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Controlled block copolymer micelle formation for encapsulation of hydrophobic ingredients

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Abstract

We report on the formation of polymeric micelles in water using triblock copolymers with a polyethylene glycol middle block and various hydrophobic outer blocks prepared with the precipitation method. We form micelles in a reproducible manner with a narrow size distribution. This suggests that during the formation of the micelles the system had time to form micelles under close-to-thermodynamic control. This may explain why it is possible to use an equilibrium self-consistent field theory to predict the hydrodynamic size and the loading capacity of the micelles in accordance with experimental finding. Yet, the micelles are structurally quenched as concluded from the observation of size stability in time. We demonstrate that our approach enables to prepare rather hydrophobic block copolymer micelles with tunable size and loading.

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Authors and Affiliations

  1. DSM Biomedical, P.O. Box 18, 6160 MD, Geleen, The Netherlands

    Jérôme G. J. L. Lebouille & Aylvin A. Dias

  2. Advanced Chemical Engineering Solutions (ACES), DSM ChemTech, P.O. Box 18, 6160 MD, Geleen, The Netherlands

    Jérôme G. J. L. Lebouille, Leo F. W. Vleugels & Remco Tuinier

  3. DSM Ahead, P.O.Box 18, 6160 MD, Geleen, The Netherlands

    Aylvin A. Dias

  4. Laboratory of Physical Chemistry and Colloid Science, Wageningen University, Dreijenplein 6, 6307 HB, Wageningen, The Netherlands

    Frans A. M. Leermakers & Martien A. Cohen Stuart

  5. Van ’t Hoff Laboratory for Physical and Colloid Chemistry, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    Remco Tuinier

Authors
  1. Jérôme G. J. L. Lebouille
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  2. Leo F. W. Vleugels
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  3. Aylvin A. Dias
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  4. Frans A. M. Leermakers
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  5. Martien A. Cohen Stuart
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  6. Remco Tuinier
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Correspondence to Remco Tuinier.

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Lebouille, J.G.J.L., Vleugels, L.F.W., Dias, A.A. et al. Controlled block copolymer micelle formation for encapsulation of hydrophobic ingredients. Eur. Phys. J. E 36, 107 (2013). https://doi.org/10.1140/epje/i2013-13107-y

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  • DOI: https://doi.org/10.1140/epje/i2013-13107-y

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