Gi Won Ha, Jong Hun Kim, and Min Ro Lee have no conflicts of interest to declare.

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Authors and Affiliations

  1. Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea

    Gi Won Ha MD, PhD, Jong Hun Kim MD, PhD & Min Ro Lee MD, PhD

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  1. Gi Won Ha MD, PhD
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Correspondence to Min Ro Lee MD, PhD.

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Ha, G.W., Kim, J.H. & Lee, M.R. Oncologic Impact of Anastomotic Leakage Following Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis. Ann Surg Oncol 24, 3289–3299 (2017). https://doi.org/10.1245/s10434-017-5881-8

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