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Ketoprofen–FA Co-crystal: In Vitro and In Vivo Investigation for the Solubility Enhancement of Drug by Design of Expert

  • Research Article
  • Theme: Advancements in Modified-release Oral Drug Delivery - Delivery throughout the Gastro-intestinal Tract
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Abstract

The present piece of research work is framed for improving the solubility of ketoprofen by forming co-crystal using fumaric acid as a coformer. Co-crystal of ketoprofen and fumaric acid was prepared by simple solvent-assisted grinding method, containing drug and coformer as independent variables and solubility and % drug release were assumed to be dependent variables. Differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, nuclear magnetic resonance and scanning electron microscopy techniques were used to characterize the preparation of optimized batch of co-crystal and further, evaluated for in vitro and in vivo anti-inflammatory and analgesic activities. Based on results of solubility and dissolution rate studies the formulation showed magnified improvement in both the properties on co-crystallization. The values of Gibbs free energy are negative at all levels of carrier demonstrating spontaneity of the drug solubilization process. The IC50 value of optimized batch of co-crystal formulation and the pure drug was observed as 327.33 μg/ml and 556.11 μg/ml, respectively, demonstrating that co-crystal formulation possesses more percentage protection against protein denaturation than the drug ketoprofen. In vivo (anti-inflammatory and analgesic) activities revealed that optimized batch of co-crystal formulation delivered a rapid pharmacological response in Wistar rats and albino mice when compared with standard drug.

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Authors and Affiliations

  1. Departmental of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India

    Sunita Devi, Ashwani Kumar, Archana Kapoor & Meenakshi Bhatia

  2. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India

    Sunita Devi

  3. Departmental of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India

    Vikas Verma

  4. Departmental of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, India

    Snehlata Yadav

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  1. Sunita Devi
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  2. Ashwani Kumar
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  4. Vikas Verma
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  6. Meenakshi Bhatia
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Contributions

Sunita Devi contributed to conceptualization and writing—original draft preparation; Meenakshi Bhatia contributed to conceptualization and supervision; Ashwini Kumar contributed to review & editing and software; Vikas Verma contributed to writing—review & editing; Snehlata Yadav contributed to review & editing and data curation.

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Correspondence to Sunita Devi or Meenakshi Bhatia.

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This investigation is approved by IAEC, Guru Jambheshwar University of Science and Technology, Hisar, India, under CPCSEA reg. no-IAEC/2021/10–19.

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Theme: Advancements in Modified-release Oral Drug Delivery - Delivery throughout the Gastro-intestinal Tract

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Devi, S., Kumar, A., Kapoor, A. et al. Ketoprofen–FA Co-crystal: In Vitro and In Vivo Investigation for the Solubility Enhancement of Drug by Design of Expert. AAPS PharmSciTech 23, 101 (2022). https://doi.org/10.1208/s12249-022-02253-5

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