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Therapeutic Potential of Nanocarrier Mediated Delivery of Peptides for Wound Healing: Current Status, Challenges and Future Prospective

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Abstract

Wound healing presents a complex physiological process that involves a sequence of events orchestrated by various cellular and molecular mechanisms. In recent years, there has been growing interest in leveraging nanomaterials and peptides to enhance wound healing outcomes. Nanocarriers offer unique properties such as high surface area-to-volume ratio, tunable physicochemical characteristics, and the ability to deliver therapeutic agents in a controlled manner. Similarly, peptides, with their diverse biological activities and low immunogenicity, hold great promise as therapeutics in wound healing applications. In this review, authors explore the potential of peptides as bioactive components in wound healing formulations, focusing on their antimicrobial, anti-inflammatory, and pro-regenerative properties. Despite the significant progress made in this field, several challenges remain, including the need for standardized characterization methods, optimization of biocompatibility and safety profiles, and translation from bench to bedside. Furthermore, developing multifunctional nanomaterial-peptide hybrid systems represents promising avenues for future research. Overall, the integration of nanomaterials made up of natural or synthetic polymers with peptide-based formulations holds tremendous therapeutic potential in advancing the field of wound healing and improving clinical outcomes for patients with acute and chronic wounds.

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Acknowledgements

The authors would like to thank the Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, India, for providing the research facilities. The authors also thank the Indian Council of Medical Research, New Delhi, India.

Funding

Research grant (5/8–4/5/Env/2020-NCD-II Dated 22/12/2021) Under Indian Council of Medical Research (ICMR), New Delhi, India.

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  1. Mohit Kumar and Dikshant Kumar contributed equally to this work.

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  1. Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India

    Mohit Kumar, Dikshant Kumar, Devesh Kumar, Yogesh Garg, Shruti Chopra & Amit Bhatia

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  1. Mohit Kumar
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  2. Dikshant Kumar
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  3. Devesh Kumar
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Contributions

Dikshant and Mohit Kumar: Writing-Original draft preparation, collecting information, methodology, Devesh Kumar and Yogesh Garg: Conceptualization, collecting information, revising draft, Amit Bhatia and Shruti Chopra: Revising draft, finalizing the manuscript.

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Correspondence to Amit Bhatia.

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Kumar, M., Kumar, D., Kumar, D. et al. Therapeutic Potential of Nanocarrier Mediated Delivery of Peptides for Wound Healing: Current Status, Challenges and Future Prospective. AAPS PharmSciTech 25, 108 (2024). https://doi.org/10.1208/s12249-024-02827-5

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