Abstract
Complete nucleotide sequences of the mitochondrial DNA of Wistar rats and premature aging rats OXYS, sensitive to cataractogenic effect of galactose, from the Center for collective usage «Gene pool of laboratory animals» of the Institute of Cytology and Genetics (ICG), Siberian Branch, Russian Academy of Sciences, were investigated (nucleotide sequences were submitted to GenBank). It was shown that two additional unique nucleotide substitutions between rats OXYS (ICG) and Wistar (ICG) are not found in other known nucleotide sequences of mitochondrial DNA of rats and do not result in amino acid substitutions, so that all differences in phenotypic data of these lines are determined only by differences in the genomic DNA. Comparative analysis showed that Wistar (ICG) rats have a significant number of nucleotide substitutions compared to rat strains derived from outbred rat Wistar colony, which contradicts possible relationship of Wistar (ICG) rats to baseline Wistar rat line or its descendants. It was assumed that the Sprague Dawley rat line is the progenitor of Wistar (ICG) rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bobko, A.A., Sergeeva, S.V., Bagryanskaya, E.G., Markel, A.L., Khramtsov, V.V., Reznikov, V.A., and Kolosova, N.G., 19F NMR measurements of NO production in hypertensive ISIAH and OXYS rats, Biochem. Biophys. Res. Commun., 2005, vol. 330, no. 2, pp. 367–370.
Bolon, B., Stolina, M., King, S., Gasser, J., Zack, D., and Feige, U., Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy, J. Biomed. Biotech., 2011. doi: 10.1155/2011/569068
Brandon, M.C., Lott, M.T., Nguyen, K.C., Spolim, S., Navathe, S.B., Baldi, P., and Wallace, D.C., MITOMAP: a human mitochondrial genome database-2004 update, Nucleic Acids Res., 2005, vol. 33, pp. 611–613.
Canzian, F., Phylogenetics of the laboratory rat Rattus norvegicus, Genome Res., 1997, vol. 7, pp. 262–267.
Felsenstein, J., Confidence limits on phylogenies: an approach using the bootstrap, Evolution, 1985, vol. 39, pp. 783–791.
Hedrich, H.J., Genetic Monitoring of Inbred Strains of Rat, New York: Fischer, 1990.
Kolosova, N.G., Aidagulova, S.V., and Nepomnyashchikh, G.I., Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats, Bull. Exp. Biol. Med., 2001, vol. 132, no. 2, pp. 814–819.
Kolosova, N.G., Lebedev, P.A., Aidagulova, S.V., and Morozkova, T.S., OXYS rats as a model of senile cataract, Bull. Exp. Biol. Med., 2003a, vol. 136, no. 4, pp. 415–419.
Kolosova, N.G., Lebedev, P.A., Fursova, A.Zh., Morozkova, T.S., and Gusarevich, O.G., Senescence-accelerated OXYS rats as a model of human senile cataract, Usp. Gerontol., 2003b, vol. 12, pp. 143–148.
Kolosova, N.G., Stefanova, N.A., and Sergeeva, S.V., OXYS rats: a prospective model for evaluation of antioxidant availability in prevention and therapy of accelerated aging and age-related cognitive decline, in Handbook of Cognitive Aging: Causes, Processes, Gariepy, Q. and Menard, R., Eds., New York: Nova Sci. Publ., 2009, pp. 47–82.
Kolosova, N.G., Muraleva, N.A., Stefanova, N.A., Fursova, A.Z., Zhdankina, A.A., and Blagosklonny, M.V., Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats, Am. J. Pathol., 2012a, vol. 181, pp. 472–477.
Kolosova, N.G., Stefanova, N.A., Muraleva, N.A., and Skulachev, V.P., The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats, Aging (Albany NY), 2012b, vol. 4, no. 10, pp. 686–694.
Kozhevnikova, O.S., Korbolina, E.E., Ershov, N.I., and Kolosova, N.G., Rat retinal transcriptome: effects of aging and AMD-like retinopathy, Cell Cycle, 2013, vol. 12, pp. 1745–1761.
Krinke, G.J., The Handbook of Experimental Animals: The Laboratory Rat, Bullock, G. and Bunton, T.E., Eds., New York: Academic Press, 2000.
Markovets, A.M., Fursova, A.Z., and Kolosova, N.G., Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression, PloS One, 2011a, vol. 6, p. e21682.
Markovets, A.M., Saprunova, V.B., Zhdankina, A.A., et al., Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats, Aging (Albany NY), 2011b, vol. 3, no. 1, pp. 44–54.
Muraleva, N.A., Ofitserov, E.N., Tikhonov, V.P., and Kolosova, N.G., Efficacy of glucosamine alendronate alone and in combination with dihydroquercetin for treatment of osteoporosis in animal model, Indian J. Med. Res., 2012, vol. 135, pp. 221–227.
Schlick, N.E., Jensen-Seaman, M.I., Orlebeke, K., et al., Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains, Am. J. Physiol. Cell Physiol., 2006, vol. 291, pp. 1183–1192.
Sergeeva, S., Bagryanskaya, E., Korbolina, E., and Kolosova, N., Development of behavioral dysfunctions in accelerated-senescence OXYS rats is associated with early postnatal alterations in brain phosphate metabolism, Exp. Gerontol., 2006, vol. 41, pp. 141–150.
Shabalina, I.G., Kolosova, N.G., Grishanova, A.Yu., Solov’eva, N.A., Solov’ev, V.N., and Salganik, R.I., Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation, Biokhimiya, 1995, vol. 66, no. 12, pp. 2045–2052.
Sharpe, P.E. and La Regina, M.C., The laboratory rat, Suckhow, M.A., Ed., New York: CRC Press, 2000, pp. 1–2.
Solov’eva, N.A., Morozkova, T.S., and Salganik, R.I., Development of a rat subline with symptoms of hereditary galactosemia and study of its biochemical characteristics, Genetika, 1975, no. 5, pp. 63–71.
Stefanova, N.A., Kozhevnikova, O.S., Vitovtov, A.O., Maksimova, K.Y., Logvinov, S.V., Rudnitskaya, E.A., Korbolina, E.E., Muraleva, N.A., and Kolosova, N.G., Senescence-accelerated oxys rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease, Cell Cycle, 2014a, vol. 15, pp. 898–909.
Stefanova, N.A., Muraleva, N.A., Skulachev, V.P., and Kolosova, N.G., Alzheimer’s disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1, J. Alzheimer’s Dis., 2014b, vol. 38, pp. 681–694.
Tamura, K., Dudley, J., Nei, M., and Kumar, S., MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0, Mol. Biol. Evol., 2007, vol. 24, pp. 1596–1599.
Thompson, J.D., Higgins, D.G., and Gibson, T.J., CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res., 1994, vol. 22, pp. 4673–4680.
Vays, V.B., Eldarov, C.M., Vangely, I.M., Kolosova, N.G., Bakeeva, L.E., and Skulachev, V.P., Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure, Aging (Albany, New York), 2014, vol. 6, pp. 140–148.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © R.A. Maksyutov, E.V. Gavrilova, T.S. Nepomniashchikh, U.N. Rotskaya, P.S. Loshchenova, N.G. Kolosova, O.I. Sinitsyna, S.N. Shchelkunov, 2014, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2014, Vol. 18, No. 3, pp. 437–445.
Rights and permissions
About this article
Cite this article
Maksyutov, R.A., Gavrilova, E.V., Nepomniashchikh, T.S. et al. Comparative analysis of the complete nucleotide sequences of mitochondrial DNA of rat strains Wistar and oxys of the institute of cytology and genetics, Siberian Branch, Russian Academy of Sciences. Russ J Genet Appl Res 5, 1–7 (2015). https://doi.org/10.1134/S2079059715010062
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079059715010062